Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H791_LEIBR

TriTrypDb:

LbrM.13.0850 , LBRM2903_130014400

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H791

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H791

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.390
CLV_NRD_NRD_1	210	212	PF00675	0.510
CLV_NRD_NRD_1	22	24	PF00675	0.502
CLV_NRD_NRD_1	49	51	PF00675	0.701
CLV_PCSK_KEX2_1	22	24	PF00082	0.502
CLV_PCSK_KEX2_1	49	51	PF00082	0.485
CLV_PCSK_SKI1_1	28	32	PF00082	0.462
CLV_PCSK_SKI1_1	328	332	PF00082	0.481
DEG_APCC_DBOX_1	27	35	PF00400	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_ODPH_VHL_1	78	89	PF01847	0.403
DEG_SPOP_SBC_1	125	129	PF00917	0.642
DEG_SPOP_SBC_1	136	140	PF00917	0.457
DEG_SPOP_SBC_1	16	20	PF00917	0.666
DEG_SPOP_SBC_1	66	70	PF00917	0.548
DOC_CDC14_PxL_1	253	261	PF14671	0.514
DOC_CDC14_PxL_1	48	56	PF14671	0.470
DOC_CKS1_1	244	249	PF01111	0.550
DOC_CYCLIN_RxL_1	22	32	PF00134	0.477
DOC_MAPK_DCC_7	166	175	PF00069	0.379
DOC_MAPK_gen_1	166	175	PF00069	0.379
DOC_MAPK_MEF2A_6	166	175	PF00069	0.379
DOC_PP1_RVXF_1	83	90	PF00149	0.537
DOC_PP2B_LxvP_1	168	171	PF13499	0.521
DOC_PP2B_LxvP_1	298	301	PF13499	0.475
DOC_PP2B_LxvP_1	324	327	PF13499	0.612
DOC_USP7_MATH_1	125	129	PF00917	0.624
DOC_USP7_MATH_1	136	140	PF00917	0.536
DOC_USP7_MATH_1	204	208	PF00917	0.637
DOC_USP7_MATH_1	229	233	PF00917	0.454
DOC_USP7_MATH_1	271	275	PF00917	0.593
DOC_USP7_MATH_1	66	70	PF00917	0.662
DOC_WW_Pin1_4	243	248	PF00397	0.576
DOC_WW_Pin1_4	269	274	PF00397	0.635
DOC_WW_Pin1_4	275	280	PF00397	0.697
DOC_WW_Pin1_4	346	351	PF00397	0.513
DOC_WW_Pin1_4	62	67	PF00397	0.735
DOC_WW_Pin1_4	71	76	PF00397	0.546
LIG_14-3-3_CanoR_1	124	132	PF00244	0.660
LIG_14-3-3_CanoR_1	203	213	PF00244	0.612
LIG_14-3-3_CanoR_1	25	31	PF00244	0.495
LIG_14-3-3_CanoR_1	5	12	PF00244	0.592
LIG_eIF4E_1	299	305	PF01652	0.461
LIG_FHA_1	317	323	PF00498	0.582
LIG_FHA_1	331	337	PF00498	0.538
LIG_FHA_1	5	11	PF00498	0.666
LIG_FHA_2	138	144	PF00498	0.399
LIG_HP1_1	327	331	PF01393	0.590
LIG_IRF3_LxIS_1	170	176	PF10401	0.428
LIG_LIR_Gen_1	161	172	PF02991	0.334
LIG_LIR_Gen_1	307	317	PF02991	0.599
LIG_LIR_Nem_3	161	167	PF02991	0.315
LIG_LIR_Nem_3	307	312	PF02991	0.591
LIG_MYND_1	76	80	PF01753	0.487
LIG_MYND_3	51	55	PF01753	0.465
LIG_PDZ_Class_2	362	367	PF00595	0.519
LIG_Pex14_1	156	160	PF04695	0.431
LIG_PTB_Apo_2	303	310	PF02174	0.429
LIG_PTB_Phospho_1	303	309	PF10480	0.434
LIG_SH2_CRK	164	168	PF00017	0.298
LIG_SH2_NCK_1	160	164	PF00017	0.328
LIG_SH2_NCK_1	309	313	PF00017	0.584
LIG_SH2_SRC	299	302	PF00017	0.472
LIG_SH2_STAP1	160	164	PF00017	0.328
LIG_SH2_STAP1	17	21	PF00017	0.667
LIG_SH2_STAP1	309	313	PF00017	0.580
LIG_SH2_STAT5	245	248	PF00017	0.567
LIG_SH2_STAT5	260	263	PF00017	0.638
LIG_SH2_STAT5	299	302	PF00017	0.527
LIG_SH2_STAT5	309	312	PF00017	0.470
LIG_SH3_3	289	295	PF00018	0.664
LIG_SH3_3	70	76	PF00018	0.608
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.439
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.518
LIG_TRAF2_1	237	240	PF00917	0.512
LIG_WRC_WIRS_1	300	305	PF05994	0.457
MOD_CK1_1	123	129	PF00069	0.479
MOD_CK1_1	137	143	PF00069	0.425
MOD_CK1_1	176	182	PF00069	0.645
MOD_CK1_1	274	280	PF00069	0.680
MOD_CK1_1	29	35	PF00069	0.606
MOD_CK1_1	3	9	PF00069	0.687
MOD_CK1_1	307	313	PF00069	0.630
MOD_CK1_1	65	71	PF00069	0.677
MOD_CK1_1	94	100	PF00069	0.458
MOD_CK2_1	137	143	PF00069	0.425
MOD_Cter_Amidation	209	212	PF01082	0.483
MOD_GlcNHglycan	128	131	PF01048	0.700
MOD_GlcNHglycan	175	178	PF01048	0.644
MOD_GlcNHglycan	2	5	PF01048	0.532
MOD_GlcNHglycan	215	219	PF01048	0.399
MOD_GlcNHglycan	273	276	PF01048	0.603
MOD_GlcNHglycan	361	364	PF01048	0.518
MOD_GSK3_1	120	127	PF00069	0.484
MOD_GSK3_1	171	178	PF00069	0.589
MOD_GSK3_1	271	278	PF00069	0.587
MOD_GSK3_1	357	364	PF00069	0.576
MOD_GSK3_1	62	69	PF00069	0.615
MOD_GSK3_1	94	101	PF00069	0.434
MOD_N-GLC_1	180	185	PF02516	0.411
MOD_N-GLC_2	225	227	PF02516	0.297
MOD_NEK2_1	173	178	PF00069	0.454
MOD_NEK2_1	304	309	PF00069	0.484
MOD_NEK2_1	361	366	PF00069	0.475
MOD_NEK2_1	67	72	PF00069	0.579
MOD_NEK2_1	98	103	PF00069	0.549
MOD_NEK2_2	17	22	PF00069	0.755
MOD_PIKK_1	88	94	PF00454	0.466
MOD_PKA_2	123	129	PF00069	0.482
MOD_PKA_2	4	10	PF00069	0.683
MOD_Plk_1	357	363	PF00069	0.701
MOD_Plk_1	94	100	PF00069	0.387
MOD_Plk_4	299	305	PF00069	0.658
MOD_Plk_4	318	324	PF00069	0.540
MOD_Plk_4	361	367	PF00069	0.498
MOD_Plk_4	94	100	PF00069	0.484
MOD_ProDKin_1	243	249	PF00069	0.575
MOD_ProDKin_1	269	275	PF00069	0.635
MOD_ProDKin_1	346	352	PF00069	0.509
MOD_ProDKin_1	62	68	PF00069	0.735
MOD_ProDKin_1	71	77	PF00069	0.545
TRG_DiLeu_BaEn_1	341	346	PF01217	0.464
TRG_DiLeu_BaEn_4	239	245	PF01217	0.525
TRG_ENDOCYTIC_2	164	167	PF00928	0.300
TRG_ENDOCYTIC_2	309	312	PF00928	0.591
TRG_ER_diArg_1	21	23	PF00400	0.509
TRG_ER_diArg_1	48	50	PF00400	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P893	Leptomonas seymouri	36%	97%
A0A3Q8ICW6	Leishmania donovani	66%	100%
A4HVN1	Leishmania infantum	66%	100%
D0A6L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9APC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QG51	Leishmania major	68%	100%
V5BK64	Trypanosoma cruzi	28%	87%