Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H774_LEIBR

TriTrypDb:

LbrM.13.0670 , LBRM2903_130012500

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H774

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H774

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.713
CLV_NRD_NRD_1	151	153	PF00675	0.657
CLV_NRD_NRD_1	60	62	PF00675	0.698
CLV_PCSK_FUR_1	298	302	PF00082	0.532
CLV_PCSK_KEX2_1	115	117	PF00082	0.594
CLV_PCSK_KEX2_1	134	136	PF00082	0.655
CLV_PCSK_KEX2_1	151	153	PF00082	0.723
CLV_PCSK_KEX2_1	235	237	PF00082	0.732
CLV_PCSK_KEX2_1	300	302	PF00082	0.545
CLV_PCSK_KEX2_1	60	62	PF00082	0.698
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.591
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.592
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.732
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.552
CLV_PCSK_PC7_1	56	62	PF00082	0.687
CLV_PCSK_SKI1_1	236	240	PF00082	0.724
DOC_CKS1_1	37	42	PF01111	0.571
DOC_MAPK_MEF2A_6	25	32	PF00069	0.455
DOC_PP4_FxxP_1	118	121	PF00568	0.695
DOC_USP7_UBL2_3	111	115	PF12436	0.592
DOC_WW_Pin1_4	12	17	PF00397	0.669
DOC_WW_Pin1_4	210	215	PF00397	0.567
DOC_WW_Pin1_4	243	248	PF00397	0.635
DOC_WW_Pin1_4	36	41	PF00397	0.503
DOC_WW_Pin1_4	47	52	PF00397	0.631
DOC_WW_Pin1_4	97	102	PF00397	0.508
LIG_14-3-3_CanoR_1	304	310	PF00244	0.407
LIG_FHA_1	244	250	PF00498	0.671
LIG_FHA_1	25	31	PF00498	0.645
LIG_FHA_2	189	195	PF00498	0.583
LIG_FHA_2	284	290	PF00498	0.501
LIG_LIR_Apic_2	160	166	PF02991	0.679
LIG_LIR_Apic_2	35	40	PF02991	0.560
LIG_LIR_Gen_1	66	77	PF02991	0.464
LIG_LIR_Nem_3	66	72	PF02991	0.510
LIG_REV1ctd_RIR_1	122	131	PF16727	0.506
LIG_SH2_CRK	37	41	PF00017	0.636
LIG_SH2_STAT5	106	109	PF00017	0.578
LIG_SH2_STAT5	242	245	PF00017	0.534
LIG_SH3_3	133	139	PF00018	0.596
LIG_SH3_3	181	187	PF00018	0.611
LIG_SH3_3	255	261	PF00018	0.704
LIG_SH3_3	96	102	PF00018	0.600
LIG_TRAF2_1	191	194	PF00917	0.738
LIG_TRAF2_2	139	144	PF00917	0.523
LIG_TYR_ITIM	67	72	PF00017	0.461
MOD_CDK_SPxxK_3	47	54	PF00069	0.603
MOD_CK2_1	188	194	PF00069	0.584
MOD_CK2_1	210	216	PF00069	0.620
MOD_CK2_1	283	289	PF00069	0.518
MOD_Cter_Amidation	113	116	PF01082	0.588
MOD_Cter_Amidation	233	236	PF01082	0.640
MOD_Cter_Amidation	58	61	PF01082	0.654
MOD_GlcNHglycan	204	207	PF01048	0.699
MOD_GlcNHglycan	229	232	PF01048	0.597
MOD_GlcNHglycan	79	82	PF01048	0.632
MOD_GSK3_1	119	126	PF00069	0.605
MOD_GSK3_1	198	205	PF00069	0.726
MOD_GSK3_1	219	226	PF00069	0.669
MOD_GSK3_1	243	250	PF00069	0.717
MOD_GSK3_1	32	39	PF00069	0.536
MOD_GSK3_1	42	49	PF00069	0.675
MOD_GSK3_1	8	15	PF00069	0.782
MOD_N-GLC_1	12	17	PF02516	0.597
MOD_N-GLC_1	157	162	PF02516	0.697
MOD_N-GLC_1	188	193	PF02516	0.472
MOD_N-GLC_1	267	272	PF02516	0.708
MOD_NEK2_1	305	310	PF00069	0.568
MOD_NEK2_1	32	37	PF00069	0.476
MOD_PIKK_1	267	273	PF00454	0.705
MOD_PIKK_1	274	280	PF00454	0.592
MOD_PIKK_1	32	38	PF00454	0.562
MOD_PKA_2	202	208	PF00069	0.544
MOD_PKA_2	24	30	PF00069	0.546
MOD_PKA_2	283	289	PF00069	0.512
MOD_Plk_1	16	22	PF00069	0.592
MOD_Plk_1	188	194	PF00069	0.558
MOD_Plk_1	267	273	PF00069	0.705
MOD_Plk_1	42	48	PF00069	0.733
MOD_Plk_4	193	199	PF00069	0.671
MOD_ProDKin_1	12	18	PF00069	0.669
MOD_ProDKin_1	210	216	PF00069	0.567
MOD_ProDKin_1	243	249	PF00069	0.638
MOD_ProDKin_1	36	42	PF00069	0.507
MOD_ProDKin_1	47	53	PF00069	0.636
MOD_ProDKin_1	97	103	PF00069	0.510
TRG_ENDOCYTIC_2	69	72	PF00928	0.466
TRG_ER_diArg_1	151	154	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I155	Leptomonas seymouri	45%	100%
A0A3Q8I8I3	Leishmania donovani	70%	85%
A4HVL4	Leishmania infantum	71%	85%
E9APB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	96%
Q4QG68	Leishmania major	71%	100%