Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania braziliensis

UniProt:

A4H738_LEIBR

TriTrypDb:

LbrM.13.0310 , LBRM2903_130008400

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H738

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H738

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.720
CLV_NRD_NRD_1	280	282	PF00675	0.439
CLV_NRD_NRD_1	292	294	PF00675	0.515
CLV_NRD_NRD_1	314	316	PF00675	0.499
CLV_NRD_NRD_1	401	403	PF00675	0.606
CLV_NRD_NRD_1	62	64	PF00675	0.264
CLV_NRD_NRD_1	79	81	PF00675	0.406
CLV_PCSK_FUR_1	399	403	PF00082	0.655
CLV_PCSK_KEX2_1	246	248	PF00082	0.742
CLV_PCSK_KEX2_1	280	282	PF00082	0.439
CLV_PCSK_KEX2_1	292	294	PF00082	0.515
CLV_PCSK_KEX2_1	314	316	PF00082	0.459
CLV_PCSK_KEX2_1	401	403	PF00082	0.580
CLV_PCSK_PC7_1	242	248	PF00082	0.690
CLV_PCSK_SKI1_1	159	163	PF00082	0.552
CLV_PCSK_SKI1_1	247	251	PF00082	0.749
DEG_Nend_Nbox_1	1	3	PF02207	0.284
DOC_CDC14_PxL_1	134	142	PF14671	0.487
DOC_CKS1_1	433	438	PF01111	0.766
DOC_CYCLIN_yCln2_LP_2	341	344	PF00134	0.409
DOC_MAPK_gen_1	43	53	PF00069	0.379
DOC_MAPK_gen_1	85	94	PF00069	0.383
DOC_PP1_RVXF_1	157	163	PF00149	0.569
DOC_PP2B_LxvP_1	2	5	PF13499	0.525
DOC_PP2B_LxvP_1	341	344	PF13499	0.409
DOC_PP4_FxxP_1	53	56	PF00568	0.227
DOC_USP7_MATH_1	222	226	PF00917	0.528
DOC_USP7_MATH_1	377	381	PF00917	0.455
DOC_USP7_MATH_1	453	457	PF00917	0.487
DOC_USP7_UBL2_3	366	370	PF12436	0.595
DOC_USP7_UBL2_3	417	421	PF12436	0.716
DOC_WW_Pin1_4	252	257	PF00397	0.768
DOC_WW_Pin1_4	432	437	PF00397	0.669
DOC_WW_Pin1_4	440	445	PF00397	0.686
DOC_WW_Pin1_4	93	98	PF00397	0.335
LIG_14-3-3_CanoR_1	170	174	PF00244	0.484
LIG_14-3-3_CanoR_1	210	218	PF00244	0.408
LIG_14-3-3_CanoR_1	246	254	PF00244	0.783
LIG_14-3-3_CanoR_1	63	68	PF00244	0.431
LIG_14-3-3_CanoR_1	87	93	PF00244	0.451
LIG_APCC_ABBA_1	117	122	PF00400	0.335
LIG_APCC_ABBA_1	50	55	PF00400	0.227
LIG_APCC_ABBAyCdc20_2	116	122	PF00400	0.335
LIG_BRCT_BRCA1_1	25	29	PF00533	0.426
LIG_CaM_IQ_9	11	26	PF13499	0.350
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.433
LIG_DLG_GKlike_1	63	71	PF00625	0.441
LIG_FHA_1	102	108	PF00498	0.238
LIG_FHA_1	134	140	PF00498	0.534
LIG_FHA_1	169	175	PF00498	0.430
LIG_FHA_1	183	189	PF00498	0.524
LIG_FHA_1	286	292	PF00498	0.455
LIG_FHA_1	433	439	PF00498	0.725
LIG_FHA_1	455	461	PF00498	0.470
LIG_FHA_1	87	93	PF00498	0.411
LIG_FHA_1	9	15	PF00498	0.574
LIG_FHA_2	144	150	PF00498	0.420
LIG_FHA_2	201	207	PF00498	0.542
LIG_FHA_2	235	241	PF00498	0.693
LIG_FHA_2	349	355	PF00498	0.385
LIG_FHA_2	356	362	PF00498	0.393
LIG_FHA_2	393	399	PF00498	0.612
LIG_LIR_Apic_2	127	131	PF02991	0.270
LIG_LIR_Gen_1	199	209	PF02991	0.418
LIG_LIR_Gen_1	26	36	PF02991	0.343
LIG_LIR_Gen_1	375	384	PF02991	0.464
LIG_LIR_Gen_1	89	98	PF02991	0.403
LIG_LIR_Nem_3	199	204	PF02991	0.465
LIG_LIR_Nem_3	26	32	PF02991	0.435
LIG_LIR_Nem_3	375	381	PF02991	0.491
LIG_LIR_Nem_3	89	93	PF02991	0.403
LIG_MYND_1	339	343	PF01753	0.532
LIG_SH2_CRK	374	378	PF00017	0.553
LIG_SH2_CRK	391	395	PF00017	0.389
LIG_SH2_CRK	54	58	PF00017	0.407
LIG_SH2_NCK_1	374	378	PF00017	0.627
LIG_SH2_PTP2	120	123	PF00017	0.447
LIG_SH2_SRC	120	123	PF00017	0.428
LIG_SH2_SRC	54	57	PF00017	0.441
LIG_SH2_STAT5	120	123	PF00017	0.447
LIG_SH2_STAT5	321	324	PF00017	0.494
LIG_SH2_STAT5	378	381	PF00017	0.454
LIG_SH2_STAT5	73	76	PF00017	0.480
LIG_SH3_3	251	257	PF00018	0.638
LIG_SH3_3	266	272	PF00018	0.489
LIG_SH3_3	359	365	PF00018	0.491
LIG_SH3_3	438	444	PF00018	0.703
LIG_SUMO_SIM_par_1	302	308	PF11976	0.584
LIG_SxIP_EBH_1	170	180	PF03271	0.551
LIG_TRAF2_1	181	184	PF00917	0.529
LIG_TRAF2_1	394	397	PF00917	0.559
LIG_TYR_ITIM	376	381	PF00017	0.477
LIG_TYR_ITIM	71	76	PF00017	0.447
LIG_UBA3_1	173	178	PF00899	0.550
MOD_CDK_SPxxK_3	93	100	PF00069	0.335
MOD_CK1_1	143	149	PF00069	0.606
MOD_CK1_1	245	251	PF00069	0.767
MOD_CK1_1	332	338	PF00069	0.447
MOD_CK1_1	380	386	PF00069	0.449
MOD_CK1_1	405	411	PF00069	0.712
MOD_CK1_1	66	72	PF00069	0.447
MOD_CK2_1	143	149	PF00069	0.390
MOD_CK2_1	200	206	PF00069	0.463
MOD_CK2_1	222	228	PF00069	0.498
MOD_CK2_1	234	240	PF00069	0.621
MOD_CK2_1	355	361	PF00069	0.497
MOD_CK2_1	392	398	PF00069	0.586
MOD_Cter_Amidation	61	64	PF01082	0.237
MOD_DYRK1A_RPxSP_1	440	444	PF00069	0.689
MOD_GlcNHglycan	146	149	PF01048	0.633
MOD_GlcNHglycan	198	201	PF01048	0.524
MOD_GlcNHglycan	220	223	PF01048	0.417
MOD_GlcNHglycan	247	250	PF01048	0.592
MOD_GlcNHglycan	334	337	PF01048	0.553
MOD_GlcNHglycan	403	407	PF01048	0.568
MOD_GSK3_1	140	147	PF00069	0.510
MOD_GSK3_1	196	203	PF00069	0.492
MOD_GSK3_1	216	223	PF00069	0.423
MOD_GSK3_1	230	237	PF00069	0.555
MOD_GSK3_1	241	248	PF00069	0.732
MOD_GSK3_1	252	259	PF00069	0.726
MOD_NEK2_1	140	145	PF00069	0.467
MOD_NEK2_1	169	174	PF00069	0.395
MOD_NEK2_1	176	181	PF00069	0.398
MOD_NEK2_1	285	290	PF00069	0.434
MOD_NEK2_1	348	353	PF00069	0.367
MOD_NEK2_1	459	464	PF00069	0.600
MOD_NEK2_1	7	12	PF00069	0.596
MOD_NEK2_2	88	93	PF00069	0.447
MOD_PIKK_1	230	236	PF00454	0.560
MOD_PKA_1	63	69	PF00069	0.349
MOD_PKA_2	169	175	PF00069	0.485
MOD_PKA_2	241	247	PF00069	0.740
MOD_PKA_2	313	319	PF00069	0.497
MOD_PKA_2	332	338	PF00069	0.636
MOD_PKA_2	86	92	PF00069	0.441
MOD_Plk_1	148	154	PF00069	0.447
MOD_Plk_1	326	332	PF00069	0.440
MOD_Plk_1	41	47	PF00069	0.354
MOD_Plk_4	140	146	PF00069	0.378
MOD_Plk_4	169	175	PF00069	0.404
MOD_Plk_4	355	361	PF00069	0.497
MOD_Plk_4	46	52	PF00069	0.289
MOD_ProDKin_1	252	258	PF00069	0.763
MOD_ProDKin_1	432	438	PF00069	0.668
MOD_ProDKin_1	440	446	PF00069	0.685
MOD_ProDKin_1	93	99	PF00069	0.335
MOD_SUMO_rev_2	225	232	PF00179	0.500
MOD_SUMO_rev_2	270	276	PF00179	0.525
TRG_DiLeu_BaEn_1	156	161	PF01217	0.501
TRG_DiLeu_BaEn_1	183	188	PF01217	0.556
TRG_DiLeu_BaEn_4	183	189	PF01217	0.560
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.293
TRG_DiLeu_LyEn_5	156	161	PF01217	0.331
TRG_ENDOCYTIC_2	321	324	PF00928	0.559
TRG_ENDOCYTIC_2	378	381	PF00928	0.496
TRG_ENDOCYTIC_2	390	393	PF00928	0.449
TRG_ENDOCYTIC_2	73	76	PF00928	0.447
TRG_ER_diArg_1	279	281	PF00400	0.475
TRG_ER_diArg_1	291	293	PF00400	0.500
TRG_ER_diArg_1	314	317	PF00400	0.454
TRG_ER_diArg_1	399	402	PF00400	0.596
TRG_ER_diArg_1	460	463	PF00400	0.641

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P925	Leptomonas seymouri	63%	92%
A0A1X0NN77	Trypanosomatidae	34%	100%
A0A3Q8I8G2	Leishmania donovani	83%	92%
A0A3R7KJL2	Trypanosoma rangeli	32%	100%
A4HVH8	Leishmania infantum	83%	92%
D0A6T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AP73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGA5	Leishmania major	83%	100%
V5BFH7	Trypanosoma cruzi	37%	100%