Coiled-coil domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1014), putative

Species:

Leishmania braziliensis

UniProt:

A4H741_LEIBR

TriTrypDb:

LbrM.13.0340 , LBRM2903_130008700

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H741

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H741

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006351	DNA-templated transcription	7	1
GO:0006366	transcription by RNA polymerase II	8	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0097659	nucleic acid-templated transcription	6	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.536
CLV_NRD_NRD_1	140	142	PF00675	0.465
CLV_NRD_NRD_1	216	218	PF00675	0.261
CLV_NRD_NRD_1	25	27	PF00675	0.598
CLV_NRD_NRD_1	252	254	PF00675	0.511
CLV_PCSK_KEX2_1	191	193	PF00082	0.250
CLV_PCSK_KEX2_1	216	218	PF00082	0.250
CLV_PCSK_KEX2_1	25	27	PF00082	0.575
CLV_PCSK_KEX2_1	252	254	PF00082	0.516
CLV_PCSK_KEX2_1	73	75	PF00082	0.493
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.261
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.415
CLV_PCSK_PC7_1	187	193	PF00082	0.250
CLV_PCSK_PC7_1	21	27	PF00082	0.616
CLV_PCSK_PC7_1	212	218	PF00082	0.228
CLV_PCSK_PC7_1	69	75	PF00082	0.633
CLV_PCSK_SKI1_1	191	195	PF00082	0.355
CLV_PCSK_SKI1_1	48	52	PF00082	0.508
DEG_APCC_KENBOX_2	36	40	PF00400	0.364
DOC_USP7_MATH_1	150	154	PF00917	0.620
DOC_USP7_MATH_1	160	164	PF00917	0.386
DOC_USP7_UBL2_3	194	198	PF12436	0.565
DOC_USP7_UBL2_3	48	52	PF12436	0.511
DOC_USP7_UBL2_3	62	66	PF12436	0.501
DOC_USP7_UBL2_3	87	91	PF12436	0.569
DOC_USP7_UBL2_3	99	103	PF12436	0.464
DOC_WW_Pin1_4	228	233	PF00397	0.474
LIG_14-3-3_CanoR_1	13	20	PF00244	0.602
LIG_14-3-3_CanoR_1	216	224	PF00244	0.476
LIG_Actin_WH2_2	201	218	PF00022	0.555
LIG_deltaCOP1_diTrp_1	222	228	PF00928	0.450
LIG_EH_1	233	237	PF12763	0.461
LIG_FHA_1	127	133	PF00498	0.604
LIG_FHA_1	163	169	PF00498	0.397
LIG_LIR_Gen_1	218	227	PF02991	0.486
LIG_LIR_Nem_3	218	223	PF02991	0.486
LIG_PCNA_yPIPBox_3	216	228	PF02747	0.461
LIG_PCNA_yPIPBox_3	91	105	PF02747	0.486
LIG_SH2_GRB2like	10	13	PF00017	0.615
LIG_SH2_SRC	201	204	PF00017	0.471
LIG_SH2_STAP1	201	205	PF00017	0.515
LIG_SH2_STAT5	10	13	PF00017	0.615
LIG_SH3_3	129	135	PF00018	0.609
LIG_SH3_3	229	235	PF00018	0.474
LIG_TYR_ITSM	216	223	PF00017	0.555
LIG_UBA3_1	223	230	PF00899	0.474
MOD_CK2_1	256	262	PF00069	0.712
MOD_CMANNOS	225	228	PF00535	0.250
MOD_Cter_Amidation	189	192	PF01082	0.250
MOD_GlcNHglycan	135	138	PF01048	0.626
MOD_GlcNHglycan	160	163	PF01048	0.281
MOD_GlcNHglycan	172	176	PF01048	0.240
MOD_GlcNHglycan	2	5	PF01048	0.565
MOD_GlcNHglycan	83	87	PF01048	0.494
MOD_GSK3_1	126	133	PF00069	0.653
MOD_GSK3_1	150	157	PF00069	0.620
MOD_GSK3_1	158	165	PF00069	0.458
MOD_GSK3_1	4	11	PF00069	0.564
MOD_NEK2_1	171	176	PF00069	0.471
MOD_NEK2_1	215	220	PF00069	0.461
MOD_PIKK_1	203	209	PF00454	0.479
MOD_PIKK_1	215	221	PF00454	0.451
MOD_PKA_2	12	18	PF00069	0.591
MOD_PKA_2	215	221	PF00069	0.474
MOD_Plk_1	130	136	PF00069	0.575
MOD_ProDKin_1	228	234	PF00069	0.474
MOD_SUMO_for_1	127	130	PF00179	0.686
MOD_SUMO_for_1	208	211	PF00179	0.510
MOD_SUMO_rev_2	44	50	PF00179	0.497
MOD_SUMO_rev_2	54	64	PF00179	0.469
TRG_DiLeu_BaEn_4	210	216	PF01217	0.423
TRG_ENDOCYTIC_2	197	200	PF00928	0.450
TRG_ENDOCYTIC_2	220	223	PF00928	0.471
TRG_ER_diArg_1	215	217	PF00400	0.474
TRG_ER_diArg_1	25	27	PF00400	0.604
TRG_ER_diArg_1	252	254	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1R4	Leptomonas seymouri	70%	100%
A0A0S4JL95	Bodo saltans	46%	100%
A0A1X0NNI4	Trypanosomatidae	54%	100%
A0A3R7NKC3	Trypanosoma rangeli	54%	100%
A0A3S7WSF4	Leishmania donovani	83%	100%
A4HVI1	Leishmania infantum	83%	100%
D0A6T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AP76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q28HN4	Xenopus tropicalis	28%	100%
Q4QGA2	Leishmania major	83%	100%
Q54GW3	Dictyostelium discoideum	26%	100%
Q68EY7	Xenopus laevis	29%	100%
Q6PHE8	Danio rerio	27%	100%
V5BAV6	Trypanosoma cruzi	55%	91%