Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H761_LEIBR

TriTrypDb:

LbrM.13.0540 , LBRM2903_130011100

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H761

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H761

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016491	oxidoreductase activity	2	13
GO:0003960	NADPH:quinone reductase activity	5	4
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	3
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	4
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	4
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.442
CLV_PCSK_KEX2_1	114	116	PF00082	0.457
CLV_PCSK_SKI1_1	115	119	PF00082	0.361
CLV_PCSK_SKI1_1	187	191	PF00082	0.368
CLV_PCSK_SKI1_1	220	224	PF00082	0.175
CLV_PCSK_SKI1_1	24	28	PF00082	0.279
CLV_PCSK_SKI1_1	41	45	PF00082	0.320
CLV_PCSK_SKI1_1	90	94	PF00082	0.348
DEG_Nend_UBRbox_3	1	3	PF02207	0.648
DOC_MAPK_DCC_7	265	275	PF00069	0.175
DOC_MAPK_gen_1	90	98	PF00069	0.175
DOC_MAPK_MEF2A_6	125	132	PF00069	0.373
DOC_MAPK_MEF2A_6	336	345	PF00069	0.349
DOC_MAPK_NFAT4_5	125	133	PF00069	0.347
DOC_PP4_FxxP_1	285	288	PF00568	0.319
DOC_USP7_MATH_1	225	229	PF00917	0.289
DOC_USP7_MATH_1	25	29	PF00917	0.532
DOC_USP7_UBL2_3	336	340	PF12436	0.380
DOC_WW_Pin1_4	181	186	PF00397	0.410
LIG_14-3-3_CanoR_1	24	33	PF00244	0.434
LIG_14-3-3_CanoR_1	246	251	PF00244	0.397
LIG_Actin_WH2_2	78	95	PF00022	0.400
LIG_BRCT_BRCA1_1	19	23	PF00533	0.404
LIG_BRCT_BRCA1_1	282	286	PF00533	0.377
LIG_CtBP_PxDLS_1	129	133	PF00389	0.289
LIG_deltaCOP1_diTrp_1	330	333	PF00928	0.447
LIG_FHA_1	134	140	PF00498	0.360
LIG_FHA_1	190	196	PF00498	0.401
LIG_FHA_1	25	31	PF00498	0.416
LIG_FHA_1	282	288	PF00498	0.340
LIG_FHA_1	58	64	PF00498	0.400
LIG_LIR_Apic_2	283	288	PF02991	0.292
LIG_LIR_Gen_1	108	117	PF02991	0.327
LIG_LIR_Gen_1	223	234	PF02991	0.411
LIG_LIR_Gen_1	323	332	PF02991	0.414
LIG_LIR_Nem_3	10	14	PF02991	0.464
LIG_LIR_Nem_3	100	106	PF02991	0.311
LIG_LIR_Nem_3	108	112	PF02991	0.315
LIG_LIR_Nem_3	126	130	PF02991	0.463
LIG_LIR_Nem_3	20	26	PF02991	0.425
LIG_LIR_Nem_3	223	229	PF02991	0.411
LIG_LIR_Nem_3	317	322	PF02991	0.405
LIG_LIR_Nem_3	323	329	PF02991	0.382
LIG_LYPXL_SIV_4	225	233	PF13949	0.400
LIG_MLH1_MIPbox_1	282	286	PF16413	0.400
LIG_PDZ_Class_2	340	345	PF00595	0.324
LIG_Pex14_2	286	290	PF04695	0.362
LIG_Pex14_2	72	76	PF04695	0.319
LIG_SH2_CRK	109	113	PF00017	0.315
LIG_SH2_GRB2like	256	259	PF00017	0.278
LIG_SH2_NCK_1	226	230	PF00017	0.319
LIG_SH2_NCK_1	326	330	PF00017	0.442
LIG_SH2_SRC	256	259	PF00017	0.278
LIG_SH2_STAT3	293	296	PF00017	0.232
LIG_SH2_STAT5	127	130	PF00017	0.410
LIG_SH2_STAT5	49	52	PF00017	0.397
LIG_SH3_3	141	147	PF00018	0.378
LIG_SH3_3	27	33	PF00018	0.464
LIG_SH3_3	65	71	PF00018	0.318
LIG_SUMO_SIM_par_1	128	133	PF11976	0.283
LIG_SUMO_SIM_par_1	81	87	PF11976	0.314
LIG_TYR_ITIM	224	229	PF00017	0.339
LIG_WRC_WIRS_1	282	287	PF05994	0.289
MOD_CDC14_SPxK_1	184	187	PF00782	0.319
MOD_CDK_SPxK_1	181	187	PF00069	0.319
MOD_CK1_1	133	139	PF00069	0.360
MOD_CK1_1	183	189	PF00069	0.391
MOD_CK1_1	281	287	PF00069	0.327
MOD_CK2_1	25	31	PF00069	0.501
MOD_GlcNHglycan	131	135	PF01048	0.375
MOD_GlcNHglycan	278	281	PF01048	0.290
MOD_GlcNHglycan	86	89	PF01048	0.382
MOD_GSK3_1	174	181	PF00069	0.360
MOD_GSK3_1	276	283	PF00069	0.325
MOD_GSK3_1	3	10	PF00069	0.443
MOD_N-GLC_1	207	212	PF02516	0.175
MOD_N-GLC_1	257	262	PF02516	0.283
MOD_N-GLC_1	52	57	PF02516	0.319
MOD_NEK2_1	130	135	PF00069	0.288
MOD_NEK2_1	191	196	PF00069	0.438
MOD_NEK2_1	276	281	PF00069	0.332
MOD_OFUCOSY	176	182	PF10250	0.392
MOD_PIKK_1	97	103	PF00454	0.345
MOD_PKA_2	264	270	PF00069	0.350
MOD_PKB_1	244	252	PF00069	0.270
MOD_Plk_4	174	180	PF00069	0.352
MOD_Plk_4	25	31	PF00069	0.494
MOD_Plk_4	281	287	PF00069	0.313
MOD_ProDKin_1	181	187	PF00069	0.410
MOD_SUMO_rev_2	87	94	PF00179	0.400
TRG_ENDOCYTIC_2	103	106	PF00928	0.366
TRG_ENDOCYTIC_2	109	112	PF00928	0.347
TRG_ENDOCYTIC_2	11	14	PF00928	0.447
TRG_ENDOCYTIC_2	127	130	PF00928	0.450
TRG_ENDOCYTIC_2	226	229	PF00928	0.319
TRG_ENDOCYTIC_2	326	329	PF00928	0.435
TRG_ENDOCYTIC_2	49	52	PF00928	0.431
TRG_ER_diArg_1	243	246	PF00400	0.270
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	41%	100%
A0A0N0P7C5	Leptomonas seymouri	75%	100%
A0A0N1I913	Leptomonas seymouri	37%	99%
A0A0N1PB21	Leptomonas seymouri	29%	100%
A0A0S4ILS9	Bodo saltans	27%	100%
A0A0S4IUY2	Bodo saltans	29%	100%
A0A0S4JMB1	Bodo saltans	51%	99%
A0A0S4KHW9	Bodo saltans	29%	100%
A0A1X0P0B2	Trypanosomatidae	52%	100%
A0A1X0P8R2	Trypanosomatidae	28%	100%
A0A3Q8IRG0	Leishmania donovani	43%	100%
A0A3R7L374	Trypanosoma rangeli	33%	100%
A0A3S7WSH2	Leishmania donovani	89%	100%
A0A422NF38	Trypanosoma rangeli	25%	100%
A0A422NKE0	Trypanosoma rangeli	56%	100%
A0A451EJQ8	Leishmania donovani	30%	100%
A4H3L9	Leishmania braziliensis	29%	100%
A4HPT6	Leishmania braziliensis	42%	100%
A4HVK0	Leishmania infantum	89%	100%
A4I4G0	Leishmania infantum	27%	99%
A4IE56	Leishmania infantum	43%	100%
A6QQF5	Bos taurus	29%	99%
A7RK30	Nematostella vectensis	27%	95%
B0BNC9	Rattus norvegicus	28%	99%
D0A480	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ACK2	Leishmania major	30%	100%
E9ADV9	Leishmania major	28%	100%
E9AG46	Leishmania infantum	30%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AP96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
K4BW79	Solanum lycopersicum	25%	89%
O23939	Fragaria vesca	25%	100%
O34812	Bacillus subtilis (strain 168)	27%	100%
O74489	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O97764	Bos taurus	25%	100%
P11415	Cavia porcellus	26%	100%
P19333	Tetronarce californica	25%	91%
P28304	Escherichia coli (strain K12)	32%	100%
P38230	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	32%	100%
P42865	Leishmania amazonensis	43%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	30%	100%
P47199	Mus musculus	25%	100%
P76113	Escherichia coli (strain K12)	27%	100%
Q08257	Homo sapiens	24%	100%
Q0MVN8	Sus scrofa	26%	100%
Q24K16	Bos taurus	42%	92%
Q28452	Lama guanicoe	27%	100%
Q39173	Arabidopsis thaliana	27%	100%
Q3MIE4	Rattus norvegicus	27%	85%
Q3UNZ8	Mus musculus	28%	99%
Q4Q0Z7	Leishmania major	44%	100%
Q4QG82	Leishmania major	90%	100%
Q53FA7	Homo sapiens	27%	100%
Q54YT4	Dictyostelium discoideum	28%	99%
Q5R4S7	Pongo abelii	24%	100%
Q62465	Mus musculus	27%	85%
Q6AYT0	Rattus norvegicus	25%	100%
Q6WAU0	Mentha piperita	31%	100%
Q84V25	Fragaria ananassa	25%	100%
Q8BGC4	Mus musculus	43%	92%
Q8JFV8	Danio rerio	27%	71%
Q8LCU7	Arabidopsis thaliana	24%	92%
Q8N4Q0	Homo sapiens	41%	92%
Q91YR9	Mus musculus	28%	100%
Q941I0	Fragaria ananassa	25%	100%
Q99536	Homo sapiens	29%	88%
Q9C0Y6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	99%
Q9SLN8	Nicotiana tabacum	28%	100%
Q9SV68	Arabidopsis thaliana	29%	100%
Q9ZUC1	Arabidopsis thaliana	24%	89%
V5BXF0	Trypanosoma cruzi	32%	100%