Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H764_LEIBR

TriTrypDb:

LbrM.13.0570 , LBRM2903_130011400

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H764

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H764

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.474
CLV_NRD_NRD_1	187	189	PF00675	0.337
CLV_PCSK_KEX2_1	102	104	PF00082	0.495
CLV_PCSK_KEX2_1	167	169	PF00082	0.438
CLV_PCSK_KEX2_1	187	189	PF00082	0.195
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.468
CLV_PCSK_SKI1_1	111	115	PF00082	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.572
DEG_SPOP_SBC_1	14	18	PF00917	0.631
DOC_CYCLIN_yCln2_LP_2	2	8	PF00134	0.499
DOC_MAPK_gen_1	167	175	PF00069	0.493
DOC_MAPK_gen_1	187	195	PF00069	0.221
DOC_MAPK_gen_1	241	248	PF00069	0.392
DOC_MAPK_MEF2A_6	167	175	PF00069	0.493
DOC_PP1_RVXF_1	217	224	PF00149	0.388
DOC_USP7_MATH_1	130	134	PF00917	0.534
DOC_USP7_MATH_1	14	18	PF00917	0.499
DOC_USP7_MATH_1	144	148	PF00917	0.501
DOC_USP7_MATH_1	237	241	PF00917	0.385
DOC_USP7_MATH_1	47	51	PF00917	0.712
DOC_USP7_MATH_1	65	69	PF00917	0.802
DOC_WW_Pin1_4	1	6	PF00397	0.509
LIG_14-3-3_CanoR_1	181	189	PF00244	0.346
LIG_BIR_III_4	63	67	PF00653	0.576
LIG_FHA_2	210	216	PF00498	0.442
LIG_GBD_Chelix_1	238	246	PF00786	0.292
LIG_HCF-1_HBM_1	89	92	PF13415	0.513
LIG_LIR_Gen_1	25	34	PF02991	0.558
LIG_LIR_Nem_3	112	117	PF02991	0.632
LIG_LIR_Nem_3	164	169	PF02991	0.423
LIG_LIR_Nem_3	194	198	PF02991	0.428
LIG_LIR_Nem_3	25	29	PF02991	0.561
LIG_Pex14_1	109	113	PF04695	0.460
LIG_Pex14_2	195	199	PF04695	0.366
LIG_REV1ctd_RIR_1	111	120	PF16727	0.495
LIG_SH2_SRC	119	122	PF00017	0.508
LIG_SH2_STAP1	191	195	PF00017	0.411
LIG_SH2_STAP1	244	248	PF00017	0.405
LIG_SH2_STAT5	177	180	PF00017	0.363
LIG_SH3_3	150	156	PF00018	0.520
LIG_TRAF2_1	133	136	PF00917	0.509
MOD_CDC14_SPxK_1	4	7	PF00782	0.489
MOD_CDK_SPxK_1	1	7	PF00069	0.500
MOD_CK1_1	10	16	PF00069	0.663
MOD_CK1_1	68	74	PF00069	0.610
MOD_CK1_1	75	81	PF00069	0.631
MOD_CK2_1	130	136	PF00069	0.508
MOD_CK2_1	180	186	PF00069	0.389
MOD_CK2_1	35	41	PF00069	0.634
MOD_GlcNHglycan	10	13	PF01048	0.633
MOD_GlcNHglycan	17	20	PF01048	0.684
MOD_GlcNHglycan	183	186	PF01048	0.382
MOD_GlcNHglycan	44	47	PF01048	0.684
MOD_GlcNHglycan	95	98	PF01048	0.706
MOD_GSK3_1	209	216	PF00069	0.449
MOD_GSK3_1	68	75	PF00069	0.674
MOD_GSK3_1	8	15	PF00069	0.548
MOD_NEK2_1	139	144	PF00069	0.536
MOD_NEK2_2	109	114	PF00069	0.572
MOD_PIKK_1	79	85	PF00454	0.648
MOD_PKA_2	139	145	PF00069	0.593
MOD_PKA_2	169	175	PF00069	0.453
MOD_PKA_2	180	186	PF00069	0.343
MOD_PKA_2	22	28	PF00069	0.722
MOD_PKA_2	47	53	PF00069	0.663
MOD_PKA_2	72	78	PF00069	0.639
MOD_Plk_1	109	115	PF00069	0.559
MOD_Plk_1	88	94	PF00069	0.622
MOD_Plk_4	109	115	PF00069	0.577
MOD_Plk_4	194	200	PF00069	0.352
MOD_Plk_4	213	219	PF00069	0.513
MOD_Plk_4	35	41	PF00069	0.683
MOD_ProDKin_1	1	7	PF00069	0.509
MOD_SUMO_for_1	131	134	PF00179	0.488
MOD_SUMO_rev_2	159	169	PF00179	0.511
TRG_DiLeu_BaEn_1	213	218	PF01217	0.381
TRG_DiLeu_BaEn_4	136	142	PF01217	0.519
TRG_DiLeu_BaEn_4	233	239	PF01217	0.407
TRG_ENDOCYTIC_2	26	29	PF00928	0.566
TRG_ER_diArg_1	168	171	PF00400	0.439
TRG_ER_diArg_1	187	190	PF00400	0.225
TRG_NES_CRM1_1	236	249	PF08389	0.419
TRG_NLS_MonoExtC_3	166	171	PF00514	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D0	Leptomonas seymouri	61%	99%
A0A0S4JSG2	Bodo saltans	25%	89%
A0A1X0NNP5	Trypanosomatidae	47%	100%
A0A3S7WSJ5	Leishmania donovani	83%	100%
A4HVK3	Leishmania infantum	84%	100%
D0A6Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AP99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QG79	Leishmania major	82%	100%