LeishMANIAdb
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Katanin p60 ATPase-containing subunit A-like 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A-like 2
Gene product:
katanin-like protein
Species:
Leishmania braziliensis
UniProt:
A4H784_LEIBR
TriTrypDb:
LbrM.13.0770 , LBRM2903_130013500 *
Length:
587

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000922 spindle pole 2 11
GO:0005737 cytoplasm 2 11
GO:0005874 microtubule 6 11
GO:0099080 supramolecular complex 2 11
GO:0099081 supramolecular polymer 3 11
GO:0099512 supramolecular fiber 4 11
GO:0099513 polymeric cytoskeletal fiber 5 11
GO:0110165 cellular anatomical entity 1 11
GO:0005815 microtubule organizing center 2 1
GO:0036064 ciliary basal body 3 1

Expansion

Sequence features

A4H784
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H784

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 11
GO:0006996 organelle organization 4 11
GO:0007010 cytoskeleton organization 5 11
GO:0007017 microtubule-based process 2 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0051013 microtubule severing 4 11
GO:0071840 cellular component organization or biogenesis 2 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0005524 ATP binding 5 11
GO:0008017 microtubule binding 5 11
GO:0008092 cytoskeletal protein binding 3 11
GO:0008568 microtubule severing ATPase activity 2 11
GO:0015631 tubulin binding 4 11
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016853 isomerase activity 2 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 11
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0140657 ATP-dependent activity 1 11
GO:0140776 protein-containing complex destabilizing activity 1 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 197 201 PF00656 0.524
CLV_C14_Caspase3-7 251 255 PF00656 0.501
CLV_C14_Caspase3-7 400 404 PF00656 0.297
CLV_C14_Caspase3-7 427 431 PF00656 0.409
CLV_C14_Caspase3-7 75 79 PF00656 0.582
CLV_NRD_NRD_1 129 131 PF00675 0.616
CLV_NRD_NRD_1 132 134 PF00675 0.628
CLV_NRD_NRD_1 242 244 PF00675 0.774
CLV_NRD_NRD_1 268 270 PF00675 0.625
CLV_NRD_NRD_1 38 40 PF00675 0.499
CLV_NRD_NRD_1 419 421 PF00675 0.297
CLV_NRD_NRD_1 435 437 PF00675 0.297
CLV_NRD_NRD_1 459 461 PF00675 0.297
CLV_NRD_NRD_1 480 482 PF00675 0.504
CLV_NRD_NRD_1 520 522 PF00675 0.409
CLV_PCSK_FUR_1 130 134 PF00082 0.682
CLV_PCSK_FUR_1 36 40 PF00082 0.431
CLV_PCSK_KEX2_1 131 133 PF00082 0.522
CLV_PCSK_KEX2_1 208 210 PF00082 0.747
CLV_PCSK_KEX2_1 242 244 PF00082 0.774
CLV_PCSK_KEX2_1 38 40 PF00082 0.427
CLV_PCSK_KEX2_1 419 421 PF00082 0.297
CLV_PCSK_KEX2_1 434 436 PF00082 0.297
CLV_PCSK_KEX2_1 459 461 PF00082 0.297
CLV_PCSK_KEX2_1 463 465 PF00082 0.297
CLV_PCSK_KEX2_1 480 482 PF00082 0.411
CLV_PCSK_PC1ET2_1 131 133 PF00082 0.531
CLV_PCSK_PC1ET2_1 208 210 PF00082 0.661
CLV_PCSK_PC1ET2_1 434 436 PF00082 0.317
CLV_PCSK_PC1ET2_1 463 465 PF00082 0.297
CLV_PCSK_PC7_1 459 465 PF00082 0.297
CLV_PCSK_SKI1_1 310 314 PF00082 0.368
CLV_PCSK_SKI1_1 335 339 PF00082 0.308
CLV_PCSK_SKI1_1 347 351 PF00082 0.274
CLV_PCSK_SKI1_1 38 42 PF00082 0.430
CLV_PCSK_SKI1_1 383 387 PF00082 0.281
CLV_PCSK_SKI1_1 419 423 PF00082 0.297
CLV_PCSK_SKI1_1 463 467 PF00082 0.297
CLV_PCSK_SKI1_1 480 484 PF00082 0.396
DEG_Nend_UBRbox_1 1 4 PF02207 0.716
DEG_SCF_FBW7_1 140 146 PF00400 0.482
DEG_SPOP_SBC_1 164 168 PF00917 0.724
DOC_CKS1_1 140 145 PF01111 0.482
DOC_CYCLIN_RxL_1 380 387 PF00134 0.297
DOC_CYCLIN_RxL_1 475 486 PF00134 0.464
DOC_MAPK_gen_1 332 340 PF00069 0.355
DOC_MAPK_gen_1 36 46 PF00069 0.396
DOC_MAPK_gen_1 380 390 PF00069 0.317
DOC_MAPK_gen_1 434 443 PF00069 0.370
DOC_MAPK_gen_1 459 469 PF00069 0.297
DOC_MAPK_HePTP_8 35 47 PF00069 0.470
DOC_MAPK_MEF2A_6 38 47 PF00069 0.408
DOC_MAPK_MEF2A_6 460 469 PF00069 0.297
DOC_MAPK_RevD_3 465 481 PF00069 0.474
DOC_PP1_RVXF_1 473 480 PF00149 0.436
DOC_PP1_SILK_1 328 333 PF00149 0.490
DOC_PP4_FxxP_1 259 262 PF00568 0.423
DOC_PP4_FxxP_1 340 343 PF00568 0.297
DOC_USP7_MATH_1 135 139 PF00917 0.623
DOC_USP7_MATH_1 15 19 PF00917 0.493
DOC_USP7_MATH_1 164 168 PF00917 0.697
DOC_USP7_MATH_1 249 253 PF00917 0.688
DOC_USP7_MATH_1 408 412 PF00917 0.442
DOC_USP7_MATH_1 530 534 PF00917 0.376
DOC_WW_Pin1_4 139 144 PF00397 0.513
DOC_WW_Pin1_4 166 171 PF00397 0.711
DOC_WW_Pin1_4 544 549 PF00397 0.289
LIG_14-3-3_CanoR_1 299 306 PF00244 0.401
LIG_14-3-3_CanoR_1 359 363 PF00244 0.317
LIG_14-3-3_CanoR_1 419 429 PF00244 0.297
LIG_14-3-3_CanoR_1 68 72 PF00244 0.502
LIG_Actin_WH2_2 169 186 PF00022 0.759
LIG_Actin_WH2_2 276 291 PF00022 0.526
LIG_BIR_III_4 112 116 PF00653 0.723
LIG_BRCT_BRCA1_1 394 398 PF00533 0.297
LIG_CaM_IQ_9 60 75 PF13499 0.497
LIG_CtBP_PxDLS_1 170 174 PF00389 0.637
LIG_FHA_1 148 154 PF00498 0.470
LIG_FHA_1 228 234 PF00498 0.716
LIG_FHA_1 275 281 PF00498 0.508
LIG_FHA_1 394 400 PF00498 0.285
LIG_FHA_1 421 427 PF00498 0.297
LIG_FHA_1 453 459 PF00498 0.340
LIG_FHA_2 195 201 PF00498 0.561
LIG_FHA_2 425 431 PF00498 0.452
LIG_FHA_2 489 495 PF00498 0.214
LIG_FHA_2 549 555 PF00498 0.317
LIG_Integrin_RGD_1 375 377 PF01839 0.297
LIG_LIR_Apic_2 257 262 PF02991 0.428
LIG_LIR_Gen_1 297 306 PF02991 0.283
LIG_LIR_Gen_1 535 545 PF02991 0.189
LIG_LIR_Nem_3 257 263 PF02991 0.630
LIG_LIR_Nem_3 297 303 PF02991 0.507
LIG_LIR_Nem_3 325 330 PF02991 0.389
LIG_LIR_Nem_3 360 365 PF02991 0.297
LIG_LIR_Nem_3 535 540 PF02991 0.400
LIG_LIR_Nem_3 88 92 PF02991 0.405
LIG_LYPXL_yS_3 323 326 PF13949 0.417
LIG_Pex14_1 577 581 PF04695 0.199
LIG_Rb_pABgroove_1 380 388 PF01858 0.340
LIG_SH2_CRK 157 161 PF00017 0.506
LIG_SH2_CRK 537 541 PF00017 0.189
LIG_SH2_SRC 392 395 PF00017 0.317
LIG_SH2_STAP1 493 497 PF00017 0.409
LIG_SH2_STAP1 56 60 PF00017 0.425
LIG_SH2_STAP1 89 93 PF00017 0.426
LIG_SH2_STAT5 93 96 PF00017 0.333
LIG_SH3_2 541 546 PF14604 0.425
LIG_SH3_3 137 143 PF00018 0.565
LIG_SH3_3 173 179 PF00018 0.660
LIG_SH3_3 314 320 PF00018 0.370
LIG_SH3_3 464 470 PF00018 0.297
LIG_SH3_3 538 544 PF00018 0.387
LIG_SH3_4 270 277 PF00018 0.479
LIG_SUMO_SIM_anti_2 507 512 PF11976 0.297
LIG_SUMO_SIM_anti_2 78 84 PF11976 0.437
LIG_SUMO_SIM_par_1 42 48 PF11976 0.436
LIG_SUMO_SIM_par_1 465 471 PF11976 0.465
LIG_TRAF2_1 28 31 PF00917 0.485
LIG_TYR_ITIM 155 160 PF00017 0.535
LIG_TYR_ITIM 321 326 PF00017 0.404
LIG_UBA3_1 326 335 PF00899 0.405
LIG_UBA3_1 425 434 PF00899 0.317
LIG_UBA3_1 457 463 PF00899 0.297
LIG_UBA3_1 478 485 PF00899 0.284
LIG_WRC_WIRS_1 92 97 PF05994 0.299
MOD_CK1_1 166 172 PF00069 0.740
MOD_CK1_1 215 221 PF00069 0.742
MOD_CK1_1 228 234 PF00069 0.743
MOD_CK1_1 366 372 PF00069 0.182
MOD_CK1_1 404 410 PF00069 0.304
MOD_CK1_1 486 492 PF00069 0.483
MOD_CK1_1 67 73 PF00069 0.429
MOD_CK2_1 135 141 PF00069 0.731
MOD_CK2_1 233 239 PF00069 0.765
MOD_CK2_1 408 414 PF00069 0.375
MOD_CK2_1 488 494 PF00069 0.212
MOD_Cter_Amidation 240 243 PF01082 0.776
MOD_GlcNHglycan 122 125 PF01048 0.642
MOD_GlcNHglycan 145 148 PF01048 0.566
MOD_GlcNHglycan 200 203 PF01048 0.718
MOD_GlcNHglycan 365 368 PF01048 0.175
MOD_GlcNHglycan 406 409 PF01048 0.370
MOD_GlcNHglycan 503 506 PF01048 0.340
MOD_GlcNHglycan 582 585 PF01048 0.435
MOD_GlcNHglycan 74 77 PF01048 0.549
MOD_GSK3_1 135 142 PF00069 0.662
MOD_GSK3_1 143 150 PF00069 0.668
MOD_GSK3_1 162 169 PF00069 0.428
MOD_GSK3_1 194 201 PF00069 0.708
MOD_GSK3_1 294 301 PF00069 0.304
MOD_GSK3_1 353 360 PF00069 0.282
MOD_GSK3_1 365 372 PF00069 0.280
MOD_GSK3_1 404 411 PF00069 0.308
MOD_GSK3_1 420 427 PF00069 0.388
MOD_GSK3_1 497 504 PF00069 0.315
MOD_GSK3_1 544 551 PF00069 0.313
MOD_GSK3_1 555 562 PF00069 0.288
MOD_GSK3_1 580 587 PF00069 0.480
MOD_N-GLC_1 192 197 PF02516 0.595
MOD_N-GLC_1 363 368 PF02516 0.177
MOD_N-GLC_2 159 161 PF02516 0.476
MOD_N-GLC_2 532 534 PF02516 0.403
MOD_NEK2_1 192 197 PF00069 0.517
MOD_NEK2_1 283 288 PF00069 0.384
MOD_NEK2_1 363 368 PF00069 0.180
MOD_NEK2_1 444 449 PF00069 0.297
MOD_NEK2_1 7 12 PF00069 0.663
MOD_NEK2_2 358 363 PF00069 0.297
MOD_PIKK_1 424 430 PF00454 0.409
MOD_PIKK_1 54 60 PF00454 0.406
MOD_PIKK_1 69 75 PF00454 0.523
MOD_PKA_2 183 189 PF00069 0.730
MOD_PKA_2 298 304 PF00069 0.400
MOD_PKA_2 358 364 PF00069 0.317
MOD_PKA_2 408 414 PF00069 0.370
MOD_PKA_2 67 73 PF00069 0.502
MOD_Plk_4 115 121 PF00069 0.670
MOD_Plk_4 283 289 PF00069 0.481
MOD_Plk_4 345 351 PF00069 0.308
MOD_Plk_4 358 364 PF00069 0.295
MOD_Plk_4 366 372 PF00069 0.285
MOD_Plk_4 393 399 PF00069 0.287
MOD_Plk_4 401 407 PF00069 0.272
MOD_Plk_4 81 87 PF00069 0.394
MOD_ProDKin_1 139 145 PF00069 0.513
MOD_ProDKin_1 166 172 PF00069 0.714
MOD_ProDKin_1 544 550 PF00069 0.289
MOD_SUMO_for_1 421 424 PF00179 0.297
MOD_SUMO_rev_2 30 35 PF00179 0.513
TRG_DiLeu_BaEn_1 401 406 PF01217 0.286
TRG_DiLeu_BaEn_1 462 467 PF01217 0.297
TRG_DiLeu_BaEn_4 30 36 PF01217 0.518
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.473
TRG_DiLeu_BaLyEn_6 478 483 PF01217 0.451
TRG_ENDOCYTIC_2 157 160 PF00928 0.538
TRG_ENDOCYTIC_2 323 326 PF00928 0.413
TRG_ENDOCYTIC_2 537 540 PF00928 0.409
TRG_ENDOCYTIC_2 92 95 PF00928 0.401
TRG_ER_diArg_1 104 107 PF00400 0.521
TRG_ER_diArg_1 130 133 PF00400 0.566
TRG_ER_diArg_1 35 38 PF00400 0.457
TRG_ER_diArg_1 419 421 PF00400 0.297
TRG_ER_diArg_1 458 460 PF00400 0.297
TRG_ER_diArg_1 479 481 PF00400 0.502
TRG_NLS_Bipartite_1 419 438 PF00514 0.317
TRG_NLS_MonoCore_2 129 134 PF00514 0.617
TRG_NLS_MonoExtC_3 433 439 PF00514 0.317
TRG_NLS_MonoExtN_4 130 135 PF00514 0.621
TRG_Pf-PMV_PEXEL_1 289 293 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 383 387 PF00026 0.297
TRG_Pf-PMV_PEXEL_1 521 526 PF00026 0.370

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P897 Leptomonas seymouri 68% 100%
A0A0S4IR32 Bodo saltans 53% 100%
A0A1X0NPJ1 Trypanosomatidae 58% 100%
A0A3Q8I9I1 Leishmania donovani 82% 100%
A0JMA9 Xenopus tropicalis 43% 100%
A4HVM4 Leishmania infantum 82% 100%
A9RA82 Papio anubis 43% 100%
B4JII0 Drosophila grimshawi 38% 75%
B4M0H8 Drosophila virilis 40% 76%
B7NZ88 Oryctolagus cuniculus 43% 100%
D0A6N0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9APC0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q3B8D5 Xenopus laevis 38% 100%
Q4QG58 Leishmania major 80% 96%
Q8IYT4 Homo sapiens 42% 100%
Q9BW62 Homo sapiens 43% 100%
Q9D3R6 Mus musculus 43% 100%
V5DBR1 Trypanosoma cruzi 56% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS