Putative proteasome regulatory ATPase subunit 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory ATPase subunit 2, putative

Species:

Leishmania braziliensis

UniProt:

A4H795_LEIBR

TriTrypDb:

LbrM.13.0890 , LBRM2903_130015000

Length:

434

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 18

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	11
GO:0005634	nucleus	5	10
GO:0005737	cytoplasm	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11
GO:0005654	nucleoplasm	2	1
GO:0008540	proteasome regulatory particle, base subcomplex	2	1

Expansion

Sequence features

A4H795

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H795

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0036402	proteasome-activating activity	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.282
CLV_C14_Caspase3-7	308	312	PF00656	0.296
CLV_NRD_NRD_1	23	25	PF00675	0.665
CLV_NRD_NRD_1	342	344	PF00675	0.296
CLV_NRD_NRD_1	356	358	PF00675	0.407
CLV_NRD_NRD_1	404	406	PF00675	0.312
CLV_NRD_NRD_1	422	424	PF00675	0.449
CLV_NRD_NRD_1	47	49	PF00675	0.527
CLV_PCSK_FUR_1	402	406	PF00082	0.312
CLV_PCSK_KEX2_1	23	25	PF00082	0.640
CLV_PCSK_KEX2_1	27	29	PF00082	0.650
CLV_PCSK_KEX2_1	287	289	PF00082	0.296
CLV_PCSK_KEX2_1	355	357	PF00082	0.525
CLV_PCSK_KEX2_1	404	406	PF00082	0.312
CLV_PCSK_KEX2_1	92	94	PF00082	0.559
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.640
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.650
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.296
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.525
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.561
CLV_PCSK_SKI1_1	226	230	PF00082	0.296
CLV_PCSK_SKI1_1	262	266	PF00082	0.290
CLV_PCSK_SKI1_1	301	305	PF00082	0.296
CLV_PCSK_SKI1_1	356	360	PF00082	0.401
CLV_PCSK_SKI1_1	404	408	PF00082	0.312
DEG_APCC_DBOX_1	300	308	PF00400	0.296
DEG_APCC_KENBOX_2	416	420	PF00400	0.407
DOC_CYCLIN_RxL_1	259	269	PF00134	0.312
DOC_MAPK_FxFP_2	347	350	PF00069	0.393
DOC_MAPK_gen_1	337	347	PF00069	0.296
DOC_MAPK_gen_1	51	61	PF00069	0.409
DOC_MAPK_MEF2A_6	158	167	PF00069	0.571
DOC_MAPK_RevD_3	273	288	PF00069	0.296
DOC_PP1_RVXF_1	341	348	PF00149	0.296
DOC_PP4_FxxP_1	347	350	PF00568	0.393
DOC_USP7_MATH_1	116	120	PF00917	0.444
DOC_USP7_MATH_1	128	132	PF00917	0.444
DOC_USP7_MATH_1	163	167	PF00917	0.447
DOC_USP7_MATH_1	5	9	PF00917	0.578
DOC_USP7_UBL2_3	23	27	PF12436	0.698
DOC_WW_Pin1_4	269	274	PF00397	0.286
DOC_WW_Pin1_4	97	102	PF00397	0.521
LIG_14-3-3_CanoR_1	236	242	PF00244	0.416
LIG_14-3-3_CanoR_1	365	369	PF00244	0.400
LIG_BIR_III_4	282	286	PF00653	0.296
LIG_BRCT_BRCA1_1	237	241	PF00533	0.296
LIG_FHA_1	294	300	PF00498	0.416
LIG_FHA_1	323	329	PF00498	0.296
LIG_FHA_2	175	181	PF00498	0.428
LIG_FHA_2	300	306	PF00498	0.296
LIG_FHA_2	98	104	PF00498	0.453
LIG_LIR_Apic_2	11	16	PF02991	0.589
LIG_LIR_Apic_2	123	128	PF02991	0.455
LIG_LIR_Apic_2	346	350	PF02991	0.296
LIG_LIR_Gen_1	175	184	PF02991	0.420
LIG_LIR_Gen_1	203	213	PF02991	0.417
LIG_LIR_Gen_1	238	249	PF02991	0.282
LIG_LIR_Gen_1	427	434	PF02991	0.532
LIG_LIR_Gen_1	57	66	PF02991	0.408
LIG_LIR_Nem_3	123	129	PF02991	0.506
LIG_LIR_Nem_3	175	181	PF02991	0.431
LIG_LIR_Nem_3	203	208	PF02991	0.426
LIG_LIR_Nem_3	238	244	PF02991	0.282
LIG_LIR_Nem_3	427	432	PF02991	0.522
LIG_LIR_Nem_3	57	61	PF02991	0.414
LIG_PCNA_yPIPBox_3	149	157	PF02747	0.468
LIG_PCNA_yPIPBox_3	297	307	PF02747	0.296
LIG_PDZ_Class_2	429	434	PF00595	0.512
LIG_RPA_C_Fungi	231	243	PF08784	0.416
LIG_SH2_CRK	219	223	PF00017	0.295
LIG_SH2_NCK_1	178	182	PF00017	0.402
LIG_SH2_NCK_1	205	209	PF00017	0.440
LIG_SH2_PTP2	126	129	PF00017	0.381
LIG_SH2_SRC	178	181	PF00017	0.417
LIG_SH2_SRC	205	208	PF00017	0.428
LIG_SH2_STAP1	87	91	PF00017	0.464
LIG_SH2_STAT5	126	129	PF00017	0.283
LIG_SH2_STAT5	58	61	PF00017	0.399
LIG_SH3_3	13	19	PF00018	0.564
LIG_SH3_3	192	198	PF00018	0.366
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.296
LIG_SUMO_SIM_par_1	100	106	PF11976	0.443
LIG_SUMO_SIM_par_1	116	121	PF11976	0.312
LIG_SUMO_SIM_par_1	302	308	PF11976	0.296
LIG_SUMO_SIM_par_1	397	403	PF11976	0.312
LIG_TRAF2_1	106	109	PF00917	0.296
LIG_WRC_WIRS_1	129	134	PF05994	0.296
MOD_CK1_1	293	299	PF00069	0.413
MOD_CK1_1	364	370	PF00069	0.412
MOD_CK1_1	427	433	PF00069	0.526
MOD_CK2_1	118	124	PF00069	0.353
MOD_CK2_1	197	203	PF00069	0.405
MOD_CK2_1	299	305	PF00069	0.296
MOD_CK2_1	5	11	PF00069	0.661
MOD_CK2_1	74	80	PF00069	0.538
MOD_CK2_1	97	103	PF00069	0.511
MOD_Cter_Amidation	21	24	PF01082	0.538
MOD_GlcNHglycan	120	123	PF01048	0.353
MOD_GlcNHglycan	237	240	PF01048	0.288
MOD_GlcNHglycan	253	256	PF01048	0.296
MOD_GlcNHglycan	292	296	PF01048	0.295
MOD_GlcNHglycan	382	387	PF01048	0.312
MOD_GSK3_1	116	123	PF00069	0.312
MOD_GSK3_1	360	367	PF00069	0.402
MOD_LATS_1	147	153	PF00433	0.353
MOD_N-GLC_1	234	239	PF02516	0.296
MOD_NEK2_1	140	145	PF00069	0.296
MOD_NEK2_1	65	70	PF00069	0.442
MOD_PIKK_1	305	311	PF00454	0.296
MOD_PK_1	149	155	PF00069	0.372
MOD_PKA_2	235	241	PF00069	0.416
MOD_PKA_2	364	370	PF00069	0.412
MOD_Plk_1	174	180	PF00069	0.503
MOD_Plk_1	424	430	PF00069	0.498
MOD_Plk_2-3	103	109	PF00069	0.296
MOD_Plk_4	128	134	PF00069	0.287
MOD_Plk_4	140	146	PF00069	0.296
MOD_Plk_4	149	155	PF00069	0.296
MOD_Plk_4	163	169	PF00069	0.381
MOD_Plk_4	224	230	PF00069	0.296
MOD_Plk_4	237	243	PF00069	0.296
MOD_ProDKin_1	269	275	PF00069	0.286
MOD_ProDKin_1	97	103	PF00069	0.518
MOD_SUMO_for_1	380	383	PF00179	0.331
MOD_SUMO_rev_2	185	194	PF00179	0.387
MOD_SUMO_rev_2	314	322	PF00179	0.296
MOD_SUMO_rev_2	346	354	PF00179	0.408
MOD_SUMO_rev_2	382	392	PF00179	0.312
MOD_SUMO_rev_2	88	94	PF00179	0.538
TRG_DiLeu_BaEn_1	256	261	PF01217	0.312
TRG_ENDOCYTIC_2	126	129	PF00928	0.296
TRG_ENDOCYTIC_2	178	181	PF00928	0.408
TRG_ENDOCYTIC_2	205	208	PF00928	0.438
TRG_ENDOCYTIC_2	58	61	PF00928	0.399
TRG_ER_diArg_1	356	358	PF00400	0.527
TRG_ER_diArg_1	404	406	PF00400	0.311
TRG_NLS_Bipartite_1	343	359	PF00514	0.521
TRG_NLS_MonoCore_2	22	27	PF00514	0.570
TRG_NLS_MonoExtC_3	22	27	PF00514	0.570
TRG_NLS_MonoExtC_3	354	360	PF00514	0.513
TRG_NLS_MonoExtC_3	47	53	PF00514	0.519
TRG_NLS_MonoExtN_4	23	30	PF00514	0.574
TRG_NLS_MonoExtN_4	353	359	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E9	Leptomonas seymouri	45%	100%
A0A0N0P5B8	Leptomonas seymouri	51%	98%
A0A0N1IGY9	Leptomonas seymouri	50%	100%
A0A0N1IM81	Leptomonas seymouri	98%	99%
A0A0N1PAS8	Leptomonas seymouri	42%	99%
A0A0S4IJE6	Bodo saltans	42%	99%
A0A0S4ITX1	Bodo saltans	51%	98%
A0A0S4IY28	Bodo saltans	47%	100%
A0A0S4JCD0	Bodo saltans	84%	100%
A0A0S4JDU3	Bodo saltans	52%	100%
A0A0S4JSD8	Bodo saltans	51%	100%
A0A1X0NMZ3	Trypanosomatidae	85%	99%
A0A1X0NNS1	Trypanosomatidae	52%	100%
A0A1X0NT86	Trypanosomatidae	48%	98%
A0A1X0NUX3	Trypanosomatidae	41%	99%
A0A1X0P1T5	Trypanosomatidae	51%	100%
A0A1X0P8T7	Trypanosomatidae	45%	100%
A0A3Q8IHU1	Leishmania donovani	33%	100%
A0A3Q8IJS0	Leishmania donovani	54%	100%
A0A3R7LUG9	Trypanosoma rangeli	45%	98%
A0A3R7N4Y5	Trypanosoma rangeli	53%	100%
A0A3S5H547	Leishmania donovani	43%	100%
A0A3S7WRY0	Leishmania donovani	48%	100%
A0A3S7WSK7	Leishmania donovani	99%	99%
A0A3S7WX14	Leishmania donovani	51%	98%
A0A3S7WX46	Leishmania donovani	42%	99%
A0A422NDS9	Trypanosoma rangeli	43%	99%
A0A422NLD8	Trypanosoma rangeli	84%	99%
A0A422NMN6	Trypanosoma rangeli	44%	100%
A0A422NUD9	Trypanosoma rangeli	53%	100%
A0JWY3	Arthrobacter sp. (strain FB24)	34%	73%
A1TAQ3	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	35%	71%
A3CV35	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	46%	100%
A4FBX6	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	36%	73%
A4G0S4	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	48%	100%
A4H3L6	Leishmania braziliensis	43%	100%
A4H6T6	Leishmania braziliensis	49%	100%
A4HCA3	Leishmania braziliensis	42%	99%
A4HCA7	Leishmania braziliensis	51%	98%
A4HME8	Leishmania braziliensis	32%	100%
A4HPV3	Leishmania braziliensis	54%	100%
A4HVN7	Leishmania infantum	99%	99%
A4HZT4	Leishmania infantum	42%	99%
A4HZT9	Leishmania infantum	51%	98%
A4IB20	Leishmania infantum	33%	100%
A4IE38	Leishmania infantum	54%	100%
A4TB65	Mycolicibacterium gilvum (strain PYR-GCK)	36%	71%
A6UQT3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	49%	100%
A6VHR1	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	49%	100%
A7I8B8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	47%	100%
A9A916	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	49%	100%
B1MAH2	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	34%	72%
B1VDV2	Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109)	37%	81%
B6YXR2	Thermococcus onnurineus (strain NA1)	47%	100%
B8GGN4	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	44%	100%
B8ZRF0	Mycobacterium leprae (strain Br4923)	33%	71%
C0ZZV2	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	32%	73%
C3MRF1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	45%	100%
C3MY47	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	45%	100%
C3MZI6	Sulfolobus islandicus (strain M.16.27)	45%	100%
C3N7K8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	45%	100%
C3NFW6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	45%	100%
C3PGA0	Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 / CN-1)	34%	83%
C4KIR6	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	45%	100%
C5A6P8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	48%	100%
C6WIC8	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)	34%	72%
C7PVU9	Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908)	35%	73%
C8XAR0	Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 / Y-104)	35%	73%
C9ZQC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZRM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
C9ZRM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
D0A259	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A4A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A6K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	99%
D0LDS6	Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)	34%	71%
D1BHU2	Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)	35%	75%
D2Q9C6	Bifidobacterium dentium (strain ATCC 27534 / DSM 20436 / JCM 1195 / Bd1)	39%	82%
D4GUJ7	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	47%	100%
E9ACJ9	Leishmania major	43%	100%
E9AEU9	Leishmania major	33%	100%
E9AG43	Leishmania infantum	43%	100%
E9AGB0	Leishmania infantum	48%	100%
E9AJT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9ANU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9APD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	99%
E9ATM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AVN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E9AVP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	98%
E9B605	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O04019	Arabidopsis thaliana	51%	100%
O14126	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	99%
O16368	Caenorhabditis elegans	68%	98%
O17071	Caenorhabditis elegans	45%	100%
O18413	Drosophila melanogaster	55%	100%
O23894	Brassica campestris	51%	100%
O26824	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	53%	100%
O28303	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	52%	100%
O32617	Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)	38%	68%
O42586	Xenopus laevis	49%	100%
O42587	Xenopus laevis	50%	100%
O42931	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	99%
O50202	Rhodococcus erythropolis	32%	73%
O57940	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	49%	100%
O64982	Prunus persica	47%	100%
O74445	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O74894	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
O76371	Caenorhabditis elegans	49%	100%
O88685	Mus musculus	50%	98%
P0DKJ9	Oryza sativa subsp. japonica	46%	100%
P0DKK0	Oryza sativa subsp. japonica	46%	100%
P17980	Homo sapiens	50%	99%
P33297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P33298	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P33299	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	93%
P34123	Dictyostelium discoideum	49%	100%
P34124	Dictyostelium discoideum	52%	100%
P35998	Homo sapiens	46%	100%
P36612	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	64%	97%
P40327	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	61%	99%
P41836	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	100%
P43686	Homo sapiens	51%	100%
P46465	Oryza sativa subsp. japonica	51%	100%
P46466	Oryza sativa subsp. japonica	66%	97%
P46470	Xenopus laevis	47%	94%
P46471	Mus musculus	46%	100%
P46472	Xenopus laevis	46%	100%
P46502	Caenorhabditis elegans	51%	100%
P46507	Manduca sexta	51%	100%
P46509	Mycobacterium leprae (strain TN)	33%	71%
P48601	Drosophila melanogaster	68%	99%
P53549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	99%
P54775	Mus musculus	51%	100%
P54776	Solanum lycopersicum	51%	100%
P54778	Solanum tuberosum	48%	100%
P54814	Manduca sexta	55%	100%
P62191	Homo sapiens	70%	99%
P62192	Mus musculus	70%	99%
P62193	Rattus norvegicus	70%	99%
P62194	Bos taurus	47%	100%
P62195	Homo sapiens	47%	100%
P62196	Mus musculus	47%	100%
P62197	Sus scrofa	47%	100%
P62198	Rattus norvegicus	47%	100%
P62333	Homo sapiens	43%	100%
P62334	Mus musculus	43%	100%
P62335	Ictidomys tridecemlineatus	43%	100%
P71408	Helicobacter pylori (strain ATCC 700392 / 26695)	37%	69%
P78578	Aspergillus niger	49%	100%
P85200	Helianthus annuus	49%	100%
Q01939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
Q0W257	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	45%	100%
Q18787	Caenorhabditis elegans	46%	100%
Q25544	Naegleria fowleri	53%	100%
Q2FQ56	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	50%	100%
Q2KIW6	Bos taurus	43%	100%
Q3T030	Bos taurus	51%	100%
Q41365	Spinacia oleracea	47%	100%
Q4JVP5	Corynebacterium jeikeium (strain K411)	35%	84%
Q4Q0X8	Leishmania major	54%	100%
Q4QBT5	Leishmania major	51%	100%
Q4QBU0	Leishmania major	42%	100%
Q4QG45	Leishmania major	99%	100%
Q4QGS2	Leishmania major	48%	100%
Q4R4R0	Macaca fascicularis	46%	100%
Q4R7L3	Macaca fascicularis	51%	100%
Q54PJ1	Dictyostelium discoideum	44%	100%
Q54PN7	Dictyostelium discoideum	50%	100%
Q55BV5	Dictyostelium discoideum	64%	99%
Q58576	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	50%	100%
Q5E9F9	Bos taurus	46%	100%
Q5JHS5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	48%	100%
Q5R8D7	Pongo abelii	46%	100%
Q5UT56	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	44%	100%
Q63347	Rattus norvegicus	46%	100%
Q63569	Rattus norvegicus	50%	99%
Q63570	Rattus norvegicus	51%	100%
Q67T82	Symbiobacterium thermophilum (strain T / IAM 14863)	37%	74%
Q6LWR0	Methanococcus maripaludis (strain S2 / LL)	49%	100%
Q86JA1	Dictyostelium discoideum	46%	100%
Q8FTE3	Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)	39%	83%
Q8PY58	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	43%	100%
Q8SQI9	Encephalitozoon cuniculi (strain GB-M1)	54%	100%
Q8SQK0	Encephalitozoon cuniculi (strain GB-M1)	56%	100%
Q8SR13	Encephalitozoon cuniculi (strain GB-M1)	47%	100%
Q8SRH0	Encephalitozoon cuniculi (strain GB-M1)	60%	100%
Q8TI88	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	43%	100%
Q8TX03	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	48%	100%
Q8U4H3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	49%	100%
Q90732	Gallus gallus	69%	99%
Q94BQ2	Arabidopsis thaliana	56%	100%
Q975U2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	46%	100%
Q980M1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	46%	100%
Q9C5U3	Arabidopsis thaliana	56%	100%
Q9HNP9	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	46%	100%
Q9HRW6	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	46%	100%
Q9MAK9	Arabidopsis thaliana	47%	100%
Q9SEI2	Arabidopsis thaliana	51%	100%
Q9SEI3	Arabidopsis thaliana	43%	100%
Q9SEI4	Arabidopsis thaliana	49%	100%
Q9SL67	Arabidopsis thaliana	66%	98%
Q9SSB4	Arabidopsis thaliana	46%	94%
Q9SSB5	Arabidopsis thaliana	46%	100%
Q9SZD4	Arabidopsis thaliana	66%	98%
Q9V287	Pyrococcus abyssi (strain GE5 / Orsay)	47%	100%
Q9XTT9	Caenorhabditis elegans	53%	100%
Q9YAC7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	51%	100%
Q9ZM66	Helicobacter pylori (strain J99 / ATCC 700824)	37%	69%
V5AV12	Trypanosoma cruzi	85%	99%
V5B5X1	Trypanosoma cruzi	43%	99%
V5B5X6	Trypanosoma cruzi	48%	99%
V5BKL6	Trypanosoma cruzi	53%	100%
V5BSS5	Trypanosoma cruzi	44%	100%