LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania braziliensis
UniProt:
A4H7A5_LEIBR
TriTrypDb:
LbrM.13.0990 , LBRM2903_130016200
Length:
500

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 52
NetGPI no yes: 0, no: 52
Cellular components
Term Name Level Count
GO:0016020 membrane 2 53
GO:0110165 cellular anatomical entity 1 53
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

A4H7A5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7A5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 53
GO:0005337 nucleoside transmembrane transporter activity 4 53
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 53
GO:0022857 transmembrane transporter activity 2 53
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 53
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 404 406 PF00675 0.205
CLV_NRD_NRD_1 86 88 PF00675 0.285
CLV_PCSK_SKI1_1 154 158 PF00082 0.292
CLV_PCSK_SKI1_1 227 231 PF00082 0.233
CLV_PCSK_SKI1_1 325 329 PF00082 0.350
CLV_PCSK_SKI1_1 405 409 PF00082 0.231
CLV_PCSK_SKI1_1 415 419 PF00082 0.284
CLV_PCSK_SKI1_1 43 47 PF00082 0.453
DEG_Nend_Nbox_1 1 3 PF02207 0.577
DEG_SCF_FBW7_1 252 259 PF00400 0.334
DEG_SCF_FBW7_1 313 320 PF00400 0.334
DEG_SPOP_SBC_1 256 260 PF00917 0.347
DOC_ANK_TNKS_1 287 294 PF00023 0.367
DOC_CDC14_PxL_1 360 368 PF14671 0.414
DOC_CKS1_1 81 86 PF01111 0.312
DOC_CYCLIN_yClb1_LxF_4 60 66 PF00134 0.292
DOC_MAPK_gen_1 372 382 PF00069 0.331
DOC_MAPK_gen_1 405 412 PF00069 0.486
DOC_MAPK_gen_1 87 93 PF00069 0.496
DOC_MAPK_HePTP_8 91 103 PF00069 0.465
DOC_MAPK_MEF2A_6 375 384 PF00069 0.346
DOC_MAPK_MEF2A_6 405 412 PF00069 0.415
DOC_MAPK_MEF2A_6 415 423 PF00069 0.304
DOC_MAPK_MEF2A_6 94 103 PF00069 0.294
DOC_MAPK_NFAT4_5 405 413 PF00069 0.446
DOC_MAPK_NFAT4_5 94 102 PF00069 0.389
DOC_PP2B_LxvP_1 110 113 PF13499 0.276
DOC_PP2B_LxvP_1 361 364 PF13499 0.288
DOC_PP2B_LxvP_1 366 369 PF13499 0.211
DOC_PP4_FxxP_1 400 403 PF00568 0.526
DOC_USP7_MATH_1 256 260 PF00917 0.557
DOC_USP7_MATH_1 294 298 PF00917 0.548
DOC_USP7_MATH_1 30 34 PF00917 0.334
DOC_USP7_MATH_1 317 321 PF00917 0.457
DOC_USP7_MATH_1 483 487 PF00917 0.335
DOC_USP7_UBL2_3 178 182 PF12436 0.146
DOC_WW_Pin1_4 252 257 PF00397 0.424
DOC_WW_Pin1_4 313 318 PF00397 0.419
DOC_WW_Pin1_4 80 85 PF00397 0.359
LIG_14-3-3_CanoR_1 214 219 PF00244 0.460
LIG_14-3-3_CanoR_1 325 334 PF00244 0.535
LIG_14-3-3_CanoR_1 393 399 PF00244 0.288
LIG_14-3-3_CanoR_1 463 472 PF00244 0.469
LIG_14-3-3_CanoR_1 87 92 PF00244 0.455
LIG_BIR_III_4 389 393 PF00653 0.256
LIG_BRCT_BRCA1_1 211 215 PF00533 0.423
LIG_BRCT_BRCA1_1 396 400 PF00533 0.437
LIG_BRCT_BRCA1_1 89 93 PF00533 0.481
LIG_Clathr_ClatBox_1 101 105 PF01394 0.331
LIG_EH1_1 355 363 PF00400 0.380
LIG_eIF4E_1 437 443 PF01652 0.303
LIG_FHA_1 13 19 PF00498 0.294
LIG_FHA_1 377 383 PF00498 0.312
LIG_FHA_1 402 408 PF00498 0.444
LIG_FHA_1 71 77 PF00498 0.289
LIG_FHA_2 314 320 PF00498 0.452
LIG_FHA_2 326 332 PF00498 0.463
LIG_IRF3_LxIS_1 18 23 PF10401 0.316
LIG_LIR_Apic_2 397 403 PF02991 0.539
LIG_LIR_Gen_1 105 114 PF02991 0.292
LIG_LIR_Gen_1 143 153 PF02991 0.438
LIG_LIR_Gen_1 183 193 PF02991 0.258
LIG_LIR_Gen_1 374 385 PF02991 0.302
LIG_LIR_Gen_1 422 431 PF02991 0.350
LIG_LIR_Nem_3 105 110 PF02991 0.222
LIG_LIR_Nem_3 143 148 PF02991 0.450
LIG_LIR_Nem_3 16 22 PF02991 0.278
LIG_LIR_Nem_3 183 188 PF02991 0.262
LIG_LIR_Nem_3 212 218 PF02991 0.328
LIG_LIR_Nem_3 225 229 PF02991 0.362
LIG_LIR_Nem_3 273 279 PF02991 0.547
LIG_LIR_Nem_3 374 380 PF02991 0.259
LIG_LIR_Nem_3 40 44 PF02991 0.285
LIG_LIR_Nem_3 422 426 PF02991 0.327
LIG_LIR_Nem_3 64 68 PF02991 0.240
LIG_LIR_Nem_3 90 96 PF02991 0.474
LIG_Pex14_2 161 165 PF04695 0.299
LIG_Pex14_2 353 357 PF04695 0.238
LIG_Pex14_2 423 427 PF04695 0.311
LIG_PTB_Apo_2 444 451 PF02174 0.286
LIG_SH2_CRK 145 149 PF00017 0.440
LIG_SH2_NCK_1 145 149 PF00017 0.478
LIG_SH2_NCK_1 66 70 PF00017 0.356
LIG_SH2_SRC 139 142 PF00017 0.341
LIG_SH2_SRC 429 432 PF00017 0.278
LIG_SH2_STAP1 14 18 PF00017 0.308
LIG_SH2_STAP1 185 189 PF00017 0.252
LIG_SH2_STAT5 12 15 PF00017 0.292
LIG_SH2_STAT5 139 142 PF00017 0.314
LIG_SH2_STAT5 193 196 PF00017 0.253
LIG_SH2_STAT5 429 432 PF00017 0.255
LIG_SH2_STAT5 437 440 PF00017 0.294
LIG_SH3_3 414 420 PF00018 0.256
LIG_SH3_3 453 459 PF00018 0.360
LIG_SH3_3 494 500 PF00018 0.481
LIG_SH3_3 50 56 PF00018 0.275
LIG_SH3_3 78 84 PF00018 0.279
LIG_SUMO_SIM_anti_2 359 365 PF11976 0.414
LIG_SUMO_SIM_anti_2 379 384 PF11976 0.272
LIG_SUMO_SIM_par_1 359 365 PF11976 0.337
LIG_TYR_ITSM 141 148 PF00017 0.436
LIG_WRC_WIRS_1 62 67 PF05994 0.238
MOD_CDK_SPxxK_3 80 87 PF00069 0.365
MOD_CK1_1 257 263 PF00069 0.518
MOD_CK1_1 70 76 PF00069 0.270
MOD_CK2_1 135 141 PF00069 0.337
MOD_CK2_1 313 319 PF00069 0.449
MOD_CK2_1 325 331 PF00069 0.477
MOD_CK2_1 4 10 PF00069 0.493
MOD_GlcNHglycan 165 168 PF01048 0.279
MOD_GlcNHglycan 32 35 PF01048 0.513
MOD_GlcNHglycan 487 490 PF01048 0.272
MOD_GSK3_1 177 184 PF00069 0.257
MOD_GSK3_1 252 259 PF00069 0.491
MOD_GSK3_1 294 301 PF00069 0.541
MOD_GSK3_1 313 320 PF00069 0.430
MOD_GSK3_1 459 466 PF00069 0.394
MOD_N-GLC_1 3 8 PF02516 0.249
MOD_N-GLC_1 325 330 PF02516 0.245
MOD_NEK2_1 127 132 PF00069 0.332
MOD_NEK2_1 140 145 PF00069 0.437
MOD_NEK2_1 147 152 PF00069 0.413
MOD_NEK2_1 194 199 PF00069 0.302
MOD_NEK2_1 20 25 PF00069 0.271
MOD_NEK2_1 209 214 PF00069 0.171
MOD_NEK2_1 333 338 PF00069 0.457
MOD_NEK2_1 356 361 PF00069 0.315
MOD_NEK2_1 443 448 PF00069 0.352
MOD_NEK2_1 477 482 PF00069 0.296
MOD_NEK2_1 89 94 PF00069 0.467
MOD_NEK2_1 97 102 PF00069 0.253
MOD_NEK2_2 394 399 PF00069 0.184
MOD_PIKK_1 115 121 PF00454 0.331
MOD_PIKK_1 70 76 PF00454 0.226
MOD_PKA_1 87 93 PF00069 0.460
MOD_Plk_1 140 146 PF00069 0.462
MOD_Plk_1 3 9 PF00069 0.617
MOD_Plk_2-3 298 304 PF00069 0.511
MOD_Plk_4 127 133 PF00069 0.251
MOD_Plk_4 135 141 PF00069 0.329
MOD_Plk_4 168 174 PF00069 0.268
MOD_Plk_4 184 190 PF00069 0.233
MOD_Plk_4 356 362 PF00069 0.256
MOD_Plk_4 419 425 PF00069 0.283
MOD_Plk_4 451 457 PF00069 0.244
MOD_Plk_4 477 483 PF00069 0.286
MOD_Plk_4 61 67 PF00069 0.253
MOD_Plk_4 77 83 PF00069 0.256
MOD_Plk_4 97 103 PF00069 0.198
MOD_ProDKin_1 252 258 PF00069 0.424
MOD_ProDKin_1 313 319 PF00069 0.419
MOD_ProDKin_1 80 86 PF00069 0.353
MOD_SUMO_for_1 289 292 PF00179 0.382
TRG_ENDOCYTIC_2 145 148 PF00928 0.449
TRG_ENDOCYTIC_2 185 188 PF00928 0.263
TRG_ENDOCYTIC_2 193 196 PF00928 0.242
TRG_ENDOCYTIC_2 276 279 PF00928 0.546
TRG_ENDOCYTIC_2 437 440 PF00928 0.328
TRG_ER_diArg_1 286 289 PF00400 0.338
TRG_ER_diArg_1 334 337 PF00400 0.547

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 37% 100%
A0A0N0P6Z5 Leptomonas seymouri 32% 100%
A0A0N1I1J0 Leptomonas seymouri 33% 100%
A0A0N1I8E8 Leptomonas seymouri 27% 100%
A0A0N1PBQ1 Leptomonas seymouri 66% 99%
A0A0S4JBS4 Bodo saltans 32% 100%
A0A1X0NN91 Trypanosomatidae 52% 100%
A0A1X0NPL0 Trypanosomatidae 58% 100%
A0A1X0NV38 Trypanosomatidae 34% 100%
A0A1X0NWJ5 Trypanosomatidae 37% 100%
A0A3Q8ICX7 Leishmania donovani 80% 100%
A0A3R7NQR3 Trypanosoma rangeli 54% 100%
A0A3S7WTL0 Leishmania donovani 33% 100%
A0A3S7XAS5 Leishmania donovani 34% 100%
A0A422MQ08 Trypanosoma rangeli 35% 100%
A0A422N8M2 Trypanosoma rangeli 30% 100%
A0A422NHH9 Trypanosoma rangeli 30% 100%
A0A422NR81 Trypanosoma rangeli 31% 100%
A1L272 Danio rerio 23% 97%
A4H6I0 Leishmania braziliensis 35% 100%
A4HG96 Leishmania braziliensis 25% 99%
A4HP60 Leishmania braziliensis 33% 100%
A4HUW2 Leishmania infantum 37% 91%
A4HVP9 Leishmania infantum 80% 100%
A4HWK9 Leishmania infantum 33% 100%
A4IDG6 Leishmania infantum 34% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AGM5 Leishmania infantum 33% 100%
E9AGM6 Leishmania infantum 34% 100%
E9AGM7 Leishmania infantum 33% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 91%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
O54698 Rattus norvegicus 22% 100%
O76343 Leishmania donovani 34% 100%
Q14542 Homo sapiens 25% 100%
Q4Q1M9 Leishmania major 34% 99%
Q4QF58 Leishmania major 34% 100%
Q4QF59 Leishmania major 34% 100%
Q4QG33 Leishmania major 80% 100%
Q4QH25 Leishmania major 36% 100%
Q7RTT9 Homo sapiens 22% 94%
Q8R139 Mus musculus 23% 95%
V5BGB1 Trypanosoma cruzi 53% 100%
V5BRM5 Trypanosoma cruzi 35% 100%
V5DSF4 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS