Alpha tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alpha tubulin

Gene product:

alpha tubulin

Species:

Leishmania braziliensis

UniProt:

A4H729_LEIBR

TriTrypDb:

LbrM.13.0210 , LBRM2903_130007500

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H729

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H729

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0005198	structural molecule activity	1	2
GO:0005200	structural constituent of cytoskeleton	2	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.905
CLV_PCSK_KEX2_1	189	191	PF00082	0.905
CLV_PCSK_SKI1_1	161	165	PF00082	0.827
CLV_PCSK_SKI1_1	64	68	PF00082	0.500
DEG_Nend_UBRbox_1	1	4	PF02207	0.736
DEG_SCF_FBW7_1	180	185	PF00400	0.876
DOC_CKS1_1	162	167	PF01111	0.824
DOC_CKS1_1	179	184	PF01111	0.572
DOC_CYCLIN_RxL_1	60	71	PF00134	0.700
DOC_MAPK_MEF2A_6	2	9	PF00069	0.600
DOC_PP4_FxxP_1	162	165	PF00568	0.821
DOC_PP4_FxxP_1	179	182	PF00568	0.565
DOC_USP7_MATH_1	120	124	PF00917	0.906
DOC_USP7_MATH_1	126	130	PF00917	0.727
DOC_USP7_MATH_1	32	36	PF00917	0.700
DOC_WW_Pin1_4	116	121	PF00397	0.917
DOC_WW_Pin1_4	144	149	PF00397	0.859
DOC_WW_Pin1_4	161	166	PF00397	0.530
DOC_WW_Pin1_4	178	183	PF00397	0.566
LIG_14-3-3_CanoR_1	104	109	PF00244	0.871
LIG_BRCT_BRCA1_1	158	162	PF00533	0.819
LIG_Clathr_ClatBox_1	23	27	PF01394	0.700
LIG_FHA_1	145	151	PF00498	0.862
LIG_FHA_1	165	171	PF00498	0.478
LIG_FHA_1	217	223	PF00498	0.861
LIG_FHA_1	78	84	PF00498	0.700
LIG_FHA_2	71	77	PF00498	0.700
LIG_LIR_Apic_2	159	165	PF02991	0.824
LIG_LIR_Gen_1	46	53	PF02991	0.700
LIG_LIR_Gen_1	65	75	PF02991	0.462
LIG_LIR_Nem_3	46	52	PF02991	0.700
LIG_LIR_Nem_3	65	70	PF02991	0.462
LIG_MYND_1	122	126	PF01753	0.885
LIG_MYND_1	184	188	PF01753	0.892
LIG_PDZ_Class_2	228	233	PF00595	0.847
LIG_Pex14_2	49	53	PF04695	0.700
LIG_Rb_LxCxE_1	22	39	PF01857	0.700
LIG_SH2_STAT5	155	158	PF00017	0.804
LIG_SH2_STAT5	202	205	PF00017	0.873
LIG_SH3_3	114	120	PF00018	0.918
LIG_WRC_WIRS_1	49	54	PF05994	0.700
MOD_CDK_SPxxK_3	144	151	PF00069	0.860
MOD_CK1_1	144	150	PF00069	0.857
MOD_CK1_1	35	41	PF00069	0.700
MOD_CK2_1	198	204	PF00069	0.881
MOD_GlcNHglycan	206	209	PF01048	0.854
MOD_GSK3_1	116	123	PF00069	0.915
MOD_GSK3_1	139	146	PF00069	0.847
MOD_GSK3_1	178	185	PF00069	0.870
MOD_GSK3_1	194	201	PF00069	0.600
MOD_GSK3_1	225	232	PF00069	0.850
MOD_LATS_1	149	155	PF00433	0.850
MOD_N-GLC_2	18	20	PF02516	0.500
MOD_NEK2_1	156	161	PF00069	0.815
MOD_NEK2_1	225	230	PF00069	0.852
MOD_NEK2_1	53	58	PF00069	0.700
MOD_NEK2_2	48	53	PF00069	0.700
MOD_Plk_4	151	157	PF00069	0.834
MOD_Plk_4	48	54	PF00069	0.700
MOD_Plk_4	70	76	PF00069	0.700
MOD_ProDKin_1	116	122	PF00069	0.917
MOD_ProDKin_1	144	150	PF00069	0.857
MOD_ProDKin_1	161	167	PF00069	0.530
MOD_ProDKin_1	178	184	PF00069	0.570
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.831
TRG_ER_diArg_1	188	190	PF00400	0.901
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A2AQ07	MOUSE	33%	52%
A5A6J1	PANTR	74%	52%
A6NHL2	HUMAN	58%	52%
A6NNZ2	HUMAN	33%	52%
B9DGT7	ARATH	77%	52%
B9DHQ0	ARATH	74%	52%
O04386	CHLIN	36%	53%
O17449	MANSE	38%	52%
O22347	ELEIN	76%	52%
O22348	ELEIN	81%	52%
O22349	ELEIN	73%	52%
O42786	DOTSE	34%	52%
O44388	TRITR	37%	52%
O49068	ORYSJ	32%	50%
O59837	PHYCI	36%	52%
O94128	ZYMTR	59%	52%
P02550	PIG	74%	52%
P02552	CHICK	67%	57%
P02554	PIG	37%	52%
P02557	YEAST	38%	51%
P04105	PHYPO	72%	52%
P04106	TRYBR	87%	52%
P04107	TRYBR	38%	53%
P04350	HUMAN	35%	52%
P04688	SCHPO	62%	51%
P04689	SCHPO	65%	52%
P04690	CHLRE	37%	53%
P05213	MOUSE	74%	52%
P05214	MOUSE	76%	52%
P05219	SCHPO	35%	52%
P05220	NEUCR	33%	52%
P05304	GIAIN	36%	52%
P06603	DROME	74%	52%
P06604	DROME	73%	52%
P06605	DROME	74%	52%
P06606	DROME	53%	50%
P07304	STYLE	77%	52%
P07436	PHYPO	37%	50%
P07437	HUMAN	36%	52%
P08070	CHICK	60%	52%
P08537	XENLA	74%	52%
P08562	TRYCR	36%	53%
P08841	DROME	34%	51%
P09203	CHICK	37%	52%
P09204	CHLRE	80%	52%
P09205	CHLRE	80%	52%
P09206	CHICK	36%	52%
P09207	CHICK	38%	52%
P09243	STYLE	76%	52%
P09244	CHICK	36%	52%
P09644	CHICK	75%	52%
P09652	CHICK	36%	52%
P09653	CHICK	37%	52%
P09733	YEAST	61%	52%
P09734	YEAST	57%	52%
P0DPH7	HUMAN	76%	52%
P0DPH8	HUMAN	76%	52%
P10653	EMENI	34%	52%
P10872	TETPY	78%	52%
P10873	TOXGO	79%	51%
P10874	EMENI	40%	52%
P10875	CANAX	34%	52%
P10876	TETPY	36%	53%
P10878	TOXGO	36%	52%
P11139	ARATH	71%	52%
P11237	NAEGR	82%	51%
P11480	PHYPO	72%	52%
P11481	VOLCA	80%	52%
P11482	VOLCA	37%	53%
P11833	PARLI	36%	52%
P11857	STYLE	36%	53%
P12411	ARATH	33%	52%
P12456	CAEEL	37%	53%
P12457	EUGGR	30%	53%
P12458	PHYPO	35%	51%
P12459	SOYBN	33%	52%
P12460	SOYBN	36%	52%
P12543	PLAYO	74%	51%
P13602	XENLA	36%	53%
P14140	PLAFA	37%	52%
P14640	MAIZE	76%	52%
P14641	MAIZE	76%	52%
P14642	PLAFK	77%	51%
P14643	PLAFK	37%	52%
P16040	BLUHO	34%	52%
P17938	EPITY	32%	52%
P18025	MAIZE	36%	52%
P18026	MAIZE	37%	52%
P18241	BRUPA	37%	52%
P18258	PARLI	76%	52%
P18288	ONCMY	76%	52%
P18695	EMENI	35%	51%
P20365	EUPCR	34%	52%
P20802	ACHKL	36%	52%
P21148	LEIME	36%	52%
P22012	ASPFL	34%	52%
P22013	COLGR	36%	52%
P22014	COLGR	32%	52%
P22275	MAIZE	71%	52%
P22852	POLAG	36%	53%
P23257	DROME	29%	49%
P23258	HUMAN	28%	52%
P23330	XENLA	28%	52%
P24633	EMENI	58%	52%
P24634	EMENI	54%	52%
P24636	ARATH	36%	52%
P24637	PNECA	31%	53%
P25295	SCHPO	35%	52%
P28268	EUPVA	74%	52%
P28287	OXYGR	79%	52%
P28551	SOYBN	36%	57%
P28752	ORYSJ	74%	52%
P29500	PEA	34%	52%
P29501	PEA	36%	52%
P29502	PEA	37%	53%
P29511	ARATH	76%	52%
P29513	ARATH	34%	52%
P29514	ARATH	37%	52%
P29515	ARATH	37%	52%
P29516	ARATH	35%	52%
P29517	ARATH	37%	52%
P30156	ECTVR	37%	52%
P30157	ECTVR	37%	52%
P30436	ONCKE	79%	52%
P30668	SCHCO	36%	52%
P30883	XENLA	36%	52%
P31017	ENTHI	59%	51%
P31863	HYPRU	38%	52%
P31864	HYPRU	37%	52%
P32255	DICDI	57%	51%
P32256	DICDI	35%	51%
P32348	USTVI	35%	50%
P32882	CHICK	37%	52%
P32924	GEOCN	38%	52%
P32925	GEOCN	37%	51%
P32928	COLGL	34%	52%
P33127	EPICN	32%	52%
P33188	PARTE	37%	53%
P33623	ANEPH	77%	52%
P33625	EUGGR	79%	52%
P33626	MAIZE	76%	100%
P33627	MAIZE	73%	52%
P33628	PICAB	73%	100%
P33629	PRUDU	76%	52%
P33630	ANEPH	36%	53%
P34108	NAEPR	36%	52%
P34690	CAEEL	63%	52%
P34785	ANEPH	32%	49%
P34786	EUPOC	31%	51%
P34787	PLAFO	28%	52%
P35394	ENTDO	38%	52%
P36220	TORMA	74%	52%
P36221	NOTNE	37%	52%
P37392	LUPAL	36%	52%
P37832	ORYSJ	35%	52%
P38557	ARATH	37%	49%
P38558	ARATH	38%	49%
P38668	NEUCR	52%	51%
P38669	NEUCR	62%	52%
P40633	COCH5	31%	51%
P40904	COLGL	32%	52%
P40905	ERYPI	34%	52%
P41351	TETTH	78%	52%
P41352	TETTH	36%	53%
P41383	PATVU	76%	52%
P41385	BOMMO	37%	52%
P41387	ONCGI	31%	52%
P41388	VENIN	34%	52%
P41741	ACRCH	32%	52%
P41742	AJECA	34%	52%
P41799	PHANO	34%	52%
P41937	CAEEL	38%	52%
P42271	DROME	37%	51%
P45960	ORYSJ	37%	52%
P46259	PEA	83%	52%
P46263	SOLTU	36%	52%
P46264	SOLTU	36%	52%
P46265	ORYSJ	36%	52%
P49741	SCHCO	63%	52%
P49742	SCHCO	59%	52%
P50258	PHYPO	78%	52%
P50259	PORPU	36%	51%
P50261	OOMCK	34%	52%
P50262	OOMCK	36%	52%
P50719	HAECO	69%	52%
P52273	BOMMO	74%	52%
P52274	CAEEL	52%	52%
P52275	CAEEL	37%	52%
P53371	AJECA	62%	56%
P53372	PNECA	61%	52%
P53373	BOTFU	34%	52%
P53374	GIBFU	32%	52%
P53375	PENDI	34%	52%
P53376	RHYSE	34%	52%
P53377	NEUCR	35%	51%
P54401	ENTHI	42%	52%
P54402	EUPAE	31%	51%
P54403	EUPCR	31%	50%
P54404	EUPCR	35%	50%
P54405	RETFI	31%	49%
P61857	DROME	34%	52%
P61858	DROHY	34%	52%
P68360	MERUN	74%	52%
P68361	CRIGR	74%	52%
P68362	CRIGR	74%	52%
P68363	HUMAN	74%	52%
P68365	CRIGR	74%	52%
P68366	HUMAN	75%	52%
P68367	MACFA	75%	52%
P68368	MOUSE	75%	52%
P68369	MOUSE	74%	52%
P68370	RAT	74%	52%
P68371	HUMAN	36%	52%
P68372	MOUSE	36%	52%
P68373	MOUSE	74%	52%
P69893	CRIGR	36%	52%
P69895	MACMU	36%	52%
P69897	RAT	36%	52%
P79008	COPC7	36%	52%
P81947	BOVIN	74%	52%
P81948	BOVIN	75%	52%
P83130	DROER	34%	52%
P83887	MOUSE	28%	52%
P83888	RAT	28%	52%
P85108	RAT	37%	52%
P86221	MESAU	36%	80%
P87066	CANAX	59%	52%
P90548	EUPOC	31%	51%
P91910	CAEEL	69%	52%
P92120	ENCHE	40%	61%
P93176	HORVU	37%	52%
P99024	MOUSE	36%	52%
Q00264	ASPPA	34%	52%
Q02245	MAIZE	72%	52%
Q04709	BABBO	36%	53%
Q06331	ENTDO	78%	52%
Q08114	EUPOC	78%	52%
Q08115	EUPOC	35%	52%
Q0VCD2	BOVIN	28%	52%
Q0WV25	ARATH	77%	52%
Q13509	HUMAN	36%	52%
Q13885	HUMAN	37%	52%
Q17299	CAEBR	37%	53%
Q24560	DROME	36%	52%
Q24829	ENCHE	37%	53%
Q25008	HOMAM	78%	52%
Q25009	HOMAM	37%	52%
Q25563	NAEPR	81%	51%
Q27352	TRYCR	86%	52%
Q27380	EIMTE	35%	52%
Q27U48	GLOMM	36%	52%
Q28IX8	XENTR	71%	52%
Q2HJ81	BOVIN	37%	52%
Q2HJ86	BOVIN	73%	52%
Q2HJB8	BOVIN	62%	52%
Q2KJD0	BOVIN	36%	52%
Q2T9S0	BOVIN	36%	52%
Q2U2U3	ASPOR	34%	52%
Q2XVP4	PIG	74%	52%
Q32KM1	BOVIN	28%	52%
Q32KN8	BOVIN	76%	52%
Q38771	AVESA	81%	52%
Q39445	CICAR	32%	52%
Q39582	CHLRE	33%	50%
Q39697	DAUCA	38%	52%
Q3KRE8	RAT	37%	52%
Q3KVN1	CERBT	34%	52%
Q3MHM5	BOVIN	36%	52%
Q3UX10	MOUSE	54%	52%
Q3ZBU7	BOVIN	35%	52%
Q3ZCJ7	BOVIN	74%	52%
Q3ZCM7	HUMAN	34%	52%
Q40106	LUPAL	35%	52%
Q40665	ORYSJ	36%	52%
Q40831	PELFA	72%	51%
Q40832	PELFA	76%	51%
Q41782	MAIZE	32%	52%
Q41783	MAIZE	37%	52%
Q41784	MAIZE	36%	52%
Q41785	MAIZE	36%	52%
Q41807	MAIZE	33%	50%
Q41808	MAIZE	33%	50%
Q42480	CHOCR	32%	51%
Q43473	HORVU	80%	52%
Q43594	ORYSJ	37%	52%
Q43695	MAIZE	33%	52%
Q43697	MAIZE	37%	52%
Q4HZS8	GIBZE	32%	52%
Q4P235	USTMA	36%	52%
Q4QRB4	RAT	36%	52%
Q4R4X8	MACFA	35%	52%
Q4R538	MACFA	74%	52%
Q4R5B3	MACFA	37%	52%
Q4R9N3	COCHE	34%	52%
Q4WA70	ASPFU	39%	52%
Q52NY7	METAN	32%	52%
Q52PV9	TYRPU	72%	52%
Q53M52	ORYSJ	76%	52%
Q55AR3	DICDI	33%	50%
Q56WH1	ARATH	74%	52%
Q56YW9	ARATH	36%	52%
Q5I2J3	GIBZE	65%	52%
Q5R1W4	PANTR	74%	52%
Q5R943	PONAB	36%	52%
Q5UBX3	TRIRU	35%	52%
Q5XIF6	RAT	75%	52%
Q60HC2	MACFA	36%	52%
Q68FR8	RAT	76%	52%
Q6AY56	RAT	62%	52%
Q6AYZ1	RAT	74%	52%
Q6B856	BOVIN	37%	52%
Q6EVK8	SUIBO	36%	52%
Q6FNU9	CANGA	36%	50%
Q6GLE7	XENTR	36%	52%
Q6P9T8	RAT	36%	52%
Q6P9V9	RAT	74%	52%
Q6PEY2	HUMAN	76%	52%
Q6QDC9	ZYMTR	34%	52%
Q6VAF4	GOSHI	36%	52%
Q6VAF5	GOSHI	31%	52%
Q6VAF6	GOSHI	32%	52%
Q6VAF7	GOSHI	35%	52%
Q6VAF8	GOSHI	37%	54%
Q6VAF9	GOSHI	84%	52%
Q6VAG0	GOSHI	84%	52%
Q6VAG1	GOSHI	76%	52%
Q71G51	NEOCA	79%	51%
Q71U36	HUMAN	74%	52%
Q752Y2	ASHGO	61%	52%
Q75A43	ASHGO	40%	50%
Q767L7	PIG	36%	52%
Q76FS2	ORYSJ	36%	52%
Q76FS3	ORYSJ	37%	52%
Q7JJU6	PANTR	36%	52%
Q7KQL5	PLAF7	37%	52%
Q7TMM9	MOUSE	37%	52%
Q7Z9Z2	COPC7	29%	51%
Q84TG9	NEOYE	38%	51%
Q86ZP5	UNCNE	34%	52%
Q875L2	HYPVI	38%	52%
Q875L3	HYPVI	35%	52%
Q8H7U1	ORYSJ	36%	52%
Q8J1R4	SUIBO	32%	52%
Q8SRD2	ENCCU	35%	54%
Q8SRI6	ENCCU	51%	53%
Q8SS99	ENCCU	36%	53%
Q8T6A5	APLCA	73%	52%
Q8VCK3	MOUSE	31%	52%
Q8WP13	PAPHA	32%	52%
Q8WP14	PANTR	34%	52%
Q8WQ47	LEPDS	72%	52%
Q8WZE0	USTVI	34%	52%
Q91060	NOTVI	72%	52%
Q91240	PSEAM	36%	52%
Q91575	XENLA	36%	52%
Q92268	PLESA	36%	52%
Q922F4	MOUSE	34%	52%
Q92335	SORMK	62%	52%
Q94570	HOMAM	74%	52%
Q94571	HOMAM	38%	52%
Q94572	HOMAM	79%	52%
Q962P8	NAEPR	49%	52%
Q96460	HORVU	83%	52%
Q96TU8	UROFA	35%	52%
Q9ASR0	ARATH	36%	52%
Q9BQE3	HUMAN	74%	52%
Q9BUF5	HUMAN	36%	52%
Q9BVA1	HUMAN	37%	52%
Q9C413	COLOR	49%	51%
Q9CWF2	MOUSE	37%	52%
Q9D6F9	MOUSE	35%	52%
Q9ERD7	MOUSE	36%	52%
Q9FT36	DAUCA	73%	52%
Q9GKK5	CANLF	28%	52%
Q9GSR5	ENCIN	36%	53%
Q9H4B7	HUMAN	33%	52%
Q9HFQ3	MELLI	34%	52%
Q9JJZ2	MOUSE	62%	52%
Q9LKI8	THAWE	36%	53%
Q9N2N6	EUPFO	35%	52%
Q9NFZ5	ECHMU	38%	53%
Q9NFZ6	ECHMU	37%	52%
Q9NFZ7	ECHMU	38%	52%
Q9NRH3	HUMAN	28%	52%
Q9NY65	HUMAN	62%	52%
Q9SCC8	GUITH	62%	52%
Q9SEV2	GUITH	32%	53%
Q9UV72	PESMI	32%	52%
Q9XFG3	PHYPA	32%	49%
Q9Y882	SCHJP	36%	52%
Q9YHC3	GADMO	36%	52%
Q9ZPN7	ELEIN	37%	52%
Q9ZPN8	ELEIN	36%	52%
Q9ZPN9	ELEIN	38%	52%
Q9ZPP0	ELEIN	36%	52%
Q9ZRA8	WHEAT	37%	52%
Q9ZRA9	WHEAT	36%	52%
Q9ZRB0	WHEAT	35%	52%
Q9ZRB1	WHEAT	37%	52%
Q9ZRB2	WHEAT	37%	52%
Q9ZRB7	WHEAT	83%	52%
Q9ZRJ4	CHLVU	79%	52%
Q9ZRR5	HORVU	76%	52%
Q9ZSW1	CYAPA	34%	52%