Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H767_LEIBR

TriTrypDb:

LbrM.13.0600 , LBRM2903_130011700

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H767

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H767

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.462
CLV_C14_Caspase3-7	385	389	PF00656	0.319
CLV_C14_Caspase3-7	57	61	PF00656	0.405
CLV_NRD_NRD_1	195	197	PF00675	0.488
CLV_NRD_NRD_1	325	327	PF00675	0.360
CLV_PCSK_KEX2_1	18	20	PF00082	0.456
CLV_PCSK_KEX2_1	195	197	PF00082	0.471
CLV_PCSK_KEX2_1	558	560	PF00082	0.538
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.507
CLV_PCSK_PC1ET2_1	558	560	PF00082	0.550
CLV_PCSK_SKI1_1	173	177	PF00082	0.425
CLV_PCSK_SKI1_1	195	199	PF00082	0.448
CLV_PCSK_SKI1_1	327	331	PF00082	0.360
CLV_PCSK_SKI1_1	348	352	PF00082	0.320
CLV_PCSK_SKI1_1	435	439	PF00082	0.300
CLV_PCSK_SKI1_1	476	480	PF00082	0.380
CLV_PCSK_SKI1_1	485	489	PF00082	0.360
CLV_PCSK_SKI1_1	575	579	PF00082	0.371
CLV_Separin_Metazoa	502	506	PF03568	0.329
DEG_APCC_DBOX_1	574	582	PF00400	0.368
DOC_CYCLIN_RxL_1	432	442	PF00134	0.360
DOC_MAPK_gen_1	18	24	PF00069	0.494
DOC_MAPK_gen_1	195	201	PF00069	0.347
DOC_MAPK_gen_1	348	357	PF00069	0.300
DOC_MAPK_gen_1	471	480	PF00069	0.219
DOC_MAPK_RevD_3	152	167	PF00069	0.280
DOC_PP4_FxxP_1	136	139	PF00568	0.348
DOC_SPAK_OSR1_1	66	70	PF12202	0.355
DOC_USP7_MATH_1	14	18	PF00917	0.541
DOC_USP7_MATH_1	214	218	PF00917	0.567
DOC_USP7_MATH_1	271	275	PF00917	0.555
DOC_USP7_MATH_1	317	321	PF00917	0.425
DOC_USP7_MATH_1	403	407	PF00917	0.285
DOC_USP7_MATH_1	459	463	PF00917	0.379
DOC_USP7_UBL2_3	484	488	PF12436	0.360
DOC_USP7_UBL2_3	590	594	PF12436	0.312
DOC_WW_Pin1_4	184	189	PF00397	0.484
DOC_WW_Pin1_4	494	499	PF00397	0.351
DOC_WW_Pin1_4	503	508	PF00397	0.256
DOC_WW_Pin1_4	78	83	PF00397	0.427
LIG_Actin_WH2_2	157	175	PF00022	0.357
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_1	1	5	PF00653	0.564
LIG_BIR_III_3	1	5	PF00653	0.564
LIG_eIF4E_1	89	95	PF01652	0.432
LIG_FHA_1	114	120	PF00498	0.350
LIG_FHA_1	29	35	PF00498	0.399
LIG_FHA_1	313	319	PF00498	0.483
LIG_FHA_1	397	403	PF00498	0.223
LIG_FHA_1	473	479	PF00498	0.360
LIG_FHA_1	495	501	PF00498	0.376
LIG_FHA_2	169	175	PF00498	0.374
LIG_FHA_2	180	186	PF00498	0.434
LIG_FHA_2	262	268	PF00498	0.590
LIG_FHA_2	286	292	PF00498	0.648
LIG_FHA_2	383	389	PF00498	0.340
LIG_FHA_2	497	503	PF00498	0.329
LIG_FHA_2	79	85	PF00498	0.497
LIG_LIR_Apic_2	134	139	PF02991	0.356
LIG_LIR_Apic_2	391	397	PF02991	0.300
LIG_LIR_Gen_1	147	156	PF02991	0.387
LIG_LIR_Gen_1	157	165	PF02991	0.343
LIG_LIR_Gen_1	33	43	PF02991	0.436
LIG_LIR_Nem_3	134	140	PF02991	0.360
LIG_LIR_Nem_3	147	151	PF02991	0.378
LIG_LIR_Nem_3	157	161	PF02991	0.356
LIG_LIR_Nem_3	322	328	PF02991	0.304
LIG_LIR_Nem_3	33	38	PF02991	0.431
LIG_LIR_Nem_3	39	44	PF02991	0.465
LIG_LIR_Nem_3	414	419	PF02991	0.363
LIG_LIR_Nem_3	451	456	PF02991	0.360
LIG_LIR_Nem_3	51	55	PF02991	0.510
LIG_LIR_Nem_3	545	550	PF02991	0.486
LIG_LIR_Nem_3	591	596	PF02991	0.485
LIG_LRP6_Inhibitor_1	478	484	PF00058	0.279
LIG_NRBOX	33	39	PF00104	0.442
LIG_NRBOX	499	505	PF00104	0.273
LIG_PTB_Apo_2	536	543	PF02174	0.311
LIG_REV1ctd_RIR_1	539	548	PF16727	0.467
LIG_SH2_CRK	148	152	PF00017	0.445
LIG_SH2_CRK	447	451	PF00017	0.219
LIG_SH2_CRK	52	56	PF00017	0.427
LIG_SH2_CRK	547	551	PF00017	0.503
LIG_SH2_NCK_1	394	398	PF00017	0.300
LIG_SH2_NCK_1	41	45	PF00017	0.429
LIG_SH2_SRC	547	550	PF00017	0.486
LIG_SH2_STAP1	190	194	PF00017	0.460
LIG_SH2_STAP1	41	45	PF00017	0.288
LIG_SH2_STAP1	439	443	PF00017	0.360
LIG_SH2_STAT5	162	165	PF00017	0.348
LIG_SH2_STAT5	170	173	PF00017	0.405
LIG_SH2_STAT5	339	342	PF00017	0.378
LIG_SH2_STAT5	382	385	PF00017	0.376
LIG_SH2_STAT5	439	442	PF00017	0.300
LIG_SH2_STAT5	54	57	PF00017	0.422
LIG_SH3_3	233	239	PF00018	0.549
LIG_SH3_3	306	312	PF00018	0.537
LIG_SH3_3	547	553	PF00018	0.524
LIG_SH3_3	66	72	PF00018	0.375
LIG_SUMO_SIM_par_1	314	320	PF11976	0.457
LIG_SUMO_SIM_par_1	398	407	PF11976	0.376
LIG_TRAF2_1	229	232	PF00917	0.554
LIG_TRAF2_1	71	74	PF00917	0.501
LIG_TRAF2_1	81	84	PF00917	0.511
LIG_TYR_ITIM	337	342	PF00017	0.308
LIG_WRC_WIRS_1	122	127	PF05994	0.293
MOD_CDK_SPxxK_3	78	85	PF00069	0.371
MOD_CK1_1	106	112	PF00069	0.546
MOD_CK1_1	360	366	PF00069	0.360
MOD_CK1_1	6	12	PF00069	0.422
MOD_CK2_1	168	174	PF00069	0.370
MOD_CK2_1	179	185	PF00069	0.434
MOD_CK2_1	285	291	PF00069	0.565
MOD_CK2_1	36	42	PF00069	0.426
MOD_CK2_1	459	465	PF00069	0.371
MOD_CK2_1	496	502	PF00069	0.329
MOD_CK2_1	604	610	PF00069	0.426
MOD_CK2_1	78	84	PF00069	0.573
MOD_GlcNHglycan	131	134	PF01048	0.357
MOD_GlcNHglycan	216	219	PF01048	0.526
MOD_GlcNHglycan	273	276	PF01048	0.550
MOD_GlcNHglycan	459	462	PF01048	0.361
MOD_GlcNHglycan	56	59	PF01048	0.407
MOD_GlcNHglycan	572	575	PF01048	0.452
MOD_GSK3_1	175	182	PF00069	0.402
MOD_GSK3_1	240	247	PF00069	0.775
MOD_GSK3_1	271	278	PF00069	0.576
MOD_GSK3_1	281	288	PF00069	0.643
MOD_GSK3_1	459	466	PF00069	0.258
MOD_GSK3_1	492	499	PF00069	0.307
MOD_GSK3_1	566	573	PF00069	0.501
MOD_N-GLC_1	106	111	PF02516	0.360
MOD_N-GLC_1	376	381	PF02516	0.379
MOD_N-GLC_1	388	393	PF02516	0.237
MOD_N-GLC_1	404	409	PF02516	0.300
MOD_NEK2_1	103	108	PF00069	0.473
MOD_NEK2_1	121	126	PF00069	0.248
MOD_NEK2_1	168	173	PF00069	0.362
MOD_NEK2_1	176	181	PF00069	0.409
MOD_NEK2_1	285	290	PF00069	0.605
MOD_NEK2_1	357	362	PF00069	0.360
MOD_NEK2_1	437	442	PF00069	0.360
MOD_NEK2_1	479	484	PF00069	0.339
MOD_NEK2_1	486	491	PF00069	0.341
MOD_NEK2_1	592	597	PF00069	0.461
MOD_NEK2_1	604	609	PF00069	0.559
MOD_NEK2_2	553	558	PF00069	0.436
MOD_PIKK_1	388	394	PF00454	0.320
MOD_PK_1	559	565	PF00069	0.536
MOD_PKA_2	363	369	PF00069	0.392
MOD_PKA_2	529	535	PF00069	0.300
MOD_Plk_1	106	112	PF00069	0.349
MOD_Plk_1	168	174	PF00069	0.370
MOD_Plk_1	176	182	PF00069	0.410
MOD_Plk_1	28	34	PF00069	0.500
MOD_Plk_1	281	287	PF00069	0.640
MOD_Plk_1	357	363	PF00069	0.360
MOD_Plk_1	388	394	PF00069	0.314
MOD_Plk_1	404	410	PF00069	0.360
MOD_Plk_1	553	559	PF00069	0.434
MOD_Plk_1	76	82	PF00069	0.594
MOD_Plk_4	147	153	PF00069	0.403
MOD_Plk_4	157	163	PF00069	0.308
MOD_Plk_4	189	195	PF00069	0.498
MOD_Plk_4	281	287	PF00069	0.534
MOD_Plk_4	382	388	PF00069	0.300
MOD_Plk_4	448	454	PF00069	0.360
MOD_Plk_4	592	598	PF00069	0.498
MOD_Plk_4	6	12	PF00069	0.556
MOD_Plk_4	90	96	PF00069	0.425
MOD_ProDKin_1	184	190	PF00069	0.474
MOD_ProDKin_1	494	500	PF00069	0.351
MOD_ProDKin_1	503	509	PF00069	0.256
MOD_ProDKin_1	78	84	PF00069	0.424
MOD_SUMO_for_1	350	353	PF00179	0.300
MOD_SUMO_for_1	598	601	PF00179	0.503
MOD_SUMO_rev_2	601	609	PF00179	0.539
TRG_DiLeu_BaEn_1	33	38	PF01217	0.421
TRG_ENDOCYTIC_2	148	151	PF00928	0.385
TRG_ENDOCYTIC_2	162	165	PF00928	0.326
TRG_ENDOCYTIC_2	325	328	PF00928	0.334
TRG_ENDOCYTIC_2	331	334	PF00928	0.346
TRG_ENDOCYTIC_2	339	342	PF00928	0.354
TRG_ENDOCYTIC_2	41	44	PF00928	0.428
TRG_ENDOCYTIC_2	447	450	PF00928	0.219
TRG_ENDOCYTIC_2	52	55	PF00928	0.436
TRG_ENDOCYTIC_2	547	550	PF00928	0.518
TRG_ER_diArg_1	194	196	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ0	Leptomonas seymouri	70%	100%
A0A3Q8I9M4	Leishmania donovani	82%	100%
A4HVK6	Leishmania infantum	82%	86%
E9APA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QG76	Leishmania major	79%	93%
V5AVM7	Trypanosoma cruzi	44%	100%