Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H768_LEIBR

TriTrypDb:

LbrM.13.0610 , LBRM2903_130011800

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H768

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H768

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	7
GO:0002098	tRNA wobble uridine modification	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006399	tRNA metabolic process	7	7
GO:0006400	tRNA modification	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008033	tRNA processing	8	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034227	tRNA thio-modification	7	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0002143	tRNA wobble position uridine thiolation	8	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	7
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016782	transferase activity, transferring sulphur-containing groups	3	1
GO:0016783	sulfurtransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	643	647	PF00656	0.613
CLV_NRD_NRD_1	173	175	PF00675	0.655
CLV_NRD_NRD_1	341	343	PF00675	0.546
CLV_NRD_NRD_1	508	510	PF00675	0.678
CLV_NRD_NRD_1	537	539	PF00675	0.572
CLV_NRD_NRD_1	82	84	PF00675	0.522
CLV_PCSK_KEX2_1	341	343	PF00082	0.546
CLV_PCSK_KEX2_1	537	539	PF00082	0.572
CLV_PCSK_KEX2_1	82	84	PF00082	0.522
CLV_PCSK_SKI1_1	195	199	PF00082	0.513
CLV_PCSK_SKI1_1	282	286	PF00082	0.522
CLV_PCSK_SKI1_1	295	299	PF00082	0.374
CLV_PCSK_SKI1_1	404	408	PF00082	0.462
CLV_PCSK_SKI1_1	417	421	PF00082	0.366
CLV_PCSK_SKI1_1	509	513	PF00082	0.739
DEG_SCF_FBW7_1	220	226	PF00400	0.807
DEG_SPOP_SBC_1	104	108	PF00917	0.536
DEG_SPOP_SBC_1	109	113	PF00917	0.533
DEG_SPOP_SBC_1	138	142	PF00917	0.799
DEG_SPOP_SBC_1	143	147	PF00917	0.706
DEG_SPOP_SBC_1	660	664	PF00917	0.467
DOC_CKS1_1	220	225	PF01111	0.808
DOC_CYCLIN_yCln2_LP_2	526	532	PF00134	0.742
DOC_PP2B_LxvP_1	130	133	PF13499	0.522
DOC_PP2B_LxvP_1	135	138	PF13499	0.662
DOC_PP2B_LxvP_1	526	529	PF13499	0.762
DOC_USP7_MATH_1	104	108	PF00917	0.702
DOC_USP7_MATH_1	138	142	PF00917	0.714
DOC_USP7_MATH_1	144	148	PF00917	0.701
DOC_USP7_MATH_1	236	240	PF00917	0.765
DOC_USP7_MATH_1	446	450	PF00917	0.640
DOC_USP7_MATH_1	498	502	PF00917	0.583
DOC_USP7_MATH_1	591	595	PF00917	0.795
DOC_USP7_MATH_1	604	608	PF00917	0.754
DOC_USP7_MATH_1	665	669	PF00917	0.562
DOC_USP7_UBL2_3	195	199	PF12436	0.766
DOC_USP7_UBL2_3	506	510	PF12436	0.809
DOC_WW_Pin1_4	139	144	PF00397	0.703
DOC_WW_Pin1_4	219	224	PF00397	0.805
DOC_WW_Pin1_4	232	237	PF00397	0.629
DOC_WW_Pin1_4	435	440	PF00397	0.541
DOC_WW_Pin1_4	48	53	PF00397	0.509
DOC_WW_Pin1_4	587	592	PF00397	0.780
DOC_WW_Pin1_4	626	631	PF00397	0.405
LIG_14-3-3_CanoR_1	163	167	PF00244	0.562
LIG_14-3-3_CanoR_1	276	285	PF00244	0.547
LIG_14-3-3_CanoR_1	303	308	PF00244	0.504
LIG_14-3-3_CanoR_1	404	413	PF00244	0.518
LIG_14-3-3_CanoR_1	414	420	PF00244	0.388
LIG_14-3-3_CanoR_1	525	529	PF00244	0.634
LIG_14-3-3_CanoR_1	537	542	PF00244	0.579
LIG_14-3-3_CanoR_1	592	599	PF00244	0.551
LIG_APCC_ABBA_1	530	535	PF00400	0.605
LIG_BIR_II_1	1	5	PF00653	0.380
LIG_BRCT_BRCA1_1	1	5	PF00533	0.380
LIG_BRCT_BRCA1_1	25	29	PF00533	0.299
LIG_deltaCOP1_diTrp_1	626	633	PF00928	0.661
LIG_EVH1_1	132	136	PF00568	0.662
LIG_FHA_1	110	116	PF00498	0.513
LIG_FHA_1	186	192	PF00498	0.531
LIG_FHA_1	220	226	PF00498	0.652
LIG_FHA_1	405	411	PF00498	0.552
LIG_FHA_1	436	442	PF00498	0.554
LIG_FHA_1	445	451	PF00498	0.440
LIG_FHA_1	525	531	PF00498	0.549
LIG_FHA_1	662	668	PF00498	0.650
LIG_FHA_2	163	169	PF00498	0.567
LIG_LIR_Gen_1	168	177	PF02991	0.550
LIG_LIR_Gen_1	296	307	PF02991	0.590
LIG_LIR_Gen_1	424	434	PF02991	0.468
LIG_LIR_Gen_1	467	476	PF02991	0.479
LIG_LIR_Gen_1	545	555	PF02991	0.362
LIG_LIR_Nem_3	168	173	PF02991	0.552
LIG_LIR_Nem_3	26	32	PF02991	0.455
LIG_LIR_Nem_3	296	302	PF02991	0.497
LIG_LIR_Nem_3	424	430	PF02991	0.463
LIG_LIR_Nem_3	467	473	PF02991	0.422
LIG_LIR_Nem_3	545	550	PF02991	0.401
LIG_LIR_Nem_3	614	619	PF02991	0.444
LIG_LIR_Nem_3	69	73	PF02991	0.333
LIG_PDZ_Class_2	670	675	PF00595	0.363
LIG_SH2_CRK	299	303	PF00017	0.500
LIG_SH2_CRK	427	431	PF00017	0.580
LIG_SH2_CRK	547	551	PF00017	0.373
LIG_SH2_NCK_1	547	551	PF00017	0.373
LIG_SH2_STAP1	269	273	PF00017	0.590
LIG_SH2_STAT5	176	179	PF00017	0.653
LIG_SH2_STAT5	24	27	PF00017	0.454
LIG_SH2_STAT5	277	280	PF00017	0.504
LIG_SH2_STAT5	32	35	PF00017	0.452
LIG_SH2_STAT5	427	430	PF00017	0.445
LIG_SH2_STAT5	437	440	PF00017	0.470
LIG_SH3_3	116	122	PF00018	0.539
LIG_SH3_3	128	134	PF00018	0.510
LIG_SH3_3	217	223	PF00018	0.595
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.500
LIG_TRAF2_1	158	161	PF00917	0.524
LIG_TRAF2_1	41	44	PF00917	0.348
LIG_TRAF2_1	485	488	PF00917	0.517
LIG_TRFH_1	581	585	PF08558	0.494
LIG_TYR_ITIM	425	430	PF00017	0.585
LIG_WW_2	133	136	PF00397	0.466
LIG_WW_3	180	184	PF00397	0.700
MOD_CDK_SPK_2	587	592	PF00069	0.780
MOD_CK1_1	105	111	PF00069	0.758
MOD_CK1_1	113	119	PF00069	0.504
MOD_CK1_1	142	148	PF00069	0.759
MOD_CK1_1	226	232	PF00069	0.704
MOD_CK1_1	235	241	PF00069	0.782
MOD_CK1_1	248	254	PF00069	0.536
MOD_CK1_1	288	294	PF00069	0.531
MOD_CK1_1	464	470	PF00069	0.492
MOD_CK1_1	587	593	PF00069	0.758
MOD_CK1_1	594	600	PF00069	0.668
MOD_CK1_1	606	612	PF00069	0.489
MOD_CK1_1	635	641	PF00069	0.616
MOD_CK1_1	649	655	PF00069	0.621
MOD_CK1_1	663	669	PF00069	0.352
MOD_CK2_1	145	151	PF00069	0.587
MOD_CK2_1	162	168	PF00069	0.544
MOD_CK2_1	290	296	PF00069	0.515
MOD_CK2_1	537	543	PF00069	0.624
MOD_GlcNHglycan	107	110	PF01048	0.605
MOD_GlcNHglycan	151	155	PF01048	0.756
MOD_GlcNHglycan	195	198	PF01048	0.579
MOD_GlcNHglycan	228	231	PF01048	0.645
MOD_GlcNHglycan	232	235	PF01048	0.675
MOD_GlcNHglycan	246	250	PF01048	0.550
MOD_GlcNHglycan	392	395	PF01048	0.378
MOD_GlcNHglycan	490	493	PF01048	0.608
MOD_GlcNHglycan	494	497	PF01048	0.636
MOD_GlcNHglycan	57	60	PF01048	0.495
MOD_GlcNHglycan	643	646	PF01048	0.743
MOD_GSK3_1	103	110	PF00069	0.650
MOD_GSK3_1	138	145	PF00069	0.709
MOD_GSK3_1	185	192	PF00069	0.501
MOD_GSK3_1	219	226	PF00069	0.732
MOD_GSK3_1	232	239	PF00069	0.698
MOD_GSK3_1	267	274	PF00069	0.491
MOD_GSK3_1	356	363	PF00069	0.661
MOD_GSK3_1	421	428	PF00069	0.433
MOD_GSK3_1	440	447	PF00069	0.673
MOD_GSK3_1	457	464	PF00069	0.434
MOD_GSK3_1	488	495	PF00069	0.599
MOD_GSK3_1	587	594	PF00069	0.681
MOD_GSK3_1	603	610	PF00069	0.515
MOD_GSK3_1	624	631	PF00069	0.402
MOD_GSK3_1	632	639	PF00069	0.546
MOD_GSK3_1	641	648	PF00069	0.643
MOD_GSK3_1	649	656	PF00069	0.583
MOD_GSK3_1	659	666	PF00069	0.404
MOD_NEK2_1	114	119	PF00069	0.520
MOD_NEK2_1	225	230	PF00069	0.567
MOD_NEK2_1	23	28	PF00069	0.301
MOD_NEK2_1	285	290	PF00069	0.510
MOD_NEK2_1	360	365	PF00069	0.733
MOD_NEK2_1	457	462	PF00069	0.424
MOD_NEK2_1	624	629	PF00069	0.357
MOD_NEK2_1	633	638	PF00069	0.479
MOD_NEK2_2	446	451	PF00069	0.631
MOD_OFUCOSY	93	100	PF10250	0.464
MOD_PIKK_1	236	242	PF00454	0.597
MOD_PIKK_1	498	504	PF00454	0.780
MOD_PIKK_1	665	671	PF00454	0.361
MOD_PKA_1	537	543	PF00069	0.521
MOD_PKA_2	162	168	PF00069	0.538
MOD_PKA_2	524	530	PF00069	0.682
MOD_PKA_2	537	543	PF00069	0.451
MOD_PKA_2	591	597	PF00069	0.797
MOD_PKB_1	301	309	PF00069	0.581
MOD_Plk_1	361	367	PF00069	0.650
MOD_Plk_1	594	600	PF00069	0.554
MOD_Plk_1	607	613	PF00069	0.422
MOD_Plk_2-3	356	362	PF00069	0.656
MOD_Plk_4	10	16	PF00069	0.474
MOD_Plk_4	110	116	PF00069	0.623
MOD_Plk_4	421	427	PF00069	0.433
MOD_Plk_4	457	463	PF00069	0.398
MOD_Plk_4	60	66	PF00069	0.473
MOD_Plk_4	607	613	PF00069	0.543
MOD_Plk_4	628	634	PF00069	0.681
MOD_ProDKin_1	139	145	PF00069	0.701
MOD_ProDKin_1	219	225	PF00069	0.807
MOD_ProDKin_1	232	238	PF00069	0.630
MOD_ProDKin_1	435	441	PF00069	0.542
MOD_ProDKin_1	48	54	PF00069	0.501
MOD_ProDKin_1	587	593	PF00069	0.781
MOD_ProDKin_1	626	632	PF00069	0.405
MOD_SUMO_for_1	334	337	PF00179	0.533
MOD_SUMO_rev_2	189	197	PF00179	0.511
TRG_ENDOCYTIC_2	269	272	PF00928	0.514
TRG_ENDOCYTIC_2	299	302	PF00928	0.499
TRG_ENDOCYTIC_2	427	430	PF00928	0.581
TRG_ENDOCYTIC_2	465	468	PF00928	0.520
TRG_ENDOCYTIC_2	547	550	PF00928	0.387
TRG_ER_diArg_1	340	342	PF00400	0.544
TRG_ER_diArg_1	536	538	PF00400	0.567
TRG_ER_diArg_1	81	83	PF00400	0.515
TRG_NLS_MonoExtN_4	195	202	PF00514	0.675
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC5	Leptomonas seymouri	43%	100%
A0A3Q8I9K2	Leishmania donovani	68%	97%
A4HVK7	Leishmania infantum	68%	97%
E9APA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	99%
Q4QG75	Leishmania major	66%	100%