Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H769_LEIBR

TriTrypDb:

LbrM.13.0620 , LBRM2903_130011900

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H769

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H769

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.554
CLV_C14_Caspase3-7	186	190	PF00656	0.610
CLV_NRD_NRD_1	106	108	PF00675	0.522
CLV_NRD_NRD_1	114	116	PF00675	0.538
CLV_NRD_NRD_1	204	206	PF00675	0.655
CLV_NRD_NRD_1	207	209	PF00675	0.629
CLV_NRD_NRD_1	213	215	PF00675	0.571
CLV_NRD_NRD_1	3	5	PF00675	0.536
CLV_PCSK_FUR_1	115	119	PF00082	0.429
CLV_PCSK_FUR_1	21	25	PF00082	0.679
CLV_PCSK_KEX2_1	106	108	PF00082	0.484
CLV_PCSK_KEX2_1	114	116	PF00082	0.524
CLV_PCSK_KEX2_1	117	119	PF00082	0.481
CLV_PCSK_KEX2_1	23	25	PF00082	0.737
CLV_PCSK_KEX2_1	3	5	PF00082	0.536
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.522
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.671
CLV_PCSK_SKI1_1	114	118	PF00082	0.584
CLV_PCSK_SKI1_1	199	203	PF00082	0.753
CLV_PCSK_SKI1_1	208	212	PF00082	0.609
CLV_PCSK_SKI1_1	92	96	PF00082	0.555
DEG_APCC_DBOX_1	91	99	PF00400	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SPOP_SBC_1	127	131	PF00917	0.451
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.467
DOC_MAPK_gen_1	3	11	PF00069	0.532
DOC_USP7_MATH_1	127	131	PF00917	0.474
DOC_USP7_MATH_1	15	19	PF00917	0.637
DOC_USP7_MATH_1	152	156	PF00917	0.607
DOC_USP7_MATH_1	187	191	PF00917	0.536
DOC_USP7_MATH_1	35	39	PF00917	0.671
DOC_USP7_UBL2_3	117	121	PF12436	0.693
DOC_USP7_UBL2_3	202	206	PF12436	0.667
DOC_USP7_UBL2_3	211	215	PF12436	0.553
DOC_WW_Pin1_4	146	151	PF00397	0.609
LIG_14-3-3_CanoR_1	58	67	PF00244	0.522
LIG_FHA_1	54	60	PF00498	0.567
LIG_FHA_2	157	163	PF00498	0.565
LIG_FHA_2	179	185	PF00498	0.496
LIG_HP1_1	101	105	PF01393	0.544
LIG_LIR_Gen_1	182	193	PF02991	0.472
LIG_LIR_Gen_1	5	15	PF02991	0.461
LIG_LIR_Gen_1	68	79	PF02991	0.523
LIG_LIR_Nem_3	182	188	PF02991	0.477
LIG_LIR_Nem_3	5	11	PF02991	0.452
LIG_LIR_Nem_3	62	67	PF02991	0.430
LIG_LIR_Nem_3	68	74	PF02991	0.430
LIG_PDZ_Class_2	228	233	PF00595	0.618
LIG_Pex14_1	53	57	PF04695	0.560
LIG_Pex14_2	8	12	PF04695	0.464
LIG_RPA_C_Fungi	102	114	PF08784	0.475
LIG_SH2_NCK_1	185	189	PF00017	0.474
LIG_SH2_NCK_1	30	34	PF00017	0.504
LIG_SH2_STAP1	30	34	PF00017	0.504
LIG_SH2_STAT5	30	33	PF00017	0.688
LIG_SH2_STAT5	45	48	PF00017	0.498
LIG_SH3_3	41	47	PF00018	0.529
LIG_SUMO_SIM_anti_2	189	196	PF11976	0.538
MOD_CK1_1	129	135	PF00069	0.599
MOD_CK1_1	156	162	PF00069	0.704
MOD_CK1_1	174	180	PF00069	0.664
MOD_CK1_1	204	210	PF00069	0.679
MOD_CK1_1	223	229	PF00069	0.419
MOD_CK2_1	178	184	PF00069	0.700
MOD_GlcNHglycan	13	16	PF01048	0.564
MOD_GlcNHglycan	136	139	PF01048	0.541
MOD_GlcNHglycan	150	153	PF01048	0.600
MOD_GlcNHglycan	17	20	PF01048	0.558
MOD_GlcNHglycan	181	184	PF01048	0.729
MOD_GlcNHglycan	37	40	PF01048	0.528
MOD_GSK3_1	11	18	PF00069	0.560
MOD_GSK3_1	122	129	PF00069	0.613
MOD_GSK3_1	142	149	PF00069	0.577
MOD_GSK3_1	152	159	PF00069	0.632
MOD_GSK3_1	163	170	PF00069	0.634
MOD_GSK3_1	174	181	PF00069	0.621
MOD_GSK3_1	19	26	PF00069	0.634
MOD_N-GLC_1	179	184	PF02516	0.496
MOD_NEK2_1	11	16	PF00069	0.515
MOD_NEK2_1	134	139	PF00069	0.619
MOD_NEK2_1	2	7	PF00069	0.571
MOD_NEK2_1	201	206	PF00069	0.702
MOD_NEK2_1	210	215	PF00069	0.711
MOD_NEK2_1	66	71	PF00069	0.446
MOD_PIKK_1	129	135	PF00454	0.615
MOD_PIKK_1	163	169	PF00454	0.503
MOD_PIKK_1	59	65	PF00454	0.446
MOD_PKA_1	23	29	PF00069	0.513
MOD_PKA_2	2	8	PF00069	0.606
MOD_PKA_2	204	210	PF00069	0.613
MOD_PKA_2	213	219	PF00069	0.585
MOD_PKA_2	23	29	PF00069	0.557
MOD_Plk_4	171	177	PF00069	0.521
MOD_Plk_4	66	72	PF00069	0.424
MOD_ProDKin_1	146	152	PF00069	0.609
TRG_ENDOCYTIC_2	185	188	PF00928	0.545
TRG_ER_diArg_1	105	107	PF00400	0.482
TRG_ER_diArg_1	114	116	PF00400	0.501
TRG_ER_diArg_1	2	4	PF00400	0.544
TRG_NLS_Bipartite_1	199	218	PF00514	0.511
TRG_NLS_MonoExtC_3	204	209	PF00514	0.651
TRG_NLS_MonoExtC_3	213	218	PF00514	0.550
TRG_NLS_MonoExtN_4	202	209	PF00514	0.664
TRG_NLS_MonoExtN_4	211	218	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM08	Leptomonas seymouri	50%	91%
A0A3Q8I9H5	Leishmania donovani	68%	100%
A4HVK8	Leishmania infantum	68%	100%
E9APA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QG74	Leishmania major	70%	96%