Anticodon_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H785_LEIBR

TriTrypDb:

LbrM.13.0780 , LBRM2903_130013600

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H785

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H785

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.649
CLV_C14_Caspase3-7	388	392	PF00656	0.788
CLV_NRD_NRD_1	257	259	PF00675	0.480
CLV_NRD_NRD_1	3	5	PF00675	0.673
CLV_NRD_NRD_1	348	350	PF00675	0.637
CLV_NRD_NRD_1	41	43	PF00675	0.542
CLV_NRD_NRD_1	619	621	PF00675	0.499
CLV_PCSK_KEX2_1	3	5	PF00082	0.673
CLV_PCSK_KEX2_1	552	554	PF00082	0.485
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.485
CLV_PCSK_SKI1_1	224	228	PF00082	0.744
CLV_PCSK_SKI1_1	251	255	PF00082	0.544
CLV_PCSK_SKI1_1	587	591	PF00082	0.482
CLV_PCSK_SKI1_1	632	636	PF00082	0.457
CLV_Separin_Metazoa	157	161	PF03568	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DEG_SCF_FBW7_1	612	619	PF00400	0.558
DEG_SPOP_SBC_1	253	257	PF00917	0.537
DEG_SPOP_SBC_1	91	95	PF00917	0.815
DOC_MAPK_gen_1	322	330	PF00069	0.548
DOC_PP1_RVXF_1	314	321	PF00149	0.481
DOC_PP1_RVXF_1	590	597	PF00149	0.515
DOC_PP4_FxxP_1	49	52	PF00568	0.554
DOC_PP4_MxPP_1	518	521	PF00568	0.635
DOC_USP7_MATH_1	135	139	PF00917	0.599
DOC_USP7_MATH_1	140	144	PF00917	0.711
DOC_USP7_MATH_1	161	165	PF00917	0.399
DOC_USP7_MATH_1	237	241	PF00917	0.712
DOC_USP7_MATH_1	361	365	PF00917	0.775
DOC_USP7_MATH_1	415	419	PF00917	0.692
DOC_USP7_MATH_1	435	439	PF00917	0.664
DOC_USP7_MATH_1	452	456	PF00917	0.826
DOC_USP7_MATH_1	497	501	PF00917	0.821
DOC_USP7_MATH_1	577	581	PF00917	0.588
DOC_USP7_MATH_1	90	94	PF00917	0.822
DOC_USP7_UBL2_3	220	224	PF12436	0.703
DOC_WW_Pin1_4	24	29	PF00397	0.729
DOC_WW_Pin1_4	304	309	PF00397	0.523
DOC_WW_Pin1_4	48	53	PF00397	0.549
DOC_WW_Pin1_4	571	576	PF00397	0.522
DOC_WW_Pin1_4	612	617	PF00397	0.542
DOC_WW_Pin1_4	92	97	PF00397	0.803
LIG_14-3-3_CanoR_1	160	166	PF00244	0.571
LIG_14-3-3_CanoR_1	34	38	PF00244	0.651
LIG_14-3-3_CanoR_1	42	48	PF00244	0.544
LIG_14-3-3_CanoR_1	464	470	PF00244	0.592
LIG_APCC_ABBA_1	384	389	PF00400	0.794
LIG_APCC_ABBA_1	623	628	PF00400	0.452
LIG_BIR_III_4	369	373	PF00653	0.780
LIG_BRCT_BRCA1_1	45	49	PF00533	0.543
LIG_Clathr_ClatBox_1	531	535	PF01394	0.466
LIG_EVH1_1	519	523	PF00568	0.509
LIG_FHA_1	145	151	PF00498	0.690
LIG_FHA_1	236	242	PF00498	0.529
LIG_FHA_1	379	385	PF00498	0.793
LIG_FHA_1	401	407	PF00498	0.658
LIG_FHA_1	408	414	PF00498	0.656
LIG_FHA_1	480	486	PF00498	0.724
LIG_FHA_1	531	537	PF00498	0.488
LIG_FHA_1	617	623	PF00498	0.491
LIG_FHA_1	99	105	PF00498	0.532
LIG_FHA_2	151	157	PF00498	0.721
LIG_FHA_2	171	177	PF00498	0.282
LIG_FHA_2	228	234	PF00498	0.510
LIG_FHA_2	240	246	PF00498	0.491
LIG_FHA_2	386	392	PF00498	0.791
LIG_FHA_2	395	401	PF00498	0.648
LIG_FHA_2	482	488	PF00498	0.629
LIG_GBD_Chelix_1	578	586	PF00786	0.618
LIG_GSK3_LRP6_1	24	29	PF00069	0.566
LIG_LIR_Apic_2	46	52	PF02991	0.545
LIG_LIR_Apic_2	468	472	PF02991	0.509
LIG_LIR_Gen_1	400	409	PF02991	0.515
LIG_LIR_Gen_1	509	519	PF02991	0.569
LIG_LIR_Gen_1	558	569	PF02991	0.507
LIG_LIR_Nem_3	400	405	PF02991	0.512
LIG_LIR_Nem_3	509	514	PF02991	0.557
LIG_LIR_Nem_3	548	554	PF02991	0.485
LIG_LIR_Nem_3	558	564	PF02991	0.514
LIG_LIR_Nem_3	628	634	PF02991	0.428
LIG_NRBOX	577	583	PF00104	0.366
LIG_SH2_CRK	402	406	PF00017	0.501
LIG_SH2_CRK	551	555	PF00017	0.484
LIG_SH2_GRB2like	329	332	PF00017	0.548
LIG_SH2_GRB2like	557	560	PF00017	0.527
LIG_SH2_NCK_1	561	565	PF00017	0.495
LIG_SH2_PTP2	469	472	PF00017	0.513
LIG_SH2_PTP2	511	514	PF00017	0.664
LIG_SH2_STAP1	186	190	PF00017	0.480
LIG_SH2_STAP1	402	406	PF00017	0.501
LIG_SH2_STAP1	543	547	PF00017	0.508
LIG_SH2_STAP1	557	561	PF00017	0.563
LIG_SH2_STAT3	626	629	PF00017	0.573
LIG_SH2_STAT5	106	109	PF00017	0.780
LIG_SH2_STAT5	311	314	PF00017	0.500
LIG_SH2_STAT5	329	332	PF00017	0.548
LIG_SH2_STAT5	347	350	PF00017	0.622
LIG_SH2_STAT5	402	405	PF00017	0.501
LIG_SH2_STAT5	469	472	PF00017	0.513
LIG_SH2_STAT5	511	514	PF00017	0.567
LIG_SH2_STAT5	67	70	PF00017	0.590
LIG_SH3_3	22	28	PF00018	0.596
LIG_SH3_3	517	523	PF00018	0.534
LIG_SH3_3	533	539	PF00018	0.480
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.471
LIG_SUMO_SIM_anti_2	272	279	PF11976	0.615
LIG_SUMO_SIM_anti_2	533	538	PF11976	0.477
LIG_SUMO_SIM_par_1	530	535	PF11976	0.465
LIG_SxIP_EBH_1	271	282	PF03271	0.500
LIG_TRAF2_1	173	176	PF00917	0.519
LIG_TRAF2_1	500	503	PF00917	0.793
LIG_TRAF2_1	71	74	PF00917	0.832
LIG_TYR_ITAM	548	564	PF00017	0.502
LIG_UBA3_1	319	325	PF00899	0.509
LIG_UBA3_1	585	592	PF00899	0.374
LIG_WRC_WIRS_1	162	167	PF05994	0.402
MOD_CDK_SPK_2	571	576	PF00069	0.522
MOD_CK1_1	240	246	PF00069	0.703
MOD_CK1_1	269	275	PF00069	0.407
MOD_CK1_1	304	310	PF00069	0.517
MOD_CK1_1	455	461	PF00069	0.737
MOD_CK1_1	476	482	PF00069	0.697
MOD_CK1_1	51	57	PF00069	0.794
MOD_CK2_1	119	125	PF00069	0.583
MOD_CK2_1	170	176	PF00069	0.527
MOD_CK2_1	240	246	PF00069	0.790
MOD_CK2_1	394	400	PF00069	0.792
MOD_CK2_1	428	434	PF00069	0.615
MOD_CK2_1	448	454	PF00069	0.572
MOD_CK2_1	497	503	PF00069	0.816
MOD_CK2_1	68	74	PF00069	0.734
MOD_Cter_Amidation	438	441	PF01082	0.577
MOD_GlcNHglycan	137	140	PF01048	0.711
MOD_GlcNHglycan	142	145	PF01048	0.635
MOD_GlcNHglycan	192	195	PF01048	0.472
MOD_GlcNHglycan	358	361	PF01048	0.717
MOD_GlcNHglycan	363	366	PF01048	0.679
MOD_GlcNHglycan	430	433	PF01048	0.734
MOD_GlcNHglycan	437	440	PF01048	0.606
MOD_GlcNHglycan	441	444	PF01048	0.593
MOD_GlcNHglycan	450	453	PF01048	0.659
MOD_GlcNHglycan	454	457	PF01048	0.517
MOD_GlcNHglycan	458	461	PF01048	0.620
MOD_GlcNHglycan	524	527	PF01048	0.623
MOD_GlcNHglycan	70	73	PF01048	0.839
MOD_GlcNHglycan	76	79	PF01048	0.709
MOD_GSK3_1	131	138	PF00069	0.712
MOD_GSK3_1	140	147	PF00069	0.714
MOD_GSK3_1	235	242	PF00069	0.658
MOD_GSK3_1	24	31	PF00069	0.737
MOD_GSK3_1	262	269	PF00069	0.665
MOD_GSK3_1	300	307	PF00069	0.525
MOD_GSK3_1	409	416	PF00069	0.676
MOD_GSK3_1	435	442	PF00069	0.794
MOD_GSK3_1	448	455	PF00069	0.693
MOD_GSK3_1	456	463	PF00069	0.617
MOD_GSK3_1	612	619	PF00069	0.558
MOD_GSK3_1	91	98	PF00069	0.732
MOD_N-GLC_1	135	140	PF02516	0.564
MOD_N-GLC_1	300	305	PF02516	0.536
MOD_N-GLC_1	407	412	PF02516	0.521
MOD_N-GLC_2	170	172	PF02516	0.537
MOD_NEK2_1	254	259	PF00069	0.640
MOD_NEK2_1	262	267	PF00069	0.557
MOD_NEK2_1	284	289	PF00069	0.475
MOD_NEK2_1	596	601	PF00069	0.530
MOD_NEK2_1	627	632	PF00069	0.450
MOD_PIKK_1	28	34	PF00454	0.590
MOD_PIKK_1	51	57	PF00454	0.560
MOD_PIKK_1	610	616	PF00454	0.584
MOD_PKA_1	42	48	PF00069	0.545
MOD_PKA_2	33	39	PF00069	0.575
MOD_PKA_2	435	441	PF00069	0.783
MOD_PKA_2	5	11	PF00069	0.666
MOD_Plk_1	300	306	PF00069	0.529
MOD_Plk_1	339	345	PF00069	0.563
MOD_Plk_1	400	406	PF00069	0.662
MOD_Plk_1	487	493	PF00069	0.569
MOD_Plk_1	627	633	PF00069	0.450
MOD_Plk_4	262	268	PF00069	0.563
MOD_Plk_4	270	276	PF00069	0.508
MOD_Plk_4	284	290	PF00069	0.451
MOD_Plk_4	33	39	PF00069	0.629
MOD_Plk_4	400	406	PF00069	0.662
MOD_Plk_4	465	471	PF00069	0.521
MOD_Plk_4	506	512	PF00069	0.579
MOD_Plk_4	577	583	PF00069	0.507
MOD_ProDKin_1	24	30	PF00069	0.733
MOD_ProDKin_1	304	310	PF00069	0.517
MOD_ProDKin_1	48	54	PF00069	0.551
MOD_ProDKin_1	571	577	PF00069	0.525
MOD_ProDKin_1	612	618	PF00069	0.531
MOD_ProDKin_1	92	98	PF00069	0.798
MOD_SUMO_for_1	226	229	PF00179	0.656
MOD_SUMO_rev_2	310	318	PF00179	0.487
MOD_SUMO_rev_2	69	77	PF00179	0.702
TRG_DiLeu_BaEn_1	154	159	PF01217	0.563
TRG_DiLeu_BaEn_1	174	179	PF01217	0.277
TRG_DiLeu_BaEn_1	217	222	PF01217	0.577
TRG_DiLeu_BaEn_2	399	405	PF01217	0.611
TRG_ENDOCYTIC_2	185	188	PF00928	0.466
TRG_ENDOCYTIC_2	402	405	PF00928	0.501
TRG_ENDOCYTIC_2	511	514	PF00928	0.664
TRG_ENDOCYTIC_2	551	554	PF00928	0.481
TRG_ENDOCYTIC_2	561	564	PF00928	0.495
TRG_ENDOCYTIC_2	631	634	PF00928	0.442
TRG_ER_diArg_1	2	4	PF00400	0.677
TRG_NLS_MonoCore_2	257	262	PF00514	0.471
TRG_NLS_MonoExtC_3	258	264	PF00514	0.460
TRG_NLS_MonoExtN_4	258	263	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM83	Leptomonas seymouri	55%	100%
A0A3S7WSI1	Leishmania donovani	77%	100%
A4HVM5	Leishmania infantum	76%	100%
E9APC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QG57	Leishmania major	78%	99%