HSF_DOMAIN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H773_LEIBR

TriTrypDb:

LbrM.13.0660 , LBRM2903_130012400

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H773

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H773

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.610
CLV_C14_Caspase3-7	276	280	PF00656	0.495
CLV_C14_Caspase3-7	484	488	PF00656	0.498
CLV_C14_Caspase3-7	61	65	PF00656	0.618
CLV_C14_Caspase3-7	70	74	PF00656	0.625
CLV_NRD_NRD_1	307	309	PF00675	0.543
CLV_NRD_NRD_1	417	419	PF00675	0.578
CLV_NRD_NRD_1	435	437	PF00675	0.534
CLV_NRD_NRD_1	439	441	PF00675	0.551
CLV_NRD_NRD_1	511	513	PF00675	0.579
CLV_NRD_NRD_1	669	671	PF00675	0.611
CLV_NRD_NRD_1	689	691	PF00675	0.573
CLV_NRD_NRD_1	758	760	PF00675	0.673
CLV_PCSK_FUR_1	436	440	PF00082	0.438
CLV_PCSK_KEX2_1	307	309	PF00082	0.543
CLV_PCSK_KEX2_1	417	419	PF00082	0.503
CLV_PCSK_KEX2_1	435	437	PF00082	0.526
CLV_PCSK_KEX2_1	438	440	PF00082	0.565
CLV_PCSK_KEX2_1	511	513	PF00082	0.579
CLV_PCSK_KEX2_1	669	671	PF00082	0.486
CLV_PCSK_KEX2_1	689	691	PF00082	0.573
CLV_PCSK_KEX2_1	758	760	PF00082	0.668
CLV_PCSK_PC7_1	435	441	PF00082	0.496
CLV_PCSK_SKI1_1	325	329	PF00082	0.516
CLV_PCSK_SKI1_1	462	466	PF00082	0.406
CLV_PCSK_SKI1_1	587	591	PF00082	0.580
CLV_PCSK_SKI1_1	627	631	PF00082	0.510
CLV_PCSK_SKI1_1	654	658	PF00082	0.423
CLV_PCSK_SKI1_1	727	731	PF00082	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.573
DEG_SCF_FBW7_1	711	718	PF00400	0.550
DEG_SCF_FBW7_1	777	784	PF00400	0.653
DEG_SPOP_SBC_1	410	414	PF00917	0.581
DEG_SPOP_SBC_1	753	757	PF00917	0.628
DOC_ANK_TNKS_1	757	764	PF00023	0.523
DOC_CKS1_1	221	226	PF01111	0.569
DOC_CYCLIN_RxL_1	322	331	PF00134	0.519
DOC_PP1_RVXF_1	640	646	PF00149	0.543
DOC_PP2B_LxvP_1	227	230	PF13499	0.553
DOC_PP2B_LxvP_1	678	681	PF13499	0.535
DOC_PP4_FxxP_1	464	467	PF00568	0.469
DOC_USP7_MATH_1	128	132	PF00917	0.696
DOC_USP7_MATH_1	177	181	PF00917	0.696
DOC_USP7_MATH_1	262	266	PF00917	0.683
DOC_USP7_MATH_1	293	297	PF00917	0.625
DOC_USP7_MATH_1	379	383	PF00917	0.664
DOC_USP7_MATH_1	410	414	PF00917	0.581
DOC_USP7_MATH_1	655	659	PF00917	0.545
DOC_USP7_MATH_1	679	683	PF00917	0.750
DOC_USP7_MATH_1	703	707	PF00917	0.780
DOC_USP7_MATH_1	754	758	PF00917	0.677
DOC_USP7_MATH_1	761	765	PF00917	0.612
DOC_WW_Pin1_4	114	119	PF00397	0.610
DOC_WW_Pin1_4	209	214	PF00397	0.648
DOC_WW_Pin1_4	220	225	PF00397	0.642
DOC_WW_Pin1_4	260	265	PF00397	0.640
DOC_WW_Pin1_4	267	272	PF00397	0.659
DOC_WW_Pin1_4	27	32	PF00397	0.814
DOC_WW_Pin1_4	295	300	PF00397	0.527
DOC_WW_Pin1_4	331	336	PF00397	0.563
DOC_WW_Pin1_4	387	392	PF00397	0.738
DOC_WW_Pin1_4	493	498	PF00397	0.640
DOC_WW_Pin1_4	64	69	PF00397	0.715
DOC_WW_Pin1_4	711	716	PF00397	0.550
DOC_WW_Pin1_4	732	737	PF00397	0.795
DOC_WW_Pin1_4	777	782	PF00397	0.784
LIG_14-3-3_CanoR_1	26	34	PF00244	0.633
LIG_14-3-3_CanoR_1	289	293	PF00244	0.468
LIG_14-3-3_CanoR_1	325	335	PF00244	0.541
LIG_14-3-3_CanoR_1	354	358	PF00244	0.513
LIG_14-3-3_CanoR_1	392	402	PF00244	0.695
LIG_14-3-3_CanoR_1	443	449	PF00244	0.541
LIG_14-3-3_CanoR_1	537	543	PF00244	0.695
LIG_14-3-3_CanoR_1	596	605	PF00244	0.487
LIG_14-3-3_CanoR_1	742	749	PF00244	0.667
LIG_BIR_III_2	184	188	PF00653	0.579
LIG_BIR_III_2	197	201	PF00653	0.535
LIG_BIR_III_4	124	128	PF00653	0.566
LIG_BRCT_BRCA1_1	402	406	PF00533	0.637
LIG_BRCT_BRCA1_1	460	464	PF00533	0.520
LIG_EVH1_1	227	231	PF00568	0.552
LIG_EVH1_2	518	522	PF00568	0.594
LIG_FHA_1	174	180	PF00498	0.609
LIG_FHA_1	216	222	PF00498	0.635
LIG_FHA_1	28	34	PF00498	0.778
LIG_FHA_1	346	352	PF00498	0.528
LIG_FHA_1	472	478	PF00498	0.565
LIG_FHA_1	556	562	PF00498	0.573
LIG_FHA_1	658	664	PF00498	0.447
LIG_FHA_2	139	145	PF00498	0.572
LIG_FHA_2	18	24	PF00498	0.590
LIG_FHA_2	274	280	PF00498	0.518
LIG_FHA_2	399	405	PF00498	0.646
LIG_FHA_2	47	53	PF00498	0.597
LIG_FHA_2	519	525	PF00498	0.688
LIG_FHA_2	59	65	PF00498	0.550
LIG_FHA_2	605	611	PF00498	0.513
LIG_FHA_2	88	94	PF00498	0.579
LIG_LIR_Apic_2	279	285	PF02991	0.716
LIG_LIR_Apic_2	387	391	PF02991	0.671
LIG_LIR_Apic_2	461	467	PF02991	0.495
LIG_LIR_Gen_1	270	278	PF02991	0.523
LIG_LIR_Gen_1	403	411	PF02991	0.499
LIG_LIR_Nem_3	270	275	PF02991	0.532
LIG_LIR_Nem_3	322	326	PF02991	0.534
LIG_LIR_Nem_3	403	409	PF02991	0.503
LIG_LIR_Nem_3	489	494	PF02991	0.590
LIG_Pex14_2	338	342	PF04695	0.437
LIG_SH2_CRK	272	276	PF00017	0.534
LIG_SH2_CRK	388	392	PF00017	0.678
LIG_SH2_GRB2like	456	459	PF00017	0.474
LIG_SH2_NCK_1	272	276	PF00017	0.600
LIG_SH2_NCK_1	282	286	PF00017	0.539
LIG_SH2_STAP1	323	327	PF00017	0.542
LIG_SH2_STAT3	598	601	PF00017	0.508
LIG_SH2_STAT5	272	275	PF00017	0.642
LIG_SH2_STAT5	326	329	PF00017	0.511
LIG_SH2_STAT5	454	457	PF00017	0.461
LIG_SH2_STAT5	598	601	PF00017	0.508
LIG_SH2_STAT5	619	622	PF00017	0.548
LIG_SH2_STAT5	779	782	PF00017	0.684
LIG_SH3_3	223	229	PF00018	0.665
LIG_SH3_3	28	34	PF00018	0.610
LIG_SH3_3	35	41	PF00018	0.594
LIG_SH3_3	464	470	PF00018	0.525
LIG_SH3_3	491	497	PF00018	0.661
LIG_SH3_3	673	679	PF00018	0.652
LIG_SH3_3	730	736	PF00018	0.799
LIG_SUMO_SIM_anti_2	429	435	PF11976	0.405
LIG_TRAF2_1	6	9	PF00917	0.607
LIG_TRAF2_1	607	610	PF00917	0.505
LIG_TYR_ITIM	477	482	PF00017	0.635
LIG_WRC_WIRS_1	482	487	PF05994	0.502
LIG_WW_3	229	233	PF00397	0.557
LIG_WW_3	517	521	PF00397	0.595
MOD_CDK_SPK_2	387	392	PF00069	0.543
MOD_CDK_SPK_2	777	782	PF00069	0.551
MOD_CK1_1	157	163	PF00069	0.595
MOD_CK1_1	17	23	PF00069	0.696
MOD_CK1_1	265	271	PF00069	0.551
MOD_CK1_1	27	33	PF00069	0.653
MOD_CK1_1	380	386	PF00069	0.734
MOD_CK1_1	390	396	PF00069	0.652
MOD_CK1_1	412	418	PF00069	0.459
MOD_CK1_1	429	435	PF00069	0.356
MOD_CK1_1	555	561	PF00069	0.696
MOD_CK1_1	565	571	PF00069	0.506
MOD_CK1_1	585	591	PF00069	0.624
MOD_CK1_1	658	664	PF00069	0.651
MOD_CK1_1	674	680	PF00069	0.690
MOD_CK1_1	682	688	PF00069	0.780
MOD_CK1_1	752	758	PF00069	0.621
MOD_CK1_1	787	793	PF00069	0.678
MOD_CK2_1	128	134	PF00069	0.574
MOD_CK2_1	157	163	PF00069	0.655
MOD_CK2_1	444	450	PF00069	0.568
MOD_CK2_1	518	524	PF00069	0.604
MOD_CK2_1	604	610	PF00069	0.518
MOD_CK2_1	64	70	PF00069	0.630
MOD_CK2_1	87	93	PF00069	0.567
MOD_Cter_Amidation	687	690	PF01082	0.647
MOD_GlcNHglycan	130	133	PF01048	0.609
MOD_GlcNHglycan	179	182	PF01048	0.696
MOD_GlcNHglycan	253	256	PF01048	0.641
MOD_GlcNHglycan	264	267	PF01048	0.550
MOD_GlcNHglycan	361	364	PF01048	0.585
MOD_GlcNHglycan	379	382	PF01048	0.582
MOD_GlcNHglycan	395	398	PF01048	0.549
MOD_GlcNHglycan	428	431	PF01048	0.494
MOD_GlcNHglycan	527	530	PF01048	0.557
MOD_GlcNHglycan	64	67	PF01048	0.626
MOD_GlcNHglycan	657	660	PF01048	0.634
MOD_GlcNHglycan	684	687	PF01048	0.601
MOD_GlcNHglycan	720	723	PF01048	0.558
MOD_GlcNHglycan	745	748	PF01048	0.633
MOD_GlcNHglycan	751	754	PF01048	0.615
MOD_GlcNHglycan	789	792	PF01048	0.688
MOD_GlcNHglycan	98	102	PF01048	0.582
MOD_GSK3_1	173	180	PF00069	0.685
MOD_GSK3_1	260	267	PF00069	0.762
MOD_GSK3_1	327	334	PF00069	0.678
MOD_GSK3_1	359	366	PF00069	0.542
MOD_GSK3_1	380	387	PF00069	0.712
MOD_GSK3_1	398	405	PF00069	0.783
MOD_GSK3_1	518	525	PF00069	0.623
MOD_GSK3_1	538	545	PF00069	0.730
MOD_GSK3_1	562	569	PF00069	0.654
MOD_GSK3_1	576	583	PF00069	0.685
MOD_GSK3_1	58	65	PF00069	0.609
MOD_GSK3_1	654	661	PF00069	0.614
MOD_GSK3_1	680	687	PF00069	0.732
MOD_GSK3_1	711	718	PF00069	0.607
MOD_GSK3_1	728	735	PF00069	0.779
MOD_GSK3_1	743	750	PF00069	0.620
MOD_GSK3_1	777	784	PF00069	0.784
MOD_N-GLC_1	139	144	PF02516	0.671
MOD_N-GLC_1	157	162	PF02516	0.564
MOD_N-GLC_1	363	368	PF02516	0.615
MOD_N-GLC_1	426	431	PF02516	0.398
MOD_N-GLC_1	542	547	PF02516	0.529
MOD_N-GLC_1	777	782	PF02516	0.685
MOD_N-GLC_1	87	92	PF02516	0.566
MOD_NEK2_1	338	343	PF00069	0.509
MOD_NEK2_1	402	407	PF00069	0.756
MOD_NEK2_1	522	527	PF00069	0.563
MOD_NEK2_1	532	537	PF00069	0.553
MOD_NEK2_1	564	569	PF00069	0.760
MOD_NEK2_1	597	602	PF00069	0.567
MOD_NEK2_1	62	67	PF00069	0.703
MOD_NEK2_1	672	677	PF00069	0.556
MOD_NEK2_1	684	689	PF00069	0.615
MOD_NEK2_1	749	754	PF00069	0.540
MOD_NEK2_2	353	358	PF00069	0.485
MOD_NEK2_2	542	547	PF00069	0.535
MOD_NEK2_2	582	587	PF00069	0.602
MOD_PIKK_1	532	538	PF00454	0.581
MOD_PIKK_1	566	572	PF00454	0.584
MOD_PIKK_1	576	582	PF00454	0.648
MOD_PIKK_1	597	603	PF00454	0.564
MOD_PIKK_1	781	787	PF00454	0.574
MOD_PKA_2	25	31	PF00069	0.591
MOD_PKA_2	288	294	PF00069	0.413
MOD_PKA_2	353	359	PF00069	0.537
MOD_PKA_2	391	397	PF00069	0.684
MOD_PKA_2	398	404	PF00069	0.632
MOD_PKA_2	525	531	PF00069	0.509
MOD_PKA_2	555	561	PF00069	0.650
MOD_PKA_2	741	747	PF00069	0.670
MOD_PKA_2	781	787	PF00069	0.549
MOD_PKB_1	574	582	PF00069	0.571
MOD_Plk_1	139	145	PF00069	0.572
MOD_Plk_1	310	316	PF00069	0.632
MOD_Plk_1	338	344	PF00069	0.507
MOD_Plk_1	426	432	PF00069	0.397
MOD_Plk_1	87	93	PF00069	0.567
MOD_Plk_2-3	58	64	PF00069	0.583
MOD_Plk_2-3	87	93	PF00069	0.624
MOD_Plk_4	298	304	PF00069	0.455
MOD_Plk_4	429	435	PF00069	0.412
MOD_Plk_4	471	477	PF00069	0.544
MOD_Plk_4	542	548	PF00069	0.536
MOD_Plk_4	703	709	PF00069	0.566
MOD_ProDKin_1	114	120	PF00069	0.610
MOD_ProDKin_1	209	215	PF00069	0.641
MOD_ProDKin_1	220	226	PF00069	0.641
MOD_ProDKin_1	260	266	PF00069	0.639
MOD_ProDKin_1	267	273	PF00069	0.658
MOD_ProDKin_1	27	33	PF00069	0.814
MOD_ProDKin_1	295	301	PF00069	0.520
MOD_ProDKin_1	331	337	PF00069	0.557
MOD_ProDKin_1	387	393	PF00069	0.739
MOD_ProDKin_1	493	499	PF00069	0.643
MOD_ProDKin_1	64	70	PF00069	0.716
MOD_ProDKin_1	711	717	PF00069	0.550
MOD_ProDKin_1	732	738	PF00069	0.797
MOD_ProDKin_1	777	783	PF00069	0.783
MOD_SUMO_rev_2	48	55	PF00179	0.636
MOD_SUMO_rev_2	635	643	PF00179	0.608
TRG_DiLeu_BaEn_4	2	8	PF01217	0.573
TRG_ENDOCYTIC_2	272	275	PF00928	0.537
TRG_ENDOCYTIC_2	479	482	PF00928	0.572
TRG_ER_diArg_1	306	308	PF00400	0.539
TRG_ER_diArg_1	416	418	PF00400	0.648
TRG_ER_diArg_1	434	436	PF00400	0.477
TRG_ER_diArg_1	438	440	PF00400	0.520
TRG_ER_diArg_1	553	556	PF00400	0.743
TRG_ER_diArg_1	603	606	PF00400	0.465
TRG_ER_diArg_1	689	692	PF00400	0.637
TRG_ER_diArg_1	758	760	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T9	Leptomonas seymouri	43%	100%
A0A3S7WSK5	Leishmania donovani	60%	73%
A4HVL3	Leishmania infantum	60%	76%
E9APA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	91%
Q4QG69	Leishmania major	60%	100%