Protein-tyrosine-phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H766_LEIBR

TriTrypDb:

LbrM.13.0590 , LBRM2903_130011600

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H766

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H766

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.668
CLV_NRD_NRD_1	432	434	PF00675	0.350
CLV_NRD_NRD_1	63	65	PF00675	0.493
CLV_PCSK_KEX2_1	124	126	PF00082	0.547
CLV_PCSK_KEX2_1	432	434	PF00082	0.350
CLV_PCSK_KEX2_1	65	67	PF00082	0.511
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.547
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.559
CLV_PCSK_PC7_1	61	67	PF00082	0.565
CLV_PCSK_SKI1_1	112	116	PF00082	0.591
CLV_PCSK_SKI1_1	124	128	PF00082	0.630
CLV_PCSK_SKI1_1	205	209	PF00082	0.511
CLV_PCSK_SKI1_1	421	425	PF00082	0.628
CLV_PCSK_SKI1_1	499	503	PF00082	0.365
CLV_PCSK_SKI1_1	66	70	PF00082	0.514
DEG_APCC_DBOX_1	111	119	PF00400	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.517
DEG_SCF_FBW7_1	411	417	PF00400	0.468
DEG_SPOP_SBC_1	195	199	PF00917	0.602
DEG_SPOP_SBC_1	317	321	PF00917	0.514
DEG_SPOP_SBC_1	397	401	PF00917	0.455
DEG_SPOP_SBC_1	402	406	PF00917	0.510
DOC_ANK_TNKS_1	130	137	PF00023	0.572
DOC_CKS1_1	363	368	PF01111	0.424
DOC_CKS1_1	411	416	PF01111	0.476
DOC_CYCLIN_RxL_1	61	72	PF00134	0.488
DOC_MAPK_gen_1	61	70	PF00069	0.513
DOC_MAPK_HePTP_8	520	532	PF00069	0.411
DOC_MAPK_MEF2A_6	523	532	PF00069	0.408
DOC_MAPK_RevD_3	51	66	PF00069	0.452
DOC_PP4_FxxP_1	439	442	PF00568	0.415
DOC_USP7_MATH_1	130	134	PF00917	0.827
DOC_USP7_MATH_1	151	155	PF00917	0.712
DOC_USP7_MATH_1	156	160	PF00917	0.715
DOC_USP7_MATH_1	195	199	PF00917	0.590
DOC_USP7_MATH_1	402	406	PF00917	0.630
DOC_USP7_MATH_1	456	460	PF00917	0.508
DOC_USP7_MATH_1	80	84	PF00917	0.637
DOC_WW_Pin1_4	124	129	PF00397	0.632
DOC_WW_Pin1_4	138	143	PF00397	0.619
DOC_WW_Pin1_4	208	213	PF00397	0.407
DOC_WW_Pin1_4	24	29	PF00397	0.541
DOC_WW_Pin1_4	362	367	PF00397	0.438
DOC_WW_Pin1_4	40	45	PF00397	0.462
DOC_WW_Pin1_4	410	415	PF00397	0.668
DOC_WW_Pin1_4	460	465	PF00397	0.451
DOC_WW_Pin1_4	479	484	PF00397	0.388
DOC_WW_Pin1_4	545	550	PF00397	0.584
DOC_WW_Pin1_4	75	80	PF00397	0.604
DOC_WW_Pin1_4	8	13	PF00397	0.404
DOC_WW_Pin1_4	82	87	PF00397	0.679
LIG_14-3-3_CanoR_1	112	118	PF00244	0.594
LIG_14-3-3_CanoR_1	131	135	PF00244	0.609
LIG_14-3-3_CanoR_1	157	166	PF00244	0.439
LIG_14-3-3_CanoR_1	362	366	PF00244	0.510
LIG_14-3-3_CanoR_1	425	435	PF00244	0.576
LIG_14-3-3_CanoR_1	499	509	PF00244	0.534
LIG_Actin_WH2_2	267	285	PF00022	0.490
LIG_Actin_WH2_2	484	501	PF00022	0.452
LIG_ActinCP_TwfCPI_2	439	448	PF01115	0.465
LIG_BIR_III_4	376	380	PF00653	0.432
LIG_Clathr_ClatBox_1	488	492	PF01394	0.356
LIG_CSL_BTD_1	148	151	PF09270	0.605
LIG_FHA_1	106	112	PF00498	0.682
LIG_FHA_1	158	164	PF00498	0.438
LIG_FHA_1	318	324	PF00498	0.535
LIG_FHA_1	335	341	PF00498	0.439
LIG_FHA_1	362	368	PF00498	0.466
LIG_FHA_1	384	390	PF00498	0.414
LIG_FHA_1	415	421	PF00498	0.643
LIG_FHA_1	52	58	PF00498	0.474
LIG_FHA_1	83	89	PF00498	0.545
LIG_FHA_1	9	15	PF00498	0.399
LIG_FHA_2	317	323	PF00498	0.513
LIG_FHA_2	353	359	PF00498	0.474
LIG_FHA_2	4	10	PF00498	0.469
LIG_LIR_Gen_1	108	118	PF02991	0.662
LIG_LIR_Nem_3	108	113	PF02991	0.663
LIG_LIR_Nem_3	510	515	PF02991	0.396
LIG_NRBOX	287	293	PF00104	0.442
LIG_NRBOX	52	58	PF00104	0.510
LIG_SH2_CRK	343	347	PF00017	0.499
LIG_SH2_STAP1	334	338	PF00017	0.327
LIG_SH2_STAT3	165	168	PF00017	0.556
LIG_SH2_STAT5	165	168	PF00017	0.457
LIG_SH3_3	145	151	PF00018	0.563
LIG_SH3_3	378	384	PF00018	0.454
LIG_SH3_3	446	452	PF00018	0.635
LIG_SH3_3	490	496	PF00018	0.453
LIG_SH3_3	546	552	PF00018	0.711
LIG_SH3_3	70	76	PF00018	0.478
LIG_SUMO_SIM_par_1	507	513	PF11976	0.322
LIG_TRAF2_1	87	90	PF00917	0.551
LIG_TYR_ITIM	488	493	PF00017	0.349
LIG_UBA3_1	536	541	PF00899	0.289
MOD_CDK_SPxxK_3	124	131	PF00069	0.555
MOD_CDK_SPxxK_3	414	421	PF00069	0.507
MOD_CK1_1	198	204	PF00069	0.513
MOD_CK1_1	233	239	PF00069	0.585
MOD_CK1_1	27	33	PF00069	0.735
MOD_CK1_1	316	322	PF00069	0.744
MOD_CK1_1	328	334	PF00069	0.422
MOD_CK1_1	404	410	PF00069	0.659
MOD_CK1_1	426	432	PF00069	0.362
MOD_CK1_1	463	469	PF00069	0.455
MOD_CK1_1	78	84	PF00069	0.524
MOD_CK2_1	302	308	PF00069	0.490
MOD_CK2_1	352	358	PF00069	0.475
MOD_CK2_1	84	90	PF00069	0.550
MOD_CMANNOS	540	543	PF00535	0.306
MOD_DYRK1A_RPxSP_1	545	549	PF00069	0.425
MOD_GlcNHglycan	100	103	PF01048	0.768
MOD_GlcNHglycan	132	135	PF01048	0.705
MOD_GlcNHglycan	153	156	PF01048	0.612
MOD_GlcNHglycan	189	192	PF01048	0.613
MOD_GlcNHglycan	29	32	PF01048	0.583
MOD_GlcNHglycan	304	307	PF01048	0.621
MOD_GlcNHglycan	315	318	PF01048	0.744
MOD_GlcNHglycan	465	468	PF01048	0.372
MOD_GlcNHglycan	502	505	PF01048	0.567
MOD_GlcNHglycan	516	519	PF01048	0.318
MOD_GlcNHglycan	545	548	PF01048	0.555
MOD_GlcNHglycan	82	85	PF01048	0.666
MOD_GSK3_1	120	127	PF00069	0.613
MOD_GSK3_1	19	26	PF00069	0.513
MOD_GSK3_1	194	201	PF00069	0.693
MOD_GSK3_1	235	242	PF00069	0.717
MOD_GSK3_1	3	10	PF00069	0.478
MOD_GSK3_1	313	320	PF00069	0.750
MOD_GSK3_1	321	328	PF00069	0.627
MOD_GSK3_1	397	404	PF00069	0.449
MOD_GSK3_1	406	413	PF00069	0.587
MOD_GSK3_1	419	426	PF00069	0.509
MOD_GSK3_1	456	463	PF00069	0.495
MOD_GSK3_1	477	484	PF00069	0.385
MOD_GSK3_1	78	85	PF00069	0.635
MOD_N-GLC_1	106	111	PF02516	0.521
MOD_N-GLC_1	138	143	PF02516	0.681
MOD_N-GLC_2	529	531	PF02516	0.456
MOD_NEK2_1	113	118	PF00069	0.617
MOD_NEK2_1	423	428	PF00069	0.343
MOD_NEK2_1	477	482	PF00069	0.397
MOD_NEK2_1	52	57	PF00069	0.407
MOD_NEK2_1	69	74	PF00069	0.608
MOD_NEK2_1	7	12	PF00069	0.538
MOD_PIKK_1	157	163	PF00454	0.442
MOD_PIKK_1	321	327	PF00454	0.712
MOD_PIKK_1	328	334	PF00454	0.395
MOD_PIKK_1	383	389	PF00454	0.483
MOD_PK_1	481	487	PF00069	0.359
MOD_PKA_2	130	136	PF00069	0.571
MOD_PKA_2	156	162	PF00069	0.457
MOD_PKA_2	361	367	PF00069	0.512
MOD_Plk_1	106	112	PF00069	0.514
MOD_Plk_1	321	327	PF00069	0.606
MOD_Plk_1	334	340	PF00069	0.381
MOD_Plk_4	106	112	PF00069	0.695
MOD_Plk_4	113	119	PF00069	0.507
MOD_Plk_4	258	264	PF00069	0.387
MOD_Plk_4	481	487	PF00069	0.359
MOD_Plk_4	507	513	PF00069	0.322
MOD_Plk_4	52	58	PF00069	0.450
MOD_Plk_4	535	541	PF00069	0.414
MOD_ProDKin_1	124	130	PF00069	0.634
MOD_ProDKin_1	138	144	PF00069	0.601
MOD_ProDKin_1	208	214	PF00069	0.413
MOD_ProDKin_1	24	30	PF00069	0.546
MOD_ProDKin_1	362	368	PF00069	0.433
MOD_ProDKin_1	40	46	PF00069	0.453
MOD_ProDKin_1	410	416	PF00069	0.655
MOD_ProDKin_1	460	466	PF00069	0.446
MOD_ProDKin_1	479	485	PF00069	0.387
MOD_ProDKin_1	545	551	PF00069	0.588
MOD_ProDKin_1	75	81	PF00069	0.607
MOD_ProDKin_1	8	14	PF00069	0.399
MOD_ProDKin_1	82	88	PF00069	0.679
MOD_SUMO_rev_2	87	93	PF00179	0.552
TRG_DiLeu_BaEn_2	429	435	PF01217	0.334
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.424
TRG_ENDOCYTIC_2	343	346	PF00928	0.496
TRG_ENDOCYTIC_2	490	493	PF00928	0.363
TRG_ER_diArg_1	431	433	PF00400	0.494
TRG_NLS_MonoExtN_4	61	68	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI5	Leptomonas seymouri	31%	94%
A0A3S7WSG2	Leishmania donovani	69%	100%
A4HVK5	Leishmania infantum	69%	100%
E9APA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QG77	Leishmania major	68%	99%