TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H797_LEIBR

TriTrypDb:

LbrM.13.0910 , LBRM2903_130015200

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H797

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H797

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.369
CLV_C14_Caspase3-7	293	297	PF00656	0.575
CLV_C14_Caspase3-7	94	98	PF00656	0.592
CLV_NRD_NRD_1	12	14	PF00675	0.525
CLV_NRD_NRD_1	217	219	PF00675	0.479
CLV_NRD_NRD_1	227	229	PF00675	0.523
CLV_NRD_NRD_1	249	251	PF00675	0.619
CLV_NRD_NRD_1	264	266	PF00675	0.554
CLV_NRD_NRD_1	315	317	PF00675	0.574
CLV_NRD_NRD_1	402	404	PF00675	0.642
CLV_NRD_NRD_1	427	429	PF00675	0.590
CLV_NRD_NRD_1	444	446	PF00675	0.378
CLV_NRD_NRD_1	473	475	PF00675	0.521
CLV_NRD_NRD_1	508	510	PF00675	0.581
CLV_NRD_NRD_1	58	60	PF00675	0.586
CLV_NRD_NRD_1	6	8	PF00675	0.591
CLV_NRD_NRD_1	66	68	PF00675	0.500
CLV_PCSK_KEX2_1	12	14	PF00082	0.598
CLV_PCSK_KEX2_1	163	165	PF00082	0.478
CLV_PCSK_KEX2_1	217	219	PF00082	0.533
CLV_PCSK_KEX2_1	229	231	PF00082	0.491
CLV_PCSK_KEX2_1	249	251	PF00082	0.646
CLV_PCSK_KEX2_1	264	266	PF00082	0.542
CLV_PCSK_KEX2_1	299	301	PF00082	0.582
CLV_PCSK_KEX2_1	402	404	PF00082	0.663
CLV_PCSK_KEX2_1	427	429	PF00082	0.615
CLV_PCSK_KEX2_1	444	446	PF00082	0.367
CLV_PCSK_KEX2_1	462	464	PF00082	0.500
CLV_PCSK_KEX2_1	473	475	PF00082	0.473
CLV_PCSK_KEX2_1	65	67	PF00082	0.542
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.478
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.504
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.582
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.629
CLV_PCSK_SKI1_1	140	144	PF00082	0.457
CLV_PCSK_SKI1_1	159	163	PF00082	0.629
CLV_PCSK_SKI1_1	265	269	PF00082	0.706
CLV_PCSK_SKI1_1	300	304	PF00082	0.515
CLV_PCSK_SKI1_1	509	513	PF00082	0.536
CLV_PCSK_SKI1_1	96	100	PF00082	0.404
DEG_APCC_DBOX_1	123	131	PF00400	0.593
DOC_CYCLIN_yClb5_NLxxxL_5	203	211	PF00134	0.580
DOC_MAPK_gen_1	444	451	PF00069	0.628
DOC_MAPK_JIP1_4	329	335	PF00069	0.475
DOC_MAPK_MEF2A_6	203	211	PF00069	0.482
DOC_MAPK_RevD_3	205	218	PF00069	0.479
DOC_PP1_RVXF_1	33	40	PF00149	0.602
DOC_USP7_UBL2_3	115	119	PF12436	0.355
DOC_USP7_UBL2_3	159	163	PF12436	0.466
DOC_USP7_UBL2_3	188	192	PF12436	0.374
DOC_USP7_UBL2_3	416	420	PF12436	0.595
LIG_14-3-3_CanoR_1	137	143	PF00244	0.500
LIG_AP2alpha_2	504	506	PF02296	0.354
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_CaM_IQ_9	454	470	PF13499	0.509
LIG_FHA_1	336	342	PF00498	0.626
LIG_Integrin_RGD_1	387	389	PF01839	0.791
LIG_LIR_Nem_3	488	494	PF02991	0.462
LIG_PCNA_PIPBox_1	103	112	PF02747	0.578
LIG_PCNA_yPIPBox_3	96	110	PF02747	0.584
LIG_PTB_Apo_2	253	260	PF02174	0.644
LIG_PTB_Phospho_1	253	259	PF10480	0.676
LIG_Rb_pABgroove_1	348	356	PF01858	0.663
LIG_REV1ctd_RIR_1	37	46	PF16727	0.617
LIG_SH2_SRC	494	497	PF00017	0.492
LIG_SH2_STAP1	110	114	PF00017	0.565
LIG_SH2_STAP1	354	358	PF00017	0.595
LIG_SH2_STAT3	110	113	PF00017	0.568
LIG_SH2_STAT3	336	339	PF00017	0.703
LIG_SH2_STAT3	429	432	PF00017	0.657
LIG_SH2_STAT5	324	327	PF00017	0.651
LIG_SH2_STAT5	494	497	PF00017	0.443
LIG_TRAF2_1	123	126	PF00917	0.575
LIG_TRAF2_1	235	238	PF00917	0.510
LIG_TRAF2_1	290	293	PF00917	0.561
LIG_TRAF2_1	312	315	PF00917	0.666
LIG_TRAF2_1	482	485	PF00917	0.568
MOD_CK2_1	30	36	PF00069	0.549
MOD_GlcNHglycan	391	394	PF01048	0.777
MOD_LATS_1	190	196	PF00433	0.383
MOD_NEK2_1	1	6	PF00069	0.659
MOD_NEK2_1	24	29	PF00069	0.645
MOD_NEK2_1	268	273	PF00069	0.602
MOD_PIKK_1	268	274	PF00454	0.431
MOD_PIKK_1	335	341	PF00454	0.606
MOD_PIKK_1	45	51	PF00454	0.679
MOD_PIKK_1	509	515	PF00454	0.593
MOD_PKA_1	509	515	PF00069	0.626
MOD_PKA_2	276	282	PF00069	0.421
MOD_PKB_1	65	73	PF00069	0.536
MOD_Plk_1	24	30	PF00069	0.641
MOD_Plk_4	345	351	PF00069	0.600
MOD_Plk_4	494	500	PF00069	0.547
MOD_SUMO_for_1	114	117	PF00179	0.432
MOD_SUMO_for_1	162	165	PF00179	0.508
MOD_SUMO_for_1	282	285	PF00179	0.642
MOD_SUMO_rev_2	112	121	PF00179	0.588
MOD_SUMO_rev_2	291	295	PF00179	0.564
MOD_SUMO_rev_2	304	311	PF00179	0.534
MOD_SUMO_rev_2	314	319	PF00179	0.649
MOD_SUMO_rev_2	374	384	PF00179	0.598
TRG_DiLeu_BaEn_3	116	122	PF01217	0.475
TRG_ENDOCYTIC_2	158	161	PF00928	0.627
TRG_ER_diArg_1	102	105	PF00400	0.422
TRG_ER_diArg_1	11	13	PF00400	0.600
TRG_ER_diArg_1	134	137	PF00400	0.523
TRG_ER_diArg_1	228	231	PF00400	0.539
TRG_ER_diArg_1	249	252	PF00400	0.673
TRG_ER_diArg_1	274	277	PF00400	0.476
TRG_ER_diArg_1	401	403	PF00400	0.558
TRG_ER_diArg_1	426	428	PF00400	0.613
TRG_ER_diArg_1	473	475	PF00400	0.440
TRG_ER_diArg_1	65	67	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD47	Leptomonas seymouri	66%	96%
A0A1X0NPL9	Trypanosomatidae	39%	100%
A0A3R7MPR3	Trypanosoma rangeli	38%	100%
A0A3S5H6P4	Leishmania donovani	85%	100%
A4HVN9	Leishmania infantum	85%	100%
D0A6K6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9APD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QG43	Leishmania major	83%	100%
V5BBN8	Trypanosoma cruzi	37%	100%