Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H763_LEIBR

TriTrypDb:

LbrM.13.0560 , LBRM2903_130011300

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H763

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H763

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006820	monoatomic anion transport	5	1
GO:0006821	chloride transport	7	1
GO:0009987	cellular process	1	1
GO:0015698	inorganic anion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1
GO:1902476	chloride transmembrane transport	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005216	monoatomic ion channel activity	4	1
GO:0005253	monoatomic anion channel activity	5	1
GO:0005254	chloride channel activity	6	1
GO:0008509	monoatomic anion transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015103	inorganic anion transmembrane transporter activity	4	1
GO:0015108	chloride transmembrane transporter activity	5	1
GO:0015267	channel activity	4	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022803	passive transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.568
CLV_NRD_NRD_1	128	130	PF00675	0.410
CLV_NRD_NRD_1	140	142	PF00675	0.431
CLV_NRD_NRD_1	234	236	PF00675	0.468
CLV_NRD_NRD_1	445	447	PF00675	0.492
CLV_NRD_NRD_1	477	479	PF00675	0.275
CLV_NRD_NRD_1	568	570	PF00675	0.509
CLV_NRD_NRD_1	686	688	PF00675	0.509
CLV_NRD_NRD_1	788	790	PF00675	0.255
CLV_PCSK_FUR_1	138	142	PF00082	0.383
CLV_PCSK_KEX2_1	128	130	PF00082	0.376
CLV_PCSK_KEX2_1	140	142	PF00082	0.431
CLV_PCSK_KEX2_1	234	236	PF00082	0.510
CLV_PCSK_KEX2_1	445	447	PF00082	0.492
CLV_PCSK_KEX2_1	477	479	PF00082	0.275
CLV_PCSK_KEX2_1	568	570	PF00082	0.509
CLV_PCSK_KEX2_1	630	632	PF00082	0.248
CLV_PCSK_KEX2_1	685	687	PF00082	0.509
CLV_PCSK_KEX2_1	788	790	PF00082	0.255
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.248
CLV_PCSK_SKI1_1	141	145	PF00082	0.340
CLV_PCSK_SKI1_1	347	351	PF00082	0.294
CLV_PCSK_SKI1_1	358	362	PF00082	0.343
CLV_PCSK_SKI1_1	391	395	PF00082	0.368
CLV_PCSK_SKI1_1	52	56	PF00082	0.394
CLV_PCSK_SKI1_1	625	629	PF00082	0.275
CLV_PCSK_SKI1_1	631	635	PF00082	0.262
CLV_PCSK_SKI1_1	642	646	PF00082	0.249
CLV_PCSK_SKI1_1	835	839	PF00082	0.406
CLV_Separin_Metazoa	49	53	PF03568	0.706
DEG_APCC_DBOX_1	251	259	PF00400	0.491
DEG_APCC_DBOX_1	776	784	PF00400	0.455
DEG_SPOP_SBC_1	30	34	PF00917	0.600
DEG_SPOP_SBC_1	437	441	PF00917	0.287
DOC_ANK_TNKS_1	568	575	PF00023	0.309
DOC_CKS1_1	108	113	PF01111	0.567
DOC_CKS1_1	709	714	PF01111	0.249
DOC_CKS1_1	910	915	PF01111	0.455
DOC_CYCLIN_RxL_1	137	145	PF00134	0.507
DOC_CYCLIN_RxL_1	388	396	PF00134	0.211
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.590
DOC_MAPK_DCC_7	252	260	PF00069	0.498
DOC_MAPK_DCC_7	788	796	PF00069	0.509
DOC_MAPK_gen_1	249	258	PF00069	0.487
DOC_MAPK_gen_1	309	318	PF00069	0.452
DOC_MAPK_gen_1	358	366	PF00069	0.466
DOC_MAPK_gen_1	788	796	PF00069	0.455
DOC_MAPK_gen_1	920	930	PF00069	0.566
DOC_MAPK_HePTP_8	6	18	PF00069	0.596
DOC_MAPK_MEF2A_6	252	260	PF00069	0.563
DOC_MAPK_MEF2A_6	262	269	PF00069	0.547
DOC_MAPK_MEF2A_6	311	320	PF00069	0.457
DOC_MAPK_MEF2A_6	788	796	PF00069	0.455
DOC_MAPK_MEF2A_6	9	18	PF00069	0.601
DOC_MAPK_NFAT4_5	9	17	PF00069	0.595
DOC_PP1_RVXF_1	628	635	PF00149	0.423
DOC_PP1_RVXF_1	640	646	PF00149	0.358
DOC_PP1_RVXF_1	883	890	PF00149	0.231
DOC_PP2B_LxvP_1	12	15	PF13499	0.592
DOC_PP2B_LxvP_1	562	565	PF13499	0.255
DOC_PP4_FxxP_1	245	248	PF00568	0.547
DOC_SPAK_OSR1_1	244	248	PF12202	0.553
DOC_USP7_MATH_1	155	159	PF00917	0.677
DOC_USP7_MATH_1	227	231	PF00917	0.720
DOC_USP7_MATH_1	30	34	PF00917	0.695
DOC_USP7_MATH_1	370	374	PF00917	0.509
DOC_USP7_MATH_1	436	440	PF00917	0.305
DOC_USP7_MATH_1	563	567	PF00917	0.197
DOC_USP7_MATH_1	667	671	PF00917	0.232
DOC_USP7_MATH_1	762	766	PF00917	0.292
DOC_USP7_MATH_1	822	826	PF00917	0.292
DOC_USP7_MATH_1	888	892	PF00917	0.211
DOC_USP7_UBL2_3	605	609	PF12436	0.397
DOC_WW_Pin1_4	107	112	PF00397	0.638
DOC_WW_Pin1_4	161	166	PF00397	0.603
DOC_WW_Pin1_4	323	328	PF00397	0.639
DOC_WW_Pin1_4	500	505	PF00397	0.475
DOC_WW_Pin1_4	708	713	PF00397	0.317
DOC_WW_Pin1_4	723	728	PF00397	0.224
DOC_WW_Pin1_4	825	830	PF00397	0.197
DOC_WW_Pin1_4	909	914	PF00397	0.455
LIG_14-3-3_CanoR_1	244	248	PF00244	0.665
LIG_14-3-3_CanoR_1	410	417	PF00244	0.197
LIG_14-3-3_CanoR_1	445	449	PF00244	0.309
LIG_14-3-3_CanoR_1	477	482	PF00244	0.475
LIG_14-3-3_CanoR_1	625	630	PF00244	0.492
LIG_14-3-3_CanoR_1	650	660	PF00244	0.236
LIG_14-3-3_CanoR_1	671	680	PF00244	0.271
LIG_14-3-3_CanoR_1	703	713	PF00244	0.205
LIG_14-3-3_CanoR_1	847	854	PF00244	0.212
LIG_14-3-3_CanoR_1	88	98	PF00244	0.635
LIG_14-3-3_CanoR_1	927	931	PF00244	0.628
LIG_Actin_WH2_2	113	130	PF00022	0.606
LIG_Actin_WH2_2	394	412	PF00022	0.368
LIG_BRCT_BRCA1_1	600	604	PF00533	0.292
LIG_BRCT_BRCA1_1	777	781	PF00533	0.455
LIG_CSL_BTD_1	831	834	PF09270	0.189
LIG_deltaCOP1_diTrp_1	300	304	PF00928	0.477
LIG_deltaCOP1_diTrp_1	348	355	PF00928	0.508
LIG_FHA_1	11	17	PF00498	0.591
LIG_FHA_1	30	36	PF00498	0.605
LIG_FHA_1	324	330	PF00498	0.608
LIG_FHA_1	333	339	PF00498	0.525
LIG_FHA_1	394	400	PF00498	0.211
LIG_FHA_1	428	434	PF00498	0.204
LIG_FHA_1	528	534	PF00498	0.374
LIG_FHA_1	693	699	PF00498	0.225
LIG_FHA_1	816	822	PF00498	0.291
LIG_FHA_1	858	864	PF00498	0.197
LIG_FHA_1	919	925	PF00498	0.574
LIG_FHA_2	174	180	PF00498	0.560
LIG_FHA_2	363	369	PF00498	0.557
LIG_FHA_2	910	916	PF00498	0.509
LIG_GBD_Chelix_1	466	474	PF00786	0.211
LIG_GBD_Chelix_1	98	106	PF00786	0.404
LIG_IRF3_LxIS_1	360	367	PF10401	0.570
LIG_LIR_Apic_2	828	834	PF02991	0.189
LIG_LIR_Gen_1	348	357	PF02991	0.513
LIG_LIR_Gen_1	519	529	PF02991	0.404
LIG_LIR_Gen_1	739	749	PF02991	0.247
LIG_LIR_Gen_1	74	83	PF02991	0.621
LIG_LIR_Gen_1	765	774	PF02991	0.292
LIG_LIR_Gen_1	92	102	PF02991	0.609
LIG_LIR_Nem_3	348	354	PF02991	0.504
LIG_LIR_Nem_3	528	534	PF02991	0.368
LIG_LIR_Nem_3	601	607	PF02991	0.331
LIG_LIR_Nem_3	635	640	PF02991	0.296
LIG_LIR_Nem_3	707	713	PF02991	0.197
LIG_LIR_Nem_3	739	744	PF02991	0.220
LIG_LIR_Nem_3	74	78	PF02991	0.628
LIG_LIR_Nem_3	765	769	PF02991	0.292
LIG_LIR_Nem_3	800	805	PF02991	0.504
LIG_LIR_Nem_3	92	98	PF02991	0.613
LIG_LRP6_Inhibitor_1	769	775	PF00058	0.211
LIG_LYPXL_yS_3	761	764	PF13949	0.211
LIG_NRBOX	316	322	PF00104	0.528
LIG_PCNA_yPIPBox_3	309	317	PF02747	0.563
LIG_Pex14_1	385	389	PF04695	0.455
LIG_Pex14_2	297	301	PF04695	0.526
LIG_Pex14_2	381	385	PF04695	0.455
LIG_Pex14_2	753	757	PF04695	0.211
LIG_REV1ctd_RIR_1	275	283	PF16727	0.489
LIG_RPA_C_Fungi	666	678	PF08784	0.258
LIG_RPA_C_Fungi	680	692	PF08784	0.334
LIG_SH2_CRK	640	644	PF00017	0.292
LIG_SH2_CRK	95	99	PF00017	0.441
LIG_SH2_PTP2	75	78	PF00017	0.536
LIG_SH2_SRC	184	187	PF00017	0.430
LIG_SH2_STAP1	389	393	PF00017	0.292
LIG_SH2_STAP1	593	597	PF00017	0.282
LIG_SH2_STAP1	95	99	PF00017	0.510
LIG_SH2_STAT5	171	174	PF00017	0.528
LIG_SH2_STAT5	184	187	PF00017	0.490
LIG_SH2_STAT5	374	377	PF00017	0.331
LIG_SH2_STAT5	450	453	PF00017	0.211
LIG_SH2_STAT5	623	626	PF00017	0.242
LIG_SH2_STAT5	665	668	PF00017	0.292
LIG_SH2_STAT5	75	78	PF00017	0.536
LIG_SH2_STAT5	785	788	PF00017	0.292
LIG_SH3_3	105	111	PF00018	0.666
LIG_SH3_3	149	155	PF00018	0.570
LIG_SH3_3	162	168	PF00018	0.433
LIG_SH3_3	194	200	PF00018	0.527
LIG_SH3_3	292	298	PF00018	0.388
LIG_SH3_3	324	330	PF00018	0.478
LIG_SH3_3	430	436	PF00018	0.266
LIG_SH3_3	552	558	PF00018	0.292
LIG_SH3_3	710	716	PF00018	0.336
LIG_SH3_3	867	873	PF00018	0.230
LIG_SH3_3	907	913	PF00018	0.292
LIG_SUMO_SIM_anti_2	453	458	PF11976	0.368
LIG_SUMO_SIM_anti_2	743	749	PF11976	0.235
LIG_SUMO_SIM_anti_2	765	771	PF11976	0.292
LIG_SUMO_SIM_par_1	329	335	PF11976	0.377
LIG_SUMO_SIM_par_1	678	683	PF11976	0.211
LIG_SUMO_SIM_par_1	818	825	PF11976	0.344
LIG_TRAF2_1	176	179	PF00917	0.523
LIG_TRAF2_1	43	46	PF00917	0.618
LIG_UBA3_1	769	775	PF00899	0.211
LIG_WRC_WIRS_1	222	227	PF05994	0.585
LIG_WRC_WIRS_1	763	768	PF05994	0.292
LIG_WRC_WIRS_1	816	821	PF05994	0.211
LIG_WW_3	49	53	PF00397	0.510
MOD_CDK_SPK_2	107	112	PF00069	0.446
MOD_CDK_SPK_2	909	914	PF00069	0.292
MOD_CK1_1	177	183	PF00069	0.477
MOD_CK1_1	209	215	PF00069	0.762
MOD_CK1_1	33	39	PF00069	0.520
MOD_CK1_1	353	359	PF00069	0.474
MOD_CK1_1	404	410	PF00069	0.293
MOD_CK1_1	427	433	PF00069	0.272
MOD_CK1_1	440	446	PF00069	0.343
MOD_CK1_1	500	506	PF00069	0.241
MOD_CK1_1	702	708	PF00069	0.361
MOD_CK1_1	723	729	PF00069	0.368
MOD_CK1_1	825	831	PF00069	0.360
MOD_CK1_1	845	851	PF00069	0.170
MOD_CK1_1	857	863	PF00069	0.354
MOD_CK2_1	173	179	PF00069	0.518
MOD_CK2_1	362	368	PF00069	0.437
MOD_CK2_1	649	655	PF00069	0.238
MOD_CK2_1	909	915	PF00069	0.368
MOD_CMANNOS	301	304	PF00535	0.316
MOD_GlcNHglycan	161	164	PF01048	0.700
MOD_GlcNHglycan	214	218	PF01048	0.586
MOD_GlcNHglycan	35	38	PF01048	0.588
MOD_GlcNHglycan	355	358	PF01048	0.399
MOD_GlcNHglycan	426	429	PF01048	0.315
MOD_GlcNHglycan	717	720	PF01048	0.361
MOD_GlcNHglycan	856	859	PF01048	0.305
MOD_GSK3_1	155	162	PF00069	0.578
MOD_GSK3_1	173	180	PF00069	0.477
MOD_GSK3_1	205	212	PF00069	0.614
MOD_GSK3_1	261	268	PF00069	0.441
MOD_GSK3_1	29	36	PF00069	0.505
MOD_GSK3_1	349	356	PF00069	0.359
MOD_GSK3_1	401	408	PF00069	0.302
MOD_GSK3_1	424	431	PF00069	0.335
MOD_GSK3_1	436	443	PF00069	0.298
MOD_GSK3_1	553	560	PF00069	0.368
MOD_GSK3_1	587	594	PF00069	0.267
MOD_GSK3_1	651	658	PF00069	0.257
MOD_GSK3_1	667	674	PF00069	0.370
MOD_GSK3_1	694	701	PF00069	0.368
MOD_GSK3_1	704	711	PF00069	0.388
MOD_GSK3_1	775	782	PF00069	0.211
MOD_GSK3_1	835	842	PF00069	0.258
MOD_N-GLC_1	798	803	PF02516	0.292
MOD_N-GLC_1	825	830	PF02516	0.211
MOD_N-GLC_1	866	871	PF02516	0.209
MOD_NEK2_1	159	164	PF00069	0.625
MOD_NEK2_1	23	28	PF00069	0.520
MOD_NEK2_1	265	270	PF00069	0.388
MOD_NEK2_1	350	355	PF00069	0.362
MOD_NEK2_1	393	398	PF00069	0.290
MOD_NEK2_1	405	410	PF00069	0.350
MOD_NEK2_1	444	449	PF00069	0.329
MOD_NEK2_1	538	543	PF00069	0.329
MOD_NEK2_1	545	550	PF00069	0.259
MOD_NEK2_1	577	582	PF00069	0.292
MOD_NEK2_1	591	596	PF00069	0.292
MOD_NEK2_1	600	605	PF00069	0.282
MOD_NEK2_1	636	641	PF00069	0.292
MOD_NEK2_1	673	678	PF00069	0.329
MOD_NEK2_1	680	685	PF00069	0.259
MOD_NEK2_1	692	697	PF00069	0.187
MOD_NEK2_1	854	859	PF00069	0.365
MOD_NEK2_1	866	871	PF00069	0.172
MOD_PIKK_1	510	516	PF00454	0.240
MOD_PIKK_1	655	661	PF00454	0.331
MOD_PIKK_1	705	711	PF00454	0.211
MOD_PIKK_1	842	848	PF00454	0.211
MOD_PK_1	31	37	PF00069	0.512
MOD_PK_1	477	483	PF00069	0.235
MOD_PK_1	694	700	PF00069	0.211
MOD_PKA_1	477	483	PF00069	0.292
MOD_PKA_2	243	249	PF00069	0.587
MOD_PKA_2	444	450	PF00069	0.368
MOD_PKA_2	477	483	PF00069	0.321
MOD_PKA_2	649	655	PF00069	0.205
MOD_PKA_2	702	708	PF00069	0.239
MOD_PKA_2	846	852	PF00069	0.271
MOD_PKA_2	854	860	PF00069	0.228
MOD_Plk_1	177	183	PF00069	0.439
MOD_Plk_1	18	24	PF00069	0.509
MOD_Plk_1	577	583	PF00069	0.205
MOD_Plk_1	798	804	PF00069	0.292
MOD_Plk_1	866	872	PF00069	0.211
MOD_Plk_2-3	174	180	PF00069	0.439
MOD_Plk_2-3	890	896	PF00069	0.211
MOD_Plk_4	18	24	PF00069	0.496
MOD_Plk_4	206	212	PF00069	0.613
MOD_Plk_4	350	356	PF00069	0.371
MOD_Plk_4	370	376	PF00069	0.163
MOD_Plk_4	401	407	PF00069	0.302
MOD_Plk_4	428	434	PF00069	0.269
MOD_Plk_4	465	471	PF00069	0.308
MOD_Plk_4	477	483	PF00069	0.257
MOD_Plk_4	587	593	PF00069	0.313
MOD_Plk_4	673	679	PF00069	0.394
MOD_Plk_4	71	77	PF00069	0.542
MOD_Plk_4	762	768	PF00069	0.292
MOD_Plk_4	815	821	PF00069	0.285
MOD_ProDKin_1	107	113	PF00069	0.548
MOD_ProDKin_1	161	167	PF00069	0.499
MOD_ProDKin_1	323	329	PF00069	0.547
MOD_ProDKin_1	500	506	PF00069	0.320
MOD_ProDKin_1	708	714	PF00069	0.379
MOD_ProDKin_1	723	729	PF00069	0.249
MOD_ProDKin_1	825	831	PF00069	0.211
MOD_ProDKin_1	909	915	PF00069	0.292
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.355
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.322
TRG_ENDOCYTIC_2	383	386	PF00928	0.315
TRG_ENDOCYTIC_2	486	489	PF00928	0.292
TRG_ENDOCYTIC_2	521	524	PF00928	0.205
TRG_ENDOCYTIC_2	640	643	PF00928	0.292
TRG_ENDOCYTIC_2	741	744	PF00928	0.255
TRG_ENDOCYTIC_2	75	78	PF00928	0.536
TRG_ENDOCYTIC_2	761	764	PF00928	0.242
TRG_ENDOCYTIC_2	95	98	PF00928	0.388
TRG_ER_diArg_1	127	129	PF00400	0.525
TRG_ER_diArg_1	138	141	PF00400	0.533
TRG_ER_diArg_1	234	236	PF00400	0.624
TRG_ER_diArg_1	309	312	PF00400	0.356
TRG_ER_diArg_1	444	446	PF00400	0.344
TRG_ER_diArg_1	567	569	PF00400	0.368
TRG_ER_diArg_1	611	614	PF00400	0.219
TRG_ER_diArg_1	685	687	PF00400	0.292
TRG_ER_diArg_1	787	789	PF00400	0.292
TRG_ER_diArg_1	852	855	PF00400	0.211
TRG_NES_CRM1_1	134	145	PF08389	0.369
TRG_NES_CRM1_1	179	195	PF08389	0.607
TRG_NES_CRM1_1	739	750	PF08389	0.344
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	568	573	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ1	Leptomonas seymouri	50%	85%
A0A3S5H6N8	Leishmania donovani	71%	95%
A1A5B4	Homo sapiens	22%	100%
A4HVK2	Leishmania infantum	71%	95%
E9AP98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	94%
P86044	Mus musculus	20%	100%
Q4QG80	Leishmania major	70%	100%