Protein Smaug

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein Smaug

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H779_LEIBR

TriTrypDb:

LbrM.13.0720 , LBRM2903_130013000

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4H779

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H779

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.571
CLV_C14_Caspase3-7	404	408	PF00656	0.594
CLV_C14_Caspase3-7	520	524	PF00656	0.536
CLV_C14_Caspase3-7	697	701	PF00656	0.365
CLV_NRD_NRD_1	342	344	PF00675	0.748
CLV_NRD_NRD_1	44	46	PF00675	0.617
CLV_NRD_NRD_1	458	460	PF00675	0.603
CLV_NRD_NRD_1	558	560	PF00675	0.504
CLV_NRD_NRD_1	694	696	PF00675	0.247
CLV_NRD_NRD_1	828	830	PF00675	0.721
CLV_NRD_NRD_1	890	892	PF00675	0.579
CLV_PCSK_FUR_1	555	559	PF00082	0.516
CLV_PCSK_FUR_1	692	696	PF00082	0.247
CLV_PCSK_KEX2_1	190	192	PF00082	0.576
CLV_PCSK_KEX2_1	342	344	PF00082	0.740
CLV_PCSK_KEX2_1	36	38	PF00082	0.610
CLV_PCSK_KEX2_1	43	45	PF00082	0.653
CLV_PCSK_KEX2_1	458	460	PF00082	0.583
CLV_PCSK_KEX2_1	555	557	PF00082	0.522
CLV_PCSK_KEX2_1	558	560	PF00082	0.497
CLV_PCSK_KEX2_1	694	696	PF00082	0.247
CLV_PCSK_KEX2_1	828	830	PF00082	0.721
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.515
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.610
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.571
CLV_PCSK_SKI1_1	176	180	PF00082	0.570
CLV_PCSK_SKI1_1	183	187	PF00082	0.490
CLV_PCSK_SKI1_1	190	194	PF00082	0.443
CLV_PCSK_SKI1_1	854	858	PF00082	0.547
CLV_PCSK_SKI1_1	865	869	PF00082	0.512
CLV_Separin_Metazoa	630	634	PF03568	0.355
DEG_APCC_DBOX_1	175	183	PF00400	0.407
DEG_APCC_DBOX_1	557	565	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DEG_SCF_FBW7_1	48	53	PF00400	0.677
DEG_SPOP_SBC_1	241	245	PF00917	0.612
DOC_CKS1_1	51	56	PF01111	0.545
DOC_CKS1_1	62	67	PF01111	0.533
DOC_CKS1_1	771	776	PF01111	0.480
DOC_CYCLIN_RxL_1	180	189	PF00134	0.563
DOC_CYCLIN_RxL_1	689	700	PF00134	0.380
DOC_MAPK_DCC_7	813	823	PF00069	0.574
DOC_MAPK_gen_1	689	698	PF00069	0.405
DOC_MAPK_gen_1	854	862	PF00069	0.542
DOC_MAPK_HePTP_8	856	868	PF00069	0.540
DOC_MAPK_JIP1_4	760	766	PF00069	0.383
DOC_MAPK_MEF2A_6	146	154	PF00069	0.599
DOC_MAPK_MEF2A_6	156	163	PF00069	0.473
DOC_MAPK_MEF2A_6	857	864	PF00069	0.540
DOC_PP1_SILK_1	434	439	PF00149	0.542
DOC_PP2B_LxvP_1	548	551	PF13499	0.554
DOC_PP2B_LxvP_1	821	824	PF13499	0.706
DOC_PP4_FxxP_1	51	54	PF00568	0.701
DOC_USP7_MATH_1	100	104	PF00917	0.754
DOC_USP7_MATH_1	196	200	PF00917	0.462
DOC_USP7_MATH_1	231	235	PF00917	0.707
DOC_USP7_MATH_1	251	255	PF00917	0.525
DOC_USP7_MATH_1	282	286	PF00917	0.648
DOC_USP7_MATH_1	289	293	PF00917	0.668
DOC_USP7_MATH_1	313	317	PF00917	0.599
DOC_USP7_MATH_1	382	386	PF00917	0.766
DOC_USP7_MATH_1	489	493	PF00917	0.598
DOC_USP7_MATH_1	631	635	PF00917	0.497
DOC_USP7_MATH_1	797	801	PF00917	0.614
DOC_USP7_MATH_1	805	809	PF00917	0.595
DOC_USP7_MATH_1	842	846	PF00917	0.560
DOC_USP7_MATH_1	94	98	PF00917	0.685
DOC_WW_Pin1_4	314	319	PF00397	0.586
DOC_WW_Pin1_4	342	347	PF00397	0.662
DOC_WW_Pin1_4	353	358	PF00397	0.764
DOC_WW_Pin1_4	396	401	PF00397	0.713
DOC_WW_Pin1_4	459	464	PF00397	0.742
DOC_WW_Pin1_4	46	51	PF00397	0.657
DOC_WW_Pin1_4	479	484	PF00397	0.562
DOC_WW_Pin1_4	491	496	PF00397	0.686
DOC_WW_Pin1_4	61	66	PF00397	0.603
DOC_WW_Pin1_4	770	775	PF00397	0.458
DOC_WW_Pin1_4	828	833	PF00397	0.560
DOC_WW_Pin1_4	876	881	PF00397	0.544
DOC_WW_Pin1_4	884	889	PF00397	0.539
DOC_WW_Pin1_4	96	101	PF00397	0.701
LIG_14-3-3_CanoR_1	253	261	PF00244	0.578
LIG_14-3-3_CanoR_1	43	51	PF00244	0.641
LIG_14-3-3_CanoR_1	633	637	PF00244	0.495
LIG_14-3-3_CanoR_1	741	747	PF00244	0.389
LIG_14-3-3_CanoR_1	748	754	PF00244	0.320
LIG_14-3-3_CanoR_1	813	819	PF00244	0.596
LIG_14-3-3_CanoR_1	820	824	PF00244	0.581
LIG_Actin_WH2_2	619	635	PF00022	0.502
LIG_AP_GAE_1	598	604	PF02883	0.462
LIG_AP2alpha_2	56	58	PF02296	0.546
LIG_BIR_III_4	579	583	PF00653	0.608
LIG_CtBP_PxDLS_1	832	836	PF00389	0.562
LIG_CtBP_PxDLS_1	9	13	PF00389	0.559
LIG_FHA_1	397	403	PF00498	0.692
LIG_FHA_1	491	497	PF00498	0.732
LIG_FHA_1	501	507	PF00498	0.610
LIG_FHA_1	530	536	PF00498	0.534
LIG_FHA_1	576	582	PF00498	0.509
LIG_FHA_1	664	670	PF00498	0.489
LIG_FHA_1	774	780	PF00498	0.602
LIG_FHA_1	80	86	PF00498	0.542
LIG_FHA_2	1	7	PF00498	0.553
LIG_FHA_2	402	408	PF00498	0.557
LIG_FHA_2	51	57	PF00498	0.541
LIG_FHA_2	625	631	PF00498	0.421
LIG_GBD_Chelix_1	123	131	PF00786	0.536
LIG_Integrin_isoDGR_2	263	265	PF01839	0.644
LIG_LIR_Apic_2	49	54	PF02991	0.690
LIG_LIR_Gen_1	358	367	PF02991	0.722
LIG_LIR_Gen_1	598	609	PF02991	0.518
LIG_LIR_Nem_3	358	364	PF02991	0.725
LIG_LIR_Nem_3	385	390	PF02991	0.703
LIG_LIR_Nem_3	562	568	PF02991	0.635
LIG_LIR_Nem_3	598	604	PF02991	0.531
LIG_LIR_Nem_3	607	612	PF02991	0.451
LIG_NRBOX	147	153	PF00104	0.599
LIG_NRBOX	181	187	PF00104	0.503
LIG_NRBOX	748	754	PF00104	0.494
LIG_SH2_CRK	137	141	PF00017	0.583
LIG_SH2_CRK	609	613	PF00017	0.428
LIG_SH2_NCK_1	589	593	PF00017	0.506
LIG_SH2_STAP1	589	593	PF00017	0.506
LIG_SH2_STAP1	609	613	PF00017	0.380
LIG_SH2_STAT5	121	124	PF00017	0.577
LIG_SH2_STAT5	304	307	PF00017	0.580
LIG_SH2_STAT5	361	364	PF00017	0.717
LIG_SH2_STAT5	636	639	PF00017	0.463
LIG_SH3_1	343	349	PF00018	0.724
LIG_SH3_1	473	479	PF00018	0.641
LIG_SH3_2	346	351	PF14604	0.574
LIG_SH3_3	165	171	PF00018	0.542
LIG_SH3_3	195	201	PF00018	0.460
LIG_SH3_3	343	349	PF00018	0.790
LIG_SH3_3	376	382	PF00018	0.559
LIG_SH3_3	473	479	PF00018	0.677
LIG_SH3_3	51	57	PF00018	0.698
LIG_SH3_3	534	540	PF00018	0.539
LIG_SH3_3	59	65	PF00018	0.495
LIG_SH3_3	768	774	PF00018	0.437
LIG_SH3_3	809	815	PF00018	0.718
LIG_SH3_3	867	873	PF00018	0.526
LIG_SH3_3	88	94	PF00018	0.565
LIG_SUMO_SIM_anti_2	164	171	PF11976	0.459
LIG_SUMO_SIM_par_1	5	13	PF11976	0.555
LIG_SUMO_SIM_par_1	678	685	PF11976	0.301
LIG_TYR_ITIM	135	140	PF00017	0.569
LIG_UBA3_1	30	36	PF00899	0.555
LIG_WRC_WIRS_1	384	389	PF05994	0.556
LIG_WW_3	200	204	PF00397	0.454
MOD_CDK_SPK_2	96	101	PF00069	0.701
MOD_CDK_SPxK_1	479	485	PF00069	0.611
MOD_CDK_SPxxK_3	884	891	PF00069	0.565
MOD_CK1_1	219	225	PF00069	0.631
MOD_CK1_1	243	249	PF00069	0.624
MOD_CK1_1	254	260	PF00069	0.688
MOD_CK1_1	26	32	PF00069	0.586
MOD_CK1_1	294	300	PF00069	0.574
MOD_CK1_1	302	308	PF00069	0.561
MOD_CK1_1	316	322	PF00069	0.638
MOD_CK1_1	429	435	PF00069	0.575
MOD_CK1_1	618	624	PF00069	0.592
MOD_CK1_1	663	669	PF00069	0.494
MOD_CK1_1	76	82	PF00069	0.736
MOD_CK1_1	831	837	PF00069	0.567
MOD_CK1_1	840	846	PF00069	0.542
MOD_CK1_1	879	885	PF00069	0.554
MOD_CK1_1	96	102	PF00069	0.547
MOD_CK2_1	282	288	PF00069	0.586
MOD_CK2_1	425	431	PF00069	0.723
MOD_CK2_1	521	527	PF00069	0.541
MOD_CK2_1	624	630	PF00069	0.428
MOD_CK2_1	703	709	PF00069	0.405
MOD_CK2_1	96	102	PF00069	0.734
MOD_Cter_Amidation	553	556	PF01082	0.525
MOD_Cter_Amidation	889	892	PF01082	0.569
MOD_GlcNHglycan	213	216	PF01048	0.755
MOD_GlcNHglycan	228	231	PF01048	0.587
MOD_GlcNHglycan	233	236	PF01048	0.566
MOD_GlcNHglycan	256	259	PF01048	0.684
MOD_GlcNHglycan	269	272	PF01048	0.700
MOD_GlcNHglycan	278	281	PF01048	0.660
MOD_GlcNHglycan	296	299	PF01048	0.700
MOD_GlcNHglycan	309	312	PF01048	0.646
MOD_GlcNHglycan	318	321	PF01048	0.671
MOD_GlcNHglycan	391	394	PF01048	0.797
MOD_GlcNHglycan	413	416	PF01048	0.649
MOD_GlcNHglycan	421	424	PF01048	0.697
MOD_GlcNHglycan	431	434	PF01048	0.586
MOD_GlcNHglycan	438	441	PF01048	0.640
MOD_GlcNHglycan	647	650	PF01048	0.353
MOD_GlcNHglycan	705	708	PF01048	0.332
MOD_GlcNHglycan	75	78	PF01048	0.752
MOD_GlcNHglycan	795	798	PF01048	0.545
MOD_GlcNHglycan	799	802	PF01048	0.575
MOD_GlcNHglycan	807	810	PF01048	0.635
MOD_GlcNHglycan	842	845	PF01048	0.562
MOD_GSK3_1	19	26	PF00069	0.671
MOD_GSK3_1	240	247	PF00069	0.734
MOD_GSK3_1	252	259	PF00069	0.670
MOD_GSK3_1	401	408	PF00069	0.618
MOD_GSK3_1	425	432	PF00069	0.630
MOD_GSK3_1	459	466	PF00069	0.687
MOD_GSK3_1	46	53	PF00069	0.770
MOD_GSK3_1	487	494	PF00069	0.722
MOD_GSK3_1	495	502	PF00069	0.615
MOD_GSK3_1	517	524	PF00069	0.591
MOD_GSK3_1	632	639	PF00069	0.495
MOD_GSK3_1	69	76	PF00069	0.701
MOD_GSK3_1	766	773	PF00069	0.454
MOD_GSK3_1	789	796	PF00069	0.626
MOD_GSK3_1	797	804	PF00069	0.573
MOD_GSK3_1	96	103	PF00069	0.702
MOD_N-GLC_1	294	299	PF02516	0.729
MOD_N-GLC_1	701	706	PF02516	0.367
MOD_N-GLC_1	724	729	PF02516	0.405
MOD_NEK2_1	10	15	PF00069	0.567
MOD_NEK2_1	186	191	PF00069	0.486
MOD_NEK2_1	19	24	PF00069	0.492
MOD_NEK2_1	242	247	PF00069	0.571
MOD_NEK2_1	256	261	PF00069	0.530
MOD_NEK2_1	266	271	PF00069	0.565
MOD_NEK2_1	521	526	PF00069	0.541
MOD_NEK2_1	632	637	PF00069	0.489
MOD_NEK2_1	682	687	PF00069	0.463
MOD_NEK2_1	69	74	PF00069	0.700
MOD_NEK2_1	711	716	PF00069	0.401
MOD_NEK2_1	724	729	PF00069	0.271
MOD_NEK2_1	753	758	PF00069	0.508
MOD_NEK2_2	171	176	PF00069	0.442
MOD_NEK2_2	282	287	PF00069	0.630
MOD_PIKK_1	299	305	PF00454	0.581
MOD_PIKK_1	591	597	PF00454	0.522
MOD_PK_1	837	843	PF00069	0.570
MOD_PKA_1	43	49	PF00069	0.628
MOD_PKA_2	252	258	PF00069	0.615
MOD_PKA_2	264	270	PF00069	0.697
MOD_PKA_2	426	432	PF00069	0.656
MOD_PKA_2	43	49	PF00069	0.628
MOD_PKA_2	632	638	PF00069	0.454
MOD_PKA_2	645	651	PF00069	0.373
MOD_PKA_2	747	753	PF00069	0.504
MOD_PKA_2	819	825	PF00069	0.596
MOD_Plk_1	660	666	PF00069	0.423
MOD_Plk_2-3	660	666	PF00069	0.419
MOD_Plk_4	100	106	PF00069	0.753
MOD_Plk_4	150	156	PF00069	0.597
MOD_Plk_4	256	262	PF00069	0.645
MOD_Plk_4	26	32	PF00069	0.590
MOD_Plk_4	282	288	PF00069	0.629
MOD_Plk_4	432	438	PF00069	0.615
MOD_Plk_4	443	449	PF00069	0.659
MOD_Plk_4	496	502	PF00069	0.559
MOD_Plk_4	517	523	PF00069	0.543
MOD_Plk_4	632	638	PF00069	0.497
MOD_Plk_4	663	669	PF00069	0.368
MOD_Plk_4	682	688	PF00069	0.425
MOD_ProDKin_1	314	320	PF00069	0.585
MOD_ProDKin_1	342	348	PF00069	0.658
MOD_ProDKin_1	353	359	PF00069	0.764
MOD_ProDKin_1	396	402	PF00069	0.715
MOD_ProDKin_1	459	465	PF00069	0.742
MOD_ProDKin_1	46	52	PF00069	0.661
MOD_ProDKin_1	479	485	PF00069	0.562
MOD_ProDKin_1	491	497	PF00069	0.686
MOD_ProDKin_1	61	67	PF00069	0.600
MOD_ProDKin_1	770	776	PF00069	0.469
MOD_ProDKin_1	828	834	PF00069	0.560
MOD_ProDKin_1	876	882	PF00069	0.544
MOD_ProDKin_1	884	890	PF00069	0.542
MOD_ProDKin_1	96	102	PF00069	0.704
MOD_SUMO_rev_2	184	192	PF00179	0.415
TRG_DiLeu_BaEn_1	188	193	PF01217	0.542
TRG_DiLeu_BaEn_4	7	13	PF01217	0.555
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.690
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.405
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.409
TRG_DiLeu_LyEn_5	188	193	PF01217	0.542
TRG_ENDOCYTIC_2	137	140	PF00928	0.581
TRG_ENDOCYTIC_2	361	364	PF00928	0.727
TRG_ENDOCYTIC_2	565	568	PF00928	0.636
TRG_ENDOCYTIC_2	609	612	PF00928	0.434
TRG_ER_diArg_1	342	344	PF00400	0.740
TRG_ER_diArg_1	43	45	PF00400	0.611
TRG_ER_diArg_1	555	558	PF00400	0.519
TRG_ER_diArg_1	644	647	PF00400	0.367
TRG_ER_diArg_1	691	694	PF00400	0.495
TRG_ER_diArg_1	828	830	PF00400	0.721
TRG_NLS_MonoExtN_4	455	462	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	559	563	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	854	858	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSJ0	Leishmania donovani	64%	100%
A4HVL9	Leishmania infantum	64%	100%
E9APB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QG63	Leishmania major	64%	99%