Peptidase_M24 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Metallopeptidase family M24, putative

Species:

Leishmania braziliensis

UniProt:

A4H757_LEIBR

TriTrypDb:

LbrM.13.0500 , LBRM2903_130010600

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4H757

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H757

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004177	aminopeptidase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008238	exopeptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.483
CLV_MEL_PAP_1	446	452	PF00089	0.348
CLV_NRD_NRD_1	27	29	PF00675	0.733
CLV_NRD_NRD_1	331	333	PF00675	0.435
CLV_NRD_NRD_1	37	39	PF00675	0.729
CLV_NRD_NRD_1	378	380	PF00675	0.376
CLV_NRD_NRD_1	497	499	PF00675	0.445
CLV_NRD_NRD_1	71	73	PF00675	0.622
CLV_NRD_NRD_1	89	91	PF00675	0.620
CLV_PCSK_FUR_1	316	320	PF00082	0.370
CLV_PCSK_FUR_1	35	39	PF00082	0.723
CLV_PCSK_KEX2_1	174	176	PF00082	0.400
CLV_PCSK_KEX2_1	318	320	PF00082	0.367
CLV_PCSK_KEX2_1	331	333	PF00082	0.481
CLV_PCSK_KEX2_1	37	39	PF00082	0.723
CLV_PCSK_KEX2_1	378	380	PF00082	0.376
CLV_PCSK_KEX2_1	459	461	PF00082	0.400
CLV_PCSK_KEX2_1	497	499	PF00082	0.481
CLV_PCSK_KEX2_1	523	525	PF00082	0.621
CLV_PCSK_KEX2_1	71	73	PF00082	0.512
CLV_PCSK_KEX2_1	89	91	PF00082	0.630
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.390
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.367
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.443
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.622
CLV_PCSK_SKI1_1	162	166	PF00082	0.335
CLV_PCSK_SKI1_1	274	278	PF00082	0.341
CLV_PCSK_SKI1_1	29	33	PF00082	0.736
CLV_PCSK_SKI1_1	331	335	PF00082	0.494
CLV_PCSK_SKI1_1	372	376	PF00082	0.447
CLV_PCSK_SKI1_1	459	463	PF00082	0.437
DEG_APCC_DBOX_1	27	35	PF00400	0.603
DEG_APCC_DBOX_1	273	281	PF00400	0.309
DEG_APCC_DBOX_1	88	96	PF00400	0.533
DEG_Nend_UBRbox_3	1	3	PF02207	0.474
DOC_CYCLIN_RxL_1	159	168	PF00134	0.372
DOC_CYCLIN_yCln2_LP_2	496	502	PF00134	0.413
DOC_MAPK_FxFP_2	405	408	PF00069	0.457
DOC_MAPK_gen_1	35	44	PF00069	0.468
DOC_MAPK_gen_1	419	426	PF00069	0.402
DOC_MAPK_MEF2A_6	207	216	PF00069	0.279
DOC_MAPK_MEF2A_6	35	44	PF00069	0.468
DOC_MAPK_MEF2A_6	419	426	PF00069	0.380
DOC_PP4_FxxP_1	405	408	PF00568	0.457
DOC_USP7_MATH_1	15	19	PF00917	0.788
DOC_USP7_MATH_1	24	28	PF00917	0.653
DOC_USP7_MATH_1	241	245	PF00917	0.237
DOC_USP7_MATH_1	250	254	PF00917	0.276
DOC_USP7_MATH_1	529	533	PF00917	0.594
DOC_USP7_MATH_1	75	79	PF00917	0.654
DOC_WW_Pin1_4	193	198	PF00397	0.338
DOC_WW_Pin1_4	377	382	PF00397	0.495
DOC_WW_Pin1_4	516	521	PF00397	0.654
LIG_14-3-3_CanoR_1	178	183	PF00244	0.327
LIG_14-3-3_CanoR_1	28	32	PF00244	0.574
LIG_14-3-3_CanoR_1	331	338	PF00244	0.489
LIG_14-3-3_CanoR_1	366	370	PF00244	0.499
LIG_14-3-3_CanoR_1	449	455	PF00244	0.340
LIG_14-3-3_CanoR_1	460	464	PF00244	0.379
LIG_14-3-3_CanoR_1	480	488	PF00244	0.256
LIG_14-3-3_CanoR_1	82	92	PF00244	0.506
LIG_Actin_WH2_2	271	287	PF00022	0.421
LIG_BIR_III_4	170	174	PF00653	0.197
LIG_BRCT_BRCA1_1	84	88	PF00533	0.622
LIG_DLG_GKlike_1	38	46	PF00625	0.466
LIG_FHA_1	144	150	PF00498	0.309
LIG_FHA_1	228	234	PF00498	0.301
LIG_FHA_1	28	34	PF00498	0.771
LIG_FHA_1	292	298	PF00498	0.296
LIG_FHA_1	451	457	PF00498	0.323
LIG_FHA_1	468	474	PF00498	0.441
LIG_FHA_1	47	53	PF00498	0.482
LIG_FHA_2	146	152	PF00498	0.357
LIG_FHA_2	238	244	PF00498	0.402
LIG_FHA_2	332	338	PF00498	0.521
LIG_FHA_2	358	364	PF00498	0.467
LIG_FHA_2	366	372	PF00498	0.501
LIG_FHA_2	378	384	PF00498	0.425
LIG_FHA_2	394	400	PF00498	0.391
LIG_FHA_2	480	486	PF00498	0.566
LIG_LIR_Gen_1	501	510	PF02991	0.462
LIG_LIR_Nem_3	356	362	PF02991	0.182
LIG_LIR_Nem_3	501	505	PF02991	0.426
LIG_PCNA_yPIPBox_3	285	297	PF02747	0.374
LIG_Pex14_2	405	409	PF04695	0.417
LIG_PTAP_UEV_1	468	473	PF05743	0.362
LIG_PTB_Apo_2	399	406	PF02174	0.403
LIG_SH2_STAT3	304	307	PF00017	0.421
LIG_SH2_STAT5	445	448	PF00017	0.408
LIG_SH3_3	466	472	PF00018	0.390
LIG_SUMO_SIM_anti_2	491	497	PF11976	0.514
LIG_SUMO_SIM_par_1	229	235	PF11976	0.425
LIG_SUMO_SIM_par_1	451	457	PF11976	0.334
LIG_TRAF2_1	244	247	PF00917	0.358
LIG_TRAF2_1	396	399	PF00917	0.422
MOD_CDC14_SPxK_1	196	199	PF00782	0.421
MOD_CDK_SPxK_1	193	199	PF00069	0.421
MOD_CDK_SPxxK_3	516	523	PF00069	0.654
MOD_CK1_1	181	187	PF00069	0.300
MOD_CK1_1	254	260	PF00069	0.411
MOD_CK1_1	261	267	PF00069	0.424
MOD_CK1_1	27	33	PF00069	0.535
MOD_CK1_1	314	320	PF00069	0.346
MOD_CK1_1	484	490	PF00069	0.525
MOD_CK1_1	519	525	PF00069	0.665
MOD_CK1_1	78	84	PF00069	0.507
MOD_CK2_1	103	109	PF00069	0.585
MOD_CK2_1	184	190	PF00069	0.406
MOD_CK2_1	237	243	PF00069	0.355
MOD_CK2_1	365	371	PF00069	0.468
MOD_CK2_1	393	399	PF00069	0.395
MOD_CK2_1	479	485	PF00069	0.599
MOD_Cter_Amidation	172	175	PF01082	0.382
MOD_Cter_Amidation	69	72	PF01082	0.461
MOD_GlcNHglycan	12	16	PF01048	0.742
MOD_GlcNHglycan	225	228	PF01048	0.353
MOD_GlcNHglycan	253	256	PF01048	0.373
MOD_GlcNHglycan	450	453	PF01048	0.323
MOD_GlcNHglycan	77	80	PF01048	0.553
MOD_GSK3_1	11	18	PF00069	0.774
MOD_GSK3_1	223	230	PF00069	0.302
MOD_GSK3_1	237	244	PF00069	0.299
MOD_GSK3_1	250	257	PF00069	0.364
MOD_GSK3_1	357	364	PF00069	0.267
MOD_GSK3_1	40	47	PF00069	0.692
MOD_GSK3_1	444	451	PF00069	0.361
MOD_GSK3_1	511	518	PF00069	0.635
MOD_GSK3_1	56	63	PF00069	0.727
MOD_GSK3_1	71	78	PF00069	0.601
MOD_N-GLC_1	114	119	PF02516	0.459
MOD_N-GLC_1	184	189	PF02516	0.309
MOD_N-GLC_1	193	198	PF02516	0.309
MOD_N-GLC_1	393	398	PF02516	0.529
MOD_NEK2_1	114	119	PF00069	0.539
MOD_NEK2_1	259	264	PF00069	0.291
MOD_NEK2_1	44	49	PF00069	0.586
MOD_NEK2_1	450	455	PF00069	0.321
MOD_PIKK_1	80	86	PF00454	0.688
MOD_PK_1	64	70	PF00069	0.454
MOD_PKA_1	251	257	PF00069	0.249
MOD_PKA_1	331	337	PF00069	0.483
MOD_PKA_1	459	465	PF00069	0.385
MOD_PKA_1	71	77	PF00069	0.547
MOD_PKA_2	27	33	PF00069	0.535
MOD_PKA_2	331	337	PF00069	0.483
MOD_PKA_2	365	371	PF00069	0.468
MOD_PKA_2	448	454	PF00069	0.336
MOD_PKA_2	459	465	PF00069	0.357
MOD_PKA_2	479	485	PF00069	0.261
MOD_PKA_2	71	77	PF00069	0.580
MOD_Plk_1	109	115	PF00069	0.484
MOD_Plk_1	184	190	PF00069	0.309
MOD_Plk_1	393	399	PF00069	0.512
MOD_Plk_1	484	490	PF00069	0.571
MOD_Plk_4	109	115	PF00069	0.452
MOD_Plk_4	201	207	PF00069	0.386
MOD_Plk_4	372	378	PF00069	0.318
MOD_Plk_4	459	465	PF00069	0.352
MOD_ProDKin_1	193	199	PF00069	0.338
MOD_ProDKin_1	377	383	PF00069	0.507
MOD_ProDKin_1	516	522	PF00069	0.656
TRG_DiLeu_BaEn_1	491	496	PF01217	0.296
TRG_ER_diArg_1	331	333	PF00400	0.481
TRG_ER_diArg_1	34	37	PF00400	0.729
TRG_ER_diArg_1	377	379	PF00400	0.378
TRG_ER_diArg_1	496	498	PF00400	0.532
TRG_ER_diArg_1	524	527	PF00400	0.661
TRG_ER_diArg_1	88	90	PF00400	0.578
TRG_NES_CRM1_1	155	170	PF08389	0.327
TRG_NLS_MonoExtC_3	522	528	PF00514	0.595
TRG_NLS_MonoExtN_4	520	527	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIM1	Leptomonas seymouri	30%	100%
A0A0N1IM06	Leptomonas seymouri	68%	93%
A0A0S4J160	Bodo saltans	31%	100%
A0A1X0NPS8	Trypanosomatidae	45%	97%
A0A1X0P6E6	Trypanosomatidae	30%	100%
A0A3Q8IBA7	Leishmania donovani	30%	100%
A0A3Q8IBP5	Leishmania donovani	80%	93%
A0A3R7KN75	Trypanosoma rangeli	52%	100%
A0A422NCW7	Trypanosoma rangeli	32%	100%
A4H9X3	Leishmania braziliensis	30%	100%
A4HVJ6	Leishmania infantum	81%	93%
D0A0D4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A6Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9AGR8	Leishmania infantum	30%	100%
E9AP92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	95%
E9ARW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O60180	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q09184	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4QDK5	Leishmania major	30%	94%
Q4QG86	Leishmania major	79%	100%
V5BFG1	Trypanosoma cruzi	48%	100%
V5BS99	Trypanosoma cruzi	31%	100%