VQ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H726_LEIBR

TriTrypDb:

LbrM.13.0180 , LBRM2903_130007000

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H726

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H726

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.662
CLV_NRD_NRD_1	245	247	PF00675	0.613
CLV_NRD_NRD_1	84	86	PF00675	0.562
CLV_PCSK_FUR_1	82	86	PF00082	0.552
CLV_PCSK_KEX2_1	118	120	PF00082	0.663
CLV_PCSK_KEX2_1	177	179	PF00082	0.626
CLV_PCSK_KEX2_1	232	234	PF00082	0.549
CLV_PCSK_KEX2_1	247	249	PF00082	0.628
CLV_PCSK_KEX2_1	84	86	PF00082	0.562
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.601
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.505
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.431
CLV_PCSK_PC7_1	114	120	PF00082	0.519
CLV_PCSK_SKI1_1	174	178	PF00082	0.613
CLV_PCSK_SKI1_1	187	191	PF00082	0.568
CLV_PCSK_SKI1_1	232	236	PF00082	0.656
DEG_Kelch_Keap1_1	279	284	PF01344	0.611
DEG_ODPH_VHL_1	155	167	PF01847	0.526
DEG_ODPH_VHL_1	5	18	PF01847	0.463
DEG_SPOP_SBC_1	261	265	PF00917	0.554
DOC_ANK_TNKS_1	117	124	PF00023	0.521
DOC_CKS1_1	113	118	PF01111	0.518
DOC_CKS1_1	193	198	PF01111	0.686
DOC_MAPK_FxFP_2	29	32	PF00069	0.464
DOC_MAPK_gen_1	118	126	PF00069	0.523
DOC_MAPK_MEF2A_6	118	126	PF00069	0.523
DOC_PP2B_LxvP_1	158	161	PF13499	0.578
DOC_PP4_FxxP_1	29	32	PF00568	0.464
DOC_USP7_MATH_1	125	129	PF00917	0.772
DOC_USP7_MATH_1	188	192	PF00917	0.506
DOC_USP7_MATH_1	23	27	PF00917	0.474
DOC_USP7_MATH_1	261	265	PF00917	0.562
DOC_USP7_MATH_1	267	271	PF00917	0.644
DOC_USP7_MATH_1	95	99	PF00917	0.534
DOC_WW_Pin1_4	112	117	PF00397	0.493
DOC_WW_Pin1_4	19	24	PF00397	0.467
DOC_WW_Pin1_4	192	197	PF00397	0.688
DOC_WW_Pin1_4	257	262	PF00397	0.623
DOC_WW_Pin1_4	263	268	PF00397	0.677
DOC_WW_Pin1_4	302	307	PF00397	0.539
DOC_WW_Pin1_4	75	80	PF00397	0.526
DOC_WW_Pin1_4	99	104	PF00397	0.520
LIG_14-3-3_CanoR_1	118	126	PF00244	0.734
LIG_14-3-3_CanoR_1	187	193	PF00244	0.633
LIG_14-3-3_CanoR_1	233	238	PF00244	0.648
LIG_14-3-3_CanoR_1	84	90	PF00244	0.685
LIG_APCC_ABBA_1	341	346	PF00400	0.518
LIG_BRCT_BRCA1_1	25	29	PF00533	0.463
LIG_EVH1_1	192	196	PF00568	0.687
LIG_FHA_1	107	113	PF00498	0.592
LIG_FHA_1	13	19	PF00498	0.534
LIG_FHA_1	160	166	PF00498	0.599
LIG_FHA_1	23	29	PF00498	0.471
LIG_FHA_1	99	105	PF00498	0.560
LIG_FHA_2	88	94	PF00498	0.565
LIG_LIR_Apic_2	26	32	PF02991	0.467
LIG_LIR_Gen_1	270	278	PF02991	0.685
LIG_LIR_Gen_1	72	79	PF02991	0.637
LIG_LIR_Nem_3	175	179	PF02991	0.626
LIG_LIR_Nem_3	236	240	PF02991	0.635
LIG_LIR_Nem_3	241	245	PF02991	0.563
LIG_LIR_Nem_3	265	271	PF02991	0.694
LIG_LIR_Nem_3	72	77	PF02991	0.636
LIG_Pex14_2	206	210	PF04695	0.459
LIG_Pex14_2	29	33	PF04695	0.467
LIG_PTB_Apo_2	204	211	PF02174	0.517
LIG_PTB_Apo_2	236	243	PF02174	0.565
LIG_SH2_CRK	312	316	PF00017	0.538
LIG_SH2_GRB2like	271	274	PF00017	0.690
LIG_SH2_NCK_1	180	184	PF00017	0.619
LIG_SH2_NCK_1	271	275	PF00017	0.687
LIG_SH2_STAT5	147	150	PF00017	0.583
LIG_SH2_STAT5	347	350	PF00017	0.550
LIG_SH2_STAT5	356	359	PF00017	0.515
LIG_SH2_STAT5	61	64	PF00017	0.478
LIG_SH3_3	158	164	PF00018	0.664
LIG_SH3_3	190	196	PF00018	0.682
LIG_TYR_ITIM	235	240	PF00017	0.578
LIG_WRC_WIRS_1	74	79	PF05994	0.523
MOD_CDK_SPxK_1	112	118	PF00069	0.519
MOD_CDK_SPxxK_3	112	119	PF00069	0.520
MOD_CDK_SPxxK_3	192	199	PF00069	0.527
MOD_CDK_SPxxK_3	75	82	PF00069	0.529
MOD_CK1_1	21	27	PF00069	0.584
MOD_CK1_1	260	266	PF00069	0.667
MOD_CK1_1	67	73	PF00069	0.497
MOD_CK1_1	87	93	PF00069	0.530
MOD_CK1_1	98	104	PF00069	0.524
MOD_CK2_1	216	222	PF00069	0.554
MOD_CK2_1	269	275	PF00069	0.687
MOD_CK2_1	278	284	PF00069	0.614
MOD_CK2_1	301	307	PF00069	0.557
MOD_GlcNHglycan	119	122	PF01048	0.726
MOD_GlcNHglycan	127	130	PF01048	0.759
MOD_GlcNHglycan	142	145	PF01048	0.548
MOD_GlcNHglycan	331	334	PF01048	0.698
MOD_GlcNHglycan	64	67	PF01048	0.482
MOD_GlcNHglycan	69	72	PF01048	0.489
MOD_GSK3_1	134	141	PF00069	0.549
MOD_GSK3_1	159	166	PF00069	0.651
MOD_GSK3_1	18	25	PF00069	0.539
MOD_GSK3_1	183	190	PF00069	0.667
MOD_GSK3_1	257	264	PF00069	0.687
MOD_GSK3_1	278	285	PF00069	0.692
MOD_GSK3_1	69	76	PF00069	0.510
MOD_GSK3_1	80	87	PF00069	0.528
MOD_GSK3_1	89	96	PF00069	0.522
MOD_N-GLC_1	329	334	PF02516	0.572
MOD_NEK2_1	106	111	PF00069	0.714
MOD_NEK2_1	278	283	PF00069	0.692
MOD_NEK2_1	62	67	PF00069	0.600
MOD_NEK2_1	69	74	PF00069	0.578
MOD_OFUCOSY	214	220	PF10250	0.570
MOD_PIKK_1	87	93	PF00454	0.568
MOD_PKA_1	246	252	PF00069	0.746
MOD_PKA_1	84	90	PF00069	0.566
MOD_PKA_2	117	123	PF00069	0.733
MOD_PKA_2	55	61	PF00069	0.478
MOD_PKA_2	84	90	PF00069	0.566
MOD_PKB_1	82	90	PF00069	0.560
MOD_Plk_4	23	29	PF00069	0.476
MOD_Plk_4	64	70	PF00069	0.607
MOD_ProDKin_1	112	118	PF00069	0.494
MOD_ProDKin_1	19	25	PF00069	0.466
MOD_ProDKin_1	192	198	PF00069	0.686
MOD_ProDKin_1	257	263	PF00069	0.622
MOD_ProDKin_1	302	308	PF00069	0.532
MOD_ProDKin_1	75	81	PF00069	0.526
MOD_ProDKin_1	99	105	PF00069	0.520
MOD_SUMO_rev_2	170	179	PF00179	0.598
TRG_ENDOCYTIC_2	180	183	PF00928	0.618
TRG_ENDOCYTIC_2	237	240	PF00928	0.641
TRG_ENDOCYTIC_2	271	274	PF00928	0.790
TRG_ENDOCYTIC_2	312	315	PF00928	0.540
TRG_ENDOCYTIC_2	74	77	PF00928	0.650
TRG_ER_diArg_1	117	119	PF00400	0.661
TRG_ER_diArg_1	245	248	PF00400	0.582
TRG_ER_diArg_1	82	85	PF00400	0.549
TRG_NLS_Bipartite_1	232	250	PF00514	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9J1	Leishmania donovani	78%	100%
A4HVF5	Leishmania infantum	75%	100%
E9AP53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QGD5	Leishmania major	79%	100%