Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H742_LEIBR

TriTrypDb:

LbrM.13.0350 , LBRM2903_130008800

Length:

986

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H742

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H742

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.475
CLV_C14_Caspase3-7	866	870	PF00656	0.521
CLV_C14_Caspase3-7	935	939	PF00656	0.553
CLV_NRD_NRD_1	209	211	PF00675	0.463
CLV_NRD_NRD_1	261	263	PF00675	0.517
CLV_NRD_NRD_1	339	341	PF00675	0.509
CLV_NRD_NRD_1	356	358	PF00675	0.364
CLV_NRD_NRD_1	45	47	PF00675	0.426
CLV_NRD_NRD_1	450	452	PF00675	0.490
CLV_NRD_NRD_1	547	549	PF00675	0.469
CLV_NRD_NRD_1	554	556	PF00675	0.415
CLV_NRD_NRD_1	562	564	PF00675	0.386
CLV_NRD_NRD_1	625	627	PF00675	0.460
CLV_NRD_NRD_1	629	631	PF00675	0.469
CLV_NRD_NRD_1	727	729	PF00675	0.574
CLV_PCSK_FUR_1	337	341	PF00082	0.506
CLV_PCSK_FUR_1	354	358	PF00082	0.450
CLV_PCSK_KEX2_1	184	186	PF00082	0.551
CLV_PCSK_KEX2_1	209	211	PF00082	0.477
CLV_PCSK_KEX2_1	261	263	PF00082	0.478
CLV_PCSK_KEX2_1	337	339	PF00082	0.466
CLV_PCSK_KEX2_1	356	358	PF00082	0.369
CLV_PCSK_KEX2_1	45	47	PF00082	0.500
CLV_PCSK_KEX2_1	450	452	PF00082	0.588
CLV_PCSK_KEX2_1	547	549	PF00082	0.463
CLV_PCSK_KEX2_1	554	556	PF00082	0.412
CLV_PCSK_KEX2_1	629	631	PF00082	0.474
CLV_PCSK_KEX2_1	726	728	PF00082	0.715
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.551
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.665
CLV_PCSK_PC7_1	543	549	PF00082	0.534
CLV_PCSK_SKI1_1	123	127	PF00082	0.485
CLV_PCSK_SKI1_1	224	228	PF00082	0.450
CLV_PCSK_SKI1_1	245	249	PF00082	0.384
CLV_PCSK_SKI1_1	280	284	PF00082	0.481
CLV_PCSK_SKI1_1	451	455	PF00082	0.531
CLV_PCSK_SKI1_1	548	552	PF00082	0.460
CLV_PCSK_SKI1_1	917	921	PF00082	0.483
CLV_PCSK_SKI1_1	942	946	PF00082	0.519
DEG_Nend_UBRbox_2	1	3	PF02207	0.381
DEG_SPOP_SBC_1	141	145	PF00917	0.485
DEG_SPOP_SBC_1	375	379	PF00917	0.461
DEG_SPOP_SBC_1	503	507	PF00917	0.568
DEG_SPOP_SBC_1	979	983	PF00917	0.526
DOC_CYCLIN_RxL_1	242	251	PF00134	0.304
DOC_CYCLIN_RxL_1	543	553	PF00134	0.487
DOC_MAPK_gen_1	102	112	PF00069	0.537
DOC_MAPK_MEF2A_6	105	114	PF00069	0.538
DOC_MAPK_MEF2A_6	594	603	PF00069	0.555
DOC_PP2B_LxvP_1	500	503	PF13499	0.602
DOC_PP4_FxxP_1	850	853	PF00568	0.562
DOC_USP7_MATH_1	141	145	PF00917	0.556
DOC_USP7_MATH_1	189	193	PF00917	0.368
DOC_USP7_MATH_1	204	208	PF00917	0.454
DOC_USP7_MATH_1	376	380	PF00917	0.613
DOC_USP7_MATH_1	496	500	PF00917	0.566
DOC_USP7_MATH_1	503	507	PF00917	0.623
DOC_USP7_MATH_1	59	63	PF00917	0.511
DOC_USP7_MATH_1	678	682	PF00917	0.636
DOC_USP7_MATH_1	709	713	PF00917	0.719
DOC_USP7_MATH_1	745	749	PF00917	0.749
DOC_USP7_MATH_1	755	759	PF00917	0.640
DOC_USP7_MATH_1	874	878	PF00917	0.627
DOC_USP7_MATH_1	880	884	PF00917	0.574
DOC_USP7_MATH_1	959	963	PF00917	0.662
DOC_USP7_MATH_1	979	983	PF00917	0.492
DOC_WW_Pin1_4	154	159	PF00397	0.490
DOC_WW_Pin1_4	505	510	PF00397	0.594
DOC_WW_Pin1_4	707	712	PF00397	0.595
DOC_WW_Pin1_4	714	719	PF00397	0.602
DOC_WW_Pin1_4	738	743	PF00397	0.611
DOC_WW_Pin1_4	849	854	PF00397	0.596
DOC_WW_Pin1_4	893	898	PF00397	0.682
DOC_WW_Pin1_4	975	980	PF00397	0.556
LIG_14-3-3_CanoR_1	268	275	PF00244	0.438
LIG_14-3-3_CanoR_1	364	368	PF00244	0.408
LIG_14-3-3_CanoR_1	451	461	PF00244	0.629
LIG_14-3-3_CanoR_1	547	551	PF00244	0.559
LIG_14-3-3_CanoR_1	554	562	PF00244	0.503
LIG_14-3-3_CanoR_1	594	601	PF00244	0.591
LIG_14-3-3_CanoR_1	828	834	PF00244	0.631
LIG_14-3-3_CanoR_1	862	872	PF00244	0.507
LIG_Actin_WH2_2	171	189	PF00022	0.548
LIG_Actin_WH2_2	341	358	PF00022	0.362
LIG_Actin_WH2_2	385	403	PF00022	0.660
LIG_APCC_ABBA_1	114	119	PF00400	0.548
LIG_BIR_III_4	153	157	PF00653	0.488
LIG_BRCT_BRCA1_1	719	723	PF00533	0.662
LIG_CaM_IQ_9	272	287	PF13499	0.389
LIG_CaM_IQ_9	533	549	PF13499	0.504
LIG_Clathr_ClatBox_1	21	25	PF01394	0.510
LIG_eIF4E_1	242	248	PF01652	0.346
LIG_FHA_1	129	135	PF00498	0.534
LIG_FHA_1	162	168	PF00498	0.482
LIG_FHA_1	17	23	PF00498	0.472
LIG_FHA_1	197	203	PF00498	0.417
LIG_FHA_1	24	30	PF00498	0.391
LIG_FHA_1	347	353	PF00498	0.553
LIG_FHA_1	452	458	PF00498	0.478
LIG_FHA_1	466	472	PF00498	0.402
LIG_FHA_1	52	58	PF00498	0.375
LIG_FHA_1	528	534	PF00498	0.504
LIG_FHA_1	594	600	PF00498	0.378
LIG_FHA_1	633	639	PF00498	0.598
LIG_FHA_1	659	665	PF00498	0.746
LIG_FHA_1	669	675	PF00498	0.716
LIG_FHA_1	840	846	PF00498	0.677
LIG_FHA_1	883	889	PF00498	0.484
LIG_FHA_1	958	964	PF00498	0.643
LIG_FHA_2	163	169	PF00498	0.598
LIG_FHA_2	308	314	PF00498	0.500
LIG_FHA_2	31	37	PF00498	0.558
LIG_FHA_2	668	674	PF00498	0.506
LIG_FHA_2	830	836	PF00498	0.491
LIG_FHA_2	854	860	PF00498	0.513
LIG_FHA_2	926	932	PF00498	0.606
LIG_FHA_2	943	949	PF00498	0.689
LIG_LIR_Apic_2	518	524	PF02991	0.609
LIG_LIR_Apic_2	849	853	PF02991	0.566
LIG_LIR_Gen_1	298	308	PF02991	0.419
LIG_LIR_Gen_1	366	375	PF02991	0.475
LIG_LIR_Gen_1	684	692	PF02991	0.631
LIG_LIR_Gen_1	753	763	PF02991	0.512
LIG_LIR_Gen_1	823	834	PF02991	0.493
LIG_LIR_Gen_1	924	933	PF02991	0.674
LIG_LIR_Gen_1	967	976	PF02991	0.611
LIG_LIR_Nem_3	298	304	PF02991	0.423
LIG_LIR_Nem_3	366	370	PF02991	0.462
LIG_LIR_Nem_3	650	654	PF02991	0.527
LIG_LIR_Nem_3	684	690	PF02991	0.694
LIG_LIR_Nem_3	753	759	PF02991	0.512
LIG_LIR_Nem_3	823	829	PF02991	0.496
LIG_LIR_Nem_3	924	929	PF02991	0.674
LIG_LIR_Nem_3	967	972	PF02991	0.608
LIG_LYPXL_SIV_4	116	124	PF13949	0.518
LIG_NRBOX	274	280	PF00104	0.507
LIG_REV1ctd_RIR_1	224	233	PF16727	0.391
LIG_RPA_C_Fungi	410	422	PF08784	0.380
LIG_SH2_CRK	301	305	PF00017	0.332
LIG_SH2_CRK	521	525	PF00017	0.596
LIG_SH2_CRK	826	830	PF00017	0.493
LIG_SH2_NCK_1	117	121	PF00017	0.513
LIG_SH2_NCK_1	521	525	PF00017	0.596
LIG_SH2_STAP1	64	68	PF00017	0.511
LIG_SH2_STAT5	181	184	PF00017	0.524
LIG_SH2_STAT5	196	199	PF00017	0.505
LIG_SH2_STAT5	516	519	PF00017	0.638
LIG_SH2_STAT5	52	55	PF00017	0.571
LIG_SH2_STAT5	561	564	PF00017	0.354
LIG_SH2_STAT5	826	829	PF00017	0.497
LIG_SH2_STAT5	932	935	PF00017	0.489
LIG_SH3_3	152	158	PF00018	0.473
LIG_SH3_3	705	711	PF00018	0.555
LIG_SH3_3	728	734	PF00018	0.642
LIG_Sin3_3	969	976	PF02671	0.444
LIG_SUMO_SIM_par_1	17	27	PF11976	0.526
LIG_TRAF2_1	296	299	PF00917	0.517
LIG_TRAF2_1	928	931	PF00917	0.655
LIG_WW_3	914	918	PF00397	0.474
MOD_CDK_SPK_2	849	854	PF00069	0.539
MOD_CK1_1	128	134	PF00069	0.580
MOD_CK1_1	142	148	PF00069	0.633
MOD_CK1_1	409	415	PF00069	0.430
MOD_CK1_1	456	462	PF00069	0.496
MOD_CK1_1	505	511	PF00069	0.570
MOD_CK1_1	681	687	PF00069	0.670
MOD_CK1_1	710	716	PF00069	0.641
MOD_CK1_1	717	723	PF00069	0.602
MOD_CK1_1	748	754	PF00069	0.698
MOD_CK1_1	922	928	PF00069	0.618
MOD_CK1_1	978	984	PF00069	0.649
MOD_CK2_1	162	168	PF00069	0.560
MOD_CK2_1	30	36	PF00069	0.518
MOD_CK2_1	307	313	PF00069	0.598
MOD_CK2_1	344	350	PF00069	0.550
MOD_CK2_1	740	746	PF00069	0.747
MOD_CK2_1	829	835	PF00069	0.491
MOD_CK2_1	853	859	PF00069	0.509
MOD_CK2_1	924	930	PF00069	0.601
MOD_GlcNHglycan	158	161	PF01048	0.715
MOD_GlcNHglycan	357	360	PF01048	0.490
MOD_GlcNHglycan	404	407	PF01048	0.640
MOD_GlcNHglycan	408	411	PF01048	0.554
MOD_GlcNHglycan	426	429	PF01048	0.394
MOD_GlcNHglycan	558	561	PF01048	0.346
MOD_GlcNHglycan	583	586	PF01048	0.533
MOD_GlcNHglycan	703	706	PF01048	0.772
MOD_GlcNHglycan	793	796	PF01048	0.655
MOD_GlcNHglycan	935	938	PF01048	0.753
MOD_GSK3_1	135	142	PF00069	0.657
MOD_GSK3_1	156	163	PF00069	0.606
MOD_GSK3_1	280	287	PF00069	0.510
MOD_GSK3_1	402	409	PF00069	0.484
MOD_GSK3_1	452	459	PF00069	0.652
MOD_GSK3_1	504	511	PF00069	0.533
MOD_GSK3_1	546	553	PF00069	0.481
MOD_GSK3_1	581	588	PF00069	0.561
MOD_GSK3_1	628	635	PF00069	0.422
MOD_GSK3_1	663	670	PF00069	0.635
MOD_GSK3_1	681	688	PF00069	0.784
MOD_GSK3_1	690	697	PF00069	0.648
MOD_GSK3_1	710	717	PF00069	0.543
MOD_GSK3_1	741	748	PF00069	0.715
MOD_GSK3_1	750	757	PF00069	0.615
MOD_GSK3_1	769	776	PF00069	0.498
MOD_GSK3_1	778	785	PF00069	0.663
MOD_GSK3_1	849	856	PF00069	0.631
MOD_GSK3_1	864	871	PF00069	0.605
MOD_GSK3_1	888	895	PF00069	0.650
MOD_GSK3_1	917	924	PF00069	0.488
MOD_GSK3_1	971	978	PF00069	0.501
MOD_N-GLC_1	681	686	PF02516	0.636
MOD_N-GLC_1	694	699	PF02516	0.548
MOD_NEK2_1	162	167	PF00069	0.446
MOD_NEK2_1	197	202	PF00069	0.325
MOD_NEK2_1	24	29	PF00069	0.370
MOD_NEK2_1	286	291	PF00069	0.342
MOD_NEK2_1	453	458	PF00069	0.469
MOD_NEK2_1	465	470	PF00069	0.545
MOD_NEK2_1	550	555	PF00069	0.531
MOD_NEK2_1	647	652	PF00069	0.543
MOD_NEK2_1	829	834	PF00069	0.504
MOD_NEK2_1	868	873	PF00069	0.568
MOD_NEK2_1	919	924	PF00069	0.546
MOD_NEK2_1	957	962	PF00069	0.673
MOD_NEK2_2	204	209	PF00069	0.482
MOD_PIKK_1	162	168	PF00454	0.459
MOD_PIKK_1	287	293	PF00454	0.582
MOD_PIKK_1	376	382	PF00454	0.612
MOD_PIKK_1	585	591	PF00454	0.523
MOD_PIKK_1	593	599	PF00454	0.514
MOD_PIKK_1	663	669	PF00454	0.484
MOD_PIKK_1	750	756	PF00454	0.659
MOD_PIKK_1	782	788	PF00454	0.662
MOD_PIKK_1	919	925	PF00454	0.636
MOD_PKA_1	701	707	PF00069	0.682
MOD_PKA_2	189	195	PF00069	0.434
MOD_PKA_2	355	361	PF00069	0.558
MOD_PKA_2	363	369	PF00069	0.587
MOD_PKA_2	546	552	PF00069	0.566
MOD_PKA_2	593	599	PF00069	0.501
MOD_PKA_2	628	634	PF00069	0.523
MOD_PKA_2	827	833	PF00069	0.630
MOD_PKA_2	853	859	PF00069	0.707
MOD_PKB_1	541	549	PF00069	0.354
MOD_Plk_1	167	173	PF00069	0.397
MOD_Plk_1	24	30	PF00069	0.376
MOD_Plk_1	694	700	PF00069	0.584
MOD_Plk_1	820	826	PF00069	0.634
MOD_Plk_1	830	836	PF00069	0.547
MOD_Plk_1	868	874	PF00069	0.626
MOD_Plk_1	917	923	PF00069	0.487
MOD_Plk_2-3	344	350	PF00069	0.520
MOD_Plk_2-3	74	80	PF00069	0.423
MOD_Plk_4	130	136	PF00069	0.448
MOD_Plk_4	189	195	PF00069	0.329
MOD_Plk_4	24	30	PF00069	0.504
MOD_Plk_4	307	313	PF00069	0.501
MOD_Plk_4	437	443	PF00069	0.594
MOD_Plk_4	496	502	PF00069	0.577
MOD_Plk_4	755	761	PF00069	0.513
MOD_Plk_4	874	880	PF00069	0.541
MOD_ProDKin_1	154	160	PF00069	0.489
MOD_ProDKin_1	505	511	PF00069	0.594
MOD_ProDKin_1	707	713	PF00069	0.598
MOD_ProDKin_1	714	720	PF00069	0.601
MOD_ProDKin_1	738	744	PF00069	0.613
MOD_ProDKin_1	849	855	PF00069	0.596
MOD_ProDKin_1	893	899	PF00069	0.681
MOD_ProDKin_1	975	981	PF00069	0.560
MOD_SUMO_for_1	15	18	PF00179	0.385
MOD_SUMO_rev_2	44	51	PF00179	0.407
TRG_DiLeu_BaEn_1	106	111	PF01217	0.513
TRG_DiLeu_BaEn_1	17	22	PF01217	0.517
TRG_DiLeu_BaEn_1	25	30	PF01217	0.507
TRG_DiLeu_BaEn_1	299	304	PF01217	0.482
TRG_DiLeu_BaEn_4	17	23	PF01217	0.504
TRG_DiLeu_BaEn_4	387	393	PF01217	0.595
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.494
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.503
TRG_ENDOCYTIC_2	238	241	PF00928	0.434
TRG_ENDOCYTIC_2	301	304	PF00928	0.334
TRG_ENDOCYTIC_2	826	829	PF00928	0.497
TRG_ER_diArg_1	208	210	PF00400	0.477
TRG_ER_diArg_1	260	262	PF00400	0.458
TRG_ER_diArg_1	337	340	PF00400	0.515
TRG_ER_diArg_1	354	357	PF00400	0.379
TRG_ER_diArg_1	449	451	PF00400	0.500
TRG_ER_diArg_1	540	543	PF00400	0.518
TRG_ER_diArg_1	727	729	PF00400	0.579
TRG_NES_CRM1_1	20	34	PF08389	0.596
TRG_NES_CRM1_1	86	98	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.333
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMF5	Leptomonas seymouri	46%	81%
A0A3S7WSE4	Leishmania donovani	75%	80%
A0A422NQU2	Trypanosoma rangeli	27%	98%
A4HVI2	Leishmania infantum	75%	80%
E9AP77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	80%
Q4QGA1	Leishmania major	75%	100%
V5BFH3	Trypanosoma cruzi	26%	94%