Glucosamine 6-phosphate N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actyltransferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H750_LEIBR

TriTrypDb:

LbrM.13.0430 , LBRM2903_130009600

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H750

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H750

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	7
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	7
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009225	nucleotide-sugar metabolic process	4	7
GO:0009226	nucleotide-sugar biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046349	amino sugar biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004343	glucosamine 6-phosphate N-acetyltransferase activity	7	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.390
CLV_C14_Caspase3-7	26	30	PF00656	0.305
CLV_NRD_NRD_1	180	182	PF00675	0.420
CLV_PCSK_FUR_1	178	182	PF00082	0.362
CLV_PCSK_KEX2_1	180	182	PF00082	0.420
CLV_PCSK_KEX2_1	42	44	PF00082	0.336
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.336
CLV_PCSK_SKI1_1	116	120	PF00082	0.427
CLV_PCSK_SKI1_1	225	229	PF00082	0.342
CLV_PCSK_SKI1_1	231	235	PF00082	0.284
CLV_PCSK_SKI1_1	42	46	PF00082	0.450
CLV_PCSK_SKI1_1	59	63	PF00082	0.404
DEG_MDM2_SWIB_1	228	235	PF02201	0.231
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.255
DOC_MAPK_MEF2A_6	151	159	PF00069	0.636
DOC_PP2B_LxvP_1	261	264	PF13499	0.315
DOC_USP7_MATH_1	146	150	PF00917	0.536
DOC_USP7_MATH_1	273	277	PF00917	0.416
DOC_USP7_MATH_1	36	40	PF00917	0.420
DOC_USP7_UBL2_3	218	222	PF12436	0.231
LIG_14-3-3_CanoR_1	145	155	PF00244	0.529
LIG_Actin_WH2_2	104	121	PF00022	0.401
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BIR_III_4	138	142	PF00653	0.507
LIG_BRCT_BRCA1_1	240	244	PF00533	0.388
LIG_eIF4E_1	98	104	PF01652	0.357
LIG_FHA_1	2	8	PF00498	0.480
LIG_FHA_2	24	30	PF00498	0.427
LIG_FHA_2	255	261	PF00498	0.341
LIG_HP1_1	264	268	PF01393	0.255
LIG_LIR_Gen_1	188	198	PF02991	0.231
LIG_LIR_Gen_1	46	55	PF02991	0.457
LIG_LIR_Nem_3	188	194	PF02991	0.231
LIG_LIR_Nem_3	46	51	PF02991	0.432
LIG_Pex14_2	228	232	PF04695	0.388
LIG_REV1ctd_RIR_1	42	51	PF16727	0.303
LIG_SH2_CRK	245	249	PF00017	0.304
LIG_SH2_CRK	48	52	PF00017	0.323
LIG_SH2_CRK	63	67	PF00017	0.311
LIG_SH2_NCK_1	245	249	PF00017	0.388
LIG_SH2_STAT5	166	169	PF00017	0.385
LIG_SH2_STAT5	265	268	PF00017	0.231
LIG_SH2_STAT5	48	51	PF00017	0.366
LIG_SH2_STAT5	98	101	PF00017	0.342
LIG_TRAF2_1	81	84	PF00917	0.450
LIG_TYR_ITIM	61	66	PF00017	0.274
MOD_CK1_1	183	189	PF00069	0.527
MOD_CK1_1	2	8	PF00069	0.480
MOD_CK1_1	65	71	PF00069	0.433
MOD_CK2_1	254	260	PF00069	0.231
MOD_GlcNHglycan	10	13	PF01048	0.499
MOD_GlcNHglycan	124	128	PF01048	0.506
MOD_GlcNHglycan	138	142	PF01048	0.676
MOD_GlcNHglycan	18	21	PF01048	0.500
MOD_GSK3_1	185	192	PF00069	0.383
MOD_GSK3_1	46	53	PF00069	0.385
MOD_N-GLC_1	36	41	PF02516	0.408
MOD_NEK2_1	1	6	PF00069	0.646
MOD_NEK2_1	117	122	PF00069	0.601
MOD_NEK2_1	123	128	PF00069	0.518
MOD_NEK2_1	50	55	PF00069	0.362
MOD_NEK2_1	62	67	PF00069	0.403
MOD_NEK2_2	146	151	PF00069	0.561
MOD_PKA_1	180	186	PF00069	0.600
MOD_PKA_2	146	152	PF00069	0.547
MOD_PKA_2	180	186	PF00069	0.600
MOD_PKB_1	178	186	PF00069	0.468
MOD_Plk_1	162	168	PF00069	0.414
MOD_Plk_4	46	52	PF00069	0.371
MOD_SUMO_rev_2	106	111	PF00179	0.392
MOD_SUMO_rev_2	39	44	PF00179	0.384
TRG_DiLeu_BaEn_1	107	112	PF01217	0.388
TRG_DiLeu_BaEn_4	83	89	PF01217	0.353
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.415
TRG_ENDOCYTIC_2	101	104	PF00928	0.384
TRG_ENDOCYTIC_2	245	248	PF00928	0.318
TRG_ENDOCYTIC_2	265	268	PF00928	0.207
TRG_ENDOCYTIC_2	48	51	PF00928	0.366
TRG_ENDOCYTIC_2	63	66	PF00928	0.388
TRG_ER_diArg_1	144	147	PF00400	0.542
TRG_ER_diArg_1	177	180	PF00400	0.369
TRG_ER_diArg_1	66	69	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B9	Leptomonas seymouri	50%	100%
A0A3S7WSF7	Leishmania donovani	67%	100%
A4HVJ0	Leishmania infantum	67%	100%
E9AP85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QG93	Leishmania major	70%	99%