Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H751_LEIBR

TriTrypDb:

LbrM.13.0440 , LBRM2903_130009900

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H751

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H751

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.380
CLV_C14_Caspase3-7	397	401	PF00656	0.314
CLV_NRD_NRD_1	123	125	PF00675	0.725
CLV_NRD_NRD_1	185	187	PF00675	0.636
CLV_NRD_NRD_1	278	280	PF00675	0.459
CLV_NRD_NRD_1	306	308	PF00675	0.431
CLV_NRD_NRD_1	313	315	PF00675	0.422
CLV_NRD_NRD_1	329	331	PF00675	0.444
CLV_NRD_NRD_1	382	384	PF00675	0.412
CLV_PCSK_KEX2_1	123	125	PF00082	0.725
CLV_PCSK_KEX2_1	278	280	PF00082	0.459
CLV_PCSK_KEX2_1	306	308	PF00082	0.431
CLV_PCSK_KEX2_1	313	315	PF00082	0.422
CLV_PCSK_KEX2_1	329	331	PF00082	0.444
CLV_PCSK_SKI1_1	313	317	PF00082	0.459
CLV_PCSK_SKI1_1	343	347	PF00082	0.409
CLV_PCSK_SKI1_1	383	387	PF00082	0.489
CLV_PCSK_SKI1_1	410	414	PF00082	0.404
DEG_SCF_FBW7_1	103	109	PF00400	0.561
DEG_SCF_FBW7_1	214	219	PF00400	0.672
DEG_SCF_FBW7_1	43	50	PF00400	0.648
DEG_SPOP_SBC_1	135	139	PF00917	0.656
DEG_SPOP_SBC_1	157	161	PF00917	0.678
DEG_SPOP_SBC_1	176	180	PF00917	0.491
DEG_SPOP_SBC_1	90	94	PF00917	0.641
DEG_SPOP_SBC_1	96	100	PF00917	0.595
DOC_CKS1_1	103	108	PF01111	0.559
DOC_CKS1_1	20	25	PF01111	0.598
DOC_CKS1_1	213	218	PF01111	0.679
DOC_CKS1_1	44	49	PF01111	0.651
DOC_MAPK_DCC_7	414	422	PF00069	0.483
DOC_MAPK_gen_1	79	88	PF00069	0.509
DOC_MAPK_MEF2A_6	364	371	PF00069	0.319
DOC_MAPK_MEF2A_6	414	422	PF00069	0.483
DOC_MAPK_MEF2A_6	81	90	PF00069	0.513
DOC_USP7_MATH_1	106	110	PF00917	0.521
DOC_USP7_MATH_1	136	140	PF00917	0.674
DOC_USP7_MATH_1	150	154	PF00917	0.558
DOC_USP7_MATH_1	157	161	PF00917	0.637
DOC_USP7_MATH_1	171	175	PF00917	0.542
DOC_USP7_MATH_1	232	236	PF00917	0.742
DOC_USP7_MATH_1	255	259	PF00917	0.600
DOC_USP7_MATH_1	96	100	PF00917	0.609
DOC_WW_Pin1_4	102	107	PF00397	0.577
DOC_WW_Pin1_4	131	136	PF00397	0.788
DOC_WW_Pin1_4	158	163	PF00397	0.658
DOC_WW_Pin1_4	19	24	PF00397	0.569
DOC_WW_Pin1_4	212	217	PF00397	0.660
DOC_WW_Pin1_4	251	256	PF00397	0.523
DOC_WW_Pin1_4	36	41	PF00397	0.533
DOC_WW_Pin1_4	43	48	PF00397	0.604
LIG_14-3-3_CanoR_1	107	114	PF00244	0.619
LIG_14-3-3_CanoR_1	306	315	PF00244	0.422
LIG_14-3-3_CanoR_1	383	392	PF00244	0.549
LIG_14-3-3_CanoR_1	81	87	PF00244	0.514
LIG_APCC_ABBA_1	315	320	PF00400	0.422
LIG_APCC_ABBAyCdc20_2	314	320	PF00400	0.422
LIG_BRCT_BRCA1_1	97	101	PF00533	0.517
LIG_EH_1	55	59	PF12763	0.647
LIG_EVH1_1	213	217	PF00568	0.536
LIG_FHA_1	139	145	PF00498	0.623
LIG_FHA_1	177	183	PF00498	0.526
LIG_FHA_1	213	219	PF00498	0.583
LIG_FHA_1	43	49	PF00498	0.626
LIG_FHA_1	83	89	PF00498	0.655
LIG_FHA_2	167	173	PF00498	0.528
LIG_FHA_2	294	300	PF00498	0.384
LIG_FHA_2	332	338	PF00498	0.402
LIG_LIR_Apic_2	210	216	PF02991	0.621
LIG_LIR_Apic_2	9	14	PF02991	0.527
LIG_PCNA_yPIPBox_3	348	361	PF02747	0.405
LIG_SH2_CRK	11	15	PF00017	0.663
LIG_SH2_CRK	193	197	PF00017	0.542
LIG_SH2_CRK	227	231	PF00017	0.661
LIG_SH3_3	141	147	PF00018	0.561
LIG_SH3_3	211	217	PF00018	0.653
LIG_SH3_3	269	275	PF00018	0.488
LIG_SH3_3	54	60	PF00018	0.583
LIG_SUMO_SIM_anti_2	390	397	PF11976	0.413
LIG_TRAF2_1	324	327	PF00917	0.425
LIG_TRAF2_1	335	338	PF00917	0.422
LIG_TYR_ITIM	191	196	PF00017	0.495
MOD_CDK_SPK_2	102	107	PF00069	0.504
MOD_CK1_1	109	115	PF00069	0.630
MOD_CK1_1	137	143	PF00069	0.636
MOD_CK1_1	175	181	PF00069	0.535
MOD_CK1_1	219	225	PF00069	0.630
MOD_CK1_1	24	30	PF00069	0.528
MOD_CK1_1	77	83	PF00069	0.553
MOD_CK1_1	99	105	PF00069	0.710
MOD_CK2_1	166	172	PF00069	0.529
MOD_CK2_1	331	337	PF00069	0.383
MOD_Cter_Amidation	311	314	PF01082	0.425
MOD_Cter_Amidation	381	384	PF01082	0.344
MOD_GlcNHglycan	115	118	PF01048	0.712
MOD_GlcNHglycan	174	177	PF01048	0.555
MOD_GlcNHglycan	232	235	PF01048	0.649
MOD_GlcNHglycan	244	247	PF01048	0.518
MOD_GlcNHglycan	26	29	PF01048	0.514
MOD_GlcNHglycan	262	265	PF01048	0.631
MOD_GlcNHglycan	289	292	PF01048	0.549
MOD_GlcNHglycan	65	68	PF01048	0.657
MOD_GlcNHglycan	93	96	PF01048	0.582
MOD_GSK3_1	101	108	PF00069	0.525
MOD_GSK3_1	109	116	PF00069	0.495
MOD_GSK3_1	130	137	PF00069	0.816
MOD_GSK3_1	171	178	PF00069	0.588
MOD_GSK3_1	212	219	PF00069	0.657
MOD_GSK3_1	238	245	PF00069	0.787
MOD_GSK3_1	251	258	PF00069	0.598
MOD_GSK3_1	283	290	PF00069	0.531
MOD_GSK3_1	43	50	PF00069	0.677
MOD_GSK3_1	82	89	PF00069	0.786
MOD_GSK3_1	91	98	PF00069	0.571
MOD_N-GLC_1	176	181	PF02516	0.520
MOD_N-GLC_1	63	68	PF02516	0.596
MOD_N-GLC_2	16	18	PF02516	0.527
MOD_NEK2_1	130	135	PF00069	0.673
MOD_NEK2_1	308	313	PF00069	0.423
MOD_NEK2_1	341	346	PF00069	0.414
MOD_NEK2_1	86	91	PF00069	0.663
MOD_NEK2_1	97	102	PF00069	0.599
MOD_PIKK_1	148	154	PF00454	0.574
MOD_PIKK_1	22	28	PF00454	0.538
MOD_PIKK_1	74	80	PF00454	0.519
MOD_PKA_1	123	129	PF00069	0.732
MOD_PKA_1	383	389	PF00069	0.464
MOD_PKA_2	106	112	PF00069	0.625
MOD_PKA_2	123	129	PF00069	0.756
MOD_PKA_2	148	154	PF00069	0.592
MOD_PKA_2	219	225	PF00069	0.524
MOD_PKA_2	293	299	PF00069	0.388
MOD_PKA_2	390	396	PF00069	0.583
MOD_Plk_1	403	409	PF00069	0.319
MOD_Plk_2-3	293	299	PF00069	0.436
MOD_Plk_4	109	115	PF00069	0.522
MOD_Plk_4	293	299	PF00069	0.388
MOD_Plk_4	390	396	PF00069	0.473
MOD_Plk_4	403	409	PF00069	0.373
MOD_ProDKin_1	102	108	PF00069	0.578
MOD_ProDKin_1	131	137	PF00069	0.788
MOD_ProDKin_1	158	164	PF00069	0.659
MOD_ProDKin_1	19	25	PF00069	0.567
MOD_ProDKin_1	212	218	PF00069	0.660
MOD_ProDKin_1	251	257	PF00069	0.520
MOD_ProDKin_1	36	42	PF00069	0.532
MOD_ProDKin_1	43	49	PF00069	0.606
MOD_SUMO_for_1	204	207	PF00179	0.527
TRG_DiLeu_BaEn_1	337	342	PF01217	0.420
TRG_DiLeu_BaEn_4	327	333	PF01217	0.506
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.425
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.587
TRG_ENDOCYTIC_2	193	196	PF00928	0.574
TRG_ENDOCYTIC_2	227	230	PF00928	0.665
TRG_ER_diArg_1	277	279	PF00400	0.450
TRG_ER_diArg_1	306	308	PF00400	0.431
TRG_ER_diArg_1	313	315	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE7	Leptomonas seymouri	44%	100%
A0A3Q8I9J2	Leishmania donovani	70%	100%
A4HVJ1	Leishmania infantum	71%	100%
E9AP86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QG92	Leishmania major	74%	98%