t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H752_LEIBR

TriTrypDb:

LbrM.13.0450 , LBRM2903_130010000

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H752

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H752

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.558
CLV_NRD_NRD_1	150	152	PF00675	0.678
CLV_PCSK_KEX2_1	150	152	PF00082	0.678
CLV_PCSK_KEX2_1	41	43	PF00082	0.435
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.527
DEG_SPOP_SBC_1	89	93	PF00917	0.762
DOC_USP7_MATH_1	103	107	PF00917	0.723
DOC_USP7_MATH_1	146	150	PF00917	0.752
DOC_USP7_MATH_1	26	30	PF00917	0.588
DOC_USP7_MATH_1	88	92	PF00917	0.680
DOC_WW_Pin1_4	107	112	PF00397	0.642
DOC_WW_Pin1_4	120	125	PF00397	0.455
DOC_WW_Pin1_4	142	147	PF00397	0.570
DOC_WW_Pin1_4	171	176	PF00397	0.566
LIG_14-3-3_CanoR_1	114	124	PF00244	0.609
LIG_Actin_WH2_2	43	61	PF00022	0.534
LIG_BRCT_BRCA1_1	208	212	PF00533	0.604
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.659
LIG_eIF4E_1	52	58	PF01652	0.427
LIG_FHA_1	52	58	PF00498	0.427
LIG_LIR_Gen_1	194	204	PF02991	0.444
LIG_LIR_Gen_1	3	12	PF02991	0.468
LIG_LIR_Nem_3	121	125	PF02991	0.477
LIG_LIR_Nem_3	158	163	PF02991	0.476
LIG_LIR_Nem_3	194	200	PF02991	0.462
LIG_LIR_Nem_3	208	214	PF02991	0.447
LIG_LIR_Nem_3	3	8	PF02991	0.476
LIG_MLH1_MIPbox_1	208	212	PF16413	0.474
LIG_SH2_CRK	122	126	PF00017	0.491
LIG_SH2_NCK_1	73	77	PF00017	0.581
LIG_SH2_STAT5	122	125	PF00017	0.480
LIG_SH2_STAT5	217	220	PF00017	0.504
LIG_SH3_3	105	111	PF00018	0.474
LIG_SH3_3	121	127	PF00018	0.609
LIG_SH3_3	236	242	PF00018	0.442
MOD_CDK_SPxxK_3	107	114	PF00069	0.482
MOD_CK1_1	118	124	PF00069	0.693
MOD_CK1_1	134	140	PF00069	0.567
MOD_CK1_1	166	172	PF00069	0.627
MOD_CK1_1	243	249	PF00069	0.577
MOD_CK1_1	29	35	PF00069	0.560
MOD_CK1_1	60	66	PF00069	0.513
MOD_CK1_1	82	88	PF00069	0.680
MOD_CK1_1	91	97	PF00069	0.614
MOD_CK2_1	59	65	PF00069	0.411
MOD_DYRK1A_RPxSP_1	120	124	PF00069	0.477
MOD_GlcNHglycan	105	108	PF01048	0.650
MOD_GlcNHglycan	133	136	PF01048	0.658
MOD_GlcNHglycan	165	168	PF01048	0.571
MOD_GlcNHglycan	271	274	PF01048	0.525
MOD_GlcNHglycan	28	31	PF01048	0.501
MOD_GlcNHglycan	74	77	PF01048	0.635
MOD_GlcNHglycan	84	87	PF01048	0.687
MOD_GSK3_1	103	110	PF00069	0.650
MOD_GSK3_1	134	141	PF00069	0.651
MOD_GSK3_1	142	149	PF00069	0.615
MOD_GSK3_1	206	213	PF00069	0.509
MOD_GSK3_1	245	252	PF00069	0.609
MOD_GSK3_1	60	67	PF00069	0.480
MOD_N-GLC_1	103	108	PF02516	0.685
MOD_N-GLC_1	243	248	PF02516	0.471
MOD_N-GLC_1	97	102	PF02516	0.641
MOD_NEK2_1	51	56	PF00069	0.439
MOD_NEK2_1	57	62	PF00069	0.476
MOD_NEK2_1	72	77	PF00069	0.475
MOD_NEK2_1	90	95	PF00069	0.665
MOD_PIKK_1	115	121	PF00454	0.623
MOD_PIKK_1	206	212	PF00454	0.509
MOD_PIKK_1	264	270	PF00454	0.493
MOD_PIKK_1	29	35	PF00454	0.523
MOD_PIKK_1	45	51	PF00454	0.324
MOD_PIKK_1	79	85	PF00454	0.691
MOD_PKA_1	150	156	PF00069	0.670
MOD_PKA_2	113	119	PF00069	0.700
MOD_PKA_2	150	156	PF00069	0.719
MOD_Plk_1	15	21	PF00069	0.597
MOD_Plk_1	264	270	PF00069	0.493
MOD_Plk_1	64	70	PF00069	0.481
MOD_Plk_4	64	70	PF00069	0.513
MOD_ProDKin_1	107	113	PF00069	0.647
MOD_ProDKin_1	120	126	PF00069	0.454
MOD_ProDKin_1	142	148	PF00069	0.571
MOD_ProDKin_1	171	177	PF00069	0.568
MOD_SUMO_rev_2	34	43	PF00179	0.535
TRG_ENDOCYTIC_2	122	125	PF00928	0.480
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C2	Leptomonas seymouri	63%	96%
A0A3Q8I9G5	Leishmania donovani	78%	92%
A0A422NQM7	Trypanosoma rangeli	36%	100%
D0A6R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AGJ9	Leishmania infantum	78%	94%
E9AP87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	93%
Q4QG91	Leishmania major	78%	100%
V5AVG0	Trypanosoma cruzi	40%	100%