LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4H7B4_LEIBR
TriTrypDb:
LbrM.13.1080 , LBRM2903_130017300 *
Length:
421

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 7, no: 5
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4H7B4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7B4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 223 227 PF00656 0.338
CLV_NRD_NRD_1 20 22 PF00675 0.418
CLV_PCSK_FUR_1 18 22 PF00082 0.367
CLV_PCSK_KEX2_1 18 20 PF00082 0.394
CLV_PCSK_SKI1_1 21 25 PF00082 0.211
CLV_PCSK_SKI1_1 332 336 PF00082 0.395
CLV_PCSK_SKI1_1 338 342 PF00082 0.395
CLV_PCSK_SKI1_1 344 348 PF00082 0.380
DOC_MAPK_gen_1 18 27 PF00069 0.539
DOC_MAPK_JIP1_4 21 27 PF00069 0.417
DOC_MAPK_MEF2A_6 18 27 PF00069 0.539
DOC_PP4_FxxP_1 172 175 PF00568 0.301
DOC_PP4_FxxP_1 54 57 PF00568 0.438
DOC_USP7_MATH_1 131 135 PF00917 0.245
DOC_USP7_MATH_1 178 182 PF00917 0.275
DOC_USP7_MATH_1 198 202 PF00917 0.259
DOC_USP7_MATH_1 267 271 PF00917 0.440
DOC_USP7_MATH_1 394 398 PF00917 0.614
DOC_USP7_MATH_1 57 61 PF00917 0.428
DOC_WW_Pin1_4 174 179 PF00397 0.302
LIG_14-3-3_CanoR_1 145 153 PF00244 0.361
LIG_14-3-3_CanoR_1 20 26 PF00244 0.411
LIG_ActinCP_TwfCPI_2 54 63 PF01115 0.384
LIG_BIR_II_1 1 5 PF00653 0.605
LIG_BRCT_BRCA1_1 205 209 PF00533 0.301
LIG_EH1_1 291 299 PF00400 0.290
LIG_FHA_1 194 200 PF00498 0.355
LIG_FHA_1 22 28 PF00498 0.263
LIG_FHA_1 329 335 PF00498 0.597
LIG_FHA_1 50 56 PF00498 0.319
LIG_FHA_1 80 86 PF00498 0.309
LIG_FHA_2 221 227 PF00498 0.338
LIG_GBD_Chelix_1 27 35 PF00786 0.299
LIG_IRF3_LxIS_1 153 160 PF10401 0.301
LIG_LIR_Apic_2 52 57 PF02991 0.441
LIG_LIR_Gen_1 100 108 PF02991 0.329
LIG_LIR_Gen_1 239 244 PF02991 0.379
LIG_LIR_Gen_1 286 297 PF02991 0.265
LIG_LIR_Nem_3 100 106 PF02991 0.295
LIG_LIR_Nem_3 134 138 PF02991 0.328
LIG_LIR_Nem_3 234 238 PF02991 0.444
LIG_LIR_Nem_3 239 243 PF02991 0.468
LIG_LIR_Nem_3 286 292 PF02991 0.296
LIG_NRBOX 30 36 PF00104 0.367
LIG_Pex14_1 288 292 PF04695 0.387
LIG_Pex14_2 135 139 PF04695 0.301
LIG_Pex14_2 189 193 PF04695 0.329
LIG_Rb_LxCxE_1 65 82 PF01857 0.252
LIG_SH2_CRK 103 107 PF00017 0.331
LIG_SH2_PTP2 47 50 PF00017 0.293
LIG_SH2_SRC 47 50 PF00017 0.364
LIG_SH2_STAP1 103 107 PF00017 0.211
LIG_SH2_STAT3 183 186 PF00017 0.324
LIG_SH2_STAT3 275 278 PF00017 0.409
LIG_SH2_STAT5 105 108 PF00017 0.301
LIG_SH2_STAT5 158 161 PF00017 0.260
LIG_SH2_STAT5 171 174 PF00017 0.265
LIG_SH2_STAT5 41 44 PF00017 0.461
LIG_SH2_STAT5 47 50 PF00017 0.436
LIG_SH2_STAT5 76 79 PF00017 0.365
LIG_SH3_3 150 156 PF00018 0.301
LIG_SH3_3 172 178 PF00018 0.307
LIG_SH3_3 358 364 PF00018 0.621
LIG_SUMO_SIM_par_1 21 26 PF11976 0.570
LIG_SUMO_SIM_par_1 30 36 PF11976 0.343
LIG_TRAF2_1 327 330 PF00917 0.717
LIG_TRFH_1 171 175 PF08558 0.211
LIG_Vh1_VBS_1 291 309 PF01044 0.222
LIG_WRC_WIRS_1 51 56 PF05994 0.377
MOD_CK1_1 222 228 PF00069 0.350
MOD_CK1_1 339 345 PF00069 0.716
MOD_CK1_1 351 357 PF00069 0.814
MOD_CK1_1 414 420 PF00069 0.662
MOD_GlcNHglycan 128 131 PF01048 0.531
MOD_GlcNHglycan 205 208 PF01048 0.487
MOD_GlcNHglycan 229 232 PF01048 0.656
MOD_GlcNHglycan 240 243 PF01048 0.668
MOD_GlcNHglycan 58 62 PF01048 0.622
MOD_GSK3_1 174 181 PF00069 0.290
MOD_GSK3_1 218 225 PF00069 0.350
MOD_GSK3_1 227 234 PF00069 0.400
MOD_GSK3_1 279 286 PF00069 0.448
MOD_GSK3_1 328 335 PF00069 0.747
MOD_GSK3_1 336 343 PF00069 0.727
MOD_GSK3_1 344 351 PF00069 0.749
MOD_N-GLC_1 193 198 PF02516 0.501
MOD_N-GLC_1 244 249 PF02516 0.681
MOD_N-GLC_1 370 375 PF02516 0.598
MOD_NEK2_1 106 111 PF00069 0.256
MOD_NEK2_1 157 162 PF00069 0.301
MOD_NEK2_1 238 243 PF00069 0.434
MOD_NEK2_1 340 345 PF00069 0.716
MOD_NEK2_2 178 183 PF00069 0.231
MOD_PIKK_1 198 204 PF00454 0.287
MOD_PIKK_1 254 260 PF00454 0.409
MOD_PIKK_1 344 350 PF00454 0.748
MOD_PIKK_1 394 400 PF00454 0.679
MOD_PKA_2 144 150 PF00069 0.361
MOD_PKA_2 203 209 PF00069 0.297
MOD_PKA_2 414 420 PF00069 0.633
MOD_PKB_1 19 27 PF00069 0.411
MOD_Plk_1 219 225 PF00069 0.329
MOD_Plk_1 357 363 PF00069 0.621
MOD_Plk_1 411 417 PF00069 0.636
MOD_Plk_2-3 220 226 PF00069 0.301
MOD_Plk_4 162 168 PF00069 0.354
MOD_Plk_4 178 184 PF00069 0.255
MOD_Plk_4 188 194 PF00069 0.275
MOD_Plk_4 283 289 PF00069 0.343
MOD_Plk_4 336 342 PF00069 0.721
MOD_Plk_4 50 56 PF00069 0.386
MOD_ProDKin_1 174 180 PF00069 0.302
MOD_SUMO_rev_2 220 230 PF00179 0.287
MOD_SUMO_rev_2 325 334 PF00179 0.648
TRG_DiLeu_BaLyEn_6 111 116 PF01217 0.211
TRG_DiLeu_BaLyEn_6 64 69 PF01217 0.245
TRG_ENDOCYTIC_2 103 106 PF00928 0.329
TRG_ENDOCYTIC_2 235 238 PF00928 0.461
TRG_ENDOCYTIC_2 47 50 PF00928 0.416
TRG_ER_diArg_1 18 21 PF00400 0.627
TRG_Pf-PMV_PEXEL_1 67 71 PF00026 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY91 Leptomonas seymouri 34% 100%
A0A0N1PG18 Leptomonas seymouri 47% 94%
A0A3S5H587 Leishmania donovani 34% 100%
A0A3S5H6P8 Leishmania donovani 69% 100%
A4H3U3 Leishmania braziliensis 33% 100%
A4HS17 Leishmania infantum 34% 100%
A4HVQ9 Leishmania infantum 69% 100%
E9AK04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9APF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
Q4QG23 Leishmania major 67% 100%
Q9XZY2 Leishmania major 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS