Putative lectin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative lectin

Gene product:

lectin, putative

Species:

Leishmania braziliensis

UniProt:

A4H756_LEIBR

TriTrypDb:

LbrM.13.0490 , LBRM2903_130010500

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0000139	Golgi membrane	5	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4H756

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H756

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0030246	carbohydrate binding	2	7
GO:0005537	mannose binding	4	1
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.204
CLV_NRD_NRD_1	10	12	PF00675	0.477
CLV_NRD_NRD_1	13	15	PF00675	0.484
CLV_NRD_NRD_1	174	176	PF00675	0.496
CLV_NRD_NRD_1	394	396	PF00675	0.586
CLV_NRD_NRD_1	402	404	PF00675	0.571
CLV_NRD_NRD_1	425	427	PF00675	0.681
CLV_NRD_NRD_1	428	430	PF00675	0.649
CLV_NRD_NRD_1	431	433	PF00675	0.629
CLV_NRD_NRD_1	437	439	PF00675	0.598
CLV_PCSK_FUR_1	11	15	PF00082	0.492
CLV_PCSK_FUR_1	426	430	PF00082	0.818
CLV_PCSK_KEX2_1	10	12	PF00082	0.477
CLV_PCSK_KEX2_1	13	15	PF00082	0.484
CLV_PCSK_KEX2_1	173	175	PF00082	0.497
CLV_PCSK_KEX2_1	191	193	PF00082	0.423
CLV_PCSK_KEX2_1	402	404	PF00082	0.584
CLV_PCSK_KEX2_1	423	425	PF00082	0.711
CLV_PCSK_KEX2_1	428	430	PF00082	0.689
CLV_PCSK_KEX2_1	431	433	PF00082	0.712
CLV_PCSK_KEX2_1	437	439	PF00082	0.723
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.404
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.423
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.809
CLV_PCSK_PC7_1	424	430	PF00082	0.805
DOC_MAPK_gen_1	173	182	PF00069	0.297
DOC_MAPK_MEF2A_6	173	182	PF00069	0.297
DOC_MAPK_MEF2A_6	228	235	PF00069	0.275
DOC_MAPK_NFAT4_5	228	236	PF00069	0.242
DOC_PP2B_LxvP_1	252	255	PF13499	0.296
DOC_PP4_FxxP_1	153	156	PF00568	0.287
DOC_PP4_FxxP_1	64	67	PF00568	0.254
DOC_PP4_MxPP_1	297	300	PF00568	0.510
DOC_USP7_MATH_1	178	182	PF00917	0.327
DOC_USP7_MATH_1	29	33	PF00917	0.488
DOC_USP7_MATH_2	327	333	PF00917	0.564
DOC_USP7_MATH_2	334	340	PF00917	0.551
DOC_USP7_MATH_2	341	347	PF00917	0.530
DOC_USP7_UBL2_3	45	49	PF12436	0.359
DOC_WW_Pin1_4	212	217	PF00397	0.210
DOC_WW_Pin1_4	279	284	PF00397	0.339
DOC_WW_Pin1_4	432	437	PF00397	0.656
LIG_14-3-3_CanoR_1	13	18	PF00244	0.451
LIG_BRCT_BRCA1_1	205	209	PF00533	0.337
LIG_CtBP_PxDLS_1	216	220	PF00389	0.204
LIG_FHA_1	108	114	PF00498	0.303
LIG_FHA_1	242	248	PF00498	0.296
LIG_FHA_1	265	271	PF00498	0.279
LIG_FHA_2	240	246	PF00498	0.285
LIG_HP1_1	178	182	PF01393	0.296
LIG_LIR_Apic_2	63	67	PF02991	0.254
LIG_LIR_Gen_1	116	126	PF02991	0.282
LIG_LIR_Gen_1	206	217	PF02991	0.204
LIG_LIR_Gen_1	275	285	PF02991	0.379
LIG_LIR_Gen_1	90	99	PF02991	0.296
LIG_LIR_Nem_3	116	121	PF02991	0.282
LIG_LIR_Nem_3	158	162	PF02991	0.293
LIG_LIR_Nem_3	16	20	PF02991	0.585
LIG_LIR_Nem_3	206	212	PF02991	0.300
LIG_LIR_Nem_3	275	281	PF02991	0.370
LIG_LIR_Nem_3	410	416	PF02991	0.536
LIG_LIR_Nem_3	90	96	PF02991	0.296
LIG_Pex14_2	162	166	PF04695	0.296
LIG_SH2_CRK	23	27	PF00017	0.506
LIG_SH2_GRB2like	169	172	PF00017	0.296
LIG_SH2_PTP2	93	96	PF00017	0.296
LIG_SH2_SRC	211	214	PF00017	0.204
LIG_SH2_STAP1	23	27	PF00017	0.530
LIG_SH2_STAP1	289	293	PF00017	0.520
LIG_SH2_STAT5	211	214	PF00017	0.387
LIG_SH2_STAT5	226	229	PF00017	0.316
LIG_SH2_STAT5	5	8	PF00017	0.495
LIG_SH2_STAT5	93	96	PF00017	0.296
LIG_SH3_3	123	129	PF00018	0.296
LIG_SH3_3	139	145	PF00018	0.296
LIG_SH3_3	211	217	PF00018	0.204
LIG_Sin3_3	22	29	PF02671	0.413
LIG_SUMO_SIM_par_1	26	32	PF11976	0.447
LIG_TRAF2_1	326	329	PF00917	0.588
LIG_TRAF2_1	333	336	PF00917	0.566
LIG_TRAF2_1	340	343	PF00917	0.526
LIG_TRAF2_1	347	350	PF00917	0.563
LIG_TRAF2_1	354	357	PF00917	0.542
LIG_TRAF2_1	361	364	PF00917	0.562
LIG_TRAF2_1	368	371	PF00917	0.563
LIG_TRAF2_1	48	51	PF00917	0.476
LIG_WW_3	144	148	PF00397	0.296
MOD_CDK_SPK_2	432	437	PF00069	0.632
MOD_CDK_SPxK_1	432	438	PF00069	0.564
MOD_CK1_1	203	209	PF00069	0.324
MOD_CK1_1	236	242	PF00069	0.325
MOD_CK1_1	264	270	PF00069	0.304
MOD_CK1_1	87	93	PF00069	0.299
MOD_CK2_1	239	245	PF00069	0.271
MOD_CK2_1	45	51	PF00069	0.373
MOD_DYRK1A_RPxSP_1	432	436	PF00069	0.653
MOD_GlcNHglycan	159	162	PF01048	0.420
MOD_GlcNHglycan	263	266	PF01048	0.523
MOD_GlcNHglycan	269	273	PF01048	0.526
MOD_GlcNHglycan	31	34	PF01048	0.496
MOD_GlcNHglycan	331	334	PF01048	0.635
MOD_GlcNHglycan	338	341	PF01048	0.529
MOD_GlcNHglycan	345	348	PF01048	0.543
MOD_GSK3_1	264	271	PF00069	0.256
MOD_GSK3_1	369	376	PF00069	0.697
MOD_GSK3_1	79	86	PF00069	0.258
MOD_GSK3_1	9	16	PF00069	0.489
MOD_NEK2_1	200	205	PF00069	0.369
MOD_NEK2_1	233	238	PF00069	0.242
MOD_NEK2_1	247	252	PF00069	0.294
MOD_NEK2_1	261	266	PF00069	0.224
MOD_PIKK_1	320	326	PF00454	0.646
MOD_PIKK_1	327	333	PF00454	0.768
MOD_PIKK_1	334	340	PF00454	0.848
MOD_PIKK_1	341	347	PF00454	0.586
MOD_PIKK_1	348	354	PF00454	0.587
MOD_PIKK_1	355	361	PF00454	0.551
MOD_PIKK_1	362	368	PF00454	0.657
MOD_PIKK_1	369	375	PF00454	0.565
MOD_PKA_1	13	19	PF00069	0.447
MOD_PKA_2	247	253	PF00069	0.337
MOD_PKA_2	9	15	PF00069	0.494
MOD_PKA_2	94	100	PF00069	0.254
MOD_PKB_1	11	19	PF00069	0.453
MOD_Plk_4	1	7	PF00069	0.595
MOD_Plk_4	13	19	PF00069	0.480
MOD_Plk_4	178	184	PF00069	0.296
MOD_Plk_4	293	299	PF00069	0.557
MOD_Plk_4	84	90	PF00069	0.296
MOD_ProDKin_1	212	218	PF00069	0.210
MOD_ProDKin_1	279	285	PF00069	0.354
MOD_ProDKin_1	432	438	PF00069	0.658
MOD_SUMO_for_1	227	230	PF00179	0.296
MOD_SUMO_rev_2	391	397	PF00179	0.661
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.254
TRG_ENDOCYTIC_2	211	214	PF00928	0.249
TRG_ENDOCYTIC_2	23	26	PF00928	0.503
TRG_ENDOCYTIC_2	93	96	PF00928	0.296
TRG_ER_diArg_1	10	13	PF00400	0.473
TRG_ER_diArg_1	387	390	PF00400	0.561
TRG_ER_diArg_1	424	426	PF00400	0.678
TRG_ER_diArg_1	427	429	PF00400	0.646
TRG_ER_diArg_1	430	432	PF00400	0.623
TRG_ER_diArg_1	436	438	PF00400	0.588
TRG_NES_CRM1_1	218	230	PF08389	0.204
TRG_NLS_MonoCore_2	422	427	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD81	Leptomonas seymouri	58%	100%
A0A3Q8I8H3	Leishmania donovani	72%	100%
A4HVJ5	Leishmania infantum	72%	99%
D0A6R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	82%
E9AP91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QG87	Leishmania major	67%	100%