Putative mitochondrial processing peptidase alpha subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial processing peptidase alpha subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H775_LEIBR

TriTrypDb:

LbrM.13.0680 , LBRM2903_130012600

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H775

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H775

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	22
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.396
CLV_C14_Caspase3-7	374	378	PF00656	0.442
CLV_C14_Caspase3-7	483	487	PF00656	0.435
CLV_NRD_NRD_1	165	167	PF00675	0.663
CLV_NRD_NRD_1	3	5	PF00675	0.569
CLV_PCSK_KEX2_1	165	167	PF00082	0.654
CLV_PCSK_KEX2_1	3	5	PF00082	0.569
CLV_PCSK_SKI1_1	225	229	PF00082	0.426
CLV_PCSK_SKI1_1	356	360	PF00082	0.389
CLV_PCSK_SKI1_1	4	8	PF00082	0.580
CLV_PCSK_SKI1_1	418	422	PF00082	0.444
CLV_PCSK_SKI1_1	444	448	PF00082	0.486
CLV_PCSK_SKI1_1	70	74	PF00082	0.398
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SPOP_SBC_1	108	112	PF00917	0.344
DOC_MAPK_gen_1	137	146	PF00069	0.336
DOC_MAPK_MEF2A_6	137	146	PF00069	0.348
DOC_MAPK_MEF2A_6	368	375	PF00069	0.361
DOC_MAPK_RevD_3	415	431	PF00069	0.257
DOC_PP4_FxxP_1	395	398	PF00568	0.322
DOC_USP7_MATH_1	434	438	PF00917	0.491
DOC_USP7_MATH_1	470	474	PF00917	0.412
DOC_USP7_MATH_1	487	491	PF00917	0.314
DOC_USP7_MATH_1	79	83	PF00917	0.375
DOC_USP7_MATH_2	470	476	PF00917	0.278
DOC_USP7_UBL2_3	307	311	PF12436	0.440
DOC_USP7_UBL2_3	355	359	PF12436	0.394
DOC_USP7_UBL2_3	443	447	PF12436	0.287
DOC_USP7_UBL2_3	498	502	PF12436	0.216
DOC_WW_Pin1_4	286	291	PF00397	0.415
LIG_14-3-3_CanoR_1	123	129	PF00244	0.418
LIG_14-3-3_CanoR_1	4	10	PF00244	0.525
LIG_14-3-3_CanoR_1	418	427	PF00244	0.501
LIG_14-3-3_CanoR_1	70	79	PF00244	0.494
LIG_Clathr_ClatBox_1	118	122	PF01394	0.385
LIG_Clathr_ClatBox_1	370	374	PF01394	0.219
LIG_CtBP_PxDLS_1	179	183	PF00389	0.252
LIG_eIF4E_1	399	405	PF01652	0.315
LIG_FHA_1	251	257	PF00498	0.264
LIG_FHA_1	287	293	PF00498	0.276
LIG_FHA_1	338	344	PF00498	0.447
LIG_FHA_1	399	405	PF00498	0.399
LIG_FHA_1	419	425	PF00498	0.210
LIG_FHA_1	505	511	PF00498	0.219
LIG_FHA_1	71	77	PF00498	0.487
LIG_FHA_2	131	137	PF00498	0.261
LIG_FHA_2	316	322	PF00498	0.444
LIG_FHA_2	332	338	PF00498	0.503
LIG_FHA_2	455	461	PF00498	0.380
LIG_FHA_2	477	483	PF00498	0.428
LIG_LIR_Apic_2	214	220	PF02991	0.399
LIG_LIR_Apic_2	262	267	PF02991	0.332
LIG_LIR_Gen_1	185	196	PF02991	0.336
LIG_LIR_Nem_3	185	191	PF02991	0.324
LIG_LIR_Nem_3	259	264	PF02991	0.301
LIG_LIR_Nem_3	26	32	PF02991	0.380
LIG_LIR_Nem_3	460	464	PF02991	0.341
LIG_PTAP_UEV_1	95	100	PF05743	0.352
LIG_PTB_Apo_2	113	120	PF02174	0.362
LIG_PTB_Apo_2	237	244	PF02174	0.468
LIG_PTB_Apo_2	285	292	PF02174	0.397
LIG_SH2_CRK	93	97	PF00017	0.399
LIG_SH2_GRB2like	286	289	PF00017	0.386
LIG_SH2_NCK_1	93	97	PF00017	0.411
LIG_SH2_PTP2	264	267	PF00017	0.308
LIG_SH2_SRC	93	96	PF00017	0.371
LIG_SH2_STAP1	223	227	PF00017	0.452
LIG_SH2_STAP1	25	29	PF00017	0.646
LIG_SH2_STAP1	261	265	PF00017	0.301
LIG_SH2_STAP1	500	504	PF00017	0.322
LIG_SH2_STAT3	223	226	PF00017	0.334
LIG_SH2_STAT5	234	237	PF00017	0.337
LIG_SH2_STAT5	264	267	PF00017	0.284
LIG_SH2_STAT5	317	320	PF00017	0.423
LIG_SH2_STAT5	396	399	PF00017	0.301
LIG_SH2_STAT5	461	464	PF00017	0.334
LIG_SH2_STAT5	86	89	PF00017	0.295
LIG_SH3_1	43	49	PF00018	0.581
LIG_SH3_1	93	99	PF00018	0.506
LIG_SH3_3	43	49	PF00018	0.633
LIG_SH3_3	89	95	PF00018	0.356
LIG_SUMO_SIM_par_1	369	374	PF11976	0.362
LIG_TRAF2_1	480	483	PF00917	0.518
MOD_CK1_1	155	161	PF00069	0.547
MOD_CK1_1	250	256	PF00069	0.429
MOD_CK1_1	437	443	PF00069	0.405
MOD_CK1_1	473	479	PF00069	0.511
MOD_CK1_1	509	515	PF00069	0.314
MOD_CK2_1	130	136	PF00069	0.393
MOD_CK2_1	196	202	PF00069	0.394
MOD_CK2_1	20	26	PF00069	0.580
MOD_CK2_1	307	313	PF00069	0.428
MOD_CK2_1	315	321	PF00069	0.402
MOD_CK2_1	476	482	PF00069	0.448
MOD_CK2_1	509	515	PF00069	0.193
MOD_GlcNHglycan	16	19	PF01048	0.476
MOD_GlcNHglycan	293	296	PF01048	0.467
MOD_GlcNHglycan	301	304	PF01048	0.514
MOD_GlcNHglycan	7	10	PF01048	0.576
MOD_GlcNHglycan	96	99	PF01048	0.585
MOD_GSK3_1	152	159	PF00069	0.500
MOD_GSK3_1	247	254	PF00069	0.400
MOD_GSK3_1	472	479	PF00069	0.458
MOD_N-GLC_1	114	119	PF02516	0.417
MOD_N-GLC_1	375	380	PF02516	0.313
MOD_NEK2_1	107	112	PF00069	0.365
MOD_NEK2_1	114	119	PF00069	0.349
MOD_NEK2_1	227	232	PF00069	0.450
MOD_NEK2_1	251	256	PF00069	0.469
MOD_NEK2_1	291	296	PF00069	0.290
MOD_NEK2_1	375	380	PF00069	0.349
MOD_NEK2_1	38	43	PF00069	0.633
MOD_NEK2_1	445	450	PF00069	0.405
MOD_NEK2_1	504	509	PF00069	0.334
MOD_OFUCOSY	462	468	PF10250	0.302
MOD_PIKK_1	160	166	PF00454	0.663
MOD_PIKK_1	32	38	PF00454	0.536
MOD_PIKK_1	445	451	PF00454	0.429
MOD_PKA_2	153	159	PF00069	0.369
MOD_PKA_2	204	210	PF00069	0.391
MOD_Plk_1	114	120	PF00069	0.399
MOD_Plk_1	375	381	PF00069	0.326
MOD_Plk_1	473	479	PF00069	0.455
MOD_Plk_4	114	120	PF00069	0.401
MOD_Plk_4	247	253	PF00069	0.475
MOD_Plk_4	339	345	PF00069	0.397
MOD_Plk_4	361	367	PF00069	0.325
MOD_Plk_4	434	440	PF00069	0.512
MOD_Plk_4	506	512	PF00069	0.306
MOD_ProDKin_1	286	292	PF00069	0.423
MOD_SUMO_for_1	409	412	PF00179	0.347
MOD_SUMO_rev_2	23	29	PF00179	0.537
TRG_DiLeu_BaEn_2	286	292	PF01217	0.271
TRG_ENDOCYTIC_2	500	503	PF00928	0.321
TRG_ER_diArg_1	2	4	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.699
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM61	Leptomonas seymouri	38%	100%
A0A0N1PFG1	Leptomonas seymouri	72%	100%
A0A0S4IY11	Bodo saltans	39%	100%
A0A0S4JST8	Bodo saltans	45%	100%
A0A1X0NPP7	Trypanosomatidae	53%	100%
A0A1X0NXN6	Trypanosomatidae	37%	100%
A0A3Q8IBQ6	Leishmania donovani	82%	100%
A0A3R7JXS6	Trypanosoma rangeli	36%	100%
A0A3R7MEV0	Trypanosoma rangeli	52%	100%
A0A3S7WWC3	Leishmania donovani	40%	100%
A4HBN2	Leishmania braziliensis	38%	100%
A4HVL5	Leishmania infantum	82%	100%
A4HZ33	Leishmania infantum	39%	100%
D0A6P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9APB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AV01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
O04308	Arabidopsis thaliana	21%	100%
P29677	Solanum tuberosum	24%	100%
P43265	Euglena gracilis	23%	100%
Q4QCI1	Leishmania major	40%	93%
Q4QG67	Leishmania major	83%	100%
Q9ZU25	Arabidopsis thaliana	22%	100%
V5BB16	Trypanosoma cruzi	52%	94%
V5BQ54	Trypanosoma cruzi	38%	100%