Ribosomal RNA-processing protein 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H787_LEIBR

TriTrypDb:

LbrM.13.0800 , LBRM2903_130013800

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H787

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H787

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.791
CLV_C14_Caspase3-7	449	453	PF00656	0.755
CLV_NRD_NRD_1	193	195	PF00675	0.542
CLV_NRD_NRD_1	197	199	PF00675	0.545
CLV_NRD_NRD_1	201	203	PF00675	0.548
CLV_NRD_NRD_1	207	209	PF00675	0.546
CLV_NRD_NRD_1	236	238	PF00675	0.695
CLV_NRD_NRD_1	264	266	PF00675	0.551
CLV_NRD_NRD_1	3	5	PF00675	0.626
CLV_NRD_NRD_1	300	302	PF00675	0.729
CLV_NRD_NRD_1	304	306	PF00675	0.795
CLV_NRD_NRD_1	332	334	PF00675	0.650
CLV_NRD_NRD_1	361	363	PF00675	0.762
CLV_NRD_NRD_1	409	411	PF00675	0.740
CLV_NRD_NRD_1	479	481	PF00675	0.549
CLV_NRD_NRD_1	485	487	PF00675	0.591
CLV_NRD_NRD_1	72	74	PF00675	0.551
CLV_PCSK_FUR_1	301	305	PF00082	0.807
CLV_PCSK_KEX2_1	143	145	PF00082	0.670
CLV_PCSK_KEX2_1	16	18	PF00082	0.658
CLV_PCSK_KEX2_1	201	203	PF00082	0.544
CLV_PCSK_KEX2_1	207	209	PF00082	0.494
CLV_PCSK_KEX2_1	236	238	PF00082	0.658
CLV_PCSK_KEX2_1	271	273	PF00082	0.640
CLV_PCSK_KEX2_1	3	5	PF00082	0.626
CLV_PCSK_KEX2_1	302	304	PF00082	0.737
CLV_PCSK_KEX2_1	31	33	PF00082	0.466
CLV_PCSK_KEX2_1	334	336	PF00082	0.626
CLV_PCSK_KEX2_1	357	359	PF00082	0.789
CLV_PCSK_KEX2_1	409	411	PF00082	0.706
CLV_PCSK_KEX2_1	434	436	PF00082	0.500
CLV_PCSK_KEX2_1	478	480	PF00082	0.574
CLV_PCSK_KEX2_1	65	67	PF00082	0.511
CLV_PCSK_KEX2_1	72	74	PF00082	0.497
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.670
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.665
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.644
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.753
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.500
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.626
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.789
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.582
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.557
CLV_PCSK_PC7_1	405	411	PF00082	0.743
CLV_PCSK_PC7_1	68	74	PF00082	0.541
CLV_PCSK_SKI1_1	19	23	PF00082	0.695
CLV_PCSK_SKI1_1	224	228	PF00082	0.662
CLV_PCSK_SKI1_1	268	272	PF00082	0.548
CLV_PCSK_SKI1_1	31	35	PF00082	0.644
CLV_PCSK_SKI1_1	56	60	PF00082	0.636
CLV_PCSK_SKI1_1	73	77	PF00082	0.628
DEG_SCF_FBW7_1	129	136	PF00400	0.685
DEG_SPOP_SBC_1	134	138	PF00917	0.531
DOC_ANK_TNKS_1	292	299	PF00023	0.543
DOC_MAPK_gen_1	256	263	PF00069	0.580
DOC_MAPK_gen_1	331	338	PF00069	0.656
DOC_MAPK_gen_1	434	441	PF00069	0.510
DOC_MAPK_MEF2A_6	256	263	PF00069	0.580
DOC_PP1_RVXF_1	332	339	PF00149	0.650
DOC_USP7_MATH_1	117	121	PF00917	0.644
DOC_USP7_MATH_1	127	131	PF00917	0.771
DOC_USP7_MATH_1	133	137	PF00917	0.707
DOC_USP7_MATH_1	229	233	PF00917	0.504
DOC_USP7_MATH_1	394	398	PF00917	0.625
DOC_USP7_UBL2_3	139	143	PF12436	0.637
DOC_USP7_UBL2_3	195	199	PF12436	0.534
DOC_WW_Pin1_4	129	134	PF00397	0.787
DOC_WW_Pin1_4	161	166	PF00397	0.761
DOC_WW_Pin1_4	21	26	PF00397	0.583
DOC_WW_Pin1_4	304	309	PF00397	0.757
DOC_WW_Pin1_4	425	430	PF00397	0.426
LIG_14-3-3_CanoR_1	333	339	PF00244	0.650
LIG_14-3-3_CanoR_1	470	476	PF00244	0.520
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_FHA_2	179	185	PF00498	0.697
LIG_FHA_2	245	251	PF00498	0.515
LIG_FHA_2	447	453	PF00498	0.753
LIG_Integrin_isoDGR_2	240	242	PF01839	0.554
LIG_Integrin_isoDGR_2	316	318	PF01839	0.558
LIG_LIR_Gen_1	146	154	PF02991	0.652
LIG_LIR_Gen_1	366	374	PF02991	0.590
LIG_LIR_Nem_3	146	150	PF02991	0.636
LIG_LIR_Nem_3	366	370	PF02991	0.565
LIG_SH2_CRK	147	151	PF00017	0.467
LIG_SH2_STAP1	225	229	PF00017	0.699
LIG_SH2_STAT5	61	64	PF00017	0.506
LIG_SH3_3	377	383	PF00018	0.579
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.589
LIG_TRAF2_1	187	190	PF00917	0.616
LIG_TRAF2_1	67	70	PF00917	0.402
LIG_TRAF2_1	79	82	PF00917	0.444
LIG_TYR_ITIM	145	150	PF00017	0.569
LIG_UBA3_1	58	65	PF00899	0.669
MOD_CDK_SPxxK_3	161	168	PF00069	0.525
MOD_CDK_SPxxK_3	21	28	PF00069	0.576
MOD_CK1_1	102	108	PF00069	0.687
MOD_CK1_1	120	126	PF00069	0.665
MOD_CK1_1	164	170	PF00069	0.654
MOD_CK1_1	244	250	PF00069	0.525
MOD_CK1_1	397	403	PF00069	0.519
MOD_CK1_1	47	53	PF00069	0.758
MOD_CK1_1	94	100	PF00069	0.784
MOD_CK2_1	106	112	PF00069	0.702
MOD_CK2_1	178	184	PF00069	0.695
MOD_CK2_1	244	250	PF00069	0.637
MOD_CK2_1	64	70	PF00069	0.402
MOD_Cter_Amidation	407	410	PF01082	0.536
MOD_GlcNHglycan	104	107	PF01048	0.637
MOD_GlcNHglycan	120	123	PF01048	0.643
MOD_GlcNHglycan	129	132	PF01048	0.554
MOD_GlcNHglycan	152	157	PF01048	0.714
MOD_GlcNHglycan	175	178	PF01048	0.587
MOD_GlcNHglycan	231	234	PF01048	0.524
MOD_GlcNHglycan	308	311	PF01048	0.709
MOD_GlcNHglycan	358	361	PF01048	0.589
MOD_GlcNHglycan	93	96	PF01048	0.695
MOD_GSK3_1	129	136	PF00069	0.748
MOD_GSK3_1	173	180	PF00069	0.710
MOD_GSK3_1	225	232	PF00069	0.471
MOD_GSK3_1	244	251	PF00069	0.518
MOD_GSK3_1	40	47	PF00069	0.688
MOD_GSK3_1	411	418	PF00069	0.609
MOD_GSK3_1	87	94	PF00069	0.677
MOD_GSK3_1	95	102	PF00069	0.632
MOD_N-GLC_1	229	234	PF02516	0.605
MOD_N-GLC_1	98	103	PF02516	0.565
MOD_NEK2_1	154	159	PF00069	0.635
MOD_NEK2_1	324	329	PF00069	0.641
MOD_PIKK_1	244	250	PF00454	0.525
MOD_PIKK_1	51	57	PF00454	0.578
MOD_PKA_1	139	145	PF00069	0.612
MOD_PKA_1	334	340	PF00069	0.621
MOD_PKA_2	102	108	PF00069	0.758
MOD_PKA_2	235	241	PF00069	0.545
MOD_PKA_2	334	340	PF00069	0.648
MOD_PKA_2	397	403	PF00069	0.613
MOD_Plk_1	275	281	PF00069	0.591
MOD_Plk_2-3	146	152	PF00069	0.627
MOD_Plk_2-3	184	190	PF00069	0.550
MOD_ProDKin_1	129	135	PF00069	0.784
MOD_ProDKin_1	161	167	PF00069	0.762
MOD_ProDKin_1	21	27	PF00069	0.579
MOD_ProDKin_1	304	310	PF00069	0.757
MOD_ProDKin_1	425	431	PF00069	0.419
MOD_SUMO_for_1	270	273	PF00179	0.580
MOD_SUMO_rev_2	24	33	PF00179	0.640
MOD_SUMO_rev_2	482	489	PF00179	0.701
TRG_DiLeu_BaEn_1	419	424	PF01217	0.602
TRG_DiLeu_LyEn_5	419	424	PF01217	0.635
TRG_ENDOCYTIC_2	147	150	PF00928	0.557
TRG_ER_diArg_1	207	210	PF00400	0.619
TRG_ER_diArg_1	301	304	PF00400	0.736
TRG_ER_diArg_1	333	336	PF00400	0.663
TRG_ER_diArg_1	420	423	PF00400	0.604
TRG_ER_diArg_1	478	480	PF00400	0.601
TRG_NLS_Bipartite_1	3	20	PF00514	0.661
TRG_NLS_MonoCore_2	300	305	PF00514	0.805
TRG_NLS_MonoExtC_3	300	305	PF00514	0.735
TRG_NLS_MonoExtN_4	28	35	PF00514	0.592
TRG_NLS_MonoExtN_4	299	305	PF00514	0.682
TRG_NLS_MonoExtN_4	331	337	PF00514	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE43	Leptomonas seymouri	53%	99%
A0A3S7WSJ6	Leishmania donovani	71%	100%
A0A422NGB0	Trypanosoma rangeli	36%	100%
A4HVM7	Leishmania infantum	71%	100%
D0A6M7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QG55	Leishmania major	69%	98%