PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H7A1_LEIBR

TriTrypDb:

LbrM.13.0950 , LBRM2903_130015600

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005811	lipid droplet	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4H7A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7A1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0016042	lipid catabolic process	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019433	triglyceride catabolic process	7	1
GO:0042592	homeostatic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046461	neutral lipid catabolic process	5	1
GO:0046464	acylglycerol catabolic process	6	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0046503	glycerolipid catabolic process	5	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0004806	triglyceride lipase activity	5	1
GO:0016298	lipase activity	4	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	259	261	PF00675	0.526
CLV_NRD_NRD_1	276	278	PF00675	0.538
CLV_PCSK_KEX2_1	105	107	PF00082	0.543
CLV_PCSK_KEX2_1	276	278	PF00082	0.570
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.552
CLV_PCSK_SKI1_1	105	109	PF00082	0.582
CLV_PCSK_SKI1_1	129	133	PF00082	0.506
CLV_PCSK_SKI1_1	245	249	PF00082	0.602
CLV_PCSK_SKI1_1	29	33	PF00082	0.328
CLV_PCSK_SKI1_1	56	60	PF00082	0.336
DEG_APCC_KENBOX_2	147	151	PF00400	0.405
DOC_CYCLIN_yClb5_NLxxxL_5	299	308	PF00134	0.527
DOC_MAPK_FxFP_2	241	244	PF00069	0.427
DOC_MAPK_gen_1	127	136	PF00069	0.407
DOC_MAPK_gen_1	14	23	PF00069	0.402
DOC_MAPK_MEF2A_6	127	136	PF00069	0.326
DOC_MAPK_NFAT4_5	127	135	PF00069	0.407
DOC_PP4_FxxP_1	241	244	PF00568	0.427
DOC_SPAK_OSR1_1	97	101	PF12202	0.342
DOC_USP7_UBL2_3	12	16	PF12436	0.377
DOC_USP7_UBL2_3	25	29	PF12436	0.377
DOC_WW_Pin1_4	14	19	PF00397	0.384
DOC_WW_Pin1_4	291	296	PF00397	0.445
LIG_14-3-3_CanoR_1	97	107	PF00244	0.343
LIG_BRCT_BRCA1_1	295	299	PF00533	0.442
LIG_BRCT_BRCA1_1	314	318	PF00533	0.440
LIG_deltaCOP1_diTrp_1	159	163	PF00928	0.405
LIG_deltaCOP1_diTrp_1	279	288	PF00928	0.404
LIG_FHA_1	15	21	PF00498	0.380
LIG_FHA_1	40	46	PF00498	0.328
LIG_FHA_2	159	165	PF00498	0.415
LIG_FHA_2	311	317	PF00498	0.476
LIG_FHA_2	99	105	PF00498	0.350
LIG_FXI_DFP_1	160	164	PF00024	0.602
LIG_GBD_Chelix_1	110	118	PF00786	0.544
LIG_LIR_Apic_2	239	244	PF02991	0.433
LIG_LIR_Gen_1	159	167	PF02991	0.385
LIG_LIR_Nem_3	159	163	PF02991	0.392
LIG_LIR_Nem_3	213	217	PF02991	0.279
LIG_LIR_Nem_3	298	304	PF02991	0.436
LIG_PDZ_Class_2	315	320	PF00595	0.456
LIG_PTB_Apo_2	235	242	PF02174	0.360
LIG_PTB_Apo_2	92	99	PF02174	0.378
LIG_SH2_SRC	210	213	PF00017	0.313
LIG_SH2_STAT3	143	146	PF00017	0.391
LIG_SH2_STAT3	50	53	PF00017	0.396
LIG_SH2_STAT5	152	155	PF00017	0.442
LIG_SH2_STAT5	205	208	PF00017	0.334
LIG_SH2_STAT5	210	213	PF00017	0.308
LIG_SH2_STAT5	235	238	PF00017	0.383
LIG_SH2_STAT5	287	290	PF00017	0.523
LIG_SH2_STAT5	50	53	PF00017	0.396
LIG_SH3_3	20	26	PF00018	0.411
LIG_SH3_4	25	32	PF00018	0.364
LIG_TRAF2_1	101	104	PF00917	0.348
LIG_WRC_WIRS_1	31	36	PF05994	0.328
MOD_CK1_1	197	203	PF00069	0.366
MOD_CK2_1	310	316	PF00069	0.499
MOD_CK2_1	98	104	PF00069	0.333
MOD_DYRK1A_RPxSP_1	14	18	PF00069	0.391
MOD_GlcNHglycan	68	71	PF01048	0.413
MOD_GSK3_1	130	137	PF00069	0.308
MOD_GSK3_1	171	178	PF00069	0.347
MOD_NEK2_1	130	135	PF00069	0.306
MOD_NEK2_1	191	196	PF00069	0.423
MOD_NEK2_1	39	44	PF00069	0.317
MOD_NEK2_1	59	64	PF00069	0.344
MOD_PIKK_1	142	148	PF00454	0.460
MOD_PIKK_1	175	181	PF00454	0.433
MOD_PKA_2	191	197	PF00069	0.354
MOD_Plk_4	191	197	PF00069	0.362
MOD_Plk_4	59	65	PF00069	0.344
MOD_ProDKin_1	14	20	PF00069	0.379
MOD_ProDKin_1	291	297	PF00069	0.441
MOD_SUMO_rev_2	102	107	PF00179	0.362
TRG_DiLeu_BaEn_1	54	59	PF01217	0.584
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.342
TRG_ER_diArg_1	276	278	PF00400	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P891	Leptomonas seymouri	88%	100%
A0A0S4ISG1	Bodo saltans	68%	100%
A0A1X0NN13	Trypanosomatidae	77%	100%
A0A3S7WSN3	Leishmania donovani	94%	100%
A0A422MYV8	Trypanosoma rangeli	79%	100%
A4HVP3	Leishmania infantum	94%	100%
D0A6N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9APD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QG39	Leishmania major	93%	100%
V5BB21	Trypanosoma cruzi	79%	100%