Succinate dehydrogenase assembly factor 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex1_LYR-like, putative

Species:

Leishmania braziliensis

UniProt:

A4H770_LEIBR

TriTrypDb:

LbrM.13.0630 , LBRM2903_130012100

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7
GO:0005758	mitochondrial intermembrane space	6	1
GO:0031970	organelle envelope lumen	5	1

Expansion

Sequence features

A4H770

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H770

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0033108	mitochondrial respiratory chain complex assembly	6	7
GO:0034552	respiratory chain complex II assembly	6	7
GO:0034553	mitochondrial respiratory chain complex II assembly	7	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0006082	organic acid metabolic process	3	1
GO:0006105	succinate metabolic process	7	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0043648	dicarboxylic acid metabolic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	166	168	PF00082	0.326
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.326
CLV_PCSK_SKI1_1	108	112	PF00082	0.326
CLV_PCSK_SKI1_1	159	163	PF00082	0.303
CLV_PCSK_SKI1_1	166	170	PF00082	0.303
CLV_PCSK_SKI1_1	174	178	PF00082	0.503
CLV_PCSK_SKI1_1	181	185	PF00082	0.451
CLV_PCSK_SKI1_1	36	40	PF00082	0.450
CLV_PCSK_SKI1_1	44	48	PF00082	0.258
DEG_APCC_DBOX_1	12	20	PF00400	0.524
DEG_MDM2_SWIB_1	141	149	PF02201	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.498
DOC_CYCLIN_RxL_1	102	114	PF00134	0.526
DOC_CYCLIN_RxL_1	163	172	PF00134	0.481
DOC_MAPK_gen_1	41	49	PF00069	0.526
DOC_PP1_RVXF_1	34	40	PF00149	0.479
DOC_USP7_MATH_1	176	180	PF00917	0.378
DOC_USP7_MATH_1	20	24	PF00917	0.535
DOC_USP7_MATH_1	91	95	PF00917	0.447
DOC_WW_Pin1_4	29	34	PF00397	0.581
LIG_14-3-3_CanoR_1	108	118	PF00244	0.410
LIG_14-3-3_CanoR_1	13	17	PF00244	0.591
LIG_Actin_WH2_2	173	190	PF00022	0.555
LIG_deltaCOP1_diTrp_1	26	35	PF00928	0.490
LIG_FHA_2	155	161	PF00498	0.505
LIG_FHA_2	187	193	PF00498	0.448
LIG_FHA_2	88	94	PF00498	0.514
LIG_GBD_Chelix_1	6	14	PF00786	0.397
LIG_LIR_Apic_2	27	33	PF02991	0.514
LIG_LIR_Gen_1	144	153	PF02991	0.526
LIG_LIR_Nem_3	144	149	PF02991	0.474
LIG_NRBOX	106	112	PF00104	0.526
LIG_Pex14_1	35	39	PF04695	0.471
LIG_Pex14_2	118	122	PF04695	0.474
LIG_Pex14_2	141	145	PF04695	0.474
LIG_REV1ctd_RIR_1	182	192	PF16727	0.512
LIG_SH2_CRK	146	150	PF00017	0.410
LIG_SH2_CRK	43	47	PF00017	0.474
LIG_SH2_NCK_1	30	34	PF00017	0.431
LIG_SH2_SRC	146	149	PF00017	0.526
LIG_SH2_STAP1	142	146	PF00017	0.474
LIG_SH2_STAT3	148	151	PF00017	0.503
LIG_SH2_STAT5	109	112	PF00017	0.502
LIG_SH2_STAT5	148	151	PF00017	0.526
LIG_SUMO_SIM_par_1	52	57	PF11976	0.410
LIG_TRAF2_2	22	27	PF00917	0.348
LIG_UBA3_1	46	52	PF00899	0.526
MOD_CDK_SPxxK_3	29	36	PF00069	0.503
MOD_CK1_1	154	160	PF00069	0.526
MOD_CK1_1	57	63	PF00069	0.526
MOD_CK1_1	71	77	PF00069	0.426
MOD_CK1_1	80	86	PF00069	0.390
MOD_CK2_1	154	160	PF00069	0.456
MOD_CK2_1	186	192	PF00069	0.449
MOD_CK2_1	87	93	PF00069	0.473
MOD_GlcNHglycan	153	156	PF01048	0.287
MOD_GlcNHglycan	70	73	PF01048	0.366
MOD_GlcNHglycan	85	88	PF01048	0.236
MOD_GlcNHglycan	93	96	PF01048	0.199
MOD_GSK3_1	54	61	PF00069	0.410
MOD_GSK3_1	76	83	PF00069	0.526
MOD_GSK3_1	87	94	PF00069	0.447
MOD_NEK2_1	12	17	PF00069	0.569
MOD_NEK2_1	141	146	PF00069	0.526
MOD_NEK2_1	42	47	PF00069	0.517
MOD_NEK2_1	58	63	PF00069	0.410
MOD_NEK2_2	176	181	PF00069	0.380
MOD_PIKK_1	20	26	PF00454	0.563
MOD_PIKK_1	77	83	PF00454	0.526
MOD_PKA_2	12	18	PF00069	0.601
MOD_PKA_2	187	193	PF00069	0.520
MOD_Plk_4	136	142	PF00069	0.512
MOD_ProDKin_1	29	35	PF00069	0.572
MOD_SUMO_rev_2	170	176	PF00179	0.544
MOD_SUMO_rev_2	186	196	PF00179	0.430
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.481
TRG_ENDOCYTIC_2	146	149	PF00928	0.526
TRG_ENDOCYTIC_2	43	46	PF00928	0.474
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NN19	Trypanosomatidae	29%	97%
A0A3S5H6N9	Leishmania donovani	82%	78%
A4HVL0	Leishmania infantum	82%	78%
E9APA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	79%
Q4QG72	Leishmania major	79%	100%