AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H7A0_LEIBR

TriTrypDb:

LbrM.13.0940 , LBRM2903_130015500

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H7A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H7A0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.373
CLV_NRD_NRD_1	134	136	PF00675	0.286
CLV_NRD_NRD_1	168	170	PF00675	0.414
CLV_NRD_NRD_1	62	64	PF00675	0.274
CLV_PCSK_KEX2_1	102	104	PF00082	0.292
CLV_PCSK_KEX2_1	134	136	PF00082	0.286
CLV_PCSK_KEX2_1	168	170	PF00082	0.389
CLV_PCSK_KEX2_1	62	64	PF00082	0.274
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.183
CLV_PCSK_PC7_1	58	64	PF00082	0.183
CLV_PCSK_SKI1_1	15	19	PF00082	0.550
CLV_PCSK_SKI1_1	192	196	PF00082	0.183
CLV_PCSK_SKI1_1	280	284	PF00082	0.204
CLV_PCSK_SKI1_1	4	8	PF00082	0.669
DEG_APCC_DBOX_1	252	260	PF00400	0.224
DEG_Nend_UBRbox_3	1	3	PF02207	0.652
DEG_SCF_TRCP1_1	207	212	PF00400	0.197
DOC_CYCLIN_RxL_1	189	199	PF00134	0.183
DOC_MAPK_gen_1	58	67	PF00069	0.411
DOC_MAPK_HePTP_8	57	69	PF00069	0.274
DOC_MAPK_MEF2A_6	219	228	PF00069	0.303
DOC_MAPK_MEF2A_6	343	351	PF00069	0.301
DOC_MAPK_MEF2A_6	60	69	PF00069	0.274
DOC_MAPK_NFAT4_5	62	70	PF00069	0.183
DOC_PP1_RVXF_1	190	196	PF00149	0.183
DOC_PP4_FxxP_1	105	108	PF00568	0.411
DOC_USP7_MATH_1	258	262	PF00917	0.183
DOC_USP7_MATH_1	76	80	PF00917	0.402
DOC_USP7_MATH_1	85	89	PF00917	0.402
DOC_USP7_MATH_2	234	240	PF00917	0.183
DOC_USP7_UBL2_3	292	296	PF12436	0.274
DOC_WW_Pin1_4	200	205	PF00397	0.363
DOC_WW_Pin1_4	226	231	PF00397	0.275
DOC_WW_Pin1_4	354	359	PF00397	0.306
DOC_WW_Pin1_4	72	77	PF00397	0.268
LIG_14-3-3_CanoR_1	280	289	PF00244	0.405
LIG_14-3-3_CanoR_1	343	348	PF00244	0.361
LIG_14-3-3_CanoR_1	4	9	PF00244	0.434
LIG_Actin_WH2_2	119	136	PF00022	0.321
LIG_Actin_WH2_2	86	104	PF00022	0.292
LIG_BRCT_BRCA1_1	368	372	PF00533	0.274
LIG_CtBP_PxDLS_1	10	14	PF00389	0.270
LIG_eIF4E_1	32	38	PF01652	0.274
LIG_FHA_1	264	270	PF00498	0.346
LIG_FHA_1	282	288	PF00498	0.347
LIG_FHA_1	321	327	PF00498	0.183
LIG_FHA_1	344	350	PF00498	0.365
LIG_FHA_1	374	380	PF00498	0.466
LIG_FHA_2	102	108	PF00498	0.197
LIG_FHA_2	54	60	PF00498	0.183
LIG_LIR_Apic_2	104	108	PF02991	0.222
LIG_LIR_Gen_1	261	270	PF02991	0.183
LIG_LIR_Gen_1	357	364	PF02991	0.417
LIG_LIR_Nem_3	261	265	PF02991	0.183
LIG_LIR_Nem_3	309	314	PF02991	0.298
LIG_LIR_Nem_3	357	362	PF02991	0.347
LIG_MLH1_MIPbox_1	368	372	PF16413	0.274
LIG_SH2_NCK_1	262	266	PF00017	0.421
LIG_SH2_SRC	262	265	PF00017	0.292
LIG_SH2_STAT3	364	367	PF00017	0.183
LIG_SH2_STAT5	32	35	PF00017	0.274
LIG_SH3_2	338	343	PF14604	0.183
LIG_SH3_3	285	291	PF00018	0.379
LIG_SH3_3	335	341	PF00018	0.292
LIG_SH3_3	49	55	PF00018	0.326
LIG_SH3_CIN85_PxpxPR_1	338	343	PF14604	0.183
LIG_SUMO_SIM_par_1	224	229	PF11976	0.317
LIG_TRAF2_1	234	237	PF00917	0.343
LIG_TRAF2_1	261	264	PF00917	0.386
LIG_WRC_WIRS_1	311	316	PF05994	0.411
LIG_WW_3	340	344	PF00397	0.183
MOD_CDK_SPxxK_3	226	233	PF00069	0.357
MOD_CK1_1	109	115	PF00069	0.478
MOD_CK1_1	156	162	PF00069	0.417
MOD_CK1_1	19	25	PF00069	0.579
MOD_CK1_1	202	208	PF00069	0.381
MOD_CK1_1	317	323	PF00069	0.399
MOD_CK1_1	325	331	PF00069	0.416
MOD_CK1_1	333	339	PF00069	0.402
MOD_CK1_1	373	379	PF00069	0.326
MOD_CK1_1	405	411	PF00069	0.313
MOD_CK1_1	75	81	PF00069	0.344
MOD_CK2_1	258	264	PF00069	0.336
MOD_CK2_1	85	91	PF00069	0.296
MOD_GlcNHglycan	18	21	PF01048	0.489
MOD_GlcNHglycan	207	210	PF01048	0.433
MOD_GlcNHglycan	236	241	PF01048	0.276
MOD_GlcNHglycan	333	336	PF01048	0.355
MOD_GlcNHglycan	40	43	PF01048	0.420
MOD_GlcNHglycan	407	410	PF01048	0.470
MOD_GSK3_1	106	113	PF00069	0.359
MOD_GSK3_1	151	158	PF00069	0.367
MOD_GSK3_1	184	191	PF00069	0.342
MOD_GSK3_1	19	26	PF00069	0.599
MOD_GSK3_1	198	205	PF00069	0.356
MOD_GSK3_1	306	313	PF00069	0.368
MOD_GSK3_1	316	323	PF00069	0.317
MOD_GSK3_1	366	373	PF00069	0.434
MOD_GSK3_1	72	79	PF00069	0.333
MOD_N-GLC_1	373	378	PF02516	0.348
MOD_NEK2_1	101	106	PF00069	0.363
MOD_NEK2_1	141	146	PF00069	0.397
MOD_NEK2_1	184	189	PF00069	0.375
MOD_NEK2_1	282	287	PF00069	0.329
MOD_NEK2_1	322	327	PF00069	0.415
MOD_NEK2_1	38	43	PF00069	0.309
MOD_NEK2_1	402	407	PF00069	0.432
MOD_PIKK_1	184	190	PF00454	0.357
MOD_PIKK_1	26	32	PF00454	0.477
MOD_PIKK_1	373	379	PF00454	0.321
MOD_PKA_2	249	255	PF00069	0.363
MOD_Plk_1	373	379	PF00069	0.375
MOD_Plk_2-3	53	59	PF00069	0.183
MOD_Plk_4	128	134	PF00069	0.279
MOD_Plk_4	310	316	PF00069	0.436
MOD_Plk_4	317	323	PF00069	0.427
MOD_Plk_4	402	408	PF00069	0.331
MOD_ProDKin_1	200	206	PF00069	0.342
MOD_ProDKin_1	226	232	PF00069	0.275
MOD_ProDKin_1	354	360	PF00069	0.306
MOD_ProDKin_1	72	78	PF00069	0.268
MOD_SUMO_rev_2	97	104	PF00179	0.183
TRG_ENDOCYTIC_2	262	265	PF00928	0.343
TRG_ENDOCYTIC_2	311	314	PF00928	0.278
TRG_ENDOCYTIC_2	359	362	PF00928	0.418
TRG_ER_diArg_1	133	135	PF00400	0.284
TRG_ER_diArg_1	253	256	PF00400	0.183
TRG_ER_diArg_1	61	63	PF00400	0.425
TRG_NES_CRM1_1	246	257	PF08389	0.302
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L5	Leptomonas seymouri	62%	100%
A0A0N1I6V6	Leptomonas seymouri	23%	100%
A0A0S4J886	Bodo saltans	32%	99%
A0A0S4JUT3	Bodo saltans	25%	100%
A0A1X0NNK2	Trypanosomatidae	38%	100%
A0A3Q8I9M0	Leishmania donovani	79%	100%
A0A3Q8IDU3	Leishmania donovani	24%	100%
A0A3R7LZE9	Trypanosoma rangeli	43%	100%
A4HF07	Leishmania braziliensis	25%	100%
A4HVP2	Leishmania infantum	79%	100%
A4I286	Leishmania infantum	25%	100%
D0A6K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9APD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9AYD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q942	Leishmania major	26%	100%
Q4QG40	Leishmania major	78%	99%
V5ARR6	Trypanosoma cruzi	41%	96%