Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H788_LEIBR

TriTrypDb:

LbrM.13.0810 , LBRM2903_130013900

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H788

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H788

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.640
CLV_NRD_NRD_1	114	116	PF00675	0.635
CLV_NRD_NRD_1	158	160	PF00675	0.736
CLV_NRD_NRD_1	317	319	PF00675	0.561
CLV_NRD_NRD_1	364	366	PF00675	0.630
CLV_NRD_NRD_1	8	10	PF00675	0.561
CLV_PCSK_FUR_1	305	309	PF00082	0.595
CLV_PCSK_KEX2_1	114	116	PF00082	0.635
CLV_PCSK_KEX2_1	158	160	PF00082	0.690
CLV_PCSK_KEX2_1	287	289	PF00082	0.621
CLV_PCSK_KEX2_1	307	309	PF00082	0.551
CLV_PCSK_KEX2_1	317	319	PF00082	0.613
CLV_PCSK_KEX2_1	364	366	PF00082	0.468
CLV_PCSK_KEX2_1	8	10	PF00082	0.561
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.658
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.545
CLV_PCSK_SKI1_1	184	188	PF00082	0.564
CLV_PCSK_SKI1_1	348	352	PF00082	0.664
CLV_PCSK_SKI1_1	407	411	PF00082	0.364
CLV_PCSK_SKI1_1	420	424	PF00082	0.381
DEG_APCC_DBOX_1	378	386	PF00400	0.440
DEG_SCF_FBW7_1	160	166	PF00400	0.571
DEG_SPOP_SBC_1	172	176	PF00917	0.592
DOC_ANK_TNKS_1	38	45	PF00023	0.562
DOC_CKS1_1	160	165	PF01111	0.752
DOC_CYCLIN_RxL_1	417	427	PF00134	0.388
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.536
DOC_MAPK_gen_1	64	71	PF00069	0.440
DOC_MAPK_MEF2A_6	221	228	PF00069	0.450
DOC_MAPK_MEF2A_6	231	240	PF00069	0.562
DOC_PP1_RVXF_1	405	411	PF00149	0.362
DOC_PP2B_LxvP_1	279	282	PF13499	0.535
DOC_PP4_FxxP_1	438	441	PF00568	0.484
DOC_USP7_MATH_1	13	17	PF00917	0.717
DOC_USP7_MATH_1	163	167	PF00917	0.824
DOC_USP7_MATH_1	173	177	PF00917	0.584
DOC_USP7_MATH_1	21	25	PF00917	0.633
DOC_USP7_MATH_1	244	248	PF00917	0.541
DOC_USP7_MATH_1	30	34	PF00917	0.551
DOC_USP7_MATH_2	189	195	PF00917	0.693
DOC_USP7_UBL2_3	180	184	PF12436	0.693
DOC_USP7_UBL2_3	348	352	PF12436	0.549
DOC_WW_Pin1_4	146	151	PF00397	0.557
DOC_WW_Pin1_4	159	164	PF00397	0.720
DOC_WW_Pin1_4	274	279	PF00397	0.675
DOC_WW_Pin1_4	299	304	PF00397	0.558
LIG_14-3-3_CanoR_1	121	126	PF00244	0.527
LIG_14-3-3_CanoR_1	384	393	PF00244	0.320
LIG_14-3-3_CanoR_1	433	437	PF00244	0.380
LIG_APCC_ABBAyCdc20_2	288	294	PF00400	0.553
LIG_BRCT_BRCA1_1	434	438	PF00533	0.447
LIG_FHA_1	247	253	PF00498	0.559
LIG_FHA_1	275	281	PF00498	0.540
LIG_FHA_1	445	451	PF00498	0.317
LIG_FHA_1	66	72	PF00498	0.527
LIG_FHA_1	97	103	PF00498	0.536
LIG_FHA_2	230	236	PF00498	0.438
LIG_FHA_2	30	36	PF00498	0.571
LIG_FHA_2	329	335	PF00498	0.648
LIG_FHA_2	70	76	PF00498	0.529
LIG_LIR_Apic_2	435	441	PF02991	0.473
LIG_LIR_Nem_3	397	402	PF02991	0.385
LIG_LIR_Nem_3	75	81	PF02991	0.486
LIG_SH2_CRK	67	71	PF00017	0.444
LIG_SH2_CRK	89	93	PF00017	0.415
LIG_SH2_STAP1	402	406	PF00017	0.393
LIG_SH2_STAP1	67	71	PF00017	0.444
LIG_SH2_STAP1	96	100	PF00017	0.482
LIG_SH2_STAT5	217	220	PF00017	0.509
LIG_SH2_STAT5	395	398	PF00017	0.282
LIG_SH2_STAT5	67	70	PF00017	0.484
LIG_SH2_STAT5	89	92	PF00017	0.446
LIG_SH3_3	157	163	PF00018	0.741
LIG_SH3_3	167	173	PF00018	0.626
LIG_SH3_3	223	229	PF00018	0.482
LIG_SH3_3	34	40	PF00018	0.650
LIG_SH3_4	180	187	PF00018	0.562
LIG_SUMO_SIM_par_1	67	72	PF11976	0.545
LIG_SUMO_SIM_par_1	97	103	PF11976	0.521
LIG_TRFH_1	426	430	PF08558	0.495
LIG_TYR_ITIM	65	70	PF00017	0.463
MOD_CDC14_SPxK_1	302	305	PF00782	0.555
MOD_CDK_SPxK_1	299	305	PF00069	0.550
MOD_CK1_1	166	172	PF00069	0.676
MOD_CK1_1	175	181	PF00069	0.574
MOD_CK1_1	24	30	PF00069	0.566
MOD_CK1_1	274	280	PF00069	0.700
MOD_CK1_1	3	9	PF00069	0.704
MOD_CK2_1	229	235	PF00069	0.438
MOD_CK2_1	29	35	PF00069	0.571
MOD_CK2_1	69	75	PF00069	0.548
MOD_CK2_1	91	97	PF00069	0.519
MOD_Cter_Amidation	315	318	PF01082	0.561
MOD_DYRK1A_RPxSP_1	159	163	PF00069	0.685
MOD_GlcNHglycan	134	137	PF01048	0.576
MOD_GlcNHglycan	165	168	PF01048	0.623
MOD_GlcNHglycan	177	180	PF01048	0.737
MOD_GlcNHglycan	246	249	PF01048	0.679
MOD_GlcNHglycan	26	29	PF01048	0.728
MOD_GlcNHglycan	273	276	PF01048	0.706
MOD_GlcNHglycan	283	286	PF01048	0.588
MOD_GlcNHglycan	3	6	PF01048	0.702
MOD_GlcNHglycan	32	35	PF01048	0.668
MOD_GlcNHglycan	342	345	PF01048	0.585
MOD_GSK3_1	128	135	PF00069	0.448
MOD_GSK3_1	159	166	PF00069	0.591
MOD_GSK3_1	171	178	PF00069	0.830
MOD_GSK3_1	252	259	PF00069	0.662
MOD_GSK3_1	336	343	PF00069	0.620
MOD_GSK3_1	350	357	PF00069	0.508
MOD_GSK3_1	432	439	PF00069	0.378
MOD_GSK3_1	440	447	PF00069	0.403
MOD_GSK3_1	48	55	PF00069	0.651
MOD_GSK3_1	65	72	PF00069	0.523
MOD_N-GLC_1	153	158	PF02516	0.511
MOD_N-GLC_1	24	29	PF02516	0.723
MOD_N-GLC_1	30	35	PF02516	0.666
MOD_N-GLC_1	336	341	PF02516	0.542
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	153	158	PF00069	0.653
MOD_NEK2_1	252	257	PF00069	0.566
MOD_NEK2_1	350	355	PF00069	0.633
MOD_NEK2_1	432	437	PF00069	0.374
MOD_NEK2_2	136	141	PF00069	0.420
MOD_NEK2_2	253	258	PF00069	0.565
MOD_NEK2_2	374	379	PF00069	0.307
MOD_PIKK_1	357	363	PF00454	0.396
MOD_PKA_1	184	190	PF00069	0.562
MOD_PKA_2	344	350	PF00069	0.669
MOD_PKA_2	432	438	PF00069	0.393
MOD_PKB_1	128	136	PF00069	0.438
MOD_Plk_1	136	142	PF00069	0.423
MOD_Plk_1	253	259	PF00069	0.564
MOD_Plk_1	96	102	PF00069	0.487
MOD_Plk_4	354	360	PF00069	0.565
MOD_Plk_4	412	418	PF00069	0.370
MOD_Plk_4	432	438	PF00069	0.373
MOD_Plk_4	65	71	PF00069	0.567
MOD_ProDKin_1	146	152	PF00069	0.557
MOD_ProDKin_1	159	165	PF00069	0.722
MOD_ProDKin_1	274	280	PF00069	0.676
MOD_ProDKin_1	299	305	PF00069	0.562
MOD_SUMO_for_1	257	260	PF00179	0.712
MOD_SUMO_for_1	306	309	PF00179	0.734
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.555
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.546
TRG_ENDOCYTIC_2	67	70	PF00928	0.447
TRG_ENDOCYTIC_2	89	92	PF00928	0.408
TRG_ER_diArg_1	114	116	PF00400	0.637
TRG_ER_diArg_1	127	130	PF00400	0.364
TRG_ER_diArg_1	158	160	PF00400	0.686
TRG_ER_diArg_1	210	213	PF00400	0.467
TRG_ER_diArg_1	288	291	PF00400	0.710
TRG_ER_diArg_1	363	365	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7S2	Leptomonas seymouri	45%	100%
A0A3S5H6P2	Leishmania donovani	72%	100%
A4HVM8	Leishmania infantum	72%	100%
E9APC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QG54	Leishmania major	71%	100%