C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H776_LEIBR

TriTrypDb:

LbrM.13.0690 , LBRM2903_130012700

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H776

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H776

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	627	631	PF00656	0.698
CLV_NRD_NRD_1	221	223	PF00675	0.833
CLV_NRD_NRD_1	288	290	PF00675	0.762
CLV_NRD_NRD_1	309	311	PF00675	0.790
CLV_NRD_NRD_1	499	501	PF00675	0.666
CLV_NRD_NRD_1	81	83	PF00675	0.590
CLV_PCSK_KEX2_1	221	223	PF00082	0.833
CLV_PCSK_KEX2_1	288	290	PF00082	0.762
CLV_PCSK_KEX2_1	309	311	PF00082	0.790
CLV_PCSK_KEX2_1	488	490	PF00082	0.665
CLV_PCSK_KEX2_1	499	501	PF00082	0.666
CLV_PCSK_KEX2_1	673	675	PF00082	0.790
CLV_PCSK_KEX2_1	685	687	PF00082	0.760
CLV_PCSK_KEX2_1	81	83	PF00082	0.590
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.665
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.790
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.760
CLV_PCSK_SKI1_1	384	388	PF00082	0.610
CLV_PCSK_SKI1_1	453	457	PF00082	0.652
CLV_PCSK_SKI1_1	681	685	PF00082	0.845
DEG_SCF_FBW7_1	18	25	PF00400	0.519
DEG_SCF_FBW7_1	585	591	PF00400	0.644
DEG_SPOP_SBC_1	130	134	PF00917	0.769
DOC_AGCK_PIF_2	45	50	PF00069	0.580
DOC_CKS1_1	35	40	PF01111	0.585
DOC_CKS1_1	585	590	PF01111	0.644
DOC_MAPK_DCC_7	329	337	PF00069	0.663
DOC_MAPK_gen_1	389	396	PF00069	0.730
DOC_MAPK_MEF2A_6	389	396	PF00069	0.628
DOC_MAPK_NFAT4_5	389	397	PF00069	0.740
DOC_PP2B_LxvP_1	15	18	PF13499	0.583
DOC_USP7_MATH_1	130	134	PF00917	0.773
DOC_USP7_MATH_1	145	149	PF00917	0.543
DOC_USP7_MATH_1	227	231	PF00917	0.613
DOC_USP7_MATH_1	515	519	PF00917	0.797
DOC_USP7_MATH_1	524	528	PF00917	0.776
DOC_USP7_MATH_1	545	549	PF00917	0.903
DOC_USP7_MATH_1	554	558	PF00917	0.808
DOC_USP7_MATH_1	588	592	PF00917	0.773
DOC_USP7_MATH_1	614	618	PF00917	0.768
DOC_USP7_MATH_1	661	665	PF00917	0.901
DOC_USP7_UBL2_3	453	457	PF12436	0.652
DOC_USP7_UBL2_3	663	667	PF12436	0.806
DOC_USP7_UBL2_3	668	672	PF12436	0.788
DOC_USP7_UBL2_3	681	685	PF12436	0.567
DOC_WW_Pin1_4	126	131	PF00397	0.871
DOC_WW_Pin1_4	140	145	PF00397	0.612
DOC_WW_Pin1_4	18	23	PF00397	0.628
DOC_WW_Pin1_4	223	228	PF00397	0.627
DOC_WW_Pin1_4	34	39	PF00397	0.626
DOC_WW_Pin1_4	562	567	PF00397	0.740
DOC_WW_Pin1_4	584	589	PF00397	0.799
DOC_WW_Pin1_4	66	71	PF00397	0.602
DOC_WW_Pin1_4	95	100	PF00397	0.843
LIG_14-3-3_CanoR_1	221	227	PF00244	0.631
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BIR_III_4	630	634	PF00653	0.645
LIG_BRCT_BRCA1_1	41	45	PF00533	0.593
LIG_CSL_BTD_1	15	18	PF09270	0.583
LIG_CtBP_PxDLS_1	38	42	PF00389	0.597
LIG_FHA_1	12	18	PF00498	0.586
LIG_FHA_1	168	174	PF00498	0.793
LIG_FHA_1	25	31	PF00498	0.617
LIG_FHA_1	366	372	PF00498	0.656
LIG_FHA_2	339	345	PF00498	0.745
LIG_FHA_2	35	41	PF00498	0.657
LIG_FHA_2	598	604	PF00498	0.733
LIG_FHA_2	625	631	PF00498	0.651
LIG_FHA_2	636	642	PF00498	0.642
LIG_FHA_2	67	73	PF00498	0.593
LIG_HCF-1_HBM_1	373	376	PF13415	0.570
LIG_IBAR_NPY_1	261	263	PF08397	0.816
LIG_Integrin_isoDGR_2	11	13	PF01839	0.726
LIG_Integrin_RGD_1	218	220	PF01839	0.884
LIG_IRF3_LxIS_1	5	10	PF10401	0.638
LIG_LIR_Apic_2	34	38	PF02991	0.448
LIG_LIR_Gen_1	399	408	PF02991	0.779
LIG_LIR_Nem_3	399	403	PF02991	0.790
LIG_LIR_Nem_3	418	423	PF02991	0.405
LIG_LIR_Nem_3	42	48	PF02991	0.582
LIG_LIR_Nem_3	79	83	PF02991	0.618
LIG_LYPXL_S_1	278	282	PF13949	0.603
LIG_LYPXL_yS_3	279	282	PF13949	0.605
LIG_NRBOX	168	174	PF00104	0.691
LIG_PCNA_yPIPBox_3	321	329	PF02747	0.593
LIG_SH2_CRK	350	354	PF00017	0.634
LIG_SH2_CRK	96	100	PF00017	0.847
LIG_SH2_GRB2like	350	353	PF00017	0.620
LIG_SH2_NCK_1	96	100	PF00017	0.847
LIG_SH2_PTP2	35	38	PF00017	0.587
LIG_SH2_STAP1	234	238	PF00017	0.850
LIG_SH2_STAP1	50	54	PF00017	0.678
LIG_SH2_STAT3	50	53	PF00017	0.579
LIG_SH2_STAT5	35	38	PF00017	0.587
LIG_SH2_STAT5	425	428	PF00017	0.566
LIG_SH2_STAT5	46	49	PF00017	0.580
LIG_SH2_STAT5	8	11	PF00017	0.585
LIG_SH3_3	337	343	PF00018	0.647
LIG_SH3_3	582	588	PF00018	0.649
LIG_SH3_4	668	675	PF00018	0.883
LIG_TRAF2_1	399	402	PF00917	0.792
LIG_UBA3_1	463	472	PF00899	0.652
MOD_CK1_1	129	135	PF00069	0.727
MOD_CK1_1	148	154	PF00069	0.702
MOD_CK1_1	156	162	PF00069	0.673
MOD_CK1_1	508	514	PF00069	0.665
MOD_CK1_1	610	616	PF00069	0.752
MOD_CK1_1	617	623	PF00069	0.728
MOD_CK2_1	20	26	PF00069	0.630
MOD_CK2_1	338	344	PF00069	0.748
MOD_CK2_1	34	40	PF00069	0.593
MOD_CK2_1	396	402	PF00069	0.783
MOD_CK2_1	529	535	PF00069	0.799
MOD_CK2_1	599	605	PF00069	0.672
MOD_CK2_1	66	72	PF00069	0.604
MOD_Cter_Amidation	387	390	PF01082	0.746
MOD_GlcNHglycan	1	4	PF01048	0.629
MOD_GlcNHglycan	147	150	PF01048	0.824
MOD_GlcNHglycan	155	158	PF01048	0.703
MOD_GlcNHglycan	164	167	PF01048	0.520
MOD_GlcNHglycan	183	186	PF01048	0.659
MOD_GlcNHglycan	517	520	PF01048	0.885
MOD_GlcNHglycan	552	555	PF01048	0.889
MOD_GlcNHglycan	612	615	PF01048	0.769
MOD_GSK3_1	126	133	PF00069	0.812
MOD_GSK3_1	140	147	PF00069	0.796
MOD_GSK3_1	153	160	PF00069	0.725
MOD_GSK3_1	177	184	PF00069	0.828
MOD_GSK3_1	18	25	PF00069	0.572
MOD_GSK3_1	223	230	PF00069	0.712
MOD_GSK3_1	315	322	PF00069	0.823
MOD_GSK3_1	515	522	PF00069	0.783
MOD_GSK3_1	550	557	PF00069	0.829
MOD_GSK3_1	558	565	PF00069	0.762
MOD_GSK3_1	584	591	PF00069	0.822
MOD_GSK3_1	608	615	PF00069	0.744
MOD_GSK3_1	7	14	PF00069	0.630
MOD_N-GLC_1	153	158	PF02516	0.634
MOD_N-GLC_1	195	200	PF02516	0.769
MOD_N-GLC_1	205	210	PF02516	0.595
MOD_N-GLC_1	313	318	PF02516	0.670
MOD_NEK2_1	232	237	PF00069	0.846
MOD_NEK2_1	287	292	PF00069	0.665
MOD_NEK2_1	39	44	PF00069	0.592
MOD_NEK2_1	558	563	PF00069	0.758
MOD_NEK2_1	7	12	PF00069	0.580
MOD_PIKK_1	133	139	PF00454	0.746
MOD_PIKK_1	167	173	PF00454	0.791
MOD_PIKK_1	187	193	PF00454	0.568
MOD_PIKK_1	232	238	PF00454	0.848
MOD_PIKK_1	313	319	PF00454	0.880
MOD_PIKK_1	505	511	PF00454	0.737
MOD_PIKK_1	519	525	PF00454	0.598
MOD_PIKK_1	545	551	PF00454	0.789
MOD_PIKK_1	564	570	PF00454	0.570
MOD_PKA_1	681	687	PF00069	0.865
MOD_PKA_2	287	293	PF00069	0.847
MOD_Plk_1	537	543	PF00069	0.697
MOD_Plk_2-3	338	344	PF00069	0.668
MOD_Plk_2-3	434	440	PF00069	0.456
MOD_Plk_2-3	529	535	PF00069	0.799
MOD_Plk_2-3	635	641	PF00069	0.644
MOD_Plk_4	31	37	PF00069	0.439
MOD_Plk_4	365	371	PF00069	0.505
MOD_ProDKin_1	126	132	PF00069	0.871
MOD_ProDKin_1	140	146	PF00069	0.614
MOD_ProDKin_1	18	24	PF00069	0.633
MOD_ProDKin_1	223	229	PF00069	0.626
MOD_ProDKin_1	34	40	PF00069	0.618
MOD_ProDKin_1	562	568	PF00069	0.742
MOD_ProDKin_1	584	590	PF00069	0.800
MOD_ProDKin_1	66	72	PF00069	0.604
MOD_ProDKin_1	95	101	PF00069	0.846
MOD_SUMO_rev_2	23	30	PF00179	0.729
MOD_SUMO_rev_2	344	349	PF00179	0.658
MOD_SUMO_rev_2	379	386	PF00179	0.677
MOD_SUMO_rev_2	399	409	PF00179	0.685
MOD_SUMO_rev_2	483	490	PF00179	0.763
MOD_SUMO_rev_2	652	661	PF00179	0.797
TRG_DiLeu_BaEn_2	85	91	PF01217	0.666
TRG_ENDOCYTIC_2	257	260	PF00928	0.840
TRG_ENDOCYTIC_2	279	282	PF00928	0.663
TRG_ER_diArg_1	221	223	PF00400	0.893
TRG_ER_diArg_1	287	289	PF00400	0.597
TRG_ER_diArg_1	80	82	PF00400	0.588
TRG_NLS_Bipartite_1	662	677	PF00514	0.837
TRG_NLS_MonoExtC_3	671	676	PF00514	0.785
TRG_NLS_MonoExtC_3	684	689	PF00514	0.764
TRG_NLS_MonoExtN_4	659	666	PF00514	0.794
TRG_NLS_MonoExtN_4	669	676	PF00514	0.775
TRG_NLS_MonoExtN_4	682	689	PF00514	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX4	Leptomonas seymouri	54%	100%
A0A3S5H6P0	Leishmania donovani	86%	99%
A4HVL6	Leishmania infantum	86%	99%
E9APB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QG66	Leishmania major	86%	100%