DNA/RNA non-specific endonuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA/RNA non-specific endonuclease-like protein

Species:

Leishmania braziliensis

UniProt:

A4H7B0_LEIBR

TriTrypDb:

LbrM.13.1040 , LBRM2903_130016900

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H7B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7B0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	6
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0004540	RNA nuclease activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.731
CLV_NRD_NRD_1	227	229	PF00675	0.754
CLV_NRD_NRD_1	396	398	PF00675	0.614
CLV_NRD_NRD_1	415	417	PF00675	0.411
CLV_NRD_NRD_1	46	48	PF00675	0.485
CLV_NRD_NRD_1	622	624	PF00675	0.611
CLV_NRD_NRD_1	692	694	PF00675	0.731
CLV_NRD_NRD_1	700	702	PF00675	0.754
CLV_NRD_NRD_1	761	763	PF00675	0.684
CLV_NRD_NRD_1	780	782	PF00675	0.633
CLV_PCSK_FUR_1	394	398	PF00082	0.551
CLV_PCSK_FUR_1	698	702	PF00082	0.668
CLV_PCSK_KEX2_1	171	173	PF00082	0.731
CLV_PCSK_KEX2_1	227	229	PF00082	0.754
CLV_PCSK_KEX2_1	396	398	PF00082	0.612
CLV_PCSK_KEX2_1	415	417	PF00082	0.411
CLV_PCSK_KEX2_1	46	48	PF00082	0.507
CLV_PCSK_KEX2_1	56	58	PF00082	0.491
CLV_PCSK_KEX2_1	563	565	PF00082	0.787
CLV_PCSK_KEX2_1	622	624	PF00082	0.611
CLV_PCSK_KEX2_1	698	700	PF00082	0.786
CLV_PCSK_KEX2_1	761	763	PF00082	0.684
CLV_PCSK_KEX2_1	779	781	PF00082	0.645
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.470
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.787
CLV_PCSK_SKI1_1	140	144	PF00082	0.447
CLV_PCSK_SKI1_1	171	175	PF00082	0.738
CLV_PCSK_SKI1_1	180	184	PF00082	0.802
CLV_PCSK_SKI1_1	400	404	PF00082	0.533
CLV_PCSK_SKI1_1	498	502	PF00082	0.674
DEG_APCC_DBOX_1	184	192	PF00400	0.602
DEG_COP1_1	797	808	PF00400	0.308
DEG_Nend_Nbox_1	1	3	PF02207	0.666
DEG_SCF_FBW7_1	135	141	PF00400	0.653
DEG_SCF_FBW7_1	669	675	PF00400	0.441
DEG_SPOP_SBC_1	304	308	PF00917	0.417
DEG_SPOP_SBC_1	350	354	PF00917	0.439
DEG_SPOP_SBC_1	65	69	PF00917	0.649
DOC_CKS1_1	132	137	PF01111	0.679
DOC_CKS1_1	669	674	PF01111	0.460
DOC_CYCLIN_RxL_1	394	407	PF00134	0.235
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.416
DOC_MAPK_DCC_7	801	810	PF00069	0.303
DOC_MAPK_gen_1	180	190	PF00069	0.550
DOC_MAPK_gen_1	394	404	PF00069	0.333
DOC_MAPK_gen_1	824	833	PF00069	0.393
DOC_MAPK_MEF2A_6	331	340	PF00069	0.392
DOC_MAPK_MEF2A_6	801	810	PF00069	0.303
DOC_PP1_RVXF_1	274	281	PF00149	0.525
DOC_PP1_RVXF_1	398	405	PF00149	0.333
DOC_PP2B_LxvP_1	212	215	PF13499	0.430
DOC_PP2B_LxvP_1	362	365	PF13499	0.395
DOC_PP2B_LxvP_1	585	588	PF13499	0.466
DOC_PP2B_LxvP_1	719	722	PF13499	0.401
DOC_PP2B_LxvP_1	740	743	PF13499	0.411
DOC_PP2B_LxvP_1	803	806	PF13499	0.290
DOC_PP4_FxxP_1	87	90	PF00568	0.650
DOC_USP7_MATH_1	138	142	PF00917	0.690
DOC_USP7_MATH_1	351	355	PF00917	0.436
DOC_USP7_MATH_1	433	437	PF00917	0.376
DOC_USP7_MATH_1	522	526	PF00917	0.512
DOC_USP7_MATH_1	548	552	PF00917	0.514
DOC_USP7_MATH_1	66	70	PF00917	0.768
DOC_USP7_MATH_1	760	764	PF00917	0.483
DOC_USP7_MATH_1	769	773	PF00917	0.495
DOC_USP7_MATH_1	774	778	PF00917	0.470
DOC_USP7_MATH_1	78	82	PF00917	0.744
DOC_USP7_MATH_1	845	849	PF00917	0.534
DOC_WW_Pin1_4	131	136	PF00397	0.693
DOC_WW_Pin1_4	163	168	PF00397	0.600
DOC_WW_Pin1_4	190	195	PF00397	0.554
DOC_WW_Pin1_4	2	7	PF00397	0.658
DOC_WW_Pin1_4	507	512	PF00397	0.483
DOC_WW_Pin1_4	531	536	PF00397	0.483
DOC_WW_Pin1_4	552	557	PF00397	0.522
DOC_WW_Pin1_4	668	673	PF00397	0.558
DOC_WW_Pin1_4	675	680	PF00397	0.499
DOC_WW_Pin1_4	703	708	PF00397	0.577
DOC_WW_Pin1_4	710	715	PF00397	0.506
DOC_WW_Pin1_4	782	787	PF00397	0.465
LIG_14-3-3_CanoR_1	175	184	PF00244	0.539
LIG_14-3-3_CanoR_1	250	254	PF00244	0.404
LIG_14-3-3_CanoR_1	378	382	PF00244	0.264
LIG_14-3-3_CanoR_1	400	405	PF00244	0.351
LIG_14-3-3_CanoR_1	50	54	PF00244	0.693
LIG_14-3-3_CanoR_1	539	548	PF00244	0.556
LIG_14-3-3_CanoR_1	824	833	PF00244	0.395
LIG_14-3-3_CanoR_1	836	842	PF00244	0.458
LIG_14-3-3_CanoR_1	852	858	PF00244	0.429
LIG_14-3-3_CanoR_1	95	101	PF00244	0.585
LIG_BRCT_BRCA1_1	13	17	PF00533	0.269
LIG_BRCT_BRCA1_1	83	87	PF00533	0.676
LIG_CSL_BTD_1	208	211	PF09270	0.430
LIG_CtBP_PxDLS_1	122	126	PF00389	0.645
LIG_deltaCOP1_diTrp_1	201	209	PF00928	0.514
LIG_FHA_1	148	154	PF00498	0.412
LIG_FHA_1	280	286	PF00498	0.564
LIG_FHA_1	304	310	PF00498	0.423
LIG_FHA_1	664	670	PF00498	0.495
LIG_FHA_1	672	678	PF00498	0.524
LIG_FHA_1	753	759	PF00498	0.444
LIG_FHA_1	8	14	PF00498	0.237
LIG_FHA_1	805	811	PF00498	0.416
LIG_FHA_1	837	843	PF00498	0.434
LIG_FHA_1	95	101	PF00498	0.585
LIG_FHA_2	268	274	PF00498	0.545
LIG_HCF-1_HBM_1	103	106	PF13415	0.666
LIG_Integrin_RGD_1	701	703	PF01839	0.660
LIG_LIR_Apic_2	181	187	PF02991	0.528
LIG_LIR_Apic_2	230	234	PF02991	0.387
LIG_LIR_Apic_2	84	90	PF02991	0.655
LIG_LIR_Gen_1	853	861	PF02991	0.467
LIG_LIR_LC3C_4	802	805	PF02991	0.409
LIG_LIR_Nem_3	202	208	PF02991	0.547
LIG_LIR_Nem_3	380	385	PF02991	0.271
LIG_LIR_Nem_3	723	729	PF02991	0.373
LIG_LIR_Nem_3	853	858	PF02991	0.473
LIG_PCNA_PIPBox_1	253	262	PF02747	0.425
LIG_PCNA_yPIPBox_3	250	260	PF02747	0.417
LIG_PCNA_yPIPBox_3	461	473	PF02747	0.334
LIG_Pex14_1	382	386	PF04695	0.351
LIG_Pex14_2	17	21	PF04695	0.237
LIG_Pex14_2	726	730	PF04695	0.372
LIG_PTAP_UEV_1	118	123	PF05743	0.634
LIG_REV1ctd_RIR_1	402	412	PF16727	0.351
LIG_SH2_CRK	184	188	PF00017	0.608
LIG_SH2_CRK	373	377	PF00017	0.351
LIG_SH2_NCK_1	107	111	PF00017	0.598
LIG_SH2_NCK_1	373	377	PF00017	0.351
LIG_SH2_SRC	373	376	PF00017	0.351
LIG_SH2_STAT3	475	478	PF00017	0.307
LIG_SH2_STAT3	649	652	PF00017	0.390
LIG_SH2_STAT5	386	389	PF00017	0.367
LIG_SH2_STAT5	475	478	PF00017	0.351
LIG_SH2_STAT5	615	618	PF00017	0.387
LIG_SH3_1	116	122	PF00018	0.636
LIG_SH3_1	564	570	PF00018	0.449
LIG_SH3_2	135	140	PF14604	0.735
LIG_SH3_2	211	216	PF14604	0.430
LIG_SH3_3	116	122	PF00018	0.701
LIG_SH3_3	132	138	PF00018	0.734
LIG_SH3_3	194	200	PF00018	0.427
LIG_SH3_3	208	214	PF00018	0.404
LIG_SH3_3	55	61	PF00018	0.838
LIG_SH3_3	564	570	PF00018	0.449
LIG_SH3_3	702	708	PF00018	0.550
LIG_SH3_3	740	746	PF00018	0.419
LIG_SH3_CIN85_PxpxPR_1	211	216	PF14604	0.430
LIG_SUMO_SIM_par_1	24	29	PF11976	0.274
LIG_SUMO_SIM_par_1	816	823	PF11976	0.348
LIG_SxIP_EBH_1	303	316	PF03271	0.407
LIG_TRAF2_1	791	794	PF00917	0.385
LIG_TRFH_1	855	859	PF08558	0.453
LIG_TYR_ITIM	242	247	PF00017	0.394
LIG_TYR_ITIM	371	376	PF00017	0.351
LIG_WW_3	213	217	PF00397	0.433
MOD_CDK_SPxK_1	134	140	PF00069	0.639
MOD_CDK_SPxK_1	552	558	PF00069	0.539
MOD_CK1_1	124	130	PF00069	0.768
MOD_CK1_1	136	142	PF00069	0.651
MOD_CK1_1	252	258	PF00069	0.528
MOD_CK1_1	265	271	PF00069	0.460
MOD_CK1_1	509	515	PF00069	0.461
MOD_CK1_1	531	537	PF00069	0.466
MOD_CK1_1	543	549	PF00069	0.479
MOD_CK1_1	550	556	PF00069	0.457
MOD_CK1_1	69	75	PF00069	0.723
MOD_CK1_1	706	712	PF00069	0.572
MOD_CK1_1	715	721	PF00069	0.398
MOD_CK1_1	81	87	PF00069	0.673
MOD_CK1_1	835	841	PF00069	0.551
MOD_CK1_1	88	94	PF00069	0.631
MOD_CK2_1	127	133	PF00069	0.660
MOD_CK2_1	175	181	PF00069	0.547
MOD_CK2_1	271	277	PF00069	0.571
MOD_CK2_1	49	55	PF00069	0.694
MOD_CK2_1	814	820	PF00069	0.340
MOD_CK2_1	837	843	PF00069	0.434
MOD_CMANNOS	246	249	PF00535	0.608
MOD_CMANNOS	621	624	PF00535	0.706
MOD_GlcNHglycan	127	130	PF01048	0.534
MOD_GlcNHglycan	13	16	PF01048	0.237
MOD_GlcNHglycan	140	143	PF01048	0.426
MOD_GlcNHglycan	340	343	PF01048	0.743
MOD_GlcNHglycan	353	356	PF01048	0.649
MOD_GlcNHglycan	439	442	PF01048	0.435
MOD_GlcNHglycan	524	527	PF01048	0.646
MOD_GlcNHglycan	542	545	PF01048	0.728
MOD_GlcNHglycan	591	594	PF01048	0.735
MOD_GlcNHglycan	628	631	PF01048	0.713
MOD_GlcNHglycan	689	692	PF01048	0.654
MOD_GlcNHglycan	826	829	PF01048	0.662
MOD_GlcNHglycan	83	86	PF01048	0.415
MOD_GlcNHglycan	871	874	PF01048	0.692
MOD_GSK3_1	117	124	PF00069	0.753
MOD_GSK3_1	127	134	PF00069	0.700
MOD_GSK3_1	163	170	PF00069	0.628
MOD_GSK3_1	171	178	PF00069	0.478
MOD_GSK3_1	258	265	PF00069	0.527
MOD_GSK3_1	267	274	PF00069	0.522
MOD_GSK3_1	290	297	PF00069	0.503
MOD_GSK3_1	299	306	PF00069	0.529
MOD_GSK3_1	340	347	PF00069	0.546
MOD_GSK3_1	396	403	PF00069	0.331
MOD_GSK3_1	406	413	PF00069	0.335
MOD_GSK3_1	433	440	PF00069	0.408
MOD_GSK3_1	505	512	PF00069	0.552
MOD_GSK3_1	543	550	PF00069	0.503
MOD_GSK3_1	65	72	PF00069	0.716
MOD_GSK3_1	663	670	PF00069	0.532
MOD_GSK3_1	671	678	PF00069	0.464
MOD_GSK3_1	7	14	PF00069	0.248
MOD_GSK3_1	706	713	PF00069	0.457
MOD_GSK3_1	77	84	PF00069	0.646
MOD_GSK3_1	785	792	PF00069	0.512
MOD_GSK3_1	795	802	PF00069	0.373
MOD_GSK3_1	820	827	PF00069	0.422
MOD_GSK3_1	832	839	PF00069	0.462
MOD_GSK3_1	869	876	PF00069	0.494
MOD_LATS_1	264	270	PF00433	0.568
MOD_N-GLC_1	496	501	PF02516	0.676
MOD_N-GLC_1	782	787	PF02516	0.665
MOD_N-GLC_1	836	841	PF02516	0.637
MOD_NEK2_1	125	130	PF00069	0.679
MOD_NEK2_1	26	31	PF00069	0.271
MOD_NEK2_1	33	38	PF00069	0.233
MOD_NEK2_1	410	415	PF00069	0.351
MOD_NEK2_1	48	53	PF00069	0.672
MOD_NEK2_1	725	730	PF00069	0.371
MOD_NEK2_1	796	801	PF00069	0.389
MOD_NEK2_1	814	819	PF00069	0.309
MOD_NEK2_1	851	856	PF00069	0.383
MOD_NEK2_2	609	614	PF00069	0.384
MOD_PIKK_1	175	181	PF00454	0.547
MOD_PIKK_1	249	255	PF00454	0.407
MOD_PIKK_1	515	521	PF00454	0.578
MOD_PIKK_1	774	780	PF00454	0.461
MOD_PIKK_1	785	791	PF00454	0.431
MOD_PIKK_1	94	100	PF00454	0.583
MOD_PK_1	258	264	PF00069	0.440
MOD_PKA_1	171	177	PF00069	0.428
MOD_PKA_1	396	402	PF00069	0.326
MOD_PKA_1	56	62	PF00069	0.691
MOD_PKA_2	171	177	PF00069	0.428
MOD_PKA_2	249	255	PF00069	0.523
MOD_PKA_2	262	268	PF00069	0.459
MOD_PKA_2	271	277	PF00069	0.505
MOD_PKA_2	377	383	PF00069	0.339
MOD_PKA_2	388	394	PF00069	0.368
MOD_PKA_2	396	402	PF00069	0.304
MOD_PKA_2	49	55	PF00069	0.697
MOD_PKA_2	56	62	PF00069	0.679
MOD_PKA_2	575	581	PF00069	0.380
MOD_PKA_2	760	766	PF00069	0.494
MOD_PKA_2	835	841	PF00069	0.551
MOD_PKA_2	851	857	PF00069	0.369
MOD_PKA_2	94	100	PF00069	0.583
MOD_PKB_1	394	402	PF00069	0.253
MOD_PKB_1	822	830	PF00069	0.455
MOD_Plk_1	406	412	PF00069	0.351
MOD_Plk_1	78	84	PF00069	0.642
MOD_Plk_1	796	802	PF00069	0.316
MOD_Plk_2-3	271	277	PF00069	0.455
MOD_Plk_4	252	258	PF00069	0.528
MOD_Plk_4	305	311	PF00069	0.410
MOD_Plk_4	377	383	PF00069	0.289
MOD_Plk_4	400	406	PF00069	0.253
MOD_Plk_4	49	55	PF00069	0.640
MOD_Plk_4	715	721	PF00069	0.448
MOD_Plk_4	814	820	PF00069	0.404
MOD_ProDKin_1	131	137	PF00069	0.691
MOD_ProDKin_1	163	169	PF00069	0.602
MOD_ProDKin_1	190	196	PF00069	0.552
MOD_ProDKin_1	2	8	PF00069	0.450
MOD_ProDKin_1	507	513	PF00069	0.483
MOD_ProDKin_1	531	537	PF00069	0.483
MOD_ProDKin_1	552	558	PF00069	0.524
MOD_ProDKin_1	668	674	PF00069	0.558
MOD_ProDKin_1	675	681	PF00069	0.499
MOD_ProDKin_1	703	709	PF00069	0.577
MOD_ProDKin_1	710	716	PF00069	0.502
MOD_ProDKin_1	782	788	PF00069	0.465
MOD_SUMO_for_1	808	811	PF00179	0.303
TRG_DiLeu_BaEn_1	736	741	PF01217	0.411
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.455
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.453
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.415
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.702
TRG_ENDOCYTIC_2	244	247	PF00928	0.405
TRG_ENDOCYTIC_2	373	376	PF00928	0.396
TRG_ER_diArg_1	227	229	PF00400	0.554
TRG_ER_diArg_1	394	397	PF00400	0.380
TRG_ER_diArg_1	414	416	PF00400	0.199
TRG_ER_diArg_1	46	48	PF00400	0.671
TRG_ER_diArg_1	621	623	PF00400	0.404
TRG_ER_diArg_1	698	701	PF00400	0.519
TRG_ER_diArg_1	761	764	PF00400	0.429
TRG_ER_diArg_1	779	781	PF00400	0.503
TRG_ER_diArg_1	821	824	PF00400	0.407
TRG_ER_diArg_1	861	864	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	773	778	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	864	869	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9Q8	Leishmania donovani	65%	100%
A4HVQ5	Leishmania infantum	64%	100%
E9APF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QG27	Leishmania major	63%	100%