Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H7A9_LEIBR

TriTrypDb:

LbrM.13.1030 , LBRM2903_130016700

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H7A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.570
CLV_C14_Caspase3-7	171	175	PF00656	0.633
CLV_PCSK_KEX2_1	25	27	PF00082	0.362
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.362
CLV_PCSK_SKI1_1	120	124	PF00082	0.278
CLV_PCSK_SKI1_1	25	29	PF00082	0.400
DEG_SPOP_SBC_1	19	23	PF00917	0.552
DOC_MAPK_gen_1	94	104	PF00069	0.290
DOC_MAPK_MEF2A_6	97	105	PF00069	0.335
DOC_PP4_FxxP_1	64	67	PF00568	0.227
DOC_USP7_MATH_1	39	43	PF00917	0.614
DOC_USP7_MATH_1	69	73	PF00917	0.234
LIG_14-3-3_CanoR_1	155	160	PF00244	0.687
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_deltaCOP1_diTrp_1	181	191	PF00928	0.604
LIG_deltaCOP1_diTrp_1	90	98	PF00928	0.453
LIG_EH1_1	110	118	PF00400	0.320
LIG_FHA_1	144	150	PF00498	0.600
LIG_FHA_1	69	75	PF00498	0.340
LIG_LIR_Apic_2	63	67	PF02991	0.227
LIG_LIR_Gen_1	167	176	PF02991	0.618
LIG_LIR_Nem_3	167	172	PF02991	0.626
LIG_LIR_Nem_3	90	96	PF02991	0.336
LIG_Pex14_1	92	96	PF04695	0.455
LIG_Pex14_2	153	157	PF04695	0.607
LIG_SUMO_SIM_par_1	100	107	PF11976	0.499
LIG_WRC_WIRS_1	169	174	PF05994	0.619
LIG_WRC_WIRS_1	61	66	PF05994	0.233
MOD_CK1_1	145	151	PF00069	0.638
MOD_CK1_1	170	176	PF00069	0.663
MOD_CK2_1	159	165	PF00069	0.689
MOD_GlcNHglycan	71	74	PF01048	0.233
MOD_GSK3_1	138	145	PF00069	0.685
MOD_GSK3_1	151	158	PF00069	0.667
MOD_GSK3_1	168	175	PF00069	0.633
MOD_N-GLC_1	133	138	PF02516	0.409
MOD_NEK2_1	153	158	PF00069	0.639
MOD_NEK2_1	159	164	PF00069	0.705
MOD_NEK2_1	28	33	PF00069	0.564
MOD_NEK2_1	81	86	PF00069	0.438
MOD_PKA_2	136	142	PF00069	0.705
MOD_Plk_1	167	173	PF00069	0.706
MOD_Plk_1	19	25	PF00069	0.548
MOD_Plk_2-3	161	167	PF00069	0.639
MOD_Plk_2-3	168	174	PF00069	0.722
MOD_Plk_4	104	110	PF00069	0.333
TRG_ENDOCYTIC_2	169	172	PF00928	0.608
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.224
TRG_Pf-PMV_PEXEL_1	75	80	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM79	Leptomonas seymouri	37%	100%
A0A3Q8II27	Leishmania donovani	52%	100%
A4HVQ4	Leishmania infantum	52%	100%
E9APF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
Q4QG28	Leishmania major	47%	100%