Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania braziliensis

UniProt:

A4H760_LEIBR

TriTrypDb:

LbrM.13.0530 , LBRM2903_130011000

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H760

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H760

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048200	Golgi transport vesicle coating	7	1
GO:0048205	COPI coating of Golgi vesicle	8	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.527
CLV_C14_Caspase3-7	404	408	PF00656	0.551
CLV_NRD_NRD_1	255	257	PF00675	0.476
CLV_NRD_NRD_1	265	267	PF00675	0.440
CLV_NRD_NRD_1	284	286	PF00675	0.425
CLV_PCSK_KEX2_1	139	141	PF00082	0.380
CLV_PCSK_KEX2_1	265	267	PF00082	0.359
CLV_PCSK_KEX2_1	284	286	PF00082	0.425
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.380
CLV_PCSK_SKI1_1	105	109	PF00082	0.284
CLV_PCSK_SKI1_1	115	119	PF00082	0.284
CLV_PCSK_SKI1_1	435	439	PF00082	0.445
DOC_CKS1_1	288	293	PF01111	0.504
DOC_MAPK_gen_1	79	87	PF00069	0.284
DOC_MAPK_MEF2A_6	79	87	PF00069	0.284
DOC_MAPK_MEF2A_6	99	108	PF00069	0.155
DOC_MAPK_RevD_3	194	210	PF00069	0.566
DOC_PP1_RVXF_1	49	55	PF00149	0.284
DOC_PP2B_LxvP_1	28	31	PF13499	0.498
DOC_PP4_FxxP_1	54	57	PF00568	0.284
DOC_USP7_MATH_1	12	16	PF00917	0.678
DOC_USP7_MATH_1	176	180	PF00917	0.613
DOC_USP7_MATH_1	21	25	PF00917	0.452
DOC_USP7_MATH_1	327	331	PF00917	0.766
DOC_USP7_MATH_1	348	352	PF00917	0.540
DOC_USP7_MATH_1	363	367	PF00917	0.555
DOC_USP7_MATH_1	392	396	PF00917	0.698
DOC_USP7_MATH_1	415	419	PF00917	0.572
DOC_USP7_MATH_1	7	11	PF00917	0.507
DOC_USP7_UBL2_3	115	119	PF12436	0.284
DOC_USP7_UBL2_3	220	224	PF12436	0.644
DOC_WW_Pin1_4	129	134	PF00397	0.397
DOC_WW_Pin1_4	156	161	PF00397	0.588
DOC_WW_Pin1_4	163	168	PF00397	0.560
DOC_WW_Pin1_4	172	177	PF00397	0.620
DOC_WW_Pin1_4	178	183	PF00397	0.641
DOC_WW_Pin1_4	186	191	PF00397	0.474
DOC_WW_Pin1_4	287	292	PF00397	0.517
DOC_WW_Pin1_4	3	8	PF00397	0.557
DOC_WW_Pin1_4	321	326	PF00397	0.663
LIG_14-3-3_CanoR_1	20	30	PF00244	0.428
LIG_14-3-3_CanoR_1	284	288	PF00244	0.483
LIG_FHA_1	206	212	PF00498	0.569
LIG_FHA_1	23	29	PF00498	0.588
LIG_FHA_1	238	244	PF00498	0.544
LIG_FHA_1	288	294	PF00498	0.625
LIG_FHA_1	298	304	PF00498	0.592
LIG_FHA_1	425	431	PF00498	0.564
LIG_FHA_2	183	189	PF00498	0.533
LIG_FHA_2	233	239	PF00498	0.518
LIG_FHA_2	31	37	PF00498	0.405
LIG_FHA_2	402	408	PF00498	0.565
LIG_HP1_1	195	199	PF01393	0.483
LIG_LIR_Apic_2	128	133	PF02991	0.390
LIG_LIR_Gen_1	62	71	PF02991	0.284
LIG_LIR_Nem_3	371	375	PF02991	0.575
LIG_LIR_Nem_3	62	66	PF02991	0.320
LIG_LIR_Nem_3	67	71	PF02991	0.319
LIG_PDZ_Class_3	436	441	PF00595	0.456
LIG_SH2_CRK	130	134	PF00017	0.386
LIG_SH2_NCK_1	130	134	PF00017	0.386
LIG_SH2_STAP1	249	253	PF00017	0.499
LIG_SH2_STAT5	380	383	PF00017	0.572
LIG_SH3_1	285	291	PF00018	0.651
LIG_SH3_3	1	7	PF00018	0.501
LIG_SH3_3	154	160	PF00018	0.463
LIG_SH3_3	161	167	PF00018	0.504
LIG_SH3_3	285	291	PF00018	0.651
LIG_SH3_3	319	325	PF00018	0.607
LIG_TRAF2_1	235	238	PF00917	0.518
LIG_TRAF2_1	33	36	PF00917	0.415
MOD_CDK_SPK_2	287	292	PF00069	0.504
MOD_CK1_1	15	21	PF00069	0.474
MOD_CK1_1	175	181	PF00069	0.603
MOD_CK1_1	201	207	PF00069	0.565
MOD_CK1_1	62	68	PF00069	0.284
MOD_CK2_1	232	238	PF00069	0.522
MOD_CK2_1	30	36	PF00069	0.416
MOD_Cter_Amidation	220	223	PF01082	0.643
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.495
MOD_GlcNHglycan	178	181	PF01048	0.676
MOD_GlcNHglycan	305	308	PF01048	0.665
MOD_GlcNHglycan	338	341	PF01048	0.560
MOD_GlcNHglycan	351	354	PF01048	0.674
MOD_GlcNHglycan	386	389	PF01048	0.628
MOD_GlcNHglycan	395	398	PF01048	0.644
MOD_GlcNHglycan	421	424	PF01048	0.476
MOD_GlcNHglycan	91	94	PF01048	0.287
MOD_GSK3_1	125	132	PF00069	0.293
MOD_GSK3_1	170	177	PF00069	0.596
MOD_GSK3_1	178	185	PF00069	0.596
MOD_GSK3_1	197	204	PF00069	0.581
MOD_GSK3_1	232	239	PF00069	0.565
MOD_GSK3_1	283	290	PF00069	0.523
MOD_GSK3_1	3	10	PF00069	0.559
MOD_GSK3_1	316	323	PF00069	0.561
MOD_GSK3_1	334	341	PF00069	0.540
MOD_GSK3_1	349	356	PF00069	0.686
MOD_GSK3_1	399	406	PF00069	0.477
MOD_GSK3_1	415	422	PF00069	0.527
MOD_GSK3_1	85	92	PF00069	0.309
MOD_N-GLC_1	147	152	PF02516	0.347
MOD_N-GLC_1	393	398	PF02516	0.514
MOD_NEK2_1	198	203	PF00069	0.538
MOD_NEK2_1	22	27	PF00069	0.603
MOD_NEK2_1	315	320	PF00069	0.584
MOD_NEK2_1	399	404	PF00069	0.448
MOD_NEK2_1	419	424	PF00069	0.492
MOD_PIKK_1	147	153	PF00454	0.379
MOD_PIKK_1	183	189	PF00454	0.551
MOD_PIKK_1	237	243	PF00454	0.495
MOD_PIKK_1	327	333	PF00454	0.497
MOD_PIKK_1	374	380	PF00454	0.495
MOD_PKA_2	283	289	PF00069	0.554
MOD_PKA_2	297	303	PF00069	0.728
MOD_Plk_1	315	321	PF00069	0.497
MOD_Plk_4	125	131	PF00069	0.284
MOD_ProDKin_1	129	135	PF00069	0.390
MOD_ProDKin_1	156	162	PF00069	0.595
MOD_ProDKin_1	163	169	PF00069	0.562
MOD_ProDKin_1	172	178	PF00069	0.619
MOD_ProDKin_1	186	192	PF00069	0.589
MOD_ProDKin_1	287	293	PF00069	0.517
MOD_ProDKin_1	3	9	PF00069	0.557
MOD_ProDKin_1	321	327	PF00069	0.659
MOD_SUMO_rev_2	123	129	PF00179	0.203
MOD_SUMO_rev_2	32	40	PF00179	0.408
TRG_DiLeu_BaEn_1	36	41	PF01217	0.386
TRG_ENDOCYTIC_2	138	141	PF00928	0.366
TRG_ENDOCYTIC_2	68	71	PF00928	0.324
TRG_ER_diArg_1	283	285	PF00400	0.473
TRG_NLS_Bipartite_1	209	226	PF00514	0.575
TRG_NLS_MonoExtN_4	220	226	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I148	Leptomonas seymouri	59%	99%
A0A3Q8IHZ4	Leishmania donovani	77%	100%
A1L520	Bos taurus	30%	85%
A4HVJ9	Leishmania infantum	76%	100%
E9AP95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q3MID3	Rattus norvegicus	28%	85%
Q4QG83	Leishmania major	76%	98%
Q5RAT7	Pongo abelii	31%	85%
Q8N6H7	Homo sapiens	32%	85%
Q99K28	Mus musculus	28%	85%