Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

palmitoyl acyltransferase 6, putative

Species:

Leishmania braziliensis

UniProt:

A4H754_LEIBR

TriTrypDb:

LbrM.13.0470 , LBRM2903_130010300

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0016020	membrane	2	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A4H754

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H754

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.703
CLV_C14_Caspase3-7	192	196	PF00656	0.603
CLV_C14_Caspase3-7	268	272	PF00656	0.530
CLV_C14_Caspase3-7	525	529	PF00656	0.616
CLV_MEL_PAP_1	80	86	PF00089	0.448
CLV_NRD_NRD_1	142	144	PF00675	0.415
CLV_NRD_NRD_1	245	247	PF00675	0.504
CLV_NRD_NRD_1	251	253	PF00675	0.508
CLV_NRD_NRD_1	276	278	PF00675	0.445
CLV_PCSK_KEX2_1	245	247	PF00082	0.504

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C7	Leptomonas seymouri	50%	96%
A0A1X0NNR1	Trypanosomatidae	25%	100%
A0A3Q8ICU7	Leishmania donovani	74%	100%
A4HVJ3	Leishmania infantum	74%	100%
D0A6R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AP89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QG89	Leishmania major	71%	99%
V5AVF5	Trypanosoma cruzi	26%	100%

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