Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H740_LEIBR

TriTrypDb:

LbrM.13.0330 , LBRM2903_130008600

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H740

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H740

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.408
CLV_NRD_NRD_1	13	15	PF00675	0.554
CLV_NRD_NRD_1	224	226	PF00675	0.448
CLV_NRD_NRD_1	81	83	PF00675	0.507
CLV_NRD_NRD_1	90	92	PF00675	0.563
CLV_PCSK_KEX2_1	124	126	PF00082	0.472
CLV_PCSK_KEX2_1	13	15	PF00082	0.554
CLV_PCSK_KEX2_1	224	226	PF00082	0.432
CLV_PCSK_KEX2_1	296	298	PF00082	0.626
CLV_PCSK_KEX2_1	81	83	PF00082	0.483
CLV_PCSK_KEX2_1	90	92	PF00082	0.545
CLV_PCSK_PC7_1	292	298	PF00082	0.476
CLV_PCSK_SKI1_1	24	28	PF00082	0.266
DEG_APCC_DBOX_1	110	118	PF00400	0.316
DEG_Nend_UBRbox_3	1	3	PF02207	0.693
DEG_SCF_FBW7_1	53	60	PF00400	0.507
DOC_CYCLIN_RxL_1	221	231	PF00134	0.558
DOC_MAPK_gen_1	13	21	PF00069	0.378
DOC_MAPK_MEF2A_6	13	21	PF00069	0.462
DOC_MAPK_MEF2A_6	211	220	PF00069	0.517
DOC_MAPK_RevD_3	110	125	PF00069	0.457
DOC_PP1_RVXF_1	222	229	PF00149	0.551
DOC_PP1_RVXF_1	98	104	PF00149	0.347
DOC_PP2B_LxvP_1	285	288	PF13499	0.596
DOC_USP7_MATH_1	189	193	PF00917	0.515
DOC_USP7_MATH_1	199	203	PF00917	0.500
DOC_USP7_MATH_1	57	61	PF00917	0.652
DOC_USP7_MATH_1	74	78	PF00917	0.575
DOC_USP7_MATH_1	96	100	PF00917	0.501
DOC_USP7_MATH_2	35	41	PF00917	0.423
DOC_WW_Pin1_4	183	188	PF00397	0.592
DOC_WW_Pin1_4	53	58	PF00397	0.565
LIG_14-3-3_CanoR_1	111	115	PF00244	0.488
LIG_14-3-3_CanoR_1	145	151	PF00244	0.419
LIG_14-3-3_CanoR_1	204	210	PF00244	0.550
LIG_14-3-3_CanoR_1	224	229	PF00244	0.464
LIG_BIR_III_4	290	294	PF00653	0.459
LIG_FHA_1	154	160	PF00498	0.628
LIG_FHA_2	147	153	PF00498	0.567
LIG_FHA_2	54	60	PF00498	0.597
LIG_Integrin_RGD_1	170	172	PF01839	0.617
LIG_LIR_Gen_1	134	141	PF02991	0.543
LIG_LIR_Gen_1	40	50	PF02991	0.382
LIG_LIR_Nem_3	134	139	PF02991	0.532
LIG_LIR_Nem_3	40	46	PF02991	0.522
LIG_MYND_2	17	21	PF01753	0.344
LIG_NRP_CendR_1	296	298	PF00754	0.626
LIG_SH2_CRK	43	47	PF00017	0.391
LIG_SH2_PTP2	184	187	PF00017	0.486
LIG_SH2_STAP1	43	47	PF00017	0.456
LIG_SH2_STAP1	79	83	PF00017	0.460
LIG_SH2_STAT3	83	86	PF00017	0.543
LIG_SH2_STAT5	184	187	PF00017	0.560
LIG_SH3_3	12	18	PF00018	0.667
LIG_SH3_3	206	212	PF00018	0.329
LIG_SH3_3	267	273	PF00018	0.584
LIG_SUMO_SIM_par_1	125	130	PF11976	0.431
LIG_SUMO_SIM_par_1	17	22	PF11976	0.337
LIG_TRAF2_1	149	152	PF00917	0.579
LIG_TRFH_1	26	30	PF08558	0.333
MOD_CK1_1	190	196	PF00069	0.590
MOD_CK1_1	227	233	PF00069	0.475
MOD_CK1_1	243	249	PF00069	0.416
MOD_CK1_1	9	15	PF00069	0.560
MOD_CK2_1	146	152	PF00069	0.579
MOD_CK2_1	227	233	PF00069	0.432
MOD_CK2_1	53	59	PF00069	0.601
MOD_GlcNHglycan	104	107	PF01048	0.404
MOD_GlcNHglycan	192	195	PF01048	0.725
MOD_GlcNHglycan	266	269	PF01048	0.515
MOD_GlcNHglycan	83	86	PF01048	0.534
MOD_GSK3_1	127	134	PF00069	0.470
MOD_GSK3_1	137	144	PF00069	0.496
MOD_GSK3_1	183	190	PF00069	0.504
MOD_GSK3_1	37	44	PF00069	0.501
MOD_GSK3_1	53	60	PF00069	0.517
MOD_GSK3_1	65	72	PF00069	0.630
MOD_GSK3_1	90	97	PF00069	0.574
MOD_N-GLC_1	137	142	PF02516	0.524
MOD_NEK2_1	110	115	PF00069	0.492
MOD_NEK2_1	132	137	PF00069	0.473
MOD_NEK2_1	36	41	PF00069	0.436
MOD_NEK2_2	153	158	PF00069	0.533
MOD_NEK2_2	199	204	PF00069	0.332
MOD_PIKK_1	37	43	PF00454	0.638
MOD_PKA_1	224	230	PF00069	0.439
MOD_PKA_1	81	87	PF00069	0.638
MOD_PKA_1	90	96	PF00069	0.612
MOD_PKA_2	110	116	PF00069	0.390
MOD_PKA_2	141	147	PF00069	0.615
MOD_PKA_2	224	230	PF00069	0.465
MOD_PKA_2	65	71	PF00069	0.433
MOD_PKA_2	81	87	PF00069	0.585
MOD_PKA_2	9	15	PF00069	0.733
MOD_PKA_2	90	96	PF00069	0.546
MOD_Plk_4	205	211	PF00069	0.369
MOD_Plk_4	240	246	PF00069	0.468
MOD_Plk_4	42	48	PF00069	0.543
MOD_Plk_4	74	80	PF00069	0.501
MOD_ProDKin_1	183	189	PF00069	0.605
MOD_ProDKin_1	53	59	PF00069	0.580
TRG_ENDOCYTIC_2	43	46	PF00928	0.394
TRG_ER_diArg_1	124	126	PF00400	0.413
TRG_ER_diArg_1	13	15	PF00400	0.547
TRG_ER_diArg_1	223	225	PF00400	0.580
TRG_ER_diArg_1	295	298	PF00400	0.615
TRG_ER_diArg_1	81	83	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q3	Leptomonas seymouri	53%	100%
A0A1X0NN61	Trypanosomatidae	34%	100%
A0A3S5H6N4	Leishmania donovani	80%	100%
A0A422NQK2	Trypanosoma rangeli	34%	100%
A4HVI0	Leishmania infantum	80%	100%
D0A6T1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AP75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QGA3	Leishmania major	79%	100%
V5AVG9	Trypanosoma cruzi	34%	100%