Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H778_LEIBR

TriTrypDb:

LbrM.13.0710 , LBRM2903_130012900

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H778

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H778

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.653
CLV_NRD_NRD_1	118	120	PF00675	0.558
CLV_NRD_NRD_1	132	134	PF00675	0.580
CLV_NRD_NRD_1	171	173	PF00675	0.569
CLV_NRD_NRD_1	175	177	PF00675	0.545
CLV_NRD_NRD_1	187	189	PF00675	0.568
CLV_NRD_NRD_1	226	228	PF00675	0.569
CLV_NRD_NRD_1	257	259	PF00675	0.581
CLV_NRD_NRD_1	304	306	PF00675	0.444
CLV_NRD_NRD_1	370	372	PF00675	0.775
CLV_NRD_NRD_1	521	523	PF00675	0.755
CLV_NRD_NRD_1	547	549	PF00675	0.830
CLV_PCSK_FUR_1	544	548	PF00082	0.742
CLV_PCSK_KEX2_1	118	120	PF00082	0.558
CLV_PCSK_KEX2_1	132	134	PF00082	0.580
CLV_PCSK_KEX2_1	137	139	PF00082	0.576
CLV_PCSK_KEX2_1	175	177	PF00082	0.545
CLV_PCSK_KEX2_1	226	228	PF00082	0.577
CLV_PCSK_KEX2_1	252	254	PF00082	0.537
CLV_PCSK_KEX2_1	256	258	PF00082	0.543
CLV_PCSK_KEX2_1	267	269	PF00082	0.489
CLV_PCSK_KEX2_1	33	35	PF00082	0.480
CLV_PCSK_KEX2_1	370	372	PF00082	0.598
CLV_PCSK_KEX2_1	46	48	PF00082	0.585
CLV_PCSK_KEX2_1	505	507	PF00082	0.618
CLV_PCSK_KEX2_1	521	523	PF00082	0.755
CLV_PCSK_KEX2_1	531	533	PF00082	0.699
CLV_PCSK_KEX2_1	543	545	PF00082	0.775
CLV_PCSK_KEX2_1	546	548	PF00082	0.810
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.576
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.593
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.556
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.480
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.585
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.588
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.649
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.657
CLV_PCSK_PC7_1	133	139	PF00082	0.571
CLV_PCSK_PC7_1	253	259	PF00082	0.543
CLV_PCSK_SKI1_1	176	180	PF00082	0.557
CLV_PCSK_SKI1_1	195	199	PF00082	0.587
CLV_PCSK_SKI1_1	231	235	PF00082	0.521
CLV_PCSK_SKI1_1	268	272	PF00082	0.558
CLV_PCSK_SKI1_1	298	302	PF00082	0.423
CLV_PCSK_SKI1_1	426	430	PF00082	0.646
CLV_PCSK_SKI1_1	584	588	PF00082	0.728
DEG_SPOP_SBC_1	486	490	PF00917	0.599
DEG_SPOP_SBC_1	78	82	PF00917	0.668
DOC_CYCLIN_RxL_1	264	273	PF00134	0.578
DOC_MAPK_gen_1	143	149	PF00069	0.674
DOC_MAPK_gen_1	172	183	PF00069	0.559
DOC_MAPK_gen_1	226	238	PF00069	0.569
DOC_MAPK_gen_1	252	263	PF00069	0.592
DOC_MAPK_gen_1	305	311	PF00069	0.443
DOC_MAPK_gen_1	437	445	PF00069	0.598
DOC_MAPK_MEF2A_6	175	183	PF00069	0.555
DOC_MAPK_MEF2A_6	256	265	PF00069	0.598
DOC_MAPK_NFAT4_5	176	184	PF00069	0.561
DOC_MAPK_RevD_3	291	306	PF00069	0.417
DOC_PP1_RVXF_1	204	210	PF00149	0.586
DOC_PP1_RVXF_1	265	272	PF00149	0.571
DOC_PP2B_LxvP_1	300	303	PF13499	0.595
DOC_PP2B_LxvP_1	481	484	PF13499	0.556
DOC_PP4_FxxP_1	579	582	PF00568	0.560
DOC_USP7_MATH_1	101	105	PF00917	0.632
DOC_USP7_MATH_1	245	249	PF00917	0.580
DOC_USP7_MATH_1	338	342	PF00917	0.753
DOC_USP7_MATH_1	390	394	PF00917	0.823
DOC_USP7_MATH_1	497	501	PF00917	0.706
DOC_USP7_MATH_1	517	521	PF00917	0.712
DOC_USP7_MATH_1	551	555	PF00917	0.817
DOC_USP7_MATH_1	560	564	PF00917	0.688
DOC_USP7_MATH_1	567	571	PF00917	0.569
DOC_USP7_MATH_1	582	586	PF00917	0.534
DOC_USP7_MATH_1	6	10	PF00917	0.658
DOC_USP7_MATH_1	78	82	PF00917	0.690
DOC_USP7_UBL2_3	228	232	PF12436	0.566
DOC_USP7_UBL2_3	364	368	PF12436	0.592
DOC_USP7_UBL2_3	511	515	PF12436	0.582
DOC_WW_Pin1_4	493	498	PF00397	0.643
DOC_WW_Pin1_4	499	504	PF00397	0.752
DOC_WW_Pin1_4	79	84	PF00397	0.716
DOC_WW_Pin1_4	94	99	PF00397	0.444
LIG_14-3-3_CanoR_1	268	276	PF00244	0.432
LIG_14-3-3_CanoR_1	298	303	PF00244	0.415
LIG_14-3-3_CanoR_1	392	398	PF00244	0.581
LIG_14-3-3_CanoR_1	426	432	PF00244	0.672
LIG_14-3-3_CanoR_1	439	445	PF00244	0.504
LIG_14-3-3_CanoR_1	506	511	PF00244	0.610
LIG_Actin_WH2_2	36	51	PF00022	0.618
LIG_APCC_ABBAyCdc20_2	267	273	PF00400	0.561
LIG_BRCT_BRCA1_1	108	112	PF00533	0.614
LIG_BRCT_BRCA1_1	193	197	PF00533	0.590
LIG_deltaCOP1_diTrp_1	29	39	PF00928	0.594
LIG_DLG_GKlike_1	257	265	PF00625	0.699
LIG_FHA_1	292	298	PF00498	0.567
LIG_FHA_1	299	305	PF00498	0.580
LIG_FHA_1	427	433	PF00498	0.730
LIG_FHA_1	438	444	PF00498	0.536
LIG_FHA_1	450	456	PF00498	0.495
LIG_FHA_1	488	494	PF00498	0.585
LIG_FHA_1	50	56	PF00498	0.640
LIG_FHA_2	169	175	PF00498	0.614
LIG_FHA_2	180	186	PF00498	0.508
LIG_FHA_2	331	337	PF00498	0.610
LIG_FHA_2	374	380	PF00498	0.657
LIG_FHA_2	400	406	PF00498	0.707
LIG_LIR_Apic_2	578	582	PF02991	0.561
LIG_LIR_Gen_1	107	116	PF02991	0.581
LIG_LIR_Gen_1	177	186	PF02991	0.568
LIG_LIR_Gen_1	35	43	PF02991	0.608
LIG_LIR_Nem_3	107	111	PF02991	0.597
LIG_LIR_Nem_3	177	181	PF02991	0.556
LIG_LIR_Nem_3	35	39	PF02991	0.551
LIG_MYND_1	463	467	PF01753	0.609
LIG_Pex14_2	108	112	PF04695	0.588
LIG_Pex14_2	579	583	PF04695	0.561
LIG_SH2_CRK	21	25	PF00017	0.678
LIG_SH2_CRK	240	244	PF00017	0.607
LIG_SH2_STAP1	21	25	PF00017	0.780
LIG_SH2_STAT5	110	113	PF00017	0.569
LIG_SH2_STAT5	242	245	PF00017	0.601
LIG_SH3_2	594	599	PF14604	0.572
LIG_SH3_3	290	296	PF00018	0.548
LIG_SH3_3	410	416	PF00018	0.722
LIG_SH3_3	457	463	PF00018	0.631
LIG_SH3_3	501	507	PF00018	0.766
LIG_SH3_3	591	597	PF00018	0.591
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.572
LIG_SUMO_SIM_anti_2	417	423	PF11976	0.778
LIG_SUMO_SIM_par_1	145	151	PF11976	0.572
LIG_SUMO_SIM_par_1	417	423	PF11976	0.778
LIG_TYR_ITIM	238	243	PF00017	0.601
LIG_UBA3_1	261	267	PF00899	0.595
MOD_CDK_SPK_2	493	498	PF00069	0.705
MOD_CDK_SPxK_1	499	505	PF00069	0.586
MOD_CDK_SPxxK_3	499	506	PF00069	0.684
MOD_CK1_1	104	110	PF00069	0.706
MOD_CK1_1	148	154	PF00069	0.578
MOD_CK1_1	393	399	PF00069	0.839
MOD_CK1_1	496	502	PF00069	0.700
MOD_CK1_1	520	526	PF00069	0.678
MOD_CK1_1	563	569	PF00069	0.789
MOD_CK1_1	585	591	PF00069	0.636
MOD_CK2_1	111	117	PF00069	0.562
MOD_CK2_1	168	174	PF00069	0.625
MOD_CK2_1	179	185	PF00069	0.499
MOD_CK2_1	330	336	PF00069	0.607
MOD_CK2_1	373	379	PF00069	0.771
MOD_CK2_1	399	405	PF00069	0.707
MOD_CK2_1	551	557	PF00069	0.803
MOD_Cter_Amidation	265	268	PF01082	0.595
MOD_Cter_Amidation	512	515	PF01082	0.587
MOD_GlcNHglycan	113	116	PF01048	0.403
MOD_GlcNHglycan	315	318	PF01048	0.808
MOD_GlcNHglycan	319	322	PF01048	0.760
MOD_GlcNHglycan	384	387	PF01048	0.786
MOD_GlcNHglycan	40	43	PF01048	0.613
MOD_GlcNHglycan	456	459	PF01048	0.717
MOD_GlcNHglycan	499	502	PF01048	0.653
MOD_GlcNHglycan	52	55	PF01048	0.638
MOD_GlcNHglycan	552	556	PF01048	0.754
MOD_GlcNHglycan	569	572	PF01048	0.534
MOD_GlcNHglycan	584	587	PF01048	0.590
MOD_GlcNHglycan	59	62	PF01048	0.635
MOD_GlcNHglycan	84	87	PF01048	0.771
MOD_GSK3_1	106	113	PF00069	0.612
MOD_GSK3_1	313	320	PF00069	0.633
MOD_GSK3_1	336	343	PF00069	0.586
MOD_GSK3_1	34	41	PF00069	0.589
MOD_GSK3_1	399	406	PF00069	0.619
MOD_GSK3_1	422	429	PF00069	0.651
MOD_GSK3_1	449	456	PF00069	0.567
MOD_GSK3_1	493	500	PF00069	0.817
MOD_GSK3_1	517	524	PF00069	0.715
MOD_GSK3_1	563	570	PF00069	0.670
MOD_GSK3_1	585	592	PF00069	0.731
MOD_GSK3_1	78	85	PF00069	0.649
MOD_N-GLC_1	448	453	PF02516	0.570
MOD_NEK2_1	111	116	PF00069	0.410
MOD_NEK2_1	179	184	PF00069	0.563
MOD_NEK2_1	384	389	PF00069	0.574
MOD_NEK2_1	431	436	PF00069	0.635
MOD_NEK2_1	448	453	PF00069	0.451
MOD_NEK2_1	454	459	PF00069	0.562
MOD_PIKK_1	373	379	PF00454	0.587
MOD_PK_1	506	512	PF00069	0.580
MOD_PKA_1	257	263	PF00069	0.693
MOD_PKA_1	505	511	PF00069	0.614
MOD_PKA_1	521	527	PF00069	0.679
MOD_PKA_2	257	263	PF00069	0.693
MOD_PKA_2	393	399	PF00069	0.670
MOD_PKA_2	4	10	PF00069	0.742
MOD_PKA_2	438	444	PF00069	0.595
MOD_PKA_2	449	455	PF00069	0.625
MOD_PKA_2	505	511	PF00069	0.715
MOD_PKA_2	520	526	PF00069	0.678
MOD_PKB_1	3	11	PF00069	0.702
MOD_PKB_1	47	55	PF00069	0.623
MOD_Plk_1	281	287	PF00069	0.719
MOD_Plk_1	34	40	PF00069	0.546
MOD_Plk_2-3	330	336	PF00069	0.607
MOD_Plk_2-3	403	409	PF00069	0.592
MOD_Plk_4	145	151	PF00069	0.568
MOD_Plk_4	245	251	PF00069	0.585
MOD_Plk_4	257	263	PF00069	0.592
MOD_Plk_4	281	287	PF00069	0.514
MOD_Plk_4	427	433	PF00069	0.621
MOD_ProDKin_1	493	499	PF00069	0.644
MOD_ProDKin_1	79	85	PF00069	0.717
MOD_ProDKin_1	94	100	PF00069	0.444
MOD_SUMO_rev_2	191	199	PF00179	0.626
MOD_SUMO_rev_2	523	533	PF00179	0.568
MOD_SUMO_rev_2	556	566	PF00179	0.616
TRG_DiLeu_BaEn_2	173	179	PF01217	0.652
TRG_DiLeu_BaEn_2	34	40	PF01217	0.605
TRG_ENDOCYTIC_2	21	24	PF00928	0.688
TRG_ENDOCYTIC_2	240	243	PF00928	0.565
TRG_ER_diArg_1	132	134	PF00400	0.464
TRG_ER_diArg_1	2	5	PF00400	0.785
TRG_ER_diArg_1	225	227	PF00400	0.579
TRG_ER_diArg_1	256	258	PF00400	0.604
TRG_ER_diArg_1	544	547	PF00400	0.653
TRG_ER_diLys_1	596	601	PF00400	0.662
TRG_NLS_Bipartite_1	514	535	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I995	Leptomonas seymouri	57%	100%
A0A3Q8II04	Leishmania donovani	70%	95%
A4HVL8	Leishmania infantum	72%	98%
E9APB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QG64	Leishmania major	69%	100%