C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H735_LEIBR

TriTrypDb:

LbrM.13.0280

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H735

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H735

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.390
CLV_NRD_NRD_1	225	227	PF00675	0.716
CLV_NRD_NRD_1	346	348	PF00675	0.393
CLV_NRD_NRD_1	396	398	PF00675	0.711
CLV_NRD_NRD_1	466	468	PF00675	0.648
CLV_NRD_NRD_1	489	491	PF00675	0.546
CLV_NRD_NRD_1	86	88	PF00675	0.419
CLV_PCSK_KEX2_1	395	397	PF00082	0.456
CLV_PCSK_KEX2_1	466	468	PF00082	0.550
CLV_PCSK_KEX2_1	86	88	PF00082	0.451
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.456
CLV_PCSK_SKI1_1	275	279	PF00082	0.407
CLV_PCSK_SKI1_1	297	301	PF00082	0.407
CLV_PCSK_SKI1_1	397	401	PF00082	0.451
CLV_PCSK_SKI1_1	414	418	PF00082	0.280
CLV_Separin_Metazoa	9	13	PF03568	0.385
DEG_SCF_FBW7_2	280	287	PF00400	0.420
DOC_CDC14_PxL_1	369	377	PF14671	0.372
DOC_CKS1_1	408	413	PF01111	0.272
DOC_MAPK_gen_1	106	115	PF00069	0.389
DOC_MAPK_gen_1	272	282	PF00069	0.507
DOC_MAPK_gen_1	291	301	PF00069	0.332
DOC_MAPK_gen_1	86	94	PF00069	0.416
DOC_MAPK_HePTP_8	133	145	PF00069	0.337
DOC_MAPK_MEF2A_6	136	145	PF00069	0.312
DOC_MAPK_MEF2A_6	414	423	PF00069	0.223
DOC_MAPK_MEF2A_6	86	94	PF00069	0.387
DOC_PP1_RVXF_1	61	67	PF00149	0.279
DOC_PP4_FxxP_1	111	114	PF00568	0.412
DOC_PP4_FxxP_1	423	426	PF00568	0.219
DOC_SPAK_OSR1_1	110	114	PF12202	0.421
DOC_USP7_UBL2_3	104	108	PF12436	0.421
DOC_USP7_UBL2_3	192	196	PF12436	0.428
DOC_USP7_UBL2_3	272	276	PF12436	0.586
DOC_USP7_UBL2_3	63	67	PF12436	0.273
DOC_WW_Pin1_4	280	285	PF00397	0.557
DOC_WW_Pin1_4	388	393	PF00397	0.626
DOC_WW_Pin1_4	407	412	PF00397	0.587
DOC_WW_Pin1_4	490	495	PF00397	0.452
LIG_14-3-3_CanoR_1	190	197	PF00244	0.540
LIG_14-3-3_CanoR_1	265	273	PF00244	0.455
LIG_14-3-3_CanoR_1	340	345	PF00244	0.456
LIG_14-3-3_CanoR_1	414	423	PF00244	0.272
LIG_Actin_WH2_1	297	312	PF00022	0.268
LIG_APCC_ABBA_1	113	118	PF00400	0.495
LIG_APCC_ABBA_1	158	163	PF00400	0.421
LIG_BRCT_BRCA1_1	145	149	PF00533	0.239
LIG_BRCT_BRCA1_2	145	151	PF00533	0.258
LIG_Clathr_ClatBox_1	5	9	PF01394	0.351
LIG_deltaCOP1_diTrp_1	319	325	PF00928	0.313
LIG_eIF4E_1	201	207	PF01652	0.459
LIG_FHA_1	137	143	PF00498	0.483
LIG_FHA_1	25	31	PF00498	0.410
LIG_FHA_1	257	263	PF00498	0.358
LIG_FHA_2	17	23	PF00498	0.487
LIG_FHA_2	243	249	PF00498	0.389
LIG_FHA_2	281	287	PF00498	0.518
LIG_FHA_2	328	334	PF00498	0.508
LIG_FHA_2	354	360	PF00498	0.382
LIG_FHA_2	398	404	PF00498	0.685
LIG_FHA_2	428	434	PF00498	0.363
LIG_FHA_2	78	84	PF00498	0.346
LIG_LIR_Gen_1	159	166	PF02991	0.606
LIG_LIR_Gen_1	417	428	PF02991	0.334
LIG_LIR_Gen_1	7	16	PF02991	0.310
LIG_LIR_LC3C_4	204	208	PF02991	0.258
LIG_LIR_Nem_3	159	164	PF02991	0.569
LIG_LIR_Nem_3	417	423	PF02991	0.333
LIG_LIR_Nem_3	7	11	PF02991	0.282
LIG_LRP6_Inhibitor_1	474	480	PF00058	0.455
LIG_Pex14_1	197	201	PF04695	0.323
LIG_Pex14_2	416	420	PF04695	0.349
LIG_SH2_NCK_1	161	165	PF00017	0.445
LIG_SH2_PTP2	186	189	PF00017	0.405
LIG_SH2_STAT3	95	98	PF00017	0.403
LIG_SH2_STAT5	186	189	PF00017	0.381
LIG_SH3_3	111	117	PF00018	0.350
LIG_SH3_3	333	339	PF00018	0.509
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.253
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.316
LIG_SUMO_SIM_par_1	130	135	PF11976	0.568
LIG_SUMO_SIM_par_1	141	146	PF11976	0.271
LIG_SUMO_SIM_par_1	30	36	PF11976	0.374
LIG_SUMO_SIM_par_1	98	103	PF11976	0.353
LIG_SxIP_EBH_1	365	376	PF03271	0.360
LIG_TRAF2_1	117	120	PF00917	0.509
LIG_TRAF2_1	284	287	PF00917	0.525
LIG_UBA3_1	300	308	PF00899	0.336
LIG_UBA3_1	368	376	PF00899	0.371
LIG_UBA3_1	99	106	PF00899	0.397
LIG_WRC_WIRS_1	368	373	PF05994	0.364
MOD_CDK_SPK_2	280	285	PF00069	0.424
MOD_CDK_SPK_2	490	495	PF00069	0.452
MOD_CDK_SPxxK_3	388	395	PF00069	0.455
MOD_CDK_SPxxK_3	407	414	PF00069	0.283
MOD_CK1_1	242	248	PF00069	0.420
MOD_CK1_1	82	88	PF00069	0.514
MOD_CK2_1	280	286	PF00069	0.469
MOD_CK2_1	388	394	PF00069	0.545
MOD_CK2_1	397	403	PF00069	0.685
MOD_CK2_1	427	433	PF00069	0.378
MOD_CK2_1	77	83	PF00069	0.377
MOD_Cter_Amidation	273	276	PF01082	0.288
MOD_GlcNHglycan	135	139	PF01048	0.593
MOD_GlcNHglycan	165	169	PF01048	0.564
MOD_GlcNHglycan	2	5	PF01048	0.380
MOD_GlcNHglycan	241	244	PF01048	0.508
MOD_GlcNHglycan	38	41	PF01048	0.555
MOD_GlcNHglycan	43	46	PF01048	0.511
MOD_GSK3_1	100	107	PF00069	0.323
MOD_GSK3_1	143	150	PF00069	0.383
MOD_GSK3_1	169	176	PF00069	0.406
MOD_GSK3_1	24	31	PF00069	0.584
MOD_GSK3_1	367	374	PF00069	0.517
MOD_GSK3_1	75	82	PF00069	0.518
MOD_N-GLC_2	74	76	PF02516	0.251
MOD_NEK2_1	134	139	PF00069	0.516
MOD_NEK2_1	143	148	PF00069	0.281
MOD_NEK2_1	173	178	PF00069	0.414
MOD_NEK2_1	327	332	PF00069	0.440
MOD_NEK2_1	367	372	PF00069	0.340
MOD_NEK2_1	402	407	PF00069	0.512
MOD_NEK2_1	427	432	PF00069	0.419
MOD_NEK2_1	77	82	PF00069	0.450
MOD_PIKK_1	25	31	PF00454	0.410
MOD_PIKK_1	402	408	PF00454	0.497
MOD_PIKK_1	409	415	PF00454	0.365
MOD_PKA_1	195	201	PF00069	0.469
MOD_PKA_1	226	232	PF00069	0.748
MOD_PKA_1	275	281	PF00069	0.292
MOD_Plk_1	169	175	PF00069	0.488
MOD_Plk_1	278	284	PF00069	0.435
MOD_Plk_2-3	159	165	PF00069	0.525
MOD_Plk_2-3	429	435	PF00069	0.365
MOD_Plk_4	469	475	PF00069	0.595
MOD_ProDKin_1	280	286	PF00069	0.558
MOD_ProDKin_1	388	394	PF00069	0.635
MOD_ProDKin_1	407	413	PF00069	0.505
MOD_ProDKin_1	490	496	PF00069	0.453
MOD_SUMO_for_1	284	287	PF00179	0.442
MOD_SUMO_for_1	375	378	PF00179	0.378
MOD_SUMO_for_1	66	69	PF00179	0.265
MOD_SUMO_rev_2	193	198	PF00179	0.477
MOD_SUMO_rev_2	302	309	PF00179	0.256
TRG_DiLeu_BaEn_1	296	301	PF01217	0.248
TRG_DiLeu_BaEn_3	357	363	PF01217	0.223
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.302
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.220
TRG_ENDOCYTIC_2	161	164	PF00928	0.544
TRG_ENDOCYTIC_2	186	189	PF00928	0.391
TRG_ER_diArg_1	209	212	PF00400	0.553
TRG_NES_CRM1_1	319	333	PF08389	0.394
TRG_NES_CRM1_1	36	52	PF08389	0.280
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8U7	Bodo saltans	29%	89%
A0A1X0NN86	Trypanosomatidae	31%	91%
A0A3R7ML15	Trypanosoma rangeli	32%	96%
A0A3S5H6N3	Leishmania donovani	78%	100%
A4HVH5	Leishmania infantum	79%	100%
D0A6T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AP70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QGA8	Leishmania major	78%	100%
V5AVH4	Trypanosoma cruzi	36%	100%