GPN-loop GTPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GPN-loop GTPase

Gene product:

XPA-interacting protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7B1_LEIBR

TriTrypDb:

LbrM.13.1050 , LBRM2903_130017000

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H7B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7B1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.535
CLV_PCSK_SKI1_1	236	240	PF00082	0.307
CLV_PCSK_SKI1_1	297	301	PF00082	0.555
CLV_PCSK_SKI1_1	95	99	PF00082	0.201
DOC_CKS1_1	103	108	PF01111	0.449
DOC_MAPK_DCC_7	162	170	PF00069	0.510
DOC_MAPK_HePTP_8	159	171	PF00069	0.449
DOC_MAPK_MEF2A_6	162	171	PF00069	0.449
DOC_USP7_MATH_1	232	236	PF00917	0.554
DOC_USP7_MATH_1	269	273	PF00917	0.465
DOC_WW_Pin1_4	102	107	PF00397	0.439
DOC_WW_Pin1_4	142	147	PF00397	0.492
DOC_WW_Pin1_4	42	47	PF00397	0.525
LIG_14-3-3_CanoR_1	141	146	PF00244	0.510
LIG_EH1_1	85	93	PF00400	0.451
LIG_FHA_1	129	135	PF00498	0.446
LIG_FHA_1	14	20	PF00498	0.391
LIG_FHA_1	172	178	PF00498	0.468
LIG_HP1_1	2	6	PF01393	0.331
LIG_LIR_Gen_1	261	271	PF02991	0.510
LIG_LIR_Gen_1	33	42	PF02991	0.478
LIG_LIR_Gen_1	99	106	PF02991	0.448
LIG_LIR_Nem_3	123	128	PF02991	0.501
LIG_LIR_Nem_3	261	266	PF02991	0.510
LIG_LIR_Nem_3	33	38	PF02991	0.478
LIG_LIR_Nem_3	56	62	PF02991	0.449
LIG_LIR_Nem_3	99	103	PF02991	0.448
LIG_LRP6_Inhibitor_1	26	32	PF00058	0.320
LIG_Pex14_2	125	129	PF04695	0.512
LIG_Pex14_2	258	262	PF04695	0.460
LIG_SH2_CRK	268	272	PF00017	0.535
LIG_SH2_NCK_1	25	29	PF00017	0.493
LIG_SH2_NCK_1	268	272	PF00017	0.499
LIG_SH2_SRC	25	28	PF00017	0.493
LIG_SH2_STAT5	34	37	PF00017	0.449
LIG_SH3_3	100	106	PF00018	0.460
LIG_SH3_3	140	146	PF00018	0.535
LIG_SH3_3	193	199	PF00018	0.535
LIG_SUMO_SIM_par_1	87	93	PF11976	0.490
LIG_TRFH_1	66	70	PF08558	0.460
LIG_TYR_ITIM	266	271	PF00017	0.535
LIG_TYR_ITIM	57	62	PF00017	0.449
MOD_CK1_1	145	151	PF00069	0.474
MOD_CK1_1	178	184	PF00069	0.527
MOD_CK1_1	205	211	PF00069	0.554
MOD_CK1_1	272	278	PF00069	0.482
MOD_CK1_1	30	36	PF00069	0.373
MOD_CK2_1	87	93	PF00069	0.471
MOD_GlcNHglycan	114	117	PF01048	0.249
MOD_GlcNHglycan	156	159	PF01048	0.335
MOD_GlcNHglycan	177	180	PF01048	0.335
MOD_GlcNHglycan	209	212	PF01048	0.328
MOD_GlcNHglycan	271	274	PF01048	0.246
MOD_GSK3_1	10	17	PF00069	0.399
MOD_GSK3_1	110	117	PF00069	0.443
MOD_GSK3_1	141	148	PF00069	0.511
MOD_GSK3_1	149	156	PF00069	0.462
MOD_GSK3_1	171	178	PF00069	0.460
MOD_GSK3_1	239	246	PF00069	0.468
MOD_N-GLC_1	171	176	PF02516	0.249
MOD_N-GLC_1	202	207	PF02516	0.341
MOD_NEK2_1	10	15	PF00069	0.460
MOD_NEK2_1	112	117	PF00069	0.449
MOD_NEK2_1	149	154	PF00069	0.441
MOD_NEK2_1	239	244	PF00069	0.475
MOD_NEK2_1	251	256	PF00069	0.438
MOD_NEK2_1	80	85	PF00069	0.449
MOD_PIKK_1	239	245	PF00454	0.518
MOD_PKA_2	205	211	PF00069	0.546
MOD_PKA_2	53	59	PF00069	0.449
MOD_Plk_4	128	134	PF00069	0.450
MOD_Plk_4	14	20	PF00069	0.460
MOD_Plk_4	145	151	PF00069	0.405
MOD_Plk_4	178	184	PF00069	0.480
MOD_Plk_4	253	259	PF00069	0.480
MOD_Plk_4	87	93	PF00069	0.535
MOD_ProDKin_1	102	108	PF00069	0.439
MOD_ProDKin_1	142	148	PF00069	0.492
MOD_ProDKin_1	42	48	PF00069	0.525
MOD_SUMO_rev_2	90	97	PF00179	0.493
TRG_ENDOCYTIC_2	263	266	PF00928	0.449
TRG_ENDOCYTIC_2	268	271	PF00928	0.449
TRG_ENDOCYTIC_2	59	62	PF00928	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y6	Leptomonas seymouri	79%	92%
A0A0N1PCL7	Leptomonas seymouri	27%	100%
A0A0S4IST9	Bodo saltans	49%	88%
A0A1X0NNH8	Trypanosomatidae	56%	100%
A0A3R7KPX1	Trypanosoma rangeli	59%	100%
A0A3S7WSM7	Leishmania donovani	89%	93%
A0A3S7WZ40	Leishmania donovani	29%	100%
A0A422NVI7	Trypanosoma rangeli	26%	93%
A4FUD1	Bos taurus	43%	81%
A4HVQ6	Leishmania infantum	89%	93%
A4I1I3	Leishmania infantum	29%	100%
D0A6I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9APF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	93%
E9AXL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AY30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	93%
O42906	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	83%
P46577	Caenorhabditis elegans	39%	85%
P47122	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	79%
Q4Q9E3	Leishmania major	26%	93%
Q4Q9V4	Leishmania major	28%	100%
Q4QG26	Leishmania major	89%	100%
Q54C25	Dictyostelium discoideum	41%	77%
Q6CBB5	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
Q8VCE2	Mus musculus	42%	81%
Q8W586	Arabidopsis thaliana	44%	80%
Q9HCN4	Homo sapiens	43%	81%
V5A2Y8	Trypanosoma cruzi	61%	91%
V5DR44	Trypanosoma cruzi	27%	93%