U-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H755_LEIBR

TriTrypDb:

LbrM.13.0480 , LBRM2903_130010400

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H755

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H755

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.460
CLV_NRD_NRD_1	88	90	PF00675	0.420
CLV_PCSK_FUR_1	694	698	PF00082	0.629
CLV_PCSK_KEX2_1	616	618	PF00082	0.748
CLV_PCSK_KEX2_1	696	698	PF00082	0.611
CLV_PCSK_KEX2_1	700	702	PF00082	0.646
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.724
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.644
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.643
CLV_PCSK_SKI1_1	123	127	PF00082	0.532
CLV_PCSK_SKI1_1	142	146	PF00082	0.531
CLV_PCSK_SKI1_1	319	323	PF00082	0.561
CLV_PCSK_SKI1_1	383	387	PF00082	0.450
CLV_PCSK_SKI1_1	398	402	PF00082	0.342
CLV_PCSK_SKI1_1	531	535	PF00082	0.323
CLV_PCSK_SKI1_1	55	59	PF00082	0.352
CLV_PCSK_SKI1_1	90	94	PF00082	0.481
DEG_APCC_DBOX_1	141	149	PF00400	0.576
DOC_ANK_TNKS_1	590	597	PF00023	0.533
DOC_CYCLIN_RxL_1	87	96	PF00134	0.303
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.285
DOC_MAPK_gen_1	54	60	PF00069	0.272
DOC_MAPK_gen_1	639	647	PF00069	0.339
DOC_MAPK_MEF2A_6	123	131	PF00069	0.411
DOC_MAPK_MEF2A_6	425	432	PF00069	0.516
DOC_PP2B_LxvP_1	186	189	PF13499	0.526
DOC_USP7_MATH_1	179	183	PF00917	0.524
DOC_USP7_MATH_1	201	205	PF00917	0.761
DOC_USP7_MATH_1	25	29	PF00917	0.556
DOC_USP7_MATH_1	502	506	PF00917	0.453
DOC_USP7_MATH_1	557	561	PF00917	0.638
DOC_USP7_MATH_1	608	612	PF00917	0.822
DOC_USP7_MATH_1	615	619	PF00917	0.657
DOC_USP7_UBL2_3	606	610	PF12436	0.708
DOC_USP7_UBL2_3	696	700	PF12436	0.403
DOC_WW_Pin1_4	257	262	PF00397	0.582
DOC_WW_Pin1_4	406	411	PF00397	0.379
DOC_WW_Pin1_4	454	459	PF00397	0.545
DOC_WW_Pin1_4	516	521	PF00397	0.567
LIG_14-3-3_CanoR_1	249	253	PF00244	0.506
LIG_14-3-3_CanoR_1	478	482	PF00244	0.611
LIG_14-3-3_CanoR_1	597	605	PF00244	0.776
LIG_14-3-3_CterR_2	701	704	PF00244	0.497
LIG_Actin_WH2_2	384	400	PF00022	0.448
LIG_Actin_WH2_2	567	584	PF00022	0.429
LIG_Actin_WH2_2	633	650	PF00022	0.378
LIG_APCC_ABBA_1	321	326	PF00400	0.281
LIG_BIR_II_1	1	5	PF00653	0.462
LIG_BIR_III_4	16	20	PF00653	0.314
LIG_Clathr_ClatBox_1	555	559	PF01394	0.582
LIG_CtBP_PxDLS_1	261	265	PF00389	0.718
LIG_CtBP_PxDLS_1	458	462	PF00389	0.516
LIG_FAT_LD_1	241	249	PF03623	0.544
LIG_FHA_1	139	145	PF00498	0.515
LIG_FHA_1	35	41	PF00498	0.470
LIG_FHA_1	355	361	PF00498	0.499
LIG_FHA_1	380	386	PF00498	0.544
LIG_FHA_1	407	413	PF00498	0.484
LIG_FHA_1	454	460	PF00498	0.488
LIG_FHA_1	573	579	PF00498	0.654
LIG_FHA_1	635	641	PF00498	0.335
LIG_FHA_2	192	198	PF00498	0.630
LIG_FHA_2	33	39	PF00498	0.516
LIG_FHA_2	482	488	PF00498	0.593
LIG_FHA_2	571	577	PF00498	0.629
LIG_LIR_Gen_1	124	133	PF02991	0.486
LIG_LIR_Gen_1	302	311	PF02991	0.433
LIG_LIR_Gen_1	463	473	PF02991	0.294
LIG_LIR_Gen_1	536	545	PF02991	0.341
LIG_LIR_Gen_1	654	663	PF02991	0.447
LIG_LIR_Nem_3	124	129	PF02991	0.486
LIG_LIR_Nem_3	170	176	PF02991	0.398
LIG_LIR_Nem_3	302	307	PF02991	0.435
LIG_LIR_Nem_3	463	468	PF02991	0.412
LIG_LIR_Nem_3	508	512	PF02991	0.477
LIG_LIR_Nem_3	536	541	PF02991	0.332
LIG_LIR_Nem_3	654	658	PF02991	0.447
LIG_NRBOX	240	246	PF00104	0.543
LIG_NRBOX	392	398	PF00104	0.389
LIG_NRBOX	573	579	PF00104	0.638
LIG_PCNA_PIPBox_1	177	186	PF02747	0.533
LIG_PCNA_yPIPBox_3	101	110	PF02747	0.608
LIG_Pex14_1	300	304	PF04695	0.517
LIG_SH2_CRK	402	406	PF00017	0.406
LIG_SH2_CRK	465	469	PF00017	0.497
LIG_SH2_CRK	655	659	PF00017	0.349
LIG_SH2_NCK_1	485	489	PF00017	0.467
LIG_SH2_SRC	268	271	PF00017	0.601
LIG_SH2_STAP1	184	188	PF00017	0.515
LIG_SH2_STAP1	268	272	PF00017	0.636
LIG_SH2_STAT5	193	196	PF00017	0.504
LIG_SH2_STAT5	418	421	PF00017	0.436
LIG_SH2_STAT5	632	635	PF00017	0.355
LIG_SH3_2	592	597	PF14604	0.564
LIG_SH3_2	605	610	PF14604	0.558
LIG_SH3_3	452	458	PF00018	0.578
LIG_SH3_3	589	595	PF00018	0.644
LIG_SH3_3	602	608	PF00018	0.562
LIG_SH3_3	679	685	PF00018	0.363
LIG_SH3_3	80	86	PF00018	0.496
LIG_SH3_4	606	613	PF00018	0.571
LIG_SUMO_SIM_anti_2	226	234	PF11976	0.476
LIG_SUMO_SIM_anti_2	382	389	PF11976	0.292
LIG_SUMO_SIM_par_1	226	234	PF11976	0.295
LIG_SUMO_SIM_par_1	382	389	PF11976	0.292
LIG_SUMO_SIM_par_1	554	560	PF11976	0.624
LIG_SUMO_SIM_par_1	567	573	PF11976	0.425
LIG_TRAF2_1	103	106	PF00917	0.495
LIG_TRAF2_1	43	46	PF00917	0.606
LIG_UBA3_1	468	476	PF00899	0.445
LIG_WRC_WIRS_1	216	221	PF05994	0.637
MOD_CK1_1	204	210	PF00069	0.763
MOD_CK1_1	215	221	PF00069	0.520
MOD_CK1_1	247	253	PF00069	0.391
MOD_CK1_1	260	266	PF00069	0.658
MOD_CK1_1	302	308	PF00069	0.503
MOD_CK1_1	34	40	PF00069	0.488
MOD_CK1_1	363	369	PF00069	0.610
MOD_CK1_1	389	395	PF00069	0.464
MOD_CK1_1	526	532	PF00069	0.480
MOD_CK1_1	540	546	PF00069	0.356
MOD_CK1_1	672	678	PF00069	0.480
MOD_CK1_1	99	105	PF00069	0.576
MOD_CK2_1	118	124	PF00069	0.486
MOD_CK2_1	179	185	PF00069	0.472
MOD_CK2_1	191	197	PF00069	0.581
MOD_CK2_1	248	254	PF00069	0.481
MOD_CK2_1	502	508	PF00069	0.369
MOD_CK2_1	557	563	PF00069	0.560
MOD_CK2_1	570	576	PF00069	0.670
MOD_CK2_1	672	678	PF00069	0.480
MOD_CK2_1	99	105	PF00069	0.478
MOD_GlcNHglycan	120	123	PF01048	0.476
MOD_GlcNHglycan	206	209	PF01048	0.737
MOD_GlcNHglycan	23	26	PF01048	0.447
MOD_GlcNHglycan	27	30	PF01048	0.445
MOD_GlcNHglycan	287	290	PF01048	0.621
MOD_GlcNHglycan	301	304	PF01048	0.378
MOD_GlcNHglycan	342	345	PF01048	0.511
MOD_GlcNHglycan	362	365	PF01048	0.706
MOD_GlcNHglycan	371	375	PF01048	0.564
MOD_GlcNHglycan	388	391	PF01048	0.230
MOD_GlcNHglycan	489	492	PF01048	0.748
MOD_GlcNHglycan	578	581	PF01048	0.707
MOD_GlcNHglycan	610	613	PF01048	0.733
MOD_GlcNHglycan	619	622	PF01048	0.761
MOD_GlcNHglycan	671	674	PF01048	0.447
MOD_GSK3_1	131	138	PF00069	0.479
MOD_GSK3_1	184	191	PF00069	0.428
MOD_GSK3_1	203	210	PF00069	0.642
MOD_GSK3_1	21	28	PF00069	0.440
MOD_GSK3_1	211	218	PF00069	0.596
MOD_GSK3_1	244	251	PF00069	0.493
MOD_GSK3_1	253	260	PF00069	0.585
MOD_GSK3_1	385	392	PF00069	0.511
MOD_GSK3_1	477	484	PF00069	0.549
MOD_GSK3_1	523	530	PF00069	0.542
MOD_GSK3_1	572	579	PF00069	0.615
MOD_GSK3_1	696	703	PF00069	0.431
MOD_GSK3_1	96	103	PF00069	0.567
MOD_N-GLC_1	100	105	PF02516	0.457
MOD_N-GLC_1	117	122	PF02516	0.480
MOD_N-GLC_1	527	532	PF02516	0.519
MOD_NEK2_1	108	113	PF00069	0.477
MOD_NEK2_1	131	136	PF00069	0.405
MOD_NEK2_1	244	249	PF00069	0.538
MOD_NEK2_1	386	391	PF00069	0.260
MOD_NEK2_1	412	417	PF00069	0.405
MOD_NEK2_1	468	473	PF00069	0.387
MOD_NEK2_1	481	486	PF00069	0.443
MOD_NEK2_1	570	575	PF00069	0.563
MOD_NEK2_1	623	628	PF00069	0.472
MOD_NEK2_1	93	98	PF00069	0.480
MOD_NEK2_2	179	184	PF00069	0.493
MOD_PIKK_1	557	563	PF00454	0.634
MOD_PIKK_1	78	84	PF00454	0.491
MOD_PKA_1	696	702	PF00069	0.671
MOD_PKA_2	131	137	PF00069	0.397
MOD_PKA_2	204	210	PF00069	0.673
MOD_PKA_2	248	254	PF00069	0.532
MOD_PKA_2	477	483	PF00069	0.633
MOD_PKA_2	596	602	PF00069	0.779
MOD_PKA_2	696	702	PF00069	0.676
MOD_Plk_1	100	106	PF00069	0.446
MOD_Plk_1	11	17	PF00069	0.403
MOD_Plk_1	184	190	PF00069	0.525
MOD_Plk_1	253	259	PF00069	0.354
MOD_Plk_4	179	185	PF00069	0.423
MOD_Plk_4	188	194	PF00069	0.442
MOD_Plk_4	389	395	PF00069	0.480
MOD_ProDKin_1	257	263	PF00069	0.589
MOD_ProDKin_1	406	412	PF00069	0.369
MOD_ProDKin_1	454	460	PF00069	0.543
MOD_ProDKin_1	516	522	PF00069	0.563
MOD_SUMO_rev_2	316	324	PF00179	0.519
MOD_SUMO_rev_2	519	529	PF00179	0.365
MOD_SUMO_rev_2	536	545	PF00179	0.263
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.558
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.515
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.566
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.505
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.448
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.303
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.277
TRG_ENDOCYTIC_2	402	405	PF00928	0.385
TRG_ENDOCYTIC_2	434	437	PF00928	0.402
TRG_ENDOCYTIC_2	465	468	PF00928	0.503
TRG_ENDOCYTIC_2	655	658	PF00928	0.314
TRG_ER_diArg_1	327	330	PF00400	0.513
TRG_NES_CRM1_1	312	326	PF08389	0.297
TRG_NES_CRM1_1	501	516	PF08389	0.571
TRG_NES_CRM1_1	554	566	PF08389	0.579
TRG_NLS_MonoExtN_4	615	620	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP8	Leptomonas seymouri	60%	100%
A0A1X0NN36	Trypanosomatidae	30%	100%
A0A3S7WSF2	Leishmania donovani	80%	100%
A0A422NQL1	Trypanosoma rangeli	30%	100%
A4HVJ4	Leishmania infantum	81%	100%
D0A6R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AP90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QG88	Leishmania major	80%	100%
V5BAU6	Trypanosoma cruzi	31%	100%