UPF0301 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0301 protein

Gene product:

Uncharacterized ACR, COG1678, putative

Species:

Leishmania braziliensis

UniProt:

A4H744_LEIBR

TriTrypDb:

LbrM.13.0370 , LBRM2903_130009000

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H744

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H744

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.574
CLV_NRD_NRD_1	239	241	PF00675	0.647
CLV_NRD_NRD_1	3	5	PF00675	0.615
CLV_NRD_NRD_1	310	312	PF00675	0.602
CLV_NRD_NRD_1	349	351	PF00675	0.435
CLV_NRD_NRD_1	396	398	PF00675	0.357
CLV_NRD_NRD_1	52	54	PF00675	0.516
CLV_NRD_NRD_1	598	600	PF00675	0.619
CLV_PCSK_FUR_1	595	599	PF00082	0.618
CLV_PCSK_KEX2_1	239	241	PF00082	0.637
CLV_PCSK_KEX2_1	243	245	PF00082	0.624
CLV_PCSK_KEX2_1	3	5	PF00082	0.605
CLV_PCSK_KEX2_1	310	312	PF00082	0.602
CLV_PCSK_KEX2_1	349	351	PF00082	0.485
CLV_PCSK_KEX2_1	396	398	PF00082	0.357
CLV_PCSK_KEX2_1	52	54	PF00082	0.516
CLV_PCSK_KEX2_1	557	559	PF00082	0.546
CLV_PCSK_KEX2_1	594	596	PF00082	0.615
CLV_PCSK_KEX2_1	597	599	PF00082	0.606
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.513
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.546
CLV_PCSK_PC1ET2_1	594	596	PF00082	0.612
CLV_PCSK_PC7_1	239	245	PF00082	0.541
CLV_PCSK_PC7_1	345	351	PF00082	0.378
CLV_PCSK_SKI1_1	187	191	PF00082	0.617
CLV_PCSK_SKI1_1	239	243	PF00082	0.503
CLV_PCSK_SKI1_1	345	349	PF00082	0.383
CLV_PCSK_SKI1_1	350	354	PF00082	0.377
CLV_PCSK_SKI1_1	397	401	PF00082	0.357
CLV_PCSK_SKI1_1	44	48	PF00082	0.577
CLV_PCSK_SKI1_1	588	592	PF00082	0.497
DEG_APCC_DBOX_1	349	357	PF00400	0.357
DEG_APCC_DBOX_1	43	51	PF00400	0.514
DEG_Nend_UBRbox_4	1	3	PF02207	0.474
DEG_SPOP_SBC_1	193	197	PF00917	0.669
DOC_MAPK_gen_1	349	356	PF00069	0.331
DOC_MAPK_MEF2A_6	132	140	PF00069	0.614
DOC_MAPK_MEF2A_6	349	356	PF00069	0.215
DOC_PP1_RVXF_1	298	304	PF00149	0.518
DOC_PP1_RVXF_1	586	593	PF00149	0.445
DOC_USP7_MATH_1	104	108	PF00917	0.570
DOC_USP7_MATH_1	115	119	PF00917	0.555
DOC_USP7_MATH_1	120	124	PF00917	0.499
DOC_USP7_MATH_1	193	197	PF00917	0.669
DOC_USP7_MATH_1	260	264	PF00917	0.696
DOC_USP7_MATH_1	295	299	PF00917	0.691
DOC_USP7_MATH_1	409	413	PF00917	0.363
DOC_USP7_MATH_1	434	438	PF00917	0.351
DOC_USP7_MATH_1	527	531	PF00917	0.694
DOC_USP7_MATH_1	618	622	PF00917	0.456
DOC_USP7_MATH_1	94	98	PF00917	0.659
DOC_WW_Pin1_4	154	159	PF00397	0.515
DOC_WW_Pin1_4	265	270	PF00397	0.618
DOC_WW_Pin1_4	55	60	PF00397	0.590
LIG_14-3-3_CanoR_1	122	128	PF00244	0.670
LIG_14-3-3_CanoR_1	132	137	PF00244	0.604
LIG_14-3-3_CanoR_1	231	235	PF00244	0.701
LIG_14-3-3_CanoR_1	244	254	PF00244	0.656
LIG_14-3-3_CanoR_1	349	353	PF00244	0.292
LIG_14-3-3_CanoR_1	396	406	PF00244	0.336
LIG_14-3-3_CanoR_1	617	623	PF00244	0.462
LIG_BRCT_BRCA1_1	42	46	PF00533	0.584
LIG_deltaCOP1_diTrp_1	29	33	PF00928	0.575
LIG_deltaCOP1_diTrp_1	37	46	PF00928	0.581
LIG_FAT_LD_1	445	453	PF03623	0.351
LIG_FHA_1	123	129	PF00498	0.656
LIG_FHA_1	133	139	PF00498	0.634
LIG_FHA_1	145	151	PF00498	0.450
LIG_FHA_1	253	259	PF00498	0.522
LIG_FHA_1	349	355	PF00498	0.351
LIG_FHA_1	383	389	PF00498	0.319
LIG_FHA_1	401	407	PF00498	0.433
LIG_FHA_2	43	49	PF00498	0.633
LIG_FHA_2	513	519	PF00498	0.637
LIG_LIR_Apic_2	58	64	PF02991	0.549
LIG_LIR_Gen_1	165	176	PF02991	0.570
LIG_LIR_Gen_1	302	308	PF02991	0.555
LIG_LIR_Nem_3	165	171	PF02991	0.568
LIG_LIR_Nem_3	29	33	PF02991	0.575
LIG_LIR_Nem_3	302	306	PF02991	0.558
LIG_Pex14_1	615	619	PF04695	0.380
LIG_REV1ctd_RIR_1	345	354	PF16727	0.292
LIG_SH2_CRK	143	147	PF00017	0.543
LIG_SH2_CRK	619	623	PF00017	0.410
LIG_SH2_NCK_1	619	623	PF00017	0.474
LIG_SH2_NCK_1	84	88	PF00017	0.454
LIG_SH2_PTP2	61	64	PF00017	0.605
LIG_SH2_SRC	61	64	PF00017	0.708
LIG_SH2_STAP1	23	27	PF00017	0.568
LIG_SH2_STAP1	626	630	PF00017	0.440
LIG_SH2_STAT3	76	79	PF00017	0.540
LIG_SH2_STAT5	176	179	PF00017	0.507
LIG_SH2_STAT5	61	64	PF00017	0.586
LIG_SH2_STAT5	84	87	PF00017	0.451
LIG_SH3_3	266	272	PF00018	0.529
LIG_SH3_3	424	430	PF00018	0.357
LIG_SH3_3	60	66	PF00018	0.607
LIG_SH3_3	619	625	PF00018	0.491
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.292
LIG_SUMO_SIM_anti_2	444	449	PF11976	0.465
LIG_SUMO_SIM_anti_2	460	467	PF11976	0.208
LIG_TRAF2_1	314	317	PF00917	0.677
LIG_TRAF2_1	458	461	PF00917	0.357
LIG_TRAF2_2	19	24	PF00917	0.553
LIG_TYR_ITIM	141	146	PF00017	0.566
LIG_WW_2	63	66	PF00397	0.599
MOD_CK1_1	106	112	PF00069	0.744
MOD_CK1_1	118	124	PF00069	0.625
MOD_CK1_1	144	150	PF00069	0.494
MOD_CK1_1	162	168	PF00069	0.564
MOD_CK1_1	195	201	PF00069	0.652
MOD_CK1_1	245	251	PF00069	0.695
MOD_CK1_1	340	346	PF00069	0.619
MOD_CK1_1	412	418	PF00069	0.310
MOD_CK1_1	490	496	PF00069	0.351
MOD_CK1_1	531	537	PF00069	0.551
MOD_CK1_1	82	88	PF00069	0.567
MOD_CK2_1	104	110	PF00069	0.660
MOD_CK2_1	290	296	PF00069	0.537
MOD_CK2_1	311	317	PF00069	0.730
MOD_CK2_1	412	418	PF00069	0.241
MOD_CK2_1	455	461	PF00069	0.357
MOD_CK2_1	529	535	PF00069	0.691
MOD_GlcNHglycan	106	109	PF01048	0.624
MOD_GlcNHglycan	116	120	PF01048	0.598
MOD_GlcNHglycan	143	146	PF01048	0.528
MOD_GlcNHglycan	181	184	PF01048	0.477
MOD_GlcNHglycan	262	265	PF01048	0.662
MOD_GlcNHglycan	313	316	PF01048	0.621
MOD_GlcNHglycan	322	325	PF01048	0.567
MOD_GlcNHglycan	362	365	PF01048	0.322
MOD_GlcNHglycan	411	414	PF01048	0.383
MOD_GlcNHglycan	456	460	PF01048	0.431
MOD_GlcNHglycan	489	492	PF01048	0.351
MOD_GlcNHglycan	545	548	PF01048	0.653
MOD_GlcNHglycan	96	99	PF01048	0.592
MOD_GSK3_1	100	107	PF00069	0.700
MOD_GSK3_1	118	125	PF00069	0.640
MOD_GSK3_1	192	199	PF00069	0.607
MOD_GSK3_1	316	323	PF00069	0.665
MOD_GSK3_1	378	385	PF00069	0.351
MOD_GSK3_1	412	419	PF00069	0.319
MOD_GSK3_1	490	497	PF00069	0.335
MOD_GSK3_1	501	508	PF00069	0.373
MOD_GSK3_1	521	528	PF00069	0.626
MOD_GSK3_1	79	86	PF00069	0.496
MOD_N-GLC_1	162	167	PF02516	0.569
MOD_N-GLC_1	33	38	PF02516	0.526
MOD_N-GLC_1	55	60	PF02516	0.590
MOD_NEK2_1	159	164	PF00069	0.560
MOD_NEK2_1	218	223	PF00069	0.554
MOD_NEK2_1	337	342	PF00069	0.495
MOD_NEK2_1	348	353	PF00069	0.257
MOD_NEK2_1	360	365	PF00069	0.292
MOD_NEK2_1	411	416	PF00069	0.344
MOD_NEK2_1	501	506	PF00069	0.435
MOD_NEK2_1	83	88	PF00069	0.473
MOD_NEK2_2	295	300	PF00069	0.522
MOD_NEK2_2	66	71	PF00069	0.438
MOD_PIKK_1	10	16	PF00454	0.577
MOD_PIKK_1	397	403	PF00454	0.241
MOD_PIKK_1	512	518	PF00454	0.640
MOD_PKA_1	242	248	PF00069	0.669
MOD_PKA_2	121	127	PF00069	0.670
MOD_PKA_2	131	137	PF00069	0.607
MOD_PKA_2	230	236	PF00069	0.561
MOD_PKA_2	243	249	PF00069	0.570
MOD_PKA_2	348	354	PF00069	0.292
MOD_PKA_2	506	512	PF00069	0.694
MOD_Plk_1	295	301	PF00069	0.593
MOD_Plk_1	378	384	PF00069	0.301
MOD_Plk_1	416	422	PF00069	0.335
MOD_Plk_1	494	500	PF00069	0.467
MOD_Plk_1	5	11	PF00069	0.572
MOD_Plk_1	564	570	PF00069	0.611
MOD_Plk_2-3	290	296	PF00069	0.537
MOD_Plk_2-3	42	48	PF00069	0.672
MOD_Plk_4	218	224	PF00069	0.545
MOD_Plk_4	400	406	PF00069	0.356
MOD_Plk_4	416	422	PF00069	0.298
MOD_Plk_4	611	617	PF00069	0.455
MOD_Plk_4	79	85	PF00069	0.548
MOD_ProDKin_1	154	160	PF00069	0.512
MOD_ProDKin_1	265	271	PF00069	0.610
MOD_ProDKin_1	55	61	PF00069	0.591
MOD_SUMO_for_1	568	571	PF00179	0.598
MOD_SUMO_rev_2	327	335	PF00179	0.573
MOD_SUMO_rev_2	36	41	PF00179	0.579
MOD_SUMO_rev_2	551	559	PF00179	0.539
TRG_DiLeu_BaEn_1	334	339	PF01217	0.471
TRG_DiLeu_BaEn_1	362	367	PF01217	0.450
TRG_DiLeu_BaEn_1	418	423	PF01217	0.241
TRG_DiLeu_BaEn_2	41	47	PF01217	0.583
TRG_DiLeu_BaEn_3	316	322	PF01217	0.616
TRG_ENDOCYTIC_2	143	146	PF00928	0.545
TRG_ENDOCYTIC_2	485	488	PF00928	0.351
TRG_ENDOCYTIC_2	619	622	PF00928	0.406
TRG_ENDOCYTIC_2	626	629	PF00928	0.445
TRG_ER_diArg_1	3	5	PF00400	0.605
TRG_ER_diArg_1	348	350	PF00400	0.442
TRG_ER_diArg_1	395	397	PF00400	0.357
TRG_ER_diArg_1	51	53	PF00400	0.512
TRG_ER_diArg_1	595	598	PF00400	0.615
TRG_NLS_MonoCore_2	593	598	PF00514	0.608
TRG_NLS_MonoExtC_3	593	598	PF00514	0.608
TRG_NLS_MonoExtN_4	239	246	PF00514	0.506
TRG_NLS_MonoExtN_4	591	598	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM6	Leptomonas seymouri	56%	98%
A0A3R7KQL9	Trypanosoma rangeli	35%	100%
A0A3S7WSH5	Leishmania donovani	80%	97%
A4HVI4	Leishmania infantum	80%	97%
E9AP79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	97%
Q4QG99	Leishmania major	80%	100%