TPK_B1_binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thiamin pyrophosphokinase, vitamin B1 binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H7A7_LEIBR

TriTrypDb:

LbrM.13.1010 , LBRM2903_130016500

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7A7

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006766	vitamin metabolic process	3	11
GO:0006767	water-soluble vitamin metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009110	vitamin biosynthetic process	4	11
GO:0009229	thiamine diphosphate biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	10
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0042357	thiamine diphosphate metabolic process	4	11
GO:0042364	water-soluble vitamin biosynthetic process	5	11
GO:0042723	thiamine-containing compound metabolic process	4	11
GO:0042724	thiamine-containing compound biosynthetic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044272	sulfur compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072527	pyrimidine-containing compound metabolic process	4	11
GO:0072528	pyrimidine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004788	thiamine diphosphokinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016778	diphosphotransferase activity	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0019842	vitamin binding	3	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0030975	thiamine binding	3	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0043178	alcohol binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:1901681	sulfur compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.432
CLV_NRD_NRD_1	18	20	PF00675	0.394
CLV_NRD_NRD_1	220	222	PF00675	0.501
CLV_NRD_NRD_1	326	328	PF00675	0.376
CLV_NRD_NRD_1	95	97	PF00675	0.498
CLV_PCSK_FUR_1	218	222	PF00082	0.500
CLV_PCSK_KEX2_1	218	220	PF00082	0.505
CLV_PCSK_KEX2_1	326	328	PF00082	0.479
CLV_PCSK_SKI1_1	227	231	PF00082	0.451
CLV_PCSK_SKI1_1	467	471	PF00082	0.329
CLV_PCSK_SKI1_1	76	80	PF00082	0.403
CLV_PCSK_SKI1_1	96	100	PF00082	0.441
DEG_SCF_FBW7_1	335	340	PF00400	0.392
DEG_SPOP_SBC_1	127	131	PF00917	0.453
DEG_SPOP_SBC_1	229	233	PF00917	0.461
DEG_SPOP_SBC_1	29	33	PF00917	0.382
DEG_SPOP_SBC_1	308	312	PF00917	0.317
DOC_MAPK_DCC_7	234	242	PF00069	0.431
DOC_MAPK_gen_1	380	390	PF00069	0.355
DOC_MAPK_gen_1	72	79	PF00069	0.333
DOC_MAPK_MEF2A_6	262	270	PF00069	0.521
DOC_MAPK_MEF2A_6	353	360	PF00069	0.520
DOC_PP1_RVXF_1	465	471	PF00149	0.478
DOC_PP2B_LxvP_1	268	271	PF13499	0.358
DOC_PP2B_LxvP_1	526	529	PF13499	0.425
DOC_PP4_FxxP_1	407	410	PF00568	0.280
DOC_USP7_MATH_1	127	131	PF00917	0.478
DOC_USP7_MATH_1	178	182	PF00917	0.487
DOC_USP7_MATH_1	229	233	PF00917	0.482
DOC_USP7_MATH_1	290	294	PF00917	0.418
DOC_USP7_MATH_1	308	312	PF00917	0.317
DOC_USP7_MATH_1	337	341	PF00917	0.496
DOC_USP7_MATH_1	38	42	PF00917	0.481
DOC_USP7_MATH_1	43	47	PF00917	0.354
DOC_USP7_MATH_1	78	82	PF00917	0.439
DOC_WW_Pin1_4	139	144	PF00397	0.386
DOC_WW_Pin1_4	232	237	PF00397	0.581
DOC_WW_Pin1_4	333	338	PF00397	0.531
DOC_WW_Pin1_4	411	416	PF00397	0.392
DOC_WW_Pin1_4	479	484	PF00397	0.478
DOC_WW_Pin1_4	52	57	PF00397	0.349
DOC_WW_Pin1_4	89	94	PF00397	0.738
LIG_14-3-3_CanoR_1	19	28	PF00244	0.460
LIG_Actin_WH2_2	365	382	PF00022	0.257
LIG_APCC_ABBAyCdc20_2	198	204	PF00400	0.506
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_EVH1_2	520	524	PF00568	0.351
LIG_FHA_1	10	16	PF00498	0.517
LIG_FHA_1	157	163	PF00498	0.349
LIG_FHA_1	31	37	PF00498	0.492
LIG_FHA_1	311	317	PF00498	0.565
LIG_FHA_1	345	351	PF00498	0.527
LIG_FHA_1	403	409	PF00498	0.314
LIG_FHA_1	440	446	PF00498	0.542
LIG_FHA_1	479	485	PF00498	0.480
LIG_FHA_1	523	529	PF00498	0.409
LIG_FHA_1	89	95	PF00498	0.487
LIG_FHA_2	233	239	PF00498	0.546
LIG_FHA_2	249	255	PF00498	0.270
LIG_FHA_2	273	279	PF00498	0.618
LIG_FHA_2	57	63	PF00498	0.431
LIG_FHA_2	83	89	PF00498	0.470
LIG_IBAR_NPY_1	102	104	PF08397	0.335
LIG_LIR_Apic_2	405	410	PF02991	0.266
LIG_LIR_Apic_2	412	416	PF02991	0.375
LIG_LIR_Gen_1	109	120	PF02991	0.413
LIG_LIR_Gen_1	65	70	PF02991	0.336
LIG_LIR_Nem_3	109	115	PF02991	0.320
LIG_LIR_Nem_3	139	144	PF02991	0.588
LIG_LIR_Nem_3	45	51	PF02991	0.428
LIG_LIR_Nem_3	455	460	PF02991	0.557
LIG_LIR_Nem_3	60	66	PF02991	0.283
LIG_PTB_Apo_2	99	106	PF02174	0.403
LIG_SH2_CRK	112	116	PF00017	0.458
LIG_SH2_CRK	123	127	PF00017	0.595
LIG_SH2_CRK	381	385	PF00017	0.499
LIG_SH2_CRK	393	397	PF00017	0.334
LIG_SH2_GRB2like	7	10	PF00017	0.485
LIG_SH2_NCK_1	123	127	PF00017	0.385
LIG_SH2_NCK_1	381	385	PF00017	0.361
LIG_SH2_NCK_1	7	11	PF00017	0.480
LIG_SH2_PTP2	66	69	PF00017	0.437
LIG_SH2_STAP1	123	127	PF00017	0.385
LIG_SH2_STAP1	381	385	PF00017	0.361
LIG_SH2_STAT5	104	107	PF00017	0.350
LIG_SH2_STAT5	118	121	PF00017	0.409
LIG_SH2_STAT5	303	306	PF00017	0.308
LIG_SH2_STAT5	460	463	PF00017	0.521
LIG_SH2_STAT5	66	69	PF00017	0.396
LIG_SH2_STAT5	7	10	PF00017	0.485
LIG_SH3_2	433	438	PF14604	0.380
LIG_SH3_3	233	239	PF00018	0.695
LIG_SH3_3	405	411	PF00018	0.402
LIG_SH3_3	412	418	PF00018	0.538
LIG_SH3_3	430	436	PF00018	0.416
LIG_SH3_3	477	483	PF00018	0.584
LIG_SH3_3	510	516	PF00018	0.637
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.554
LIG_SUMO_SIM_par_1	481	488	PF11976	0.454
LIG_SUMO_SIM_par_1	49	55	PF11976	0.383
LIG_TRFH_1	407	411	PF08558	0.296
LIG_TYR_ITIM	379	384	PF00017	0.373
LIG_UBA3_1	387	392	PF00899	0.364
LIG_WW_3	414	418	PF00397	0.412
MOD_CDC14_SPxK_1	414	417	PF00782	0.408
MOD_CDK_SPxK_1	139	145	PF00069	0.379
MOD_CDK_SPxK_1	411	417	PF00069	0.382
MOD_CDK_SPxxK_3	89	96	PF00069	0.530
MOD_CK1_1	130	136	PF00069	0.542
MOD_CK1_1	139	145	PF00069	0.358
MOD_CK1_1	156	162	PF00069	0.365
MOD_CK1_1	232	238	PF00069	0.546
MOD_CK1_1	339	345	PF00069	0.642
MOD_CK1_1	500	506	PF00069	0.458
MOD_CK2_1	130	136	PF00069	0.468
MOD_CK2_1	222	228	PF00069	0.492
MOD_CK2_1	232	238	PF00069	0.694
MOD_CK2_1	248	254	PF00069	0.291
MOD_GlcNHglycan	130	133	PF01048	0.734
MOD_GlcNHglycan	169	172	PF01048	0.513
MOD_GlcNHglycan	339	342	PF01048	0.726
MOD_GlcNHglycan	502	505	PF01048	0.686
MOD_GSK3_1	122	129	PF00069	0.515
MOD_GSK3_1	132	139	PF00069	0.521
MOD_GSK3_1	153	160	PF00069	0.486
MOD_GSK3_1	174	181	PF00069	0.539
MOD_GSK3_1	228	235	PF00069	0.649
MOD_GSK3_1	272	279	PF00069	0.560
MOD_GSK3_1	28	35	PF00069	0.669
MOD_GSK3_1	290	297	PF00069	0.525
MOD_GSK3_1	331	338	PF00069	0.533
MOD_GSK3_1	340	347	PF00069	0.602
MOD_GSK3_1	38	45	PF00069	0.629
MOD_GSK3_1	472	479	PF00069	0.343
MOD_GSK3_1	5	12	PF00069	0.616
MOD_GSK3_1	500	507	PF00069	0.436
MOD_GSK3_1	52	59	PF00069	0.406
MOD_GSK3_1	78	85	PF00069	0.449
MOD_GSK3_1	88	95	PF00069	0.608
MOD_N-GLC_1	8	13	PF02516	0.622
MOD_NEK2_1	230	235	PF00069	0.604
MOD_NEK2_1	28	33	PF00069	0.365
MOD_NEK2_1	331	336	PF00069	0.610
MOD_NEK2_2	43	48	PF00069	0.360
MOD_PIKK_1	157	163	PF00454	0.349
MOD_PIKK_1	402	408	PF00454	0.302
MOD_PIKK_1	458	464	PF00454	0.330
MOD_PIKK_1	9	15	PF00454	0.574
MOD_PKB_1	274	282	PF00069	0.458
MOD_Plk_1	136	142	PF00069	0.626
MOD_Plk_1	294	300	PF00069	0.464
MOD_Plk_1	38	44	PF00069	0.486
MOD_Plk_4	238	244	PF00069	0.466
MOD_Plk_4	43	49	PF00069	0.416
MOD_Plk_4	519	525	PF00069	0.393
MOD_Plk_4	62	68	PF00069	0.239
MOD_ProDKin_1	139	145	PF00069	0.379
MOD_ProDKin_1	232	238	PF00069	0.568
MOD_ProDKin_1	333	339	PF00069	0.545
MOD_ProDKin_1	411	417	PF00069	0.403
MOD_ProDKin_1	479	485	PF00069	0.330
MOD_ProDKin_1	52	58	PF00069	0.346
MOD_ProDKin_1	89	95	PF00069	0.738
TRG_DiLeu_BaEn_1	441	446	PF01217	0.259
TRG_ENDOCYTIC_2	112	115	PF00928	0.341
TRG_ENDOCYTIC_2	123	126	PF00928	0.467
TRG_ENDOCYTIC_2	381	384	PF00928	0.503
TRG_ENDOCYTIC_2	393	396	PF00928	0.343
TRG_ENDOCYTIC_2	66	69	PF00928	0.345
TRG_ER_diArg_1	217	220	PF00400	0.437
TRG_ER_diArg_1	326	329	PF00400	0.391
TRG_ER_diArg_1	74	77	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFZ8	Leptomonas seymouri	44%	100%
A0A1X0NMY7	Trypanosomatidae	30%	100%
A0A3Q8IBS6	Leishmania donovani	70%	99%
A0A422N0R9	Trypanosoma rangeli	29%	100%
A4HVQ2	Leishmania infantum	71%	100%
D0A6I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9APE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QG30	Leishmania major	68%	100%
V5ARR9	Trypanosoma cruzi	28%	100%