Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 6, putative

Species:

Leishmania braziliensis

UniProt:

A4H754_LEIBR

TriTrypDb:

LbrM.13.0470 , LBRM2903_130010300

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H754

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H754

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.703
CLV_C14_Caspase3-7	192	196	PF00656	0.603
CLV_C14_Caspase3-7	268	272	PF00656	0.530
CLV_C14_Caspase3-7	525	529	PF00656	0.616
CLV_MEL_PAP_1	80	86	PF00089	0.448
CLV_NRD_NRD_1	142	144	PF00675	0.415
CLV_NRD_NRD_1	245	247	PF00675	0.504
CLV_NRD_NRD_1	251	253	PF00675	0.508
CLV_NRD_NRD_1	276	278	PF00675	0.445
CLV_PCSK_KEX2_1	245	247	PF00082	0.504
CLV_PCSK_KEX2_1	251	253	PF00082	0.508
CLV_PCSK_SKI1_1	112	116	PF00082	0.526
CLV_PCSK_SKI1_1	137	141	PF00082	0.408
CLV_PCSK_SKI1_1	20	24	PF00082	0.314
DEG_APCC_DBOX_1	250	258	PF00400	0.652
DEG_APCC_DBOX_1	314	322	PF00400	0.502
DEG_APCC_DBOX_1	501	509	PF00400	0.621
DOC_CKS1_1	476	481	PF01111	0.582
DOC_MAPK_gen_1	245	256	PF00069	0.674
DOC_MAPK_gen_1	277	284	PF00069	0.583
DOC_MAPK_MEF2A_6	249	258	PF00069	0.632
DOC_MAPK_MEF2A_6	498	505	PF00069	0.583
DOC_MAPK_NFAT4_5	498	506	PF00069	0.586
DOC_PP1_RVXF_1	400	407	PF00149	0.444
DOC_PP4_FxxP_1	284	287	PF00568	0.565
DOC_PP4_FxxP_1	364	367	PF00568	0.247
DOC_USP7_MATH_1	191	195	PF00917	0.597
DOC_USP7_MATH_1	532	536	PF00917	0.765
DOC_USP7_MATH_1	7	11	PF00917	0.670
DOC_USP7_MATH_2	77	83	PF00917	0.591
DOC_USP7_UBL2_3	137	141	PF12436	0.704
DOC_WW_Pin1_4	445	450	PF00397	0.697
DOC_WW_Pin1_4	451	456	PF00397	0.675
DOC_WW_Pin1_4	475	480	PF00397	0.623
DOC_WW_Pin1_4	528	533	PF00397	0.709
DOC_WW_Pin1_4	545	550	PF00397	0.730
LIG_14-3-3_CanoR_1	504	509	PF00244	0.598
LIG_14-3-3_CanoR_1	577	581	PF00244	0.597
LIG_14-3-3_CanoR_1	83	89	PF00244	0.598
LIG_AP2alpha_1	493	497	PF02296	0.572
LIG_APCC_ABBA_1	187	192	PF00400	0.742
LIG_APCC_ABBAyCdc20_2	186	192	PF00400	0.741
LIG_BRCT_BRCA1_1	381	385	PF00533	0.371
LIG_eIF4E_1	17	23	PF01652	0.579
LIG_eIF4E_1	334	340	PF01652	0.569
LIG_eIF4E_1	341	347	PF01652	0.324
LIG_eIF4E_1	41	47	PF01652	0.505
LIG_FHA_1	17	23	PF00498	0.501
LIG_FHA_1	406	412	PF00498	0.574
LIG_FHA_1	41	47	PF00498	0.358
LIG_FHA_1	476	482	PF00498	0.627
LIG_FHA_1	537	543	PF00498	0.597
LIG_FHA_1	570	576	PF00498	0.740
LIG_FHA_1	597	603	PF00498	0.610
LIG_FHA_2	203	209	PF00498	0.620
LIG_FHA_2	271	277	PF00498	0.603
LIG_FHA_2	458	464	PF00498	0.617
LIG_GBD_Chelix_1	49	57	PF00786	0.272
LIG_IRF3_LxIS_1	62	67	PF10401	0.203
LIG_LIR_Apic_2	281	287	PF02991	0.569
LIG_LIR_Apic_2	362	367	PF02991	0.244
LIG_LIR_Gen_1	142	151	PF02991	0.748
LIG_LIR_Gen_1	32	41	PF02991	0.412
LIG_LIR_Gen_1	332	342	PF02991	0.552
LIG_LIR_Gen_1	358	367	PF02991	0.353
LIG_LIR_Gen_1	373	383	PF02991	0.216
LIG_LIR_Gen_1	384	393	PF02991	0.289
LIG_LIR_Nem_3	142	148	PF02991	0.755
LIG_LIR_Nem_3	32	36	PF02991	0.386
LIG_LIR_Nem_3	332	338	PF02991	0.552
LIG_LIR_Nem_3	358	364	PF02991	0.334
LIG_LIR_Nem_3	373	379	PF02991	0.201
LIG_LIR_Nem_3	382	388	PF02991	0.274
LIG_LIR_Nem_3	428	433	PF02991	0.659
LIG_NRBOX	48	54	PF00104	0.233
LIG_PCNA_PIPBox_1	348	357	PF02747	0.360
LIG_PCNA_yPIPBox_3	11	20	PF02747	0.630
LIG_Pex14_1	359	363	PF04695	0.258
LIG_Pex14_2	29	33	PF04695	0.268
LIG_Pex14_2	375	379	PF04695	0.360
LIG_Pex14_2	493	497	PF04695	0.589
LIG_Pex14_2	58	62	PF04695	0.325
LIG_PTB_Apo_2	328	335	PF02174	0.530
LIG_PTB_Phospho_1	328	334	PF10480	0.530
LIG_REV1ctd_RIR_1	362	366	PF16727	0.296
LIG_SH2_CRK	430	434	PF00017	0.631
LIG_SH2_GRB2like	329	332	PF00017	0.523
LIG_SH2_GRB2like	591	594	PF00017	0.657
LIG_SH2_NCK_1	41	45	PF00017	0.447
LIG_SH2_PTP2	591	594	PF00017	0.614
LIG_SH2_SRC	329	332	PF00017	0.590
LIG_SH2_SRC	396	399	PF00017	0.530
LIG_SH2_SRC	430	433	PF00017	0.680
LIG_SH2_SRC	591	594	PF00017	0.614
LIG_SH2_STAP1	361	365	PF00017	0.330
LIG_SH2_STAP1	381	385	PF00017	0.155
LIG_SH2_STAP1	41	45	PF00017	0.487
LIG_SH2_STAT5	335	338	PF00017	0.353
LIG_SH2_STAT5	341	344	PF00017	0.285
LIG_SH2_STAT5	355	358	PF00017	0.284
LIG_SH2_STAT5	361	364	PF00017	0.159
LIG_SH2_STAT5	376	379	PF00017	0.328
LIG_SH2_STAT5	396	399	PF00017	0.355
LIG_SH2_STAT5	472	475	PF00017	0.459
LIG_SH2_STAT5	591	594	PF00017	0.657
LIG_SH3_1	591	597	PF00018	0.611
LIG_SH3_3	476	482	PF00018	0.542
LIG_SH3_3	551	557	PF00018	0.690
LIG_SH3_3	578	584	PF00018	0.734
LIG_SH3_3	591	597	PF00018	0.718
LIG_SUMO_SIM_anti_2	255	260	PF11976	0.600
LIG_SUMO_SIM_anti_2	32	38	PF11976	0.277
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.283
LIG_SUMO_SIM_par_1	255	260	PF11976	0.600
LIG_SUMO_SIM_par_1	67	73	PF11976	0.208
LIG_TRAF2_1	173	176	PF00917	0.737
LIG_TRAF2_1	206	209	PF00917	0.638
LIG_TRAF2_1	449	452	PF00917	0.630
LIG_TYR_ITIM	339	344	PF00017	0.308
LIG_Vh1_VBS_1	379	397	PF01044	0.203
LIG_WRC_WIRS_1	30	35	PF05994	0.387
LIG_WRC_WIRS_1	59	64	PF05994	0.426
LIG_WRC_WIRS_1	89	94	PF05994	0.381
MOD_CK1_1	198	204	PF00069	0.709
MOD_CK1_1	454	460	PF00069	0.529
MOD_CK1_1	535	541	PF00069	0.647
MOD_CK1_1	65	71	PF00069	0.483
MOD_CK1_1	82	88	PF00069	0.379
MOD_CK2_1	202	208	PF00069	0.672
MOD_CK2_1	445	451	PF00069	0.673
MOD_CK2_1	457	463	PF00069	0.516
MOD_GlcNHglycan	105	108	PF01048	0.428
MOD_GlcNHglycan	195	198	PF01048	0.571
MOD_GlcNHglycan	367	370	PF01048	0.412
MOD_GlcNHglycan	381	384	PF01048	0.299
MOD_GlcNHglycan	443	448	PF01048	0.592
MOD_GlcNHglycan	532	535	PF01048	0.732
MOD_GlcNHglycan	84	87	PF01048	0.481
MOD_GSK3_1	191	198	PF00069	0.705
MOD_GSK3_1	355	362	PF00069	0.426
MOD_GSK3_1	457	464	PF00069	0.560
MOD_GSK3_1	528	535	PF00069	0.639
MOD_GSK3_1	58	65	PF00069	0.453
MOD_GSK3_1	592	599	PF00069	0.708
MOD_N-GLC_1	300	305	PF02516	0.360
MOD_N-GLC_2	126	128	PF02516	0.513
MOD_N-GLC_2	290	292	PF02516	0.360
MOD_NEK2_1	166	171	PF00069	0.636
MOD_NEK2_1	29	34	PF00069	0.249
MOD_NEK2_1	300	305	PF00069	0.308
MOD_NEK2_1	342	347	PF00069	0.383
MOD_NEK2_1	379	384	PF00069	0.355
MOD_NEK2_1	418	423	PF00069	0.392
MOD_NEK2_1	576	581	PF00069	0.496
MOD_NEK2_1	58	63	PF00069	0.317
MOD_NEK2_1	64	69	PF00069	0.294
MOD_PIKK_1	150	156	PF00454	0.694
MOD_PIKK_1	257	263	PF00454	0.301
MOD_PK_1	504	510	PF00069	0.506
MOD_PK_1	601	607	PF00069	0.504
MOD_PKA_1	143	149	PF00069	0.483
MOD_PKA_2	167	173	PF00069	0.736
MOD_PKA_2	576	582	PF00069	0.497
MOD_PKA_2	82	88	PF00069	0.534
MOD_PKB_1	502	510	PF00069	0.502
MOD_Plk_1	280	286	PF00069	0.306
MOD_Plk_2-3	220	226	PF00069	0.532
MOD_Plk_2-3	513	519	PF00069	0.669
MOD_Plk_4	280	286	PF00069	0.306
MOD_Plk_4	29	35	PF00069	0.241
MOD_Plk_4	342	348	PF00069	0.404
MOD_Plk_4	359	365	PF00069	0.227
MOD_Plk_4	370	376	PF00069	0.302
MOD_Plk_4	381	387	PF00069	0.287
MOD_Plk_4	65	71	PF00069	0.405
MOD_Plk_4	88	94	PF00069	0.495
MOD_ProDKin_1	445	451	PF00069	0.631
MOD_ProDKin_1	475	481	PF00069	0.536
MOD_ProDKin_1	528	534	PF00069	0.650
MOD_ProDKin_1	545	551	PF00069	0.681
MOD_SUMO_rev_2	136	146	PF00179	0.506
TRG_DiLeu_BaEn_1	281	286	PF01217	0.394
TRG_DiLeu_BaEn_2	279	285	PF01217	0.466
TRG_ENDOCYTIC_2	334	337	PF00928	0.340
TRG_ENDOCYTIC_2	341	344	PF00928	0.247
TRG_ENDOCYTIC_2	361	364	PF00928	0.160
TRG_ENDOCYTIC_2	376	379	PF00928	0.400
TRG_ENDOCYTIC_2	430	433	PF00928	0.544
TRG_ENDOCYTIC_2	472	475	PF00928	0.381
TRG_ER_diArg_1	186	189	PF00400	0.590
TRG_ER_diArg_1	244	246	PF00400	0.651
TRG_ER_diArg_1	250	252	PF00400	0.649
TRG_ER_diArg_1	501	504	PF00400	0.538
TRG_NES_CRM1_1	233	247	PF08389	0.592
TRG_NLS_MonoExtC_3	247	252	PF00514	0.604
TRG_NLS_MonoExtN_4	245	252	PF00514	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C7	Leptomonas seymouri	50%	96%
A0A1X0NNR1	Trypanosomatidae	25%	100%
A0A3Q8ICU7	Leishmania donovani	74%	100%
A4HVJ3	Leishmania infantum	74%	100%
D0A6R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AP89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QG89	Leishmania major	71%	99%
V5AVF5	Trypanosoma cruzi	26%	100%