Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H743_LEIBR

TriTrypDb:

LbrM.13.0360 , LBRM2903_130008900

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H743

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H743

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.497
CLV_NRD_NRD_1	54	56	PF00675	0.438
CLV_PCSK_FUR_1	45	49	PF00082	0.490
CLV_PCSK_FUR_1	52	56	PF00082	0.417
CLV_PCSK_KEX2_1	178	180	PF00082	0.444
CLV_PCSK_KEX2_1	47	49	PF00082	0.463
CLV_PCSK_KEX2_1	52	54	PF00082	0.435
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.456
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.490
CLV_PCSK_PC7_1	48	54	PF00082	0.325
CLV_PCSK_SKI1_1	128	132	PF00082	0.453
CLV_PCSK_SKI1_1	33	37	PF00082	0.456
CLV_PCSK_SKI1_1	86	90	PF00082	0.444
DEG_APCC_DBOX_1	127	135	PF00400	0.339
DEG_CRL4_CDT2_1	38	49	PF00400	0.689
DEG_CRL4_CDT2_2	38	49	PF00400	0.689
DEG_Nend_UBRbox_3	1	3	PF02207	0.682
DEG_SCF_FBW7_1	1	7	PF00400	0.601
DOC_CKS1_1	1	6	PF01111	0.780
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.417
DOC_MAPK_DCC_7	128	136	PF00069	0.339
DOC_MAPK_MEF2A_6	128	136	PF00069	0.339
DOC_PP2B_LxvP_1	129	132	PF13499	0.417
DOC_USP7_MATH_1	35	39	PF00917	0.698
DOC_USP7_MATH_1	67	71	PF00917	0.757
DOC_USP7_MATH_1	82	86	PF00917	0.670
DOC_USP7_UBL2_3	178	182	PF12436	0.738
DOC_WW_Pin1_4	188	193	PF00397	0.672
DOC_WW_Pin1_4	73	78	PF00397	0.739
LIG_14-3-3_CanoR_1	24	29	PF00244	0.653
LIG_14-3-3_CanoR_1	81	88	PF00244	0.691
LIG_BRCT_BRCA1_1	96	100	PF00533	0.564
LIG_FHA_1	139	145	PF00498	0.308
LIG_FHA_1	82	88	PF00498	0.631
LIG_FHA_2	185	191	PF00498	0.673
LIG_LIR_Gen_1	25	35	PF02991	0.593
LIG_LIR_Gen_1	93	101	PF02991	0.612
LIG_LIR_Nem_3	25	31	PF02991	0.594
LIG_LIR_Nem_3	93	99	PF02991	0.534
LIG_MLH1_MIPbox_1	96	100	PF16413	0.564
LIG_Pex14_1	96	100	PF04695	0.550
LIG_SH2_GRB2like	125	128	PF00017	0.386
LIG_SH2_GRB2like	157	160	PF00017	0.542
LIG_SH2_NCK_1	28	32	PF00017	0.671
LIG_SH2_SRC	28	31	PF00017	0.593
LIG_SH2_STAP1	28	32	PF00017	0.652
LIG_SH2_STAT5	121	124	PF00017	0.447
LIG_SH2_STAT5	157	160	PF00017	0.624
LIG_SH2_STAT5	49	52	PF00017	0.629
LIG_SH3_3	129	135	PF00018	0.274
LIG_TRAF2_1	187	190	PF00917	0.606
LIG_TYR_ITIM	26	31	PF00017	0.585
MOD_CK1_1	113	119	PF00069	0.277
MOD_CK1_1	38	44	PF00069	0.693
MOD_CK1_1	92	98	PF00069	0.556
MOD_CK2_1	184	190	PF00069	0.660
MOD_CK2_1	24	30	PF00069	0.600
MOD_CMANNOS	142	145	PF00535	0.289
MOD_GlcNHglycan	102	105	PF01048	0.381
MOD_GlcNHglycan	58	61	PF01048	0.444
MOD_GlcNHglycan	69	72	PF01048	0.474
MOD_GlcNHglycan	9	12	PF01048	0.492
MOD_GlcNHglycan	92	95	PF01048	0.412
MOD_GSK3_1	106	113	PF00069	0.226
MOD_GSK3_1	18	25	PF00069	0.711
MOD_GSK3_1	184	191	PF00069	0.557
MOD_GSK3_1	90	97	PF00069	0.607
MOD_N-GLC_1	18	23	PF02516	0.390
MOD_N-GLC_1	7	12	PF02516	0.499
MOD_NEK2_1	100	105	PF00069	0.595
MOD_NEK2_2	94	99	PF00069	0.617
MOD_PKA_2	80	86	PF00069	0.691
MOD_Plk_4	35	41	PF00069	0.685
MOD_ProDKin_1	188	194	PF00069	0.672
MOD_ProDKin_1	73	79	PF00069	0.742
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.624
TRG_ENDOCYTIC_2	121	124	PF00928	0.487
TRG_ENDOCYTIC_2	28	31	PF00928	0.583
TRG_ER_diArg_1	179	181	PF00400	0.735
TRG_ER_diArg_1	52	55	PF00400	0.636
TRG_NLS_MonoCore_2	177	182	PF00514	0.731
TRG_NLS_MonoExtC_3	177	182	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE47	Leptomonas seymouri	75%	100%
A0A0S4J5J9	Bodo saltans	39%	100%
A0A1X0NNT8	Trypanosomatidae	43%	96%
A0A3Q8IHY4	Leishmania donovani	85%	100%
A0A3R7MTA4	Trypanosoma rangeli	50%	100%
A4HVI3	Leishmania infantum	85%	100%
D0A6S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AP78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QGA0	Leishmania major	84%	100%
V5DBH6	Trypanosoma cruzi	48%	100%