Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H777_LEIBR

TriTrypDb:

LbrM.13.0700 , LBRM2903_130012800

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H777

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H777

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	16	22	PF00089	0.474
CLV_NRD_NRD_1	221	223	PF00675	0.475
CLV_NRD_NRD_1	39	41	PF00675	0.624
CLV_NRD_NRD_1	63	65	PF00675	0.525
CLV_NRD_NRD_1	91	93	PF00675	0.517
CLV_PCSK_FUR_1	219	223	PF00082	0.472
CLV_PCSK_KEX2_1	221	223	PF00082	0.457
CLV_PCSK_KEX2_1	41	43	PF00082	0.565
CLV_PCSK_KEX2_1	63	65	PF00082	0.525
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.525
CLV_PCSK_SKI1_1	271	275	PF00082	0.418
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.609
DOC_MAPK_gen_1	221	232	PF00069	0.316
DOC_MAPK_MEF2A_6	261	269	PF00069	0.476
DOC_PP1_RVXF_1	251	258	PF00149	0.327
DOC_PP4_MxPP_1	76	79	PF00568	0.421
DOC_USP7_MATH_1	10	14	PF00917	0.719
DOC_USP7_MATH_1	151	155	PF00917	0.516
DOC_USP7_MATH_1	36	40	PF00917	0.647
DOC_USP7_UBL2_3	271	275	PF12436	0.483
DOC_WW_Pin1_4	24	29	PF00397	0.604
LIG_14-3-3_CanoR_1	145	153	PF00244	0.592
LIG_14-3-3_CanoR_1	51	56	PF00244	0.496
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.413
LIG_FHA_1	194	200	PF00498	0.418
LIG_FHA_1	272	278	PF00498	0.434
LIG_FHA_1	287	293	PF00498	0.419
LIG_FHA_1	300	306	PF00498	0.654
LIG_FHA_2	235	241	PF00498	0.329
LIG_LIR_Gen_1	116	124	PF02991	0.523
LIG_LIR_Gen_1	174	183	PF02991	0.441
LIG_LIR_Gen_1	187	193	PF02991	0.390
LIG_LIR_Nem_3	116	122	PF02991	0.533
LIG_LIR_Nem_3	174	179	PF02991	0.439
LIG_LIR_Nem_3	182	186	PF02991	0.384
LIG_LIR_Nem_3	187	191	PF02991	0.403
LIG_LIR_Nem_3	50	55	PF02991	0.406
LIG_LIR_Nem_3	59	65	PF02991	0.413
LIG_PCNA_yPIPBox_3	219	230	PF02747	0.315
LIG_SH2_STAP1	214	218	PF00017	0.482
LIG_SH2_STAT3	214	217	PF00017	0.526
LIG_SH2_STAT5	176	179	PF00017	0.433
MOD_CK1_1	155	161	PF00069	0.581
MOD_CK2_1	234	240	PF00069	0.509
MOD_Cter_Amidation	90	93	PF01082	0.407
MOD_GlcNHglycan	12	15	PF01048	0.687
MOD_GlcNHglycan	138	144	PF01048	0.603
MOD_GlcNHglycan	297	300	PF01048	0.584
MOD_GlcNHglycan	4	8	PF01048	0.616
MOD_GlcNHglycan	97	100	PF01048	0.567
MOD_GSK3_1	151	158	PF00069	0.609
MOD_GSK3_1	295	302	PF00069	0.650
MOD_GSK3_1	8	15	PF00069	0.540
MOD_NEK2_1	193	198	PF00069	0.430
MOD_PIKK_1	213	219	PF00454	0.525
MOD_PKA_1	221	227	PF00069	0.525
MOD_PKA_2	144	150	PF00069	0.505
MOD_PKA_2	221	227	PF00069	0.435
MOD_PKB_1	125	133	PF00069	0.542
MOD_PKB_1	219	227	PF00069	0.525
MOD_Plk_1	193	199	PF00069	0.489
MOD_Plk_1	234	240	PF00069	0.427
MOD_Plk_1	286	292	PF00069	0.753
MOD_Plk_4	12	18	PF00069	0.484
MOD_Plk_4	172	178	PF00069	0.404
MOD_ProDKin_1	24	30	PF00069	0.605
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.426
TRG_ENDOCYTIC_2	176	179	PF00928	0.436
TRG_ER_diArg_1	218	221	PF00400	0.516
TRG_ER_diArg_1	62	64	PF00400	0.535
TRG_ER_diArg_1	86	89	PF00400	0.440
TRG_NES_CRM1_1	268	281	PF08389	0.424
TRG_NLS_MonoExtC_3	39	44	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K8	Leptomonas seymouri	54%	82%
A0A0S4IK25	Bodo saltans	33%	76%
A0A1X0NN31	Trypanosomatidae	43%	98%
A0A3S7WSI8	Leishmania donovani	77%	92%
A4HVL7	Leishmania infantum	77%	92%
D0A6N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9APB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	92%
Q4QG65	Leishmania major	74%	100%
V5BK51	Trypanosoma cruzi	41%	100%