Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function, DUF607, putative

Species:

Leishmania braziliensis

UniProt:

A4H749_LEIBR

TriTrypDb:

LbrM.13.0420 , LBRM2903_130009500

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	6
GO:0016020	membrane	2	6
GO:0019866	organelle inner membrane	4	6
GO:0031090	organelle membrane	3	6
GO:0031966	mitochondrial membrane	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4H749

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H749

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	7
GO:0006874	intracellular calcium ion homeostasis	7	7
GO:0006875	obsolete intracellular metal ion homeostasis	6	7
GO:0009987	cellular process	1	7
GO:0019725	cellular homeostasis	2	7
GO:0030003	intracellular monoatomic cation homeostasis	5	7
GO:0042592	homeostatic process	3	7
GO:0048878	chemical homeostasis	4	7
GO:0050801	monoatomic ion homeostasis	5	7
GO:0051560	mitochondrial calcium ion homeostasis	8	7
GO:0055065	obsolete metal ion homeostasis	7	7
GO:0055074	calcium ion homeostasis	8	7
GO:0055080	monoatomic cation homeostasis	6	7
GO:0055082	intracellular chemical homeostasis	3	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	7
GO:0072507	obsolete divalent inorganic cation homeostasis	7	7
GO:0098771	inorganic ion homeostasis	6	7
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006851	mitochondrial calcium ion transmembrane transport	4	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0070588	calcium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005216	monoatomic ion channel activity	4	7
GO:0005261	monoatomic cation channel activity	5	7
GO:0005262	calcium channel activity	6	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	7
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015085	calcium ion transmembrane transporter activity	6	7
GO:0015267	channel activity	4	7
GO:0015291	secondary active transmembrane transporter activity	4	7
GO:0015292	uniporter activity	5	7
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022803	passive transmembrane transporter activity	3	7
GO:0022804	active transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0022890	inorganic cation transmembrane transporter activity	4	7
GO:0046873	metal ion transmembrane transporter activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.704
CLV_NRD_NRD_1	208	210	PF00675	0.251
CLV_NRD_NRD_1	292	294	PF00675	0.269
CLV_NRD_NRD_1	314	316	PF00675	0.366
CLV_NRD_NRD_1	35	37	PF00675	0.437
CLV_PCSK_KEX2_1	314	316	PF00082	0.366
CLV_PCSK_KEX2_1	320	322	PF00082	0.336
CLV_PCSK_KEX2_1	35	37	PF00082	0.437
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.274
CLV_PCSK_SKI1_1	14	18	PF00082	0.386
CLV_PCSK_SKI1_1	209	213	PF00082	0.232
CLV_PCSK_SKI1_1	315	319	PF00082	0.359
DEG_MDM2_SWIB_1	246	253	PF02201	0.269
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DEG_SPOP_SBC_1	64	68	PF00917	0.577
DEG_SPOP_SBC_1	70	74	PF00917	0.588
DOC_MAPK_gen_1	320	328	PF00069	0.635
DOC_MAPK_MEF2A_6	142	150	PF00069	0.533
DOC_MAPK_MEF2A_6	215	224	PF00069	0.475
DOC_PP4_FxxP_1	26	29	PF00568	0.610
DOC_USP7_MATH_1	30	34	PF00917	0.721
DOC_USP7_MATH_1	324	328	PF00917	0.578
DOC_USP7_MATH_1	70	74	PF00917	0.656
DOC_USP7_UBL2_3	297	301	PF12436	0.500
DOC_WW_Pin1_4	119	124	PF00397	0.662
DOC_WW_Pin1_4	153	158	PF00397	0.663
DOC_WW_Pin1_4	161	166	PF00397	0.657
DOC_WW_Pin1_4	201	206	PF00397	0.455
DOC_WW_Pin1_4	50	55	PF00397	0.656
DOC_WW_Pin1_4	75	80	PF00397	0.699
LIG_14-3-3_CanoR_1	142	150	PF00244	0.634
LIG_14-3-3_CanoR_1	177	184	PF00244	0.646
LIG_14-3-3_CanoR_1	284	288	PF00244	0.449
LIG_14-3-3_CterR_2	325	328	PF00244	0.546
LIG_Actin_WH2_2	129	144	PF00022	0.607
LIG_Actin_WH2_2	210	228	PF00022	0.516
LIG_BRCT_BRCA1_1	58	62	PF00533	0.557
LIG_FHA_1	145	151	PF00498	0.553
LIG_FHA_1	233	239	PF00498	0.340
LIG_FHA_1	255	261	PF00498	0.269
LIG_FHA_2	112	118	PF00498	0.617
LIG_FHA_2	124	130	PF00498	0.487
LIG_FHA_2	186	192	PF00498	0.469
LIG_FHA_2	39	45	PF00498	0.706
LIG_LIR_Gen_1	249	258	PF02991	0.214
LIG_LIR_Gen_1	263	273	PF02991	0.301
LIG_LIR_Gen_1	286	295	PF02991	0.496
LIG_LIR_Gen_1	86	94	PF02991	0.745
LIG_LIR_LC3C_4	235	239	PF02991	0.248
LIG_LIR_Nem_3	161	166	PF02991	0.583
LIG_LIR_Nem_3	20	25	PF02991	0.654
LIG_LIR_Nem_3	249	253	PF02991	0.224
LIG_LIR_Nem_3	256	262	PF02991	0.339
LIG_LIR_Nem_3	263	269	PF02991	0.398
LIG_LIR_Nem_3	286	290	PF02991	0.483
LIG_LIR_Nem_3	59	65	PF02991	0.558
LIG_LIR_Nem_3	86	91	PF02991	0.757
LIG_MYND_1	158	162	PF01753	0.575
LIG_NRBOX	191	197	PF00104	0.469
LIG_Pex14_1	283	287	PF04695	0.516
LIG_Pex14_2	22	26	PF04695	0.597
LIG_Pex14_2	241	245	PF04695	0.283
LIG_Pex14_2	246	250	PF04695	0.288
LIG_SH2_CRK	262	266	PF00017	0.304
LIG_SH2_STAT3	299	302	PF00017	0.411
LIG_SH2_STAT5	125	128	PF00017	0.514
LIG_SH2_STAT5	221	224	PF00017	0.485
LIG_SH2_STAT5	240	243	PF00017	0.396
LIG_SH2_STAT5	258	261	PF00017	0.304
LIG_SH2_STAT5	262	265	PF00017	0.304
LIG_SH3_3	159	165	PF00018	0.648
LIG_SH3_3	217	223	PF00018	0.516
LIG_SH3_3	26	32	PF00018	0.613
LIG_SH3_3	51	57	PF00018	0.649
LIG_SH3_3	58	64	PF00018	0.612
LIG_SUMO_SIM_par_1	230	235	PF11976	0.227
LIG_TRFH_1	26	30	PF08558	0.612
LIG_TYR_ITIM	260	265	PF00017	0.304
LIG_UBA3_1	25	31	PF00899	0.608
MOD_CK1_1	102	108	PF00069	0.746
MOD_CK1_1	144	150	PF00069	0.638
MOD_CK1_1	161	167	PF00069	0.664
MOD_CK1_1	37	43	PF00069	0.623
MOD_CK1_1	72	78	PF00069	0.689
MOD_CK1_1	87	93	PF00069	0.774
MOD_CK2_1	185	191	PF00069	0.442
MOD_GlcNHglycan	104	107	PF01048	0.437
MOD_GlcNHglycan	166	169	PF01048	0.456
MOD_GlcNHglycan	32	35	PF01048	0.533
MOD_GlcNHglycan	67	70	PF01048	0.445
MOD_GlcNHglycan	79	82	PF01048	0.463
MOD_GSK3_1	117	124	PF00069	0.662
MOD_GSK3_1	199	206	PF00069	0.435
MOD_GSK3_1	254	261	PF00069	0.224
MOD_GSK3_1	279	286	PF00069	0.526
MOD_GSK3_1	30	37	PF00069	0.621
MOD_GSK3_1	46	53	PF00069	0.576
MOD_GSK3_1	65	72	PF00069	0.644
MOD_GSK3_1	73	80	PF00069	0.619
MOD_GSK3_1	83	90	PF00069	0.653
MOD_NEK2_1	141	146	PF00069	0.533
MOD_NEK2_1	260	265	PF00069	0.310
MOD_NEK2_1	65	70	PF00069	0.577
MOD_NEK2_1	84	89	PF00069	0.670
MOD_NEK2_2	185	190	PF00069	0.469
MOD_PIKK_1	141	147	PF00454	0.521
MOD_PIKK_1	232	238	PF00454	0.248
MOD_PKA_1	209	215	PF00069	0.414
MOD_PKA_2	102	108	PF00069	0.606
MOD_PKA_2	141	147	PF00069	0.623
MOD_PKA_2	17	23	PF00069	0.585
MOD_PKA_2	283	289	PF00069	0.441
MOD_PKA_2	34	40	PF00069	0.626
MOD_PKB_1	12	20	PF00069	0.586
MOD_Plk_1	185	191	PF00069	0.469
MOD_Plk_1	199	205	PF00069	0.469
MOD_Plk_1	295	301	PF00069	0.560
MOD_Plk_4	179	185	PF00069	0.584
MOD_Plk_4	254	260	PF00069	0.280
MOD_Plk_4	265	271	PF00069	0.422
MOD_Plk_4	3	9	PF00069	0.588
MOD_ProDKin_1	119	125	PF00069	0.656
MOD_ProDKin_1	153	159	PF00069	0.665
MOD_ProDKin_1	161	167	PF00069	0.658
MOD_ProDKin_1	201	207	PF00069	0.455
MOD_ProDKin_1	50	56	PF00069	0.654
MOD_ProDKin_1	75	81	PF00069	0.694
MOD_SUMO_for_1	319	322	PF00179	0.484
TRG_DiLeu_BaEn_1	191	196	PF01217	0.469
TRG_ENDOCYTIC_2	221	224	PF00928	0.469
TRG_ENDOCYTIC_2	227	230	PF00928	0.304
TRG_ENDOCYTIC_2	262	265	PF00928	0.304
TRG_ENDOCYTIC_2	88	91	PF00928	0.688
TRG_ER_diArg_1	314	316	PF00400	0.566
TRG_NES_CRM1_1	236	249	PF08389	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI6	Leptomonas seymouri	46%	100%
A0A3S7WSE8	Leishmania donovani	75%	100%
A4HVI9	Leishmania infantum	76%	100%
E9AP84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4QG94	Leishmania major	72%	100%