Alba domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ALBA-domain protein 1

Species:

Leishmania braziliensis

UniProt:

A4H734_LEIBR

TriTrypDb:

LbrM.13.0270 , LBRM2903_130008100

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H734

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H734

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034605	cellular response to heat	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.332
CLV_PCSK_KEX2_1	17	19	PF00082	0.332
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.349
DEG_SPOP_SBC_1	77	81	PF00917	0.638
DOC_MAPK_RevD_3	50	66	PF00069	0.484
DOC_USP7_MATH_1	109	113	PF00917	0.413
DOC_WW_Pin1_4	89	94	PF00397	0.551
LIG_14-3-3_CanoR_1	12	20	PF00244	0.542
LIG_14-3-3_CanoR_1	78	87	PF00244	0.547
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	91	95	PF00533	0.484
LIG_FHA_1	80	86	PF00498	0.545
LIG_FHA_2	78	84	PF00498	0.582
LIG_LIR_Gen_1	92	99	PF02991	0.467
LIG_LIR_Nem_3	32	37	PF02991	0.528
LIG_LIR_Nem_3	92	98	PF02991	0.470
LIG_LYPXL_yS_3	34	37	PF13949	0.571
LIG_SH2_STAT3	99	102	PF00017	0.448
LIG_SH2_STAT5	22	25	PF00017	0.484
LIG_SH3_3	87	93	PF00018	0.499
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.517
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.389
MOD_CK1_1	112	118	PF00069	0.457
MOD_CK1_1	79	85	PF00069	0.522
MOD_CK2_1	48	54	PF00069	0.517
MOD_GlcNHglycan	111	114	PF01048	0.430
MOD_GlcNHglycan	39	42	PF01048	0.291
MOD_GSK3_1	37	44	PF00069	0.561
MOD_GSK3_1	85	92	PF00069	0.415
MOD_NEK2_2	60	65	PF00069	0.514
MOD_PKA_2	11	17	PF00069	0.539
MOD_PKA_2	77	83	PF00069	0.583
MOD_Plk_1	35	41	PF00069	0.427
MOD_Plk_1	85	91	PF00069	0.365
MOD_Plk_2-3	48	54	PF00069	0.517
MOD_Plk_4	48	54	PF00069	0.515
MOD_Plk_4	85	91	PF00069	0.411
MOD_ProDKin_1	89	95	PF00069	0.546
TRG_ENDOCYTIC_2	34	37	PF00928	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P641	Leptomonas seymouri	43%	91%
A0A0N1I5Q7	Leptomonas seymouri	81%	100%
A0A1X0NN78	Trypanosomatidae	53%	97%
A0A1X0NNJ9	Trypanosomatidae	57%	100%
A0A3Q8I9F4	Leishmania donovani	88%	100%
A0A3R7L466	Trypanosoma rangeli	60%	100%
A0A422NP27	Trypanosoma rangeli	54%	98%
A4HVG8	Leishmania infantum	88%	100%
D0A6U0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
D0A6U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
E9AP69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O22969	Arabidopsis thaliana	41%	93%
Q4QGA9	Leishmania major	88%	100%