TMF_TATA_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATA element modulatory factor 1 TATA binding, putative

Species:

Leishmania braziliensis

UniProt:

A4H737_LEIBR

TriTrypDb:

LbrM.13.0300 , LBRM2903_130008300

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H737

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H737

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.374
CLV_C14_Caspase3-7	45	49	PF00656	0.533
CLV_C14_Caspase3-7	669	673	PF00656	0.502
CLV_NRD_NRD_1	503	505	PF00675	0.389
CLV_NRD_NRD_1	590	592	PF00675	0.622
CLV_NRD_NRD_1	732	734	PF00675	0.658
CLV_PCSK_KEX2_1	342	344	PF00082	0.453
CLV_PCSK_KEX2_1	503	505	PF00082	0.512
CLV_PCSK_KEX2_1	538	540	PF00082	0.569
CLV_PCSK_KEX2_1	732	734	PF00082	0.423
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.453
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.630
CLV_PCSK_SKI1_1	407	411	PF00082	0.511
CLV_Separin_Metazoa	682	686	PF03568	0.512
DEG_APCC_DBOX_1	452	460	PF00400	0.627
DEG_COP1_1	77	86	PF00400	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SIAH_1	96	104	PF03145	0.714
DEG_SPOP_SBC_1	236	240	PF00917	0.743
DOC_CKS1_1	112	117	PF01111	0.564
DOC_MAPK_gen_1	591	597	PF00069	0.623
DOC_MAPK_gen_1	603	611	PF00069	0.711
DOC_MAPK_gen_1	647	656	PF00069	0.531
DOC_MAPK_MEF2A_6	174	182	PF00069	0.690
DOC_PP2B_LxvP_1	245	248	PF13499	0.555
DOC_PP2B_LxvP_1	81	84	PF13499	0.691
DOC_PP4_FxxP_1	187	190	PF00568	0.539
DOC_PP4_FxxP_1	241	244	PF00568	0.545
DOC_PP4_FxxP_1	632	635	PF00568	0.697
DOC_USP7_MATH_1	139	143	PF00917	0.702
DOC_USP7_MATH_1	159	163	PF00917	0.711
DOC_USP7_MATH_1	208	212	PF00917	0.823
DOC_USP7_MATH_1	221	225	PF00917	0.691
DOC_USP7_MATH_1	227	231	PF00917	0.609
DOC_USP7_MATH_1	237	241	PF00917	0.565
DOC_USP7_MATH_1	308	312	PF00917	0.711
DOC_USP7_MATH_1	366	370	PF00917	0.485
DOC_USP7_MATH_1	434	438	PF00917	0.461
DOC_USP7_MATH_1	492	496	PF00917	0.599
DOC_USP7_MATH_1	60	64	PF00917	0.664
DOC_USP7_MATH_1	619	623	PF00917	0.588
DOC_USP7_MATH_1	744	748	PF00917	0.750
DOC_USP7_UBL2_3	333	337	PF12436	0.488
DOC_WW_Pin1_4	111	116	PF00397	0.651
DOC_WW_Pin1_4	162	167	PF00397	0.835
DOC_WW_Pin1_4	168	173	PF00397	0.710
DOC_WW_Pin1_4	197	202	PF00397	0.742
DOC_WW_Pin1_4	252	257	PF00397	0.565
DOC_WW_Pin1_4	637	642	PF00397	0.653
DOC_WW_Pin1_4	92	97	PF00397	0.652
LIG_14-3-3_CanoR_1	235	245	PF00244	0.539
LIG_14-3-3_CanoR_1	246	256	PF00244	0.474
LIG_14-3-3_CanoR_1	286	294	PF00244	0.635
LIG_14-3-3_CanoR_1	335	340	PF00244	0.440
LIG_14-3-3_CanoR_1	453	457	PF00244	0.627
LIG_14-3-3_CanoR_1	487	493	PF00244	0.519
LIG_14-3-3_CanoR_1	511	517	PF00244	0.636
LIG_14-3-3_CanoR_1	551	559	PF00244	0.632
LIG_14-3-3_CanoR_1	647	656	PF00244	0.660
LIG_14-3-3_CanoR_1	685	693	PF00244	0.624
LIG_Actin_WH2_2	408	426	PF00022	0.619
LIG_Actin_WH2_2	438	455	PF00022	0.629
LIG_Actin_WH2_2	590	607	PF00022	0.667
LIG_APCC_Cbox_2	571	577	PF00515	0.641
LIG_BRCT_BRCA1_1	237	241	PF00533	0.655
LIG_CaM_IQ_9	496	512	PF13499	0.381
LIG_EH_1	656	660	PF12763	0.761
LIG_FHA_1	112	118	PF00498	0.769
LIG_FHA_1	131	137	PF00498	0.550
LIG_FHA_1	138	144	PF00498	0.561
LIG_FHA_1	217	223	PF00498	0.707
LIG_FHA_1	224	230	PF00498	0.666
LIG_FHA_1	237	243	PF00498	0.450
LIG_FHA_1	307	313	PF00498	0.713
LIG_FHA_1	465	471	PF00498	0.632
LIG_FHA_1	526	532	PF00498	0.626
LIG_FHA_1	649	655	PF00498	0.690
LIG_FHA_1	736	742	PF00498	0.489
LIG_FHA_2	146	152	PF00498	0.589
LIG_FHA_2	395	401	PF00498	0.373
LIG_FHA_2	431	437	PF00498	0.599
LIG_FHA_2	459	465	PF00498	0.554
LIG_FHA_2	496	502	PF00498	0.549
LIG_FHA_2	521	527	PF00498	0.594
LIG_FHA_2	581	587	PF00498	0.669
LIG_GBD_Chelix_1	398	406	PF00786	0.615
LIG_Integrin_RGD_1	563	565	PF01839	0.366
LIG_LIR_Apic_2	185	190	PF02991	0.534
LIG_LIR_Apic_2	238	244	PF02991	0.541
LIG_LIR_Gen_1	261	271	PF02991	0.648
LIG_LIR_Gen_1	526	535	PF02991	0.553
LIG_LIR_Gen_1	570	580	PF02991	0.644
LIG_LIR_LC3C_4	78	83	PF02991	0.538
LIG_LIR_Nem_3	261	267	PF02991	0.665
LIG_LIR_Nem_3	334	339	PF02991	0.391
LIG_LIR_Nem_3	526	530	PF02991	0.625
LIG_LIR_Nem_3	532	537	PF02991	0.524
LIG_LIR_Nem_3	570	576	PF02991	0.638
LIG_Pex14_1	569	573	PF04695	0.632
LIG_PTAP_UEV_1	83	88	PF05743	0.583
LIG_SH2_CRK	336	340	PF00017	0.385
LIG_SH2_CRK	534	538	PF00017	0.536
LIG_SH2_STAP1	427	431	PF00017	0.610
LIG_SH2_STAP1	527	531	PF00017	0.627
LIG_SH2_STAT3	427	430	PF00017	0.623
LIG_SH2_STAT5	432	435	PF00017	0.383
LIG_SH2_STAT5	527	530	PF00017	0.628
LIG_SH2_STAT5	573	576	PF00017	0.646
LIG_SH3_3	112	118	PF00018	0.561
LIG_SH3_3	120	126	PF00018	0.611
LIG_SH3_3	141	147	PF00018	0.568
LIG_SH3_3	250	256	PF00018	0.580
LIG_SH3_3	625	631	PF00018	0.520
LIG_SH3_3	632	638	PF00018	0.757
LIG_SH3_3	652	658	PF00018	0.702
LIG_SH3_3	81	87	PF00018	0.665
LIG_SH3_3	99	105	PF00018	0.743
LIG_SUMO_SIM_anti_2	15	26	PF11976	0.629
LIG_SUMO_SIM_anti_2	607	613	PF11976	0.530
LIG_SUMO_SIM_par_1	37	43	PF11976	0.529
LIG_SxIP_EBH_1	235	248	PF03271	0.541
LIG_TRAF2_1	300	303	PF00917	0.627
LIG_TRAF2_1	362	365	PF00917	0.551
LIG_TRAF2_1	369	372	PF00917	0.520
LIG_TRAF2_1	575	578	PF00917	0.588
LIG_UBA3_1	325	333	PF00899	0.639
LIG_WRC_WIRS_1	61	66	PF05994	0.559
MOD_CDC14_SPxK_1	171	174	PF00782	0.689
MOD_CDK_SPxK_1	168	174	PF00069	0.693
MOD_CK1_1	110	116	PF00069	0.722
MOD_CK1_1	130	136	PF00069	0.648
MOD_CK1_1	149	155	PF00069	0.745
MOD_CK1_1	162	168	PF00069	0.582
MOD_CK1_1	194	200	PF00069	0.727
MOD_CK1_1	255	261	PF00069	0.671
MOD_CK1_1	394	400	PF00069	0.372
MOD_CK1_1	438	444	PF00069	0.630
MOD_CK1_1	495	501	PF00069	0.624
MOD_CK1_1	509	515	PF00069	0.400
MOD_CK1_1	579	585	PF00069	0.414
MOD_CK1_1	633	639	PF00069	0.726
MOD_CK1_1	640	646	PF00069	0.629
MOD_CK1_1	665	671	PF00069	0.770
MOD_CK1_1	747	753	PF00069	0.763
MOD_CK2_1	145	151	PF00069	0.589
MOD_CK2_1	296	302	PF00069	0.666
MOD_CK2_1	335	341	PF00069	0.398
MOD_CK2_1	366	372	PF00069	0.518
MOD_CK2_1	415	421	PF00069	0.430
MOD_CK2_1	430	436	PF00069	0.591
MOD_CK2_1	520	526	PF00069	0.420
MOD_CK2_1	580	586	PF00069	0.675
MOD_CK2_1	612	618	PF00069	0.783
MOD_CK2_1	64	70	PF00069	0.750
MOD_GlcNHglycan	137	140	PF01048	0.737
MOD_GlcNHglycan	298	301	PF01048	0.557
MOD_GlcNHglycan	368	371	PF01048	0.620
MOD_GlcNHglycan	427	430	PF01048	0.623
MOD_GlcNHglycan	512	515	PF01048	0.616
MOD_GlcNHglycan	642	645	PF01048	0.741
MOD_GlcNHglycan	663	667	PF01048	0.585
MOD_GlcNHglycan	686	689	PF01048	0.623
MOD_GlcNHglycan	725	731	PF01048	0.525
MOD_GlcNHglycan	749	752	PF01048	0.682
MOD_GlcNHglycan	753	756	PF01048	0.622
MOD_GlcNHglycan	84	87	PF01048	0.715
MOD_GSK3_1	104	111	PF00069	0.769
MOD_GSK3_1	135	142	PF00069	0.712
MOD_GSK3_1	145	152	PF00069	0.596
MOD_GSK3_1	162	169	PF00069	0.729
MOD_GSK3_1	191	198	PF00069	0.606
MOD_GSK3_1	217	224	PF00069	0.629
MOD_GSK3_1	225	232	PF00069	0.634
MOD_GSK3_1	247	254	PF00069	0.715
MOD_GSK3_1	286	293	PF00069	0.424
MOD_GSK3_1	306	313	PF00069	0.603
MOD_GSK3_1	387	394	PF00069	0.487
MOD_GSK3_1	430	437	PF00069	0.587
MOD_GSK3_1	458	465	PF00069	0.580
MOD_GSK3_1	506	513	PF00069	0.625
MOD_GSK3_1	533	540	PF00069	0.624
MOD_GSK3_1	576	583	PF00069	0.657
MOD_GSK3_1	60	67	PF00069	0.655
MOD_GSK3_1	633	640	PF00069	0.762
MOD_GSK3_1	745	752	PF00069	0.734
MOD_N-GLC_1	290	295	PF02516	0.667
MOD_N-GLC_1	306	311	PF02516	0.440
MOD_N-GLC_1	457	462	PF02516	0.629
MOD_NEK2_1	1	6	PF00069	0.519
MOD_NEK2_1	108	113	PF00069	0.676
MOD_NEK2_1	423	428	PF00069	0.594
MOD_NEK2_1	452	457	PF00069	0.517
MOD_NEK2_1	46	51	PF00069	0.641
MOD_NEK2_1	506	511	PF00069	0.626
MOD_NEK2_1	520	525	PF00069	0.398
MOD_NEK2_1	537	542	PF00069	0.562
MOD_NEK2_1	576	581	PF00069	0.597
MOD_NEK2_1	597	602	PF00069	0.697
MOD_NEK2_1	604	609	PF00069	0.648
MOD_NEK2_1	612	617	PF00069	0.535
MOD_NEK2_1	620	625	PF00069	0.653
MOD_NEK2_1	642	647	PF00069	0.707
MOD_NEK2_1	662	667	PF00069	0.441
MOD_NEK2_2	60	65	PF00069	0.553
MOD_PIKK_1	286	292	PF00454	0.427
MOD_PIKK_1	401	407	PF00454	0.616
MOD_PIKK_1	415	421	PF00454	0.384
MOD_PIKK_1	506	512	PF00454	0.625
MOD_PIKK_1	580	586	PF00454	0.566
MOD_PIKK_1	612	618	PF00454	0.772
MOD_PK_1	335	341	PF00069	0.378
MOD_PKA_2	149	155	PF00069	0.745
MOD_PKA_2	452	458	PF00069	0.637
MOD_PKA_2	486	492	PF00069	0.516
MOD_PKA_2	510	516	PF00069	0.634
MOD_PKA_2	550	556	PF00069	0.565
MOD_PKA_2	590	596	PF00069	0.608
MOD_PKA_2	604	610	PF00069	0.536
MOD_PKA_2	648	654	PF00069	0.531
MOD_PKA_2	684	690	PF00069	0.584
MOD_PKB_1	647	655	PF00069	0.532
MOD_Plk_1	178	184	PF00069	0.587
MOD_Plk_1	217	223	PF00069	0.638
MOD_Plk_1	290	296	PF00069	0.590
MOD_Plk_1	597	603	PF00069	0.703
MOD_Plk_1	662	668	PF00069	0.632
MOD_Plk_1	726	732	PF00069	0.530
MOD_Plk_4	1	7	PF00069	0.514
MOD_Plk_4	208	214	PF00069	0.771
MOD_Plk_4	237	243	PF00069	0.604
MOD_Plk_4	255	261	PF00069	0.615
MOD_Plk_4	320	326	PF00069	0.596
MOD_Plk_4	335	341	PF00069	0.348
MOD_Plk_4	394	400	PF00069	0.372
MOD_Plk_4	46	52	PF00069	0.659
MOD_Plk_4	590	596	PF00069	0.685
MOD_ProDKin_1	111	117	PF00069	0.651
MOD_ProDKin_1	162	168	PF00069	0.834
MOD_ProDKin_1	197	203	PF00069	0.742
MOD_ProDKin_1	252	258	PF00069	0.566
MOD_ProDKin_1	637	643	PF00069	0.656
MOD_ProDKin_1	92	98	PF00069	0.654
MOD_SUMO_rev_2	27	37	PF00179	0.641
MOD_SUMO_rev_2	296	306	PF00179	0.424
MOD_SUMO_rev_2	418	426	PF00179	0.509
MOD_SUMO_rev_2	42	49	PF00179	0.763
MOD_SUMO_rev_2	550	559	PF00179	0.468
MOD_SUMO_rev_2	668	675	PF00179	0.735
TRG_DiLeu_BaEn_1	526	531	PF01217	0.625
TRG_DiLeu_BaEn_1	712	717	PF01217	0.624
TRG_DiLeu_BaEn_1	77	82	PF01217	0.698
TRG_ENDOCYTIC_2	336	339	PF00928	0.391
TRG_ENDOCYTIC_2	527	530	PF00928	0.628
TRG_ENDOCYTIC_2	534	537	PF00928	0.504
TRG_ENDOCYTIC_2	573	576	PF00928	0.646
TRG_ENDOCYTIC_2	721	724	PF00928	0.425
TRG_ER_diArg_1	360	363	PF00400	0.622
TRG_ER_diArg_1	502	504	PF00400	0.388
TRG_ER_diArg_1	646	649	PF00400	0.638
TRG_ER_diArg_1	731	733	PF00400	0.420
TRG_NES_CRM1_1	7	23	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	572	577	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7L520	Trypanosoma rangeli	27%	100%
A0A3S7WSC1	Leishmania donovani	74%	100%
E9AP72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QGA6	Leishmania major	78%	100%
V5BJZ4	Trypanosoma cruzi	26%	100%